ONTOLOGY REPORT - ANNOTATIONS

Term:irbesartan
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Accession:CHEBI:5959 term browser browse the term
Definition:A biphenylyltetrazole that has formula C25H28N6O.
Synonyms:related_synonym: 2-butyl-3-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one;   Avapro;   BMS 186295;   C25H28N6O;   CCCCC1=NC2(CCCC2)C(=O)N1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1;   InChI=1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30);   InChIKey=YOSHYTLCDANDAN-UHFFFAOYSA-N
 xref_casrn: 138402-11-6
 xref: Beilstein:6620400 "Beilstein Registry Number";   ChEMBL:521066 "ChEMBL COMPOUND";   ChemIDplus:138402-11-6 "CAS Registry Number";   DrugBank:DB01029 "DrugBank";   KEGG COMPOUND:138402-11-6 "CAS Registry Number";   KEGG COMPOUND:C07469 "KEGG COMPOUND";   KEGG DRUG:D00523 "KEGG DRUG"
 xref_mesh: MESH:C081309
 xref: Patent:US5270317 "Patent";   Patent:WO9114679 "Patent";   Wikipedia:Irbesartan "Wikipedia"

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Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 GBrowse link affects response to substance ISO X 51,051,758 51,096,036 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link affects response to substance ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link affects response to substance ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link increases expression ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link multiple interactions ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link increases expression ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link multiple interactions ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agtr1a angiotensin II receptor, type 1a GBrowse link affects response to substance ISO 17 40,629,318 40,684,982 RGD:6480464 CTD
G Agtr1a angiotensin II receptor, type 1a GBrowse link multiple interactions ISO 17 40,629,318 40,684,982 RGD:6480464 CTD
G Agtr1a angiotensin II receptor, type 1a GBrowse link multiple interactions ISO 17 40,629,318 40,684,982 RGD:6480464 CTD
G Agtr1a angiotensin II receptor, type 1a GBrowse link multiple interactions ISO 17 40,629,318 40,684,982 RGD:6480464 CTD
G Agtr1b angiotensin II receptor, type 1b GBrowse link multiple interactions ISO 2 105,503,269 105,602,591 RGD:6480464 CTD
G Agtr1b angiotensin II receptor, type 1b GBrowse link multiple interactions ISO 2 105,503,269 105,602,591 RGD:6480464 CTD
G Agtr1b angiotensin II receptor, type 1b GBrowse link affects response to substance ISO 2 105,503,269 105,602,591 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Apob apolipoprotein B GBrowse link affects response to substance ISO 6 31,508,060 31,548,083 RGD:6480464 CTD
G Apob apolipoprotein B GBrowse link affects response to substance ISO 6 31,508,060 31,548,083 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions EXP 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bdkrb2 bradykinin receptor B2 GBrowse link affects response to substance ISO 6 129,744,781 129,748,851 RGD:6480464 CTD
G Ca1 carbonic anhydrase I GBrowse link decreases activity ISO 2 88,166,412 88,210,693 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 GBrowse link increases response to substance ISO 7 113,043,365 113,049,779 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link increases metabolic processing ISO 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 GBrowse link decreases response to substance ISO 1 243,281,320 243,320,945 RGD:6480464 CTD
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 GBrowse link decreases activity ISO 1 244,400,004 244,493,624 RGD:6480464 CTD
G Edn1 endothelin 1 GBrowse link affects response to substance ISO 17 28,303,886 28,309,775 RGD:6480464 CTD
G Erap1 endoplasmic reticulum aminopeptidase 1 GBrowse link affects response to substance ISO 2 1,453,878 1,492,671 RGD:6480464 CTD
G F3 coagulation factor III (thromboplastin, tissue factor) GBrowse link multiple interactions EXP 2 218,371,050 218,382,645 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link decreases expression ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions ISO 4 456,799 461,376 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link multiple interactions ISO 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta GBrowse link multiple interactions ISO 1 83,865,440 83,873,010 RGD:6480464 CTD
G Nphs1 nephrosis 1, congenital, Finnish type (nephrin) GBrowse link multiple interactions EXP 1 85,414,492 85,444,233 RGD:6480464 CTD
G Nppa natriuretic peptide A GBrowse link increases expression ISO 5 165,074,518 165,075,827 RGD:6480464 CTD
G Potef POTE ankyrin domain family, member F GBrowse link multiple interactions EXP 18 24,420,779 24,422,284 RGD:6480464 CTD
G Rac1 ras-related C3 botulinum toxin substrate 1 GBrowse link multiple interactions ISO 12 11,380,314 11,400,531 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Ren renin GBrowse link increases expression ISO 13 46,262,936 46,275,213 RGD:6480464 CTD
G Ret ret proto-oncogene GBrowse link increases expression ISO 4 154,448,179 154,491,103 RGD:6480464 CTD
G Smad2 SMAD family member 2 GBrowse link multiple interactions EXP 18 73,180,520 73,241,707 RGD:6480464 CTD
G Smad2 SMAD family member 2 GBrowse link affects expression EXP 18 73,180,520 73,241,707 RGD:6480464 CTD
G Smad3 SMAD family member 3 GBrowse link multiple interactions EXP 8 67,803,909 67,952,056 RGD:6480464 CTD
G Smad3 SMAD family member 3 GBrowse link affects expression EXP 8 67,803,909 67,952,056 RGD:6480464 CTD
G Tfpi tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) GBrowse link multiple interactions EXP 3 67,654,389 67,697,178 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link affects response to substance ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link decreases expression EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link affects expression EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Vcam1 vascular cell adhesion molecule 1 GBrowse link multiple interactions ISO 2 212,277,654 212,297,376 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492507
    role 482196
      application 245130
        pharmaceutical 173979
          drug 173776
            antihypertensive agent 5778
              irbesartan 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 492507
    subatomic particle 491470
      composite particle 491470
        hadron 491470
          baryon 491470
            nucleon 491470
              atomic nucleus 491470
                atom 491470
                  main group element atom 461139
                    p-block element atom 458635
                      carbon group element atom 410624
                        carbon atom 407181
                          organic molecular entity 407174
                            organic molecule 298374
                              organic cyclic compound 298293
                                organic heterocyclic compound 154322
                                  organic heteromonocyclic compound 58883
                                    mancude organic heteromonocyclic parent 8898
                                      azole 7417
                                        tetrazoles 902
                                          biphenylyltetrazole 825
                                            irbesartan 52
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