etoricoxib - Ontology Report - Rat Genome Database

Keyword

ONTOLOGY REPORT - ANNOTATIONS

Term:	etoricoxib	go back to main search page
Accession:	CHEBI:6339	browse the term
Definition:	A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively.
Synonyms:	exact_synonym:	5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
	related_synonym:	5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl; 5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine; 5-chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine; C18H15ClN2O2S; Cc1ccc(cn1)-c1ncc(Cl)cc1-c1ccc(cc1)S(C)(=O)=O; InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3; InChIKey=MNJVRJDLRVPLFE-UHFFFAOYSA-N; L791456; etoricoxibum
	alt_id:	CHEBI:106706
	xref_casrn:	202409-33-4
	xref:	ChEMBL:106706 "ChEMBL COMPOUND"; ChEMBL:11327589 "PubMed citation"; ChEMBL:14761182 "PubMed citation"; ChEMBL:15239665 "PubMed citation"; ChEMBL:15454242 "PubMed citation"; ChEMBL:15916445 "PubMed citation"; ChemIDplus:202409-33-4 "CAS Registry Number"; DrugBank:DB01628 "DrugBank"; KEGG COMPOUND:202409-33-4 "CAS Registry Number"; KEGG COMPOUND:C11718 "KEGG COMPOUND"; KEGG DRUG:D03710 "KEGG DRUG"
	xref_mesh:	MESH:C422649
	xref:	Wikipedia:Etoricoxib "Wikipedia"

etoricoxib
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	ABCB11	ATP-binding cassette, sub-family B (MDR/TAP), member 11		decreases activity	EXP	2	169,779,449	169,887,833	RGD:6480464	CTD
G	CYP1A2	cytochrome P450, family 1, subfamily A, polypeptide 2		decreases activity	EXP	15	75,041,184	75,048,941	RGD:6480464	CTD
G	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4		increases metabolic processing	EXP	7	99,354,583	99,381,811	RGD:6480464	CTD
G	ICAM1	intercellular adhesion molecule 1		decreases expression	EXP	19	10,381,517	10,397,291	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	513708
role	503229
application	255100
anti-inflammatory agent	36083
anti-inflammatory drug	22967
non-steroidal anti-inflammatory drug	18456
etoricoxib	8
Path 2
Term	Annotations
CHEBI ontology	513708
subatomic particle	512601
composite particle	512601
hadron	512601
baryon	512601
nucleon	512601
atomic nucleus	512601
atom	512601
main group element atom	480609
p-block element atom	478027
carbon group element atom	427614
carbon atom	424022
organic molecular entity	424015
organic molecule	375005
organic cyclic compound	311241
organic heterocyclic compound	160121
organonitrogen heterocyclic compound	80963
bipyridines	1619
etoricoxib	8