ONTOLOGY REPORT - ANNOTATIONS

Term:lysophosphatidic acid
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Accession:CHEBI:52288 term browser browse the term
Definition:LPA is a phospholipid derivative that acts as a potent signaling molecule. LPA acts as a potent mitogen due to its activation of three high-affinity GPCRs.
Synonyms:exact_synonym: 2-hydroxy-3-(phosphonooxy)propyl octadec-9-enoate
 related_synonym: C21H41O7P;   InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26);   InChIKey=WRGQSWVCFNIUNZ-UHFFFAOYSA-N;   LPA;   [H]C(CCCCCCCC)=C([H])CCCCCCCC(=O)OCC(O)COP(O)(O)=O
 xref_casrn: 22002-87-5
 xref: ChemIDplus:22002-87-5 "CAS Registry Number"
 xref_mesh: MESH:C032881

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lysophosphatidic acid term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link increases phosphorylation EXP 14 105,235,686 105,262,080 RGD:6480464 CTD
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions EXP 14 105,235,686 105,262,080 RGD:6480464 CTD
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions ISO 14 105,235,686 105,262,080 RGD:6480464 CTD
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link increases phosphorylation ISO 14 105,235,686 105,262,080 RGD:6480464 CTD
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions EXP 14 105,235,686 105,262,080 RGD:6480464 CTD
G AKT1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link increases phosphorylation EXP 14 105,235,686 105,262,080 RGD:6480464 CTD
G ALOX5 arachidonate 5-lipoxygenase GBrowse link multiple interactions EXP 10 45,869,624 45,941,567 RGD:6480464 CTD
G BCAR1 breast cancer anti-estrogen resistance 1 GBrowse link increases phosphorylation ISO 16 75,262,928 75,301,951 RGD:6480464 CTD
G CTGF connective tissue growth factor GBrowse link increases expression ISO 6 132,269,316 132,272,518 RGD:6480464 CTD
G CTGF connective tissue growth factor GBrowse link multiple interactions ISO 6 132,269,316 132,272,518 RGD:6480464 CTD
G CXCR1 chemokine (C-X-C motif) receptor 1 GBrowse link multiple interactions EXP 2 219,027,568 219,031,716 RGD:6480464 CTD
G CXCR1 chemokine (C-X-C motif) receptor 1 GBrowse link decreases expression EXP 2 219,027,568 219,031,716 RGD:6480464 CTD
G DGKA diacylglycerol kinase, alpha 80kDa GBrowse link multiple interactions ISO 12 56,324,946 56,347,807 RGD:6480464 CTD
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 GBrowse link multiple interactions ISO 8 37,888,020 37,917,883 RGD:6480464 CTD
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 GBrowse link increases phosphorylation ISO 8 37,888,020 37,917,883 RGD:6480464 CTD
G ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 GBrowse link multiple interactions ISO 8 120,569,317 120,651,106 RGD:6480464 CTD
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link increases expression EXP 14 62,162,119 62,214,977 RGD:6480464 CTD
G HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link multiple interactions EXP 14 62,162,119 62,214,977 RGD:6480464 CTD
G HSPB1 heat shock 27kDa protein 1 GBrowse link increases phosphorylation ISO 7 75,931,875 75,933,614 RGD:6480464 CTD
G HSPB1 heat shock 27kDa protein 1 GBrowse link multiple interactions ISO 7 75,931,875 75,933,614 RGD:6480464 CTD
G IL6 interleukin 6 (interferon, beta 2) GBrowse link increases secretion ISO 7 22,766,766 22,771,621 RGD:6480464 CTD
G KNG1 kininogen 1 GBrowse link multiple interactions ISO 3 186,435,098 186,462,199 RGD:6480464 CTD
G LAMA3 laminin, alpha 3 GBrowse link increases expression EXP 18 21,269,562 21,535,030 RGD:6480464 CTD
G LAMB3 laminin, beta 3 GBrowse link increases expression EXP 1 209,788,215 209,825,820 RGD:6480464 CTD
G LAMC2 laminin, gamma 2 GBrowse link increases expression EXP 1 183,155,174 183,214,262 RGD:6480464 CTD
G LPAR1 lysophosphatidic acid receptor 1 GBrowse link increases response to substance EXP 9 113,636,054 113,800,365 RGD:6480464 CTD
G LPAR1 lysophosphatidic acid receptor 1 GBrowse link multiple interactions EXP 9 113,636,054 113,800,365 RGD:6480464 CTD
G LPAR6 lysophosphatidic acid receptor 6 GBrowse link multiple interactions EXP 13 48,985,181 49,018,840 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link increases phosphorylation EXP 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link multiple interactions EXP 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link multiple interactions ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link multiple interactions ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link increases phosphorylation ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link increases phosphorylation ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link multiple interactions ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link multiple interactions ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link increases phosphorylation ISO 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link increases phosphorylation EXP 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK1 mitogen-activated protein kinase 1 GBrowse link multiple interactions EXP 22 22,113,946 22,221,970 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link increases phosphorylation EXP 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link multiple interactions EXP 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link multiple interactions ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link multiple interactions ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link increases phosphorylation ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link increases phosphorylation ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link multiple interactions ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link multiple interactions ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link increases phosphorylation ISO 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link multiple interactions EXP 16 30,125,426 30,134,630 RGD:6480464 CTD
G MAPK3 mitogen-activated protein kinase 3 GBrowse link increases phosphorylation EXP 16 30,125,426 30,134,630 RGD:6480464 CTD
G MTOR mechanistic target of rapamycin (serine/threonine kinase) GBrowse link increases phosphorylation ISO 1 11,166,588 11,322,608 RGD:6480464 CTD
G MYLK myosin light chain kinase GBrowse link affects response to substance EXP 3 123,331,143 123,603,149 RGD:6480464 CTD
G NPPA natriuretic peptide A GBrowse link multiple interactions ISO 1 11,905,766 11,907,840 RGD:6480464 CTD
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha GBrowse link multiple interactions ISO 1 151,171,021 151,222,007 RGD:6480464 CTD
G PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha GBrowse link increases activity ISO 1 151,171,021 151,222,007 RGD:6480464 CTD
G PLD1 phospholipase D1, phosphatidylcholine-specific GBrowse link multiple interactions ISO 3 171,318,195 171,528,284 RGD:6480464 CTD
G PLD1 phospholipase D1, phosphatidylcholine-specific GBrowse link increases activity ISO 3 171,318,195 171,528,284 RGD:6480464 CTD
G PLD1 phospholipase D1, phosphatidylcholine-specific GBrowse link multiple interactions ISO 3 171,318,195 171,528,284 RGD:6480464 CTD
G PTK2 protein tyrosine kinase 2 GBrowse link increases phosphorylation ISO 8 141,668,481 142,011,412 RGD:6480464 CTD
G PTK2 protein tyrosine kinase 2 GBrowse link increases phosphorylation ISO 8 141,668,481 142,011,412 RGD:6480464 CTD
G PTK2 protein tyrosine kinase 2 GBrowse link increases phosphorylation EXP 8 141,668,481 142,011,412 RGD:6480464 CTD
G PTK2 protein tyrosine kinase 2 GBrowse link multiple interactions ISO 8 141,668,481 142,011,412 RGD:6480464 CTD
G PTK2 protein tyrosine kinase 2 GBrowse link multiple interactions EXP 8 141,668,481 142,011,412 RGD:6480464 CTD
G PTK2B protein tyrosine kinase 2 beta GBrowse link increases phosphorylation ISO 8 27,168,999 27,316,908 RGD:6480464 CTD
G RHOA ras homolog family member A GBrowse link increases activity ISO 3 49,396,578 49,449,526 RGD:6480464 CTD
G RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 GBrowse link increases phosphorylation EXP 17 57,970,443 58,027,787 RGD:6480464 CTD
G RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 GBrowse link multiple interactions ISO 17 57,970,443 58,027,787 RGD:6480464 CTD
G RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 GBrowse link multiple interactions EXP 17 57,970,443 58,027,787 RGD:6480464 CTD
G RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 GBrowse link increases phosphorylation ISO 17 57,970,443 58,027,787 RGD:6480464 CTD
G VEGFA vascular endothelial growth factor A GBrowse link increases expression EXP 6 43,737,946 43,754,224 RGD:6480464 CTD
G VEGFA vascular endothelial growth factor A GBrowse link multiple interactions EXP 6 43,737,946 43,754,224 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 523433
    role 512890
      biological role 511047
        mitogen 1827
          lysophosphatidic acid 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 523433
    subatomic particle 522326
      composite particle 522326
        hadron 522326
          baryon 522326
            nucleon 522326
              atomic nucleus 522326
                atom 522326
                  main group element atom 490114
                    p-block element atom 487514
                      carbon group element atom 436485
                        carbon atom 432855
                          organic molecular entity 432848
                            organic group 178310
                              organic divalent group 177088
                                organodiyl group 177088
                                  carbonyl group 176771
                                    carbonyl compound 176771
                                      carboxylic acid 127819
                                        monocarboxylic acid 73684
                                          fatty acid 25967
                                            unsaturated fatty acid 1549
                                              monounsaturated fatty acid 356
                                                octadecenoic acid 174
                                                  lysophosphatidic acid 71
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