ONTOLOGY REPORT - ANNOTATIONS

Term:cetrorelix
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Accession:CHEBI:59224 term browser browse the term
Definition:A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Synonyms:exact_synonym: N-acetyl-3-(naphthalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N(5)-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide
 related_synonym: C70H92ClN17O14;   CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O;   InChI=1S/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+/m1/s1;   InChIKey=SBNPWPIBESPSIF-MHWMIDJBSA-N;   cetrorelixum
 xref_casrn: 120287-85-6
 xref: Beilstein:5860649 "Beilstein Registry Number";   ChEMBL:774441 "ChEMBL COMPOUND";   ChemIDplus:120287-85-6 "CAS Registry Number";   DrugBank:DB00050 "DrugBank";   KEGG DRUG:D07665 "KEGG DRUG"
 xref_mesh: MESH:C062876
 xref: Patent:EP299402 "Patent";   Patent:US4800191 "Patent";   Wikipedia:Cetrorelix "Wikipedia"

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cetrorelix term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Apoe apolipoprotein E GBrowse link multiple interactions ISO 7 20,281,593 20,284,515 RGD:6480464 CTD
G Bax BCL2-associated X protein GBrowse link increases expression EXP 7 52,717,065 52,722,268 RGD:6480464 CTD
G Bax BCL2-associated X protein GBrowse link increases expression ISO 7 52,717,065 52,722,268 RGD:6480464 CTD
G Bcl2 B cell leukemia/lymphoma 2 GBrowse link decreases expression ISO 1 108,434,756 108,610,867 RGD:6480464 CTD
G Bcl2l1 BCL2-like 1 GBrowse link decreases expression ISO 2 152,606,404 152,657,418 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 8 47,702,803 47,724,071 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity EXP 8 47,702,803 47,724,071 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 8 47,702,803 47,724,071 RGD:6480464 CTD
G Casp9 caspase 9 GBrowse link increases activity EXP 4 141,349,527 141,371,890 RGD:6480464 CTD
G Casp9 caspase 9 GBrowse link increases activity ISO 4 141,349,527 141,371,890 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) GBrowse link increases expression ISO 17 29,227,931 29,237,667 RGD:6480464 CTD
G Chga chromogranin A GBrowse link multiple interactions ISO 12 103,793,179 103,803,237 RGD:6480464 CTD
G Clcf1 cardiotrophin-like cytokine factor 1 GBrowse link decreases expression ISO 19 4,214,392 4,222,615 RGD:6480464 CTD
G Cst9 cystatin 9 GBrowse link multiple interactions ISO 2 148,660,883 148,664,473 RGD:6480464 CTD
G Cxcl12 chemokine (C-X-C motif) ligand 12 GBrowse link decreases expression ISO 6 117,118,553 117,131,386 RGD:6480464 CTD
G Cyb5 cytochrome b-5 GBrowse link multiple interactions ISO 18 85,020,806 85,049,255 RGD:6480464 CTD
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link multiple interactions ISO 9 57,862,824 57,874,830 RGD:6480464 CTD
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link multiple interactions ISO 19 46,741,655 46,747,490 RGD:6480464 CTD
G Ddr1 discoidin domain receptor family, member 1 GBrowse link multiple interactions ISO 17 35,818,512 35,841,084 RGD:6480464 CTD
G Dhcr24 24-dehydrocholesterol reductase GBrowse link multiple interactions ISO 4 106,233,643 106,261,718 RGD:6480464 CTD
G Dpep3 dipeptidase 3 GBrowse link multiple interactions ISO 8 108,497,420 108,503,319 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily member 6) GBrowse link increases expression EXP 19 34,365,149 34,402,260 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily member 6) GBrowse link increases expression ISO 19 34,365,149 34,402,260 RGD:6480464 CTD
G Fshb follicle stimulating hormone beta GBrowse link decreases expression ISO 2 106,896,297 106,899,808 RGD:6480464 CTD
G Fshb follicle stimulating hormone beta GBrowse link decreases expression ISO 2 106,896,297 106,899,808 RGD:6480464 CTD
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) GBrowse link multiple interactions ISO 9 78,178,827 78,194,952 RGD:6480464 CTD
G Hcrtr1 hypocretin (orexin) receptor 1 GBrowse link decreases expression ISO 4 129,807,461 129,816,406 RGD:6480464 CTD
G Hcrtr2 hypocretin (orexin) receptor 2 GBrowse link decreases expression ISO 9 76,073,687 76,171,385 RGD:6480464 CTD
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 GBrowse link multiple interactions ISO 3 98,084,354 98,114,661 RGD:6480464 CTD
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 GBrowse link multiple interactions ISO 10 127,427,992 127,444,564 RGD:6480464 CTD
G Igf1 insulin-like growth factor 1 GBrowse link decreases expression ISO 10 87,321,801 87,399,792 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link decreases expression ISO 5 30,339,701 30,346,508 RGD:6480464 CTD
G Insl3 insulin-like 3 GBrowse link multiple interactions ISO 8 74,213,151 74,214,474 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link decreases expression ISO 7 52,673,729 52,675,734 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link decreases expression ISO 7 52,673,729 52,675,734 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link decreases expression ISO 7 52,673,729 52,675,734 RGD:6480464 CTD
G Mapk1 mitogen-activated protein kinase 1 GBrowse link decreases phosphorylation ISO 16 16,983,475 17,047,546 RGD:6480464 CTD
G Mapk3 mitogen-activated protein kinase 3 GBrowse link decreases phosphorylation ISO 7 133,903,140 133,909,330 RGD:6480464 CTD
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 GBrowse link multiple interactions ISO 19 32,694,495 32,741,677 RGD:6480464 CTD
G Pgrmc1 progesterone receptor membrane component 1 GBrowse link multiple interactions ISO X 34,138,220 34,146,074 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 13 27,149,439 27,157,073 RGD:6480464 CTD
G Prok1 prokineticin 1 GBrowse link multiple interactions ISO 3 107,038,449 107,042,625 RGD:6480464 CTD
G Prps2 phosphoribosyl pyrophosphate synthetase 2 GBrowse link multiple interactions ISO X 163,784,265 163,820,631 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 19 5,637,490 5,648,130 RGD:6480464 CTD
G Rhob ras homolog gene family, member B GBrowse link multiple interactions ISO 12 8,504,564 8,506,791 RGD:6480464 CTD
G Sc4mol sterol-C4-methyl oxidase-like GBrowse link multiple interactions ISO 8 67,196,942 67,212,375 RGD:6480464 CTD
G Star steroidogenic acute regulatory protein GBrowse link multiple interactions ISO 8 26,918,985 26,926,454 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 GBrowse link decreases phosphorylation ISO 11 100,748,124 100,800,825 RGD:6480464 CTD
G Sycp1 synaptonemal complex protein 1 GBrowse link multiple interactions ISO 3 102,622,422 102,740,023 RGD:6480464 CTD
G Taf4b TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor GBrowse link multiple interactions ISO 18 14,941,754 15,058,868 RGD:6480464 CTD
G Tex19.2 testis expressed gene 19.2 GBrowse link multiple interactions ISO 11 120,977,529 120,979,991 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link decreases expression ISO 7 26,472,021 26,490,015 RGD:6480464 CTD
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 GBrowse link decreases expression ISO 11 69,496,079 69,499,056 RGD:6480464 CTD
G Trp53 transformation related protein 53 GBrowse link increases expression ISO 11 69,393,861 69,405,375 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 17 46,153,942 46,169,326 RGD:6480464 CTD
G Wisp2 WNT1 inducible signaling pathway protein 2 GBrowse link multiple interactions ISO 2 163,646,570 163,658,882 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 500578
    role 490263
      application 248534
        pharmaceutical 176100
          drug 175899
            antineoplastic agent 63558
              cetrorelix 56
                cetrorelix acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 500578
    subatomic particle 499495
      composite particle 499495
        hadron 499495
          baryon 499495
            nucleon 499495
              atomic nucleus 499495
                atom 499495
                  main group element atom 468771
                    p-block element atom 466266
                      carbon group element atom 417549
                        carbon atom 414032
                          organic molecular entity 414026
                            organic group 170717
                              organic divalent group 169532
                                organodiyl group 169532
                                  carbonyl group 169216
                                    carbonyl compound 169216
                                      carboxylic acid 123840
                                        carboacyl group 41760
                                          univalent carboacyl group 41760
                                            carbamoyl group 37916
                                              carboxamide 37905
                                                peptide 10277
                                                  oligopeptide 1201
                                                    cetrorelix 56
                                                      cetrorelix acetate 0
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