ONTOLOGY REPORT - ANNOTATIONS

Term:mitoxantrone
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Accession:CHEBI:50729 term browser browse the term
Definition:A hydroxyanthraquinone that has formula C22H28N4O6.
Synonyms:exact_synonym: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)anthracene-9,10-dione
 related_synonym: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE;   C22H28N4O6;   InChI=1S/C22H28N4O6/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32/h1-4,23-30H,5-12H2;   InChIKey=KKZJGLLVHKMTCM-UHFFFAOYSA-N;   OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12;   mitoxantrona;   mitoxantronum
 alt_id: CHEBI:43919;   CHEBI:6955
 xref_casrn: 65271-80-9
 xref: Beilstein:2795126 "Beilstein Registry Number";   ChEMBL:104504 "ChEMBL COMPOUND";   ChemIDplus:65271-80-9 "CAS Registry Number";   DrugBank:DB01204 "DrugBank";   KEGG COMPOUND:65271-80-9 "CAS Registry Number";   KEGG COMPOUND:C11195 "KEGG COMPOUND"
 xref_mesh: MESH:D008942
 xref: PDBeChem:MIX "PDBeChem";   Patent:DE2835661 "Patent";   Patent:US4197249 "Patent";   Wikipedia:Mitoxantrone "Wikipedia"

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Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abca1 ATP-binding cassette, subfamily A (ABC1), member 1 GBrowse link affects response to substance ISO 5 70,493,357 70,583,729 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link increases expression ISO 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects export ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects uptake ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link decreases response to substance ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases response to substance ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases export ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases expression ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases expression ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects export EXP 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link decreases response to substance ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link affects transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link decreases abundance ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases expression ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases export ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link increases transport ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Abcg2 ATP-binding cassette, subfamily G (WHITE), member 2 GBrowse link multiple interactions ISO 4 87,502,584 87,560,017 RGD:6480464 CTD
G Acsl3 acyl-CoA synthetase long-chain family member 3 GBrowse link affects response to substance ISO 9 78,083,239 78,106,933 RGD:6480464 CTD
G Actg2 actin, gamma 2, smooth muscle, enteric GBrowse link affects response to substance ISO 4 117,732,482 117,747,006 RGD:6480464 CTD
G Adarb1 adenosine deaminase, RNA-specific, B1 GBrowse link affects response to substance ISO 20 11,616,718 11,747,294 RGD:6480464 CTD
G Agpat5 1-acylglycerol-3-phosphate O-acyltransferase 5 GBrowse link affects response to substance ISO 16 75,745,813 75,788,182 RGD:6480464 CTD
G Ahcyl1 adenosylhomocysteinase-like 1 GBrowse link affects response to substance ISO 2 203,210,376 203,244,218 RGD:6480464 CTD
G Aldh2 aldehyde dehydrogenase 2 family (mitochondrial) GBrowse link affects response to substance ISO 12 36,081,778 36,116,445 RGD:6480464 CTD
G Amotl1 angiomotin-like 1 GBrowse link affects response to substance ISO 8 11,296,503 11,392,970 RGD:6480464 CTD
G Asns asparagine synthetase (glutamine-hydrolyzing) GBrowse link affects response to substance ISO 4 32,758,866 32,776,220 RGD:6480464 CTD
G Ass1 argininosuccinate synthase 1 GBrowse link affects response to substance ISO 3 10,578,717 10,622,332 RGD:6480464 CTD
G Atp7a ATPase, Cu++ transporting, alpha polypeptide GBrowse link decreases response to substance ISO X 94,192,540 94,249,776 RGD:6480464 CTD
G Bace2 beta-site APP-cleaving enzyme 2 GBrowse link affects response to substance ISO 11 37,345,568 37,428,155 RGD:6480464 CTD
G Bbx bobby sox homolog (Drosophila) GBrowse link affects response to substance ISO 11 51,655,446 51,799,132 RGD:6480464 CTD
G Bcam basal cell adhesion molecule (Lutheran blood group) GBrowse link affects response to substance ISO 1 79,067,352 79,081,739 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2l1 Bcl2-like 1 GBrowse link multiple interactions ISO 3 143,129,087 143,180,199 RGD:6480464 CTD
G Birc2 baculoviral IAP repeat-containing 2 GBrowse link decreases expression ISO 8 4,649,559 4,667,733 RGD:6480464 CTD
G Bmp7 bone morphogenetic protein 7 GBrowse link affects response to substance ISO 3 163,723,429 163,799,567 RGD:6480464 CTD
G Bst2 bone marrow stromal cell antigen 2 GBrowse link affects response to substance ISO 16 18,698,545 18,701,768 RGD:6480464 CTD
G Btbd3 BTB (POZ) domain containing 3 GBrowse link affects response to substance ISO 3 126,403,030 126,409,372 RGD:6480464 CTD
G Calr calreticulin GBrowse link affects localization ISO 19 24,964,775 24,969,670 RGD:6480464 CTD
G Camk2n1 calcium/calmodulin-dependent protein kinase II inhibitor 1 GBrowse link affects response to substance ISO 5 157,235,534 157,237,314 RGD:6480464 CTD
G Casc3 cancer susceptibility candidate 3 GBrowse link affects response to substance ISO 10 87,581,850 87,602,528 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link increases expression ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link increases splicing ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp6 caspase 6 GBrowse link increases activity ISO 2 227,361,538 227,373,844 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link increases activity ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link increases activity ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link multiple interactions ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Ccdc53 coiled-coil domain containing 53 GBrowse link affects response to substance ISO 7 24,894,880 24,942,581 RGD:6480464 CTD
G Cd55 Cd55 molecule GBrowse link affects response to substance ISO 13 43,322,246 43,348,334 RGD:6480464 CTD
G Celf2 CUGBP, Elav-like family member 2 GBrowse link affects response to substance ISO 17 82,708,354 83,025,139 RGD:6480464 CTD
G Ces2h carboxylesterase 2H GBrowse link affects response to substance ISO 19 34,910,981 34,925,547 RGD:6480464 CTD
G Chrdl1 chordin-like 1 GBrowse link affects response to substance ISO X 35,143,324 35,246,363 RGD:6480464 CTD
G Cklf chemokine-like factor GBrowse link affects response to substance ISO 19 655,880 665,215 RGD:6480464 CTD
G Clns1a chloride channel, nucleotide-sensitive, 1A GBrowse link affects response to substance ISO 1 154,946,713 154,966,947 RGD:6480464 CTD
G Clu clusterin GBrowse link affects response to substance ISO 15 45,365,779 45,405,314 RGD:6480464 CTD
G Coch coagulation factor C homolog, cochlin (Limulus polyphemus) GBrowse link affects response to substance ISO 6 71,692,946 71,697,056 RGD:6480464 CTD
G Col11a1 collagen, type XI, alpha 1 GBrowse link affects response to substance ISO 2 209,996,467 210,193,379 RGD:6480464 CTD
G Cpvl carboxypeptidase, vitellogenic-like GBrowse link affects response to substance ISO 4 82,238,756 82,344,130 RGD:6480464 CTD
G Crebl2 cAMP responsive element binding protein-like 2 GBrowse link affects response to substance ISO 4 171,744,836 171,771,198 RGD:6480464 CTD
G Csrnp2 cysteine-serine-rich nuclear protein 2 GBrowse link affects response to substance ISO 7 139,182,243 139,198,084 RGD:6480464 CTD
G Cth cystathionase (cystathionine gamma-lyase) GBrowse link affects response to substance ISO 2 256,056,562 256,082,248 RGD:6480464 CTD
G Cxadr coxsackie virus and adenovirus receptor GBrowse link affects response to substance ISO 11 17,193,505 17,241,549 RGD:6480464 CTD
G Dapk1 death associated protein kinase 1 GBrowse link affects response to substance ISO 17 9,617,607 9,779,457 RGD:6480464 CTD
G Ddit4 DNA-damage-inducible transcript 4 GBrowse link affects response to substance ISO 20 27,252,273 27,254,371 RGD:6480464 CTD
G Dhrs2 dehydrogenase/reductase (SDR family) member 2 GBrowse link affects response to substance ISO 15 33,286,599 33,337,467 RGD:6480464 CTD
G Dis3 DIS3 mitotic control homolog (S. cerevisiae) GBrowse link affects response to substance ISO 15 82,855,389 82,881,767 RGD:6480464 CTD
G Dusp4 dual specificity phosphatase 4 GBrowse link affects response to substance ISO 16 61,109,626 61,119,981 RGD:6480464 CTD
G Dyrk2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 GBrowse link affects response to substance ISO 7 58,114,127 58,126,547 RGD:6480464 CTD
G Egr1 early growth response 1 GBrowse link affects response to substance ISO 18 27,343,919 27,346,117 RGD:6480464 CTD
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha GBrowse link affects response to substance ISO 6 101,495,444 101,520,113 RGD:6480464 CTD
G Eif5a eukaryotic translation initiation factor 5A GBrowse link affects response to substance ISO 10 56,760,289 56,764,689 RGD:6480464 CTD
G Elavl4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 GBrowse link affects response to substance ISO 5 131,672,012 131,767,950 RGD:6480464 CTD
G Elovl5 ELOVL fatty acid elongase 5 GBrowse link affects response to substance ISO 8 82,922,551 82,948,348 RGD:6480464 CTD
G En2 engrailed homeobox 2 GBrowse link affects response to substance ISO 4 2,469,889 2,475,729 RGD:6480464 CTD
G Enc1 ectodermal-neural cortex 1 GBrowse link affects response to substance ISO 2 27,720,805 27,733,168 RGD:6480464 CTD
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 GBrowse link affects response to substance ISO 1 20,343,833 20,519,742 RGD:6480464 CTD
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link multiple interactions ISO 10 87,219,157 87,242,919 RGD:6480464 CTD
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link decreases response to substance ISO 10 87,219,157 87,242,919 RGD:6480464 CTD
G Evi5 ecotropic viral integration site 5 GBrowse link affects response to substance ISO 14 2,461,189 2,575,313 RGD:6480464 CTD
G Extl2 exostosin-like glycosyltransferase 2 GBrowse link affects response to substance ISO 2 212,163,317 212,183,756 RGD:6480464 CTD
G Fabp3 fatty acid binding protein 3, muscle and heart GBrowse link increases expression EXP 5 149,340,525 149,347,268 RGD:6480464 CTD
G Fam117a family with sequence similarity 117, member A GBrowse link affects response to substance ISO 10 84,022,262 84,067,048 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link multiple interactions ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fas Fas (TNF receptor superfamily, member 6) GBrowse link increases expression ISO 1 238,259,443 238,274,745 RGD:6480464 CTD
G Fasn fatty acid synthase decreases response to substance ISO RGD:6480464 CTD
G Fasn fatty acid synthase multiple interactions ISO RGD:6480464 CTD
G Fdft1 farnesyl diphosphate farnesyl transferase 1 GBrowse link affects response to substance ISO 15 42,425,336 42,453,390 RGD:6480464 CTD
G Flrt3 fibronectin leucine rich transmembrane protein 3 GBrowse link affects response to substance ISO 3 128,922,726 128,934,866 RGD:6480464 CTD
G Fndc3a fibronectin type III domain containing 3a GBrowse link affects response to substance ISO 15 53,124,740 53,312,367 RGD:6480464 CTD
G Fyn FYN oncogene related to SRC, FGR, YES GBrowse link affects response to substance ISO 20 43,501,853 43,695,567 RGD:6480464 CTD
G Fzd2 frizzled family receptor 2 GBrowse link affects response to substance ISO 10 91,709,222 91,711,132 RGD:6480464 CTD
G Gch1 GTP cyclohydrolase 1 GBrowse link affects response to substance ISO 15 23,023,996 23,139,794 RGD:6480464 CTD
G Glul glutamate-ammonia ligase affects response to substance ISO RGD:6480464 CTD
G Gpx3 glutathione peroxidase 3 GBrowse link affects response to substance ISO 10 40,311,094 40,319,382 RGD:6480464 CTD
G Gucy1b3 guanylate cyclase 1, soluble, beta 3 GBrowse link affects response to substance ISO 2 173,683,153 173,735,298 RGD:6480464 CTD
G Hdac4 histone deacetylase 4 GBrowse link affects response to substance ISO 9 91,147,435 91,389,810 RGD:6480464 CTD
G Hmg20b high mobility group 20 B GBrowse link affects response to substance ISO 7 9,853,290 9,857,970 RGD:6480464 CTD
G Hoxa5 homeo box A5 GBrowse link affects response to substance ISO 4 80,501,675 80,504,626 RGD:6480464 CTD
G Hspa2 heat shock protein 2 GBrowse link affects response to substance ISO 6 99,000,541 99,003,041 RGD:6480464 CTD
G Idh3a isocitrate dehydrogenase 3 (NAD+) alpha GBrowse link affects response to substance ISO 8 58,135,412 58,156,019 RGD:6480464 CTD
G Ifitm1 interferon induced transmembrane protein 1 GBrowse link affects response to substance ISO 1 201,154,494 201,155,509 RGD:6480464 CTD
G Igf1r insulin-like growth factor 1 receptor GBrowse link affects response to substance ISO 1 122,704,976 122,990,007 RGD:6480464 CTD
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 GBrowse link affects response to substance ISO 4 77,213,559 77,228,004 RGD:6480464 CTD
G Igfbp3 insulin-like growth factor binding protein 3 GBrowse link affects response to substance ISO 14 87,959,153 87,967,085 RGD:6480464 CTD
G Igfbp7 insulin-like growth factor binding protein 7 GBrowse link affects response to substance ISO 14 33,010,198 33,070,055 RGD:6480464 CTD
G Il13ra2 interleukin 13 receptor, alpha 2 GBrowse link affects response to substance ISO X 30,505,850 30,533,002 RGD:6480464 CTD
G Iqgap1 IQ motif containing GTPase activating protein 1 GBrowse link affects response to substance ISO 1 136,552,358 136,642,545 RGD:6480464 CTD
G Irf7 interferon regulatory factor 7 GBrowse link affects response to substance ISO 1 201,456,689 201,459,756 RGD:6480464 CTD
G Irx1 iroquois homeobox 1 GBrowse link affects response to substance ISO 17 1,390,894 1,396,724 RGD:6480464 CTD
G Isg15 ISG15 ubiquitin-like modifier GBrowse link affects response to substance ISO 5 173,034,479 173,035,766 RGD:6480464 CTD
G Isg20 interferon stimulated exonuclease gene 20 GBrowse link affects response to substance ISO 1 134,631,524 134,637,868 RGD:6480464 CTD
G Jun jun proto-oncogene GBrowse link multiple interactions ISO 5 115,358,166 115,361,259 RGD:6480464 CTD
G Jun jun proto-oncogene GBrowse link increases expression ISO 5 115,358,166 115,361,259 RGD:6480464 CTD
G Kcnab2 potassium voltage-gated channel, shaker-related subfamily, beta member 2 GBrowse link affects response to substance ISO 5 169,624,099 169,710,725 RGD:6480464 CTD
G Krr1 KRR1, small subunit (SSU) processome component, homolog (yeast) GBrowse link affects response to substance ISO 7 51,069,927 51,081,361 RGD:6480464 CTD
G Lama2 laminin, alpha 2 GBrowse link affects response to substance ISO 1 18,203,466 18,885,462 RGD:6480464 CTD
G Lamb1 laminin, beta 1 GBrowse link affects response to substance ISO 6 49,115,671 49,183,374 RGD:6480464 CTD
G Lamc1 laminin, gamma 1 GBrowse link affects response to substance ISO 13 68,241,453 68,369,419 RGD:6480464 CTD
G Lbh limb bud and heart development GBrowse link affects response to substance ISO 6 22,662,376 22,664,667 RGD:6480464 CTD
G Lemd2 LEM domain containing 2 GBrowse link affects response to substance ISO 20 5,425,689 5,436,856 RGD:6480464 CTD
G Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 GBrowse link affects response to substance ISO 3 95,370,049 95,471,040 RGD:6480464 CTD
G Lipa lipase A, lysosomal acid, cholesterol esterase GBrowse link affects response to substance ISO 1 238,466,493 238,500,195 RGD:6480464 CTD
G Lipg lipase, endothelial GBrowse link affects response to substance ISO 18 71,795,150 71,816,056 RGD:6480464 CTD
G Lmnb1 lamin B1 GBrowse link multiple interactions ISO 18 52,470,605 52,508,022 RGD:6480464 CTD
G LOC100363268 rCG31129-like GBrowse link affects response to substance ISO 2 189,674,857 189,675,177 RGD:6480464 CTD
G Macrod1 MACRO domain containing 1 GBrowse link affects response to substance ISO 1 209,730,907 209,871,392 RGD:6480464 CTD
G Maff v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian) GBrowse link affects response to substance ISO 7 117,328,924 117,340,276 RGD:6480464 CTD
G Maged1 melanoma antigen, family D, 1 GBrowse link affects response to substance ISO X 82,054,042 82,060,563 RGD:6480464 CTD
G Mdm2 p53 E3 ubiquitin protein ligase GBrowse link decreases response to substance ISO 7 56,996,694 57,020,926 RGD:6480464 CTD
G Mest mesoderm specific transcript homolog (mouse) affects response to substance ISO RGD:6480464 CTD
G Mocos molybdenum cofactor sulfurase GBrowse link affects response to substance ISO 18 16,420,503 16,466,040 RGD:6480464 CTD
G Mpc2 mitochondrial pyruvate carrier 2 GBrowse link affects response to substance ISO 13 81,184,656 81,203,905 RGD:6480464 CTD
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase GBrowse link affects response to substance ISO 4 117,517,611 117,529,128 RGD:6480464 CTD
G Mxi1 MAX interactor 1, dimerization protein GBrowse link affects response to substance ISO 1 259,219,584 259,259,979 RGD:6480464 CTD
G Myc myelocytomatosis oncogene GBrowse link decreases expression ISO 7 98,953,142 98,958,060 RGD:6480464 CTD
G Myc myelocytomatosis oncogene GBrowse link multiple interactions ISO 7 98,953,142 98,958,060 RGD:6480464 CTD
G Mycbp2 MYC binding protein 2, E3 ubiquitin protein ligase GBrowse link affects response to substance ISO 15 87,124,558 87,364,839 RGD:6480464 CTD
G Nampt nicotinamide phosphoribosyltransferase GBrowse link affects response to substance ISO 6 51,129,160 51,166,514 RGD:6480464 CTD
G Ndufs5 NADH dehydrogenase (ubiquinone) Fe-S protein 5 GBrowse link affects response to substance ISO 5 143,017,421 143,023,425 RGD:6480464 CTD
G Nefh neurofilament, heavy polypeptide GBrowse link affects response to substance ISO 14 85,594,789 85,604,774 RGD:6480464 CTD
G Nid2 nidogen 2 (osteonidogen) GBrowse link affects response to substance ISO 15 4,801,183 4,856,895 RGD:6480464 CTD
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 GBrowse link decreases activity ISO 18 32,371,496 32,459,145 RGD:6480464 CTD
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 GBrowse link affects response to substance ISO 3 38,866,205 38,871,678 RGD:6480464 CTD
G Nrip1 nuclear receptor interacting protein 1 GBrowse link affects response to substance ISO 11 15,066,443 15,150,137 RGD:6480464 CTD
G Oxct1 3-oxoacid CoA transferase 1 GBrowse link affects response to substance ISO 2 53,189,358 53,217,848 RGD:6480464 CTD
G P4ha1 prolyl 4-hydroxylase, alpha polypeptide I affects response to substance ISO RGD:6480464 CTD
G Pacrgl PARK2 co-regulated-like GBrowse link affects response to substance ISO 14 67,454,503 67,486,170 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Pbx1 pre-B-cell leukemia homeobox 1 GBrowse link affects response to substance ISO 13 83,839,256 84,115,516 RGD:6480464 CTD
G Pde4d phosphodiesterase 4D, cAMP-specific GBrowse link affects response to substance ISO 2 40,196,097 41,311,012 RGD:6480464 CTD
G Pde8a phosphodiesterase 8A GBrowse link affects response to substance ISO 1 137,415,852 137,544,337 RGD:6480464 CTD
G Phgdh phosphoglycerate dehydrogenase GBrowse link affects response to substance ISO 2 193,147,943 193,177,137 RGD:6480464 CTD
G Plagl1 pleiomorphic adenoma gene-like 1 GBrowse link affects response to substance ISO 1 7,882,674 7,922,504 RGD:6480464 CTD
G Plat plasminogen activator, tissue GBrowse link affects response to substance ISO 16 73,711,323 73,736,328 RGD:6480464 CTD
G Pml promyelocytic leukemia GBrowse link affects mutagenesis ISO 8 62,020,438 62,051,927 RGD:6480464 CTD
G Ppp1r2 protein phosphatase 1, regulatory (inhibitor) subunit 2 GBrowse link affects response to substance ISO 11 71,319,294 71,342,716 RGD:6480464 CTD
G Prdx2 peroxiredoxin 2 GBrowse link affects response to substance ISO 19 24,836,199 24,841,390 RGD:6480464 CTD
G Prkcdbp protein kinase C, delta binding protein GBrowse link affects response to substance ISO 1 163,212,922 163,214,511 RGD:6480464 CTD
G Prosc proline synthetase co-transcribed homolog (bacterial) GBrowse link affects response to substance ISO 16 69,330,481 69,342,072 RGD:6480464 CTD
G Ptpre protein tyrosine phosphatase, receptor type, E GBrowse link affects response to substance ISO 1 195,263,489 195,303,249 RGD:6480464 CTD
G Rara retinoic acid receptor, alpha GBrowse link affects mutagenesis ISO 10 87,740,479 87,753,265 RGD:6480464 CTD
G Rarb retinoic acid receptor, beta increases expression ISO RGD:6480464 CTD
G Rasa1 RAS p21 protein activator (GTPase activating protein) 1 GBrowse link affects response to substance ISO 2 14,203,815 14,287,824 RGD:6480464 CTD
G Rbbp8 retinoblastoma binding protein 8 GBrowse link affects response to substance ISO 18 3,266,565 3,333,153 RGD:6480464 CTD
G Rbm17 RNA binding motif protein 17 GBrowse link multiple interactions ISO 17 78,139,912 78,156,805 RGD:6480464 CTD
G Rbm17 RNA binding motif protein 17 GBrowse link decreases response to substance ISO 17 78,139,912 78,156,805 RGD:6480464 CTD
G Rcbtb1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 GBrowse link affects response to substance ISO 15 38,291,075 38,371,308 RGD:6480464 CTD
G Rchy1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase GBrowse link affects response to substance ISO 14 17,683,377 17,698,982 RGD:6480464 CTD
G RGD1306063 similar to HT021 GBrowse link affects response to substance ISO 15 14,395,450 14,412,116 RGD:6480464 CTD
G Rgs2 regulator of G-protein signaling 2 GBrowse link affects response to substance ISO 13 57,891,849 57,894,452 RGD:6480464 CTD
G Rragd Ras-related GTP binding D GBrowse link affects response to substance ISO 5 49,269,195 49,304,824 RGD:6480464 CTD
G Runx3 runt-related transcription factor 3 GBrowse link affects response to substance ISO 5 153,950,116 153,973,141 RGD:6480464 CTD
G Sall2 sal-like 2 (Drosophila) GBrowse link affects response to substance ISO 15 27,762,131 27,779,639 RGD:6480464 CTD
G Satb2 SATB homeobox 2 GBrowse link affects response to substance ISO 9 55,647,221 55,824,683 RGD:6480464 CTD
G Scd stearoyl-CoA desaturase (delta-9-desaturase) GBrowse link affects response to substance ISO 1 249,358,105 249,371,164 RGD:6480464 CTD
G Schip1 schwannomin interacting protein 1 GBrowse link affects response to substance ISO 2 157,848,639 158,631,796 RGD:6480464 CTD
G Sdc2 syndecan 2 GBrowse link affects response to substance ISO 7 68,290,558 68,405,183 RGD:6480464 CTD
G Sec31a SEC31 homolog A (S. cerevisiae) GBrowse link affects response to substance ISO 14 10,466,582 10,522,655 RGD:6480464 CTD
G Sfn stratifin GBrowse link affects response to substance ISO 5 151,475,395 151,479,996 RGD:6480464 CTD
G Sfrp4 secreted frizzled-related protein 4 GBrowse link affects response to substance ISO 17 53,121,425 53,131,507 RGD:6480464 CTD
G Slc16a6 solute carrier family 16, member 6 (monocarboxylic acid transporter 7) GBrowse link affects response to substance ISO 10 98,853,289 98,875,189 RGD:6480464 CTD
G Slc7a5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 GBrowse link affects response to substance ISO 19 52,120,728 52,149,332 RGD:6480464 CTD
G Slco4a1 solute carrier organic anion transporter family, member 4a1 GBrowse link affects response to substance ISO 3 169,520,588 169,539,579 RGD:6480464 CTD
G Slmo2 slowmo homolog 2 (Drosophila) affects response to substance ISO RGD:6480464 CTD
G Smad2 SMAD family member 2 GBrowse link affects response to substance ISO 18 73,180,520 73,241,707 RGD:6480464 CTD
G Sorbs1 sorbin and SH3 domain containing 1 GBrowse link affects response to substance ISO 1 245,419,532 245,527,846 RGD:6480464 CTD
G Spon1 spondin 1, extracellular matrix protein GBrowse link affects response to substance ISO 1 171,700,495 172,020,808 RGD:6480464 CTD
G Spon2 spondin 2, extracellular matrix protein affects response to substance ISO RGD:6480464 CTD
G Srd5a1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) GBrowse link affects response to substance ISO 17 3,845,190 3,879,165 RGD:6480464 CTD
G Sytl2 synaptotagmin-like 2 GBrowse link affects response to substance ISO 1 146,977,959 147,084,664 RGD:6480464 CTD
G Tagln transgelin GBrowse link affects response to substance ISO 8 48,902,208 48,907,682 RGD:6480464 CTD
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) GBrowse link affects response to substance ISO 20 4,790,363 4,800,730 RGD:6480464 CTD
G Tbc1d8 TBC1 domain family, member 8 GBrowse link affects response to substance ISO 9 38,443,425 38,554,183 RGD:6480464 CTD
G Tff3 trefoil factor 3, intestinal GBrowse link affects response to substance ISO 20 9,469,888 9,474,604 RGD:6480464 CTD
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein GBrowse link affects response to substance ISO 4 120,590,164 120,617,530 RGD:6480464 CTD
G Tmem47 transmembrane protein 47 GBrowse link affects response to substance ISO X 67,522,289 67,549,061 RGD:6480464 CTD
G Tnks tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase GBrowse link affects response to substance ISO 16 60,953,917 61,095,523 RGD:6480464 CTD
G Tpd52 tumor protein D52 GBrowse link affects response to substance ISO 2 94,850,203 94,880,802 RGD:6480464 CTD
G Tpm1 tropomyosin 1, alpha GBrowse link affects response to substance ISO 8 71,331,304 71,358,063 RGD:6480464 CTD
G Trib1 tribbles homolog 1 (Drosophila) GBrowse link affects response to substance ISO 7 96,442,239 96,448,785 RGD:6480464 CTD
G Trim2 tripartite motif-containing 2 GBrowse link affects response to substance ISO 2 175,908,880 175,974,709 RGD:6480464 CTD
G Ubl3 ubiquitin-like 3 GBrowse link affects response to substance ISO 12 7,019,485 7,063,818 RGD:6480464 CTD
G Uchl1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) GBrowse link affects response to substance ISO 14 44,114,392 44,124,947 RGD:6480464 CTD
G Uqcrh ubiquinol-cytochrome c reductase hinge protein GBrowse link affects response to substance ISO 5 136,255,481 136,263,676 RGD:6480464 CTD
G Utrn utrophin GBrowse link affects response to substance ISO 1 7,099,840 7,614,980 RGD:6480464 CTD
G Vcan versican GBrowse link affects response to substance ISO 2 19,712,629 19,801,443 RGD:6480464 CTD
G Wars tryptophanyl-tRNA synthetase GBrowse link affects response to substance ISO 6 133,200,866 133,232,048 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link affects localization ISO X 3,011,520 3,047,798 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link decreases expression ISO X 3,011,520 3,047,798 RGD:6480464 CTD
G Zfand1 zinc finger, AN1-type domain 1 GBrowse link affects response to substance ISO 2 93,397,689 93,407,496 RGD:6480464 CTD
G Zscan18 zinc finger and SCAN domain containing 18 GBrowse link affects response to substance ISO 1 73,243,987 73,251,347 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        pharmacological role 126923
          analgesic 22633
            mitoxantrone 230
              mitoxantrone dihydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic group 167766
                              organic divalent group 166601
                                organodiyl group 166601
                                  carbonyl group 166291
                                    carbonyl compound 166291
                                      ketone 31433
                                        cyclic ketone 13295
                                          quinone 6220
                                            acenoquinone 429
                                              anthraquinone 429
                                                hydroxyanthraquinones 427
                                                  mitoxantrone 230
                                                    mitoxantrone dihydrochloride 0
paths to the root

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