ONTOLOGY REPORT - ANNOTATIONS

Term:cladribine
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Accession:CHEBI:567361 term browser browse the term
Definition:2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
Synonyms:related_synonym: (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol;   2-CdA;   2-chloro-2'-deoxy-beta-adenosine;   2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine;   2-chloro-deoxyadenosine;   2-chlorodeoxyadenosine;   2ClAdo;   C10H12ClN5O3;   CldAdo;   InChI=1S/C10H12ClN5O3/c11-10-14-8(12)7-9(15-10)16(3-13-7)6-1-4(18)5(2-17)19-6/h3-6,17-18H,1-2H2,(H2,12,14,15)/t4-,5+,6+/m0/s1;   InChIKey=PTOAARAWEBMLNO-KVQBGUIXSA-N;   Nc1nc(Cl)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1;   cladribina;   cladribinum
 alt_id: CHEBI:31407;   CHEBI:568373
 xref_casrn: 4291-63-8
 xref: Beilstein:624220 "Beilstein Registry Number";   ChEMBL:17526755 "PubMed citation";   ChEMBL:18570408 "PubMed citation";   ChEMBL:567361 "ChEMBL COMPOUND";   ChEMBL:568373 "ChEMBL COMPOUND";   ChemIDplus:4291-63-8 "CAS Registry Number";   DrugBank:DB00242 "DrugBank";   KEGG DRUG:4291-63-8 "CAS Registry Number";   KEGG DRUG:D01370 "KEGG DRUG"
 xref_mesh: MESH:D017338
 xref: Patent:EP173059 "Patent";   Patent:US4760137 "Patent";   Wikipedia:Cladribine "Wikipedia"

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cladribine term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Birc3 baculoviral IAP repeat-containing 3 GBrowse link multiple interactions ISO 8 4,682,202 4,696,856 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp6 caspase 6 GBrowse link multiple interactions ISO 2 227,361,538 227,373,844 RGD:6480464 CTD
G Casp6 caspase 6 GBrowse link increases activity ISO 2 227,361,538 227,373,844 RGD:6480464 CTD
G Casp6 caspase 6 GBrowse link increases activity ISO 2 227,361,538 227,373,844 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link multiple interactions ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link increases activity ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases cleavage ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Daxx death-domain associated protein GBrowse link multiple interactions ISO 20 5,121,854 5,127,601 RGD:6480464 CTD
G Diablo diablo, IAP-binding mitochondrial protein GBrowse link multiple interactions ISO 12 34,196,347 34,209,633 RGD:6480464 CTD
G Il4 interleukin 4 GBrowse link increases expression ISO 10 39,074,582 39,080,134 RGD:6480464 CTD
G Lmnb1 lamin B1 GBrowse link multiple interactions ISO 18 52,470,605 52,508,022 RGD:6480464 CTD
G Lmnb1 lamin B1 GBrowse link increases cleavage ISO 18 52,470,605 52,508,022 RGD:6480464 CTD
G LOC100360940 diablo-like GBrowse link multiple interactions ISO 5 148,562,065 148,563,619 RGD:6480464 CTD
G Mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) GBrowse link increases response to substance ISO 8 47,759,175 47,834,586 RGD:6480464 CTD
G Nt5c1a 5'-nucleotidase, cytosolic IA GBrowse link decreases response to substance ISO 5 142,509,257 142,524,280 RGD:6480464 CTD
G Nt5c1a 5'-nucleotidase, cytosolic IA GBrowse link multiple interactions ISO 5 142,509,257 142,524,280 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link increases cleavage ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link increases cleavage ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Pawr PRKC, apoptosis, WT1, regulator GBrowse link multiple interactions ISO 7 47,040,162 47,119,613 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link increases phosphorylation ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link multiple interactions ISO X 3,011,520 3,047,798 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492507
    role 482196
      biological role 480389
        immunomodulator 23368
          immunosuppressive agent 17361
            cladribine 44
Path 2
Term Annotations click to browse term
  CHEBI ontology 492507
    subatomic particle 491470
      composite particle 491470
        hadron 491470
          baryon 491470
            nucleon 491470
              atomic nucleus 491470
                atom 491470
                  main group element atom 461139
                    p-block element atom 458635
                      carbon group element atom 410624
                        carbon atom 407181
                          organic molecular entity 407174
                            heteroorganic entity 324724
                              organochalcogen compound 226834
                                organooxygen compound 213621
                                  carbohydrate 20806
                                    carbohydrate derivative 16365
                                      N-glycosyl compound 7166
                                        nucleoside 6613
                                          deoxyribonucleoside 3108
                                            2'-deoxyribonucleoside 2075
                                              purine 2'-deoxyribonucleoside 53
                                                cladribine 44
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