ONTOLOGY REPORT - ANNOTATIONS

Term:pemetrexed
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Accession:CHEBI:63616 term browser browse the term
Definition:An N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT).
Synonyms:exact_synonym: N-{4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid
 related_synonym: C20H21N5O6;   InChI=1S/C20H21N5O6/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)/t13-/m0/s1;   InChIKey=WBXPDJSOTKVWSJ-ZDUSSCGKSA-N;   Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)c[nH]c2[nH]1
 xref_casrn: 137281-23-3
 xref: ChemIDplus:137281-23-3 "CAS Registry Number";   CiteXplore:21129871 "PubMed citation";   CiteXplore:21831719 "PubMed citation";   CiteXplore:21900836 "PubMed citation";   CiteXplore:21937141 "PubMed citation";   CiteXplore:22021325 "PubMed citation";   CiteXplore:22116317 "PubMed citation";   CiteXplore:22124474 "PubMed citation";   CiteXplore:22134068 "PubMed citation";   CiteXplore:22201521 "PubMed citation";   CiteXplore:22223137 "PubMed citation";   CiteXplore:22237209 "PubMed citation";   CiteXplore:22240216 "PubMed citation";   CiteXplore:22243773 "PubMed citation";   CiteXplore:22244076 "PubMed citation";   CiteXplore:22258853 "PubMed citation";   DrugBank:DB00642 "DrugBank";   KEGG DRUG:137281-23-3 "CAS Registry Number";   KEGG DRUG:D07472 "KEGG DRUG"
 xref_mesh: MESH:C085586
 xref: Patent:EP432677 "Patent";   Patent:US5344932 "Patent";   Reaxys:9097855 "Reaxys Registry Number";   Wikipedia:Pemetrexed "Wikipedia"
 cyclic_relationship: is_conjugate_acid_of CHEBI:63724

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pemetrexed term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Alk anaplastic lymphoma receptor tyrosine kinase GBrowse link affects response to substance ISO 6 23,009,061 23,730,939 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bid BH3 interacting domain death agonist GBrowse link multiple interactions ISO 4 157,296,383 157,318,481 RGD:6480464 CTD
G Ccnd1 cyclin D1 GBrowse link multiple interactions ISO 1 205,357,235 205,366,757 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link multiple interactions ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cflar CASP8 and FADD-like apoptosis regulator GBrowse link decreases response to substance ISO 9 57,309,836 57,356,635 RGD:6480464 CTD
G Ddit3 DNA-damage inducible transcript 3 GBrowse link multiple interactions ISO 7 67,247,749 67,252,571 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link increases expression ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link multiple interactions ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fpgs folylpolyglutamate synthase increases response to substance ISO RGD:6480464 CTD
G Ggh gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) GBrowse link affects response to substance ISO 5 34,670,883 34,693,791 RGD:6480464 CTD
G Rbm17 RNA binding motif protein 17 GBrowse link decreases response to substance ISO 17 78,139,912 78,156,805 RGD:6480464 CTD
G Slc19a1 solute carrier family 19 (folate transporter), member 1 GBrowse link increases response to substance ISO 20 11,984,283 12,001,865 RGD:6480464 CTD
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b GBrowse link multiple interactions ISO 15 50,138,439 50,163,254 RGD:6480464 CTD
G Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b GBrowse link increases expression ISO 15 50,138,439 50,163,254 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link affects response to substance ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link multiple interactions ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link decreases activity ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link affects response to substance ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link affects response to substance ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        biochemical role 193861
          antimetabolite 6424
            pemetrexed 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic group 167766
                              organic divalent group 166601
                                organodiyl group 166601
                                  carbonyl group 166291
                                    carbonyl compound 166291
                                      carboxylic acid 121484
                                        amino acid 49829
                                          modified amino acid 8436
                                            glutamic acid derivative 3550
                                              N-acylglutamic acid 21
                                                pemetrexed 21
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