ONTOLOGY REPORT - ANNOTATIONS

Term:ceruletide
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Accession:CHEBI:59219 term browser browse the term
Definition:A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.
Synonyms:exact_synonym: 5-oxo-L-prolyl-L-glutaminyl-L-alpha-aspartyl-O-sulfo-L-tyrosyl-L-threonylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide
 related_synonym: C58H73N13O21S2;   InChI=1S/C58H73N13O21S2/c1-29(72)49(71-57(87)40(23-31-12-14-33(15-13-31)92-94(89,90)91)68-56(86)43(26-48(78)79)69-52(82)37(16-18-44(59)73)65-51(81)36-17-19-45(74)63-36)58(88)62-28-46(75)64-41(24-32-27-61-35-11-7-6-10-34(32)35)54(84)66-38(20-21-93-2)53(83)70-42(25-47(76)77)55(85)67-39(50(60)80)22-30-8-4-3-5-9-30/h3-15,27,29,36-43,49,61,72H,16-26,28H2,1-2H3,(H2,59,73)(H2,60,80)(H,62,88)(H,63,74)(H,64,75)(H,65,81)(H,66,84)(H,67,85)(H,68,86)(H,69,82)(H,70,83)(H,71,87)(H,76,77)(H,78,79)(H,89,90,91)/t29-,36+,37+,38+,39+,40+,41+,42+,43+,49+/m1/s1;   InChIKey=YRALAIOMGQZKOW-HYAOXDFASA-N;   [H][C@](NC(=O)[C@H](Cc1ccc(OS(O)(=O)=O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)([C@@H](C)O)C(=O)NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(N)=O;   caerulein;   cerulein;   ceruletida;   ceruletidum
 xref_casrn: 17650-98-5
 xref: Beilstein:5422487 "Beilstein Registry Number";   ChEMBL:775306 "ChEMBL COMPOUND";   ChemIDplus:17650-98-5 "CAS Registry Number";   DrugBank:DB00403 "DrugBank";   KEGG DRUG:D03442 "KEGG DRUG"
 xref_mesh: MESH:D002108
 xref: Wikipedia:Ceruletide "Wikipedia"

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ceruletide term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Alb albumin GBrowse link decreases expression EXP 14 19,126,935 19,142,214 RGD:6480464 CTD
G Bdkrb1 bradykinin receptor B1 GBrowse link increases expression ISO 6 129,760,129 129,762,545 RGD:6480464 CTD
G Bdkrb2 bradykinin receptor B2 GBrowse link increases expression ISO 6 129,744,781 129,748,851 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions EXP 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions EXP 5 160,704,234 160,721,796 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link increases expression ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link increases expression ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) GBrowse link increases expression ISO 14 18,690,339 18,692,118 RGD:6480464 CTD
G Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) GBrowse link multiple interactions ISO 14 18,690,339 18,692,118 RGD:6480464 CTD
G Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) GBrowse link increases expression ISO 14 18,690,339 18,692,118 RGD:6480464 CTD
G Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) GBrowse link multiple interactions ISO 14 18,690,339 18,692,118 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link increases expression ISO 8 20,040,177 20,051,939 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link multiple interactions ISO 8 20,040,177 20,051,939 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link increases expression ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link increases expression EXP 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link increases expression ISO 4 456,799 461,376 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions ISO 4 456,799 461,376 RGD:6480464 CTD
G Jun jun proto-oncogene GBrowse link increases expression ISO 5 115,358,166 115,361,259 RGD:6480464 CTD
G Jun jun proto-oncogene GBrowse link multiple interactions ISO 5 115,358,166 115,361,259 RGD:6480464 CTD
G Mpo myeloperoxidase GBrowse link increases expression ISO 10 76,085,872 76,097,012 RGD:6480464 CTD
G Mpo myeloperoxidase GBrowse link multiple interactions ISO 10 76,085,872 76,097,012 RGD:6480464 CTD
G Pparg peroxisome proliferator-activated receptor gamma GBrowse link multiple interactions ISO 4 151,492,220 151,617,331 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link increases expression EXP 13 64,427,288 64,432,978 RGD:6480464 CTD
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 GBrowse link increases cleavage EXP 17 37,183,591 37,216,533 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link increases degradation EXP X 3,011,520 3,047,798 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501881
    role 491510
      application 249674
        pharmaceutical 177241
          diagnostic agent 487
            ceruletide 32
              ceruletide diethylamine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 501881
    subatomic particle 500845
      composite particle 500845
        hadron 500845
          baryon 500845
            nucleon 500845
              atomic nucleus 500845
                atom 500845
                  main group element atom 470301
                    p-block element atom 467779
                      carbon group element atom 419149
                        carbon atom 415667
                          organic molecular entity 415660
                            organic group 171184
                              organic divalent group 169999
                                organodiyl group 169999
                                  carbonyl group 169689
                                    carbonyl compound 169689
                                      carboxylic acid 122651
                                        carboacyl group 41284
                                          univalent carboacyl group 41284
                                            carbamoyl group 37497
                                              carboxamide 37488
                                                peptide 10080
                                                  oligopeptide 1238
                                                    ceruletide 32
                                                      ceruletide diethylamine 0
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