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Term:cetrorelix
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Accession:CHEBI:59224 term browser browse the term
Definition:A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast.
Synonyms:exact_synonym: N-acetyl-3-(naphthalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-L-tyrosyl-N(5)-carbamoyl-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide
 related_synonym: C70H92ClN17O14;   CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O;   InChI=1S/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+/m1/s1;   InChIKey=SBNPWPIBESPSIF-MHWMIDJBSA-N;   cetrorelixum
 xref_casrn: 120287-85-6
 xref: Beilstein:5860649 "Beilstein Registry Number";   ChEMBL:774441 "ChEMBL COMPOUND";   ChemIDplus:120287-85-6 "CAS Registry Number";   DrugBank:DB00050 "DrugBank";   KEGG DRUG:D07665 "KEGG DRUG"
 xref_mesh: MESH:C062876
 xref: Patent:EP299402 "Patent";   Patent:US4800191 "Patent";   Wikipedia:Cetrorelix "Wikipedia"

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cetrorelix term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Apoe apolipoprotein E GBrowse link multiple interactions ISO 1 79,003,634 79,006,387 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2l1 Bcl2-like 1 GBrowse link decreases expression ISO 3 143,129,087 143,180,199 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity EXP 5 160,704,234 160,721,796 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Chga chromogranin A (parathyroid secretory protein 1) multiple interactions ISO RGD:6480464 CTD
G Clcf1 cardiotrophin-like cytokine factor 1 GBrowse link decreases expression ISO 1 206,802,745 206,806,332 RGD:6480464 CTD
G Cst9l cystatin 9-like GBrowse link multiple interactions ISO 3 137,601,785 137,604,598 RGD:6480464 CTD
G Cxcl12 chemokine (C-X-C motif) ligand 12 GBrowse link decreases expression ISO 4 153,503,576 153,516,423 RGD:6480464 CTD
G Cyb5a cytochrome b5 type A (microsomal) GBrowse link multiple interactions ISO 18 81,415,972 81,452,606 RGD:6480464 CTD
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link multiple interactions ISO 8 61,793,976 61,805,308 RGD:6480464 CTD
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 GBrowse link multiple interactions ISO 1 251,965,458 251,971,449 RGD:6480464 CTD
G Ddr1 discoidin domain receptor tyrosine kinase 1 GBrowse link multiple interactions ISO 20 3,194,265 3,214,611 RGD:6480464 CTD
G Dhcr24 24-dehydrocholesterol reductase GBrowse link multiple interactions ISO 5 127,637,438 127,662,621 RGD:6480464 CTD
G Dpep3 dipeptidase 3 GBrowse link multiple interactions ISO 19 35,814,990 35,820,643 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link increases expression ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link increases expression EXP 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fshb follicle stimulating hormone, beta polypeptide GBrowse link decreases expression ISO 3 92,569,344 92,571,254 RGD:6480464 CTD
G Fshb follicle stimulating hormone, beta polypeptide GBrowse link decreases expression EXP 3 92,569,344 92,571,254 RGD:6480464 CTD
G Gsta2 glutathione S-transferase alpha 2 GBrowse link multiple interactions ISO 8 83,299,249 83,312,958 RGD:6480464 CTD
G Hcrtr1 hypocretin (orexin) receptor 1 GBrowse link decreases expression EXP 5 149,160,739 149,170,736 RGD:6480464 CTD
G Hcrtr2 hypocretin (orexin) receptor 2 GBrowse link decreases expression EXP 8 81,068,303 81,196,608 RGD:6480464 CTD
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) GBrowse link multiple interactions ISO 2 193,128,736 193,143,106 RGD:6480464 CTD
G Hsd17b6 hydroxysteroid (17-beta) dehydrogenase 6 GBrowse link multiple interactions ISO 7 1,118,183 1,137,670 RGD:6480464 CTD
G Igf1 insulin-like growth factor 1 GBrowse link decreases expression ISO 7 24,531,669 24,605,742 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link decreases expression ISO 4 456,799 461,376 RGD:6480464 CTD
G Insl3 insulin-like 3 GBrowse link multiple interactions ISO 16 18,890,131 18,891,475 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link decreases expression EXP 1 95,892,999 95,893,988 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link decreases expression ISO 1 95,892,999 95,893,988 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link decreases expression ISO 1 95,892,999 95,893,988 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link decreases phosphorylation ISO 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link decreases phosphorylation ISO 1 185,935,044 185,941,245 RGD:6480464 CTD
G Msmo1 methylsterol monooxygenase 1 GBrowse link multiple interactions ISO 16 26,698,324 26,716,247 RGD:6480464 CTD
G Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 GBrowse link multiple interactions ISO 1 236,592,414 236,677,379 RGD:6480464 CTD
G Pgrmc1 progesterone receptor membrane component 1 GBrowse link multiple interactions ISO X 8,265,543 8,273,667 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prok1 prokineticin 1 GBrowse link multiple interactions ISO 2 202,707,628 202,712,886 RGD:6480464 CTD
G Prps2 phosphoribosyl pyrophosphate synthetase 2 GBrowse link multiple interactions ISO X 47,274,362 47,315,274 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rhob ras homolog family member B GBrowse link multiple interactions ISO 6 32,052,333 32,054,507 RGD:6480464 CTD
G Star steroidogenic acute regulatory protein GBrowse link multiple interactions ISO 16 70,642,580 70,647,203 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link decreases phosphorylation ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Sycp1 synaptonemal complex protein 1 GBrowse link multiple interactions ISO 2 197,989,614 198,164,611 RGD:6480464 CTD
G Taf4b TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa GBrowse link multiple interactions ISO 18 6,071,848 6,168,486 RGD:6480464 CTD
G Tex19.2 testis expressed gene 19.2 GBrowse link multiple interactions ISO 10 110,325,885 110,353,003 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link decreases expression ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tnfsf13 tumor necrosis factor (ligand) superfamily, member 13 GBrowse link decreases expression ISO 10 56,499,945 56,502,928 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Wisp2 WNT1 inducible signaling pathway protein 2 GBrowse link multiple interactions ISO 3 154,748,977 154,760,324 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492507
    role 482196
      application 245130
        pharmaceutical 173979
          drug 173776
            antineoplastic agent 62937
              cetrorelix 56
                cetrorelix acetate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492507
    subatomic particle 491470
      composite particle 491470
        hadron 491470
          baryon 491470
            nucleon 491470
              atomic nucleus 491470
                atom 491470
                  main group element atom 461139
                    p-block element atom 458635
                      carbon group element atom 410624
                        carbon atom 407181
                          organic molecular entity 407174
                            organic group 167657
                              organic divalent group 166492
                                organodiyl group 166492
                                  carbonyl group 166182
                                    carbonyl compound 166182
                                      carboxylic acid 121381
                                        carboacyl group 40896
                                          univalent carboacyl group 40896
                                            carbamoyl group 37115
                                              carboxamide 37106
                                                peptide 10074
                                                  oligopeptide 1235
                                                    cetrorelix 56
                                                      cetrorelix acetate 0
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