ONTOLOGY REPORT - ANNOTATIONS

Term:dipyridamole
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Accession:CHEBI:4653 term browser browse the term
Definition:A pyrimidopyrimidine that has formula C24H40N8O4.
Synonyms:exact_synonym: 2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
 related_synonym: C24H40N8O4;   Cardoxin;   Cleridium 150;   Curantyl;   Dipyridamine;   Dipyudamine;   Dypyridamol;   InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2;   InChIKey=IZEKFCXSFNUWAM-UHFFFAOYSA-N;   OCCN(CCO)c1nc(N2CCCCC2)c2nc(nc(N3CCCCC3)c2n1)N(CCO)CCO;   Persantin;   dipiridamol;   dipyridamolum
 xref_casrn: 58-32-2
 xref: Beilstein:0068373 "Beilstein Registry Number";   ChEMBL:186042 "ChEMBL COMPOUND";   ChemIDplus:58-32-2 "CAS Registry Number";   DrugBank:DB00975 "DrugBank";   KEGG DRUG:D00302 "KEGG DRUG"
 xref_mesh: MESH:D004176
 xref: Patent:GB807826 "Patent";   Patent:US3031450 "Patent";   Wikipedia:Dipyridamole "Wikipedia"

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Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 GBrowse link decreases activity EXP 13 95,672,083 95,953,687 RGD:6480464 CTD
G ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 GBrowse link multiple interactions EXP 13 95,672,083 95,953,687 RGD:6480464 CTD
G ADORA3 adenosine A3 receptor GBrowse link increases expression ISO 1 112,025,970 112,106,597 RGD:6480464 CTD
G APOE apolipoprotein E GBrowse link multiple interactions EXP 19 45,409,039 45,412,650 RGD:6480464 CTD
G BCL2L1 BCL2-like 1 GBrowse link multiple interactions EXP 20 30,252,261 30,310,656 RGD:6480464 CTD
G CASP1 caspase 1, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 11 104,896,235 104,905,884 RGD:6480464 CTD
G CASP3 caspase 3, apoptosis-related cysteine peptidase GBrowse link multiple interactions EXP 4 185,548,850 185,570,629 RGD:6480464 CTD
G CASP3 caspase 3, apoptosis-related cysteine peptidase GBrowse link multiple interactions EXP 4 185,548,850 185,570,629 RGD:6480464 CTD
G CASP3 caspase 3, apoptosis-related cysteine peptidase GBrowse link increases activity EXP 4 185,548,850 185,570,629 RGD:6480464 CTD
G CASP7 caspase 7, apoptosis-related cysteine peptidase GBrowse link increases activity EXP 10 115,438,921 115,490,668 RGD:6480464 CTD
G CASP7 caspase 7, apoptosis-related cysteine peptidase GBrowse link multiple interactions EXP 10 115,438,921 115,490,668 RGD:6480464 CTD
G CASP8 caspase 8, apoptosis-related cysteine peptidase GBrowse link multiple interactions EXP 2 202,098,166 202,152,434 RGD:6480464 CTD
G CCL2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 17 32,582,296 32,584,222 RGD:6480464 CTD
G CCL2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 17 32,582,296 32,584,222 RGD:6480464 CTD
G CD40LG CD40 ligand GBrowse link decreases secretion EXP X 135,730,336 135,742,549 RGD:6480464 CTD
G CFLAR CASP8 and FADD-like apoptosis regulator GBrowse link multiple interactions EXP 2 201,980,877 202,037,411 RGD:6480464 CTD
G CLDN5 claudin 5 GBrowse link increases expression ISO 22 19,510,547 19,512,860 RGD:6480464 CTD
G COL1A1 collagen, type I, alpha 1 GBrowse link multiple interactions EXP 17 48,261,457 48,279,000 RGD:6480464 CTD
G COL1A1 collagen, type I, alpha 1 GBrowse link decreases expression ISO 17 48,261,457 48,279,000 RGD:6480464 CTD
G COL1A1 collagen, type I, alpha 1 GBrowse link decreases expression ISO 17 48,261,457 48,279,000 RGD:6480464 CTD
G COL3A1 collagen, type III, alpha 1 GBrowse link multiple interactions EXP 2 189,839,099 189,877,472 RGD:6480464 CTD
G CXCL12 chemokine (C-X-C motif) ligand 12 GBrowse link decreases expression ISO 10 44,865,605 44,880,545 RGD:6480464 CTD
G DIABLO diablo, IAP-binding mitochondrial protein GBrowse link multiple interactions EXP 12 122,692,209 122,712,068 RGD:6480464 CTD
G DUSP1 dual specificity phosphatase 1 GBrowse link increases phosphorylation ISO 5 172,195,093 172,198,203 RGD:6480464 CTD
G DUSP1 dual specificity phosphatase 1 GBrowse link multiple interactions ISO 5 172,195,093 172,198,203 RGD:6480464 CTD
G DUSP1 dual specificity phosphatase 1 GBrowse link increases phosphorylation ISO 5 172,195,093 172,198,203 RGD:6480464 CTD
G DUSP1 dual specificity phosphatase 1 GBrowse link multiple interactions ISO 5 172,195,093 172,198,203 RGD:6480464 CTD
G FADD Fas (TNFRSF6)-associated via death domain GBrowse link increases expression EXP 11 70,049,269 70,053,508 RGD:6480464 CTD
G FADD Fas (TNFRSF6)-associated via death domain GBrowse link multiple interactions EXP 11 70,049,269 70,053,508 RGD:6480464 CTD
G FOS FBJ murine osteosarcoma viral oncogene homolog GBrowse link increases expression EXP 14 75,745,481 75,748,937 RGD:6480464 CTD
G HMOX1 heme oxygenase (decycling) 1 GBrowse link increases expression ISO 22 35,777,060 35,790,207 RGD:6480464 CTD
G HMOX1 heme oxygenase (decycling) 1 GBrowse link multiple interactions ISO 22 35,777,060 35,790,207 RGD:6480464 CTD
G ICAM1 intercellular adhesion molecule 1 GBrowse link decreases expression ISO 19 10,381,517 10,397,291 RGD:6480464 CTD
G IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta GBrowse link multiple interactions ISO 8 42,128,820 42,190,171 RGD:6480464 CTD
G IL1B interleukin 1, beta GBrowse link multiple interactions EXP 2 113,587,337 113,594,356 RGD:6480464 CTD
G IL2 interleukin 2 GBrowse link decreases expression ISO 4 123,372,625 123,377,650 RGD:6480464 CTD
G IL6 interleukin 6 (interferon, beta 2) GBrowse link multiple interactions ISO 7 22,766,766 22,771,621 RGD:6480464 CTD
G INSR insulin receptor GBrowse link multiple interactions EXP 19 7,112,266 7,294,011 RGD:6480464 CTD
G LEP leptin GBrowse link multiple interactions ISO 7 127,881,331 127,897,682 RGD:6480464 CTD
G LEP leptin GBrowse link increases expression ISO 7 127,881,331 127,897,682 RGD:6480464 CTD
G MAPK8 mitogen-activated protein kinase 8 GBrowse link increases activity EXP 10 49,609,687 49,643,183 RGD:6480464 CTD
G NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions ISO 14 35,870,716 35,873,960 RGD:6480464 CTD
G NOS2 nitric oxide synthase 2, inducible GBrowse link multiple interactions ISO 17 26,083,792 26,127,555 RGD:6480464 CTD
G NOS2 nitric oxide synthase 2, inducible GBrowse link increases expression ISO 17 26,083,792 26,127,555 RGD:6480464 CTD
G NOS2 nitric oxide synthase 2, inducible GBrowse link increases expression ISO 17 26,083,792 26,127,555 RGD:6480464 CTD
G NPPB natriuretic peptide B GBrowse link increases expression EXP 1 11,917,521 11,918,992 RGD:6480464 CTD
G ORM1 orosomucoid 1 GBrowse link multiple interactions EXP 9 117,085,303 117,088,759 RGD:6480464 CTD
G ORM1 orosomucoid 1 GBrowse link affects binding EXP 9 117,085,303 117,088,759 RGD:6480464 CTD
G ORM2 orosomucoid 2 GBrowse link multiple interactions EXP 9 117,092,069 117,095,536 RGD:6480464 CTD
G PDE10A phosphodiesterase 10A GBrowse link multiple interactions EXP 6 165,740,776 166,075,588 RGD:6480464 CTD
G PDE11A phosphodiesterase 11A GBrowse link multiple interactions EXP 2 178,487,977 178,973,066 RGD:6480464 CTD
G PDE4B phosphodiesterase 4B, cAMP-specific GBrowse link increases expression ISO 1 66,258,193 66,840,262 RGD:6480464 CTD
G PDE5A phosphodiesterase 5A, cGMP-specific GBrowse link decreases activity EXP 4 120,415,550 120,549,981 RGD:6480464 CTD
G PDE7A phosphodiesterase 7A GBrowse link multiple interactions EXP 8 66,626,569 66,753,969 RGD:6480464 CTD
G PDE7B phosphodiesterase 7B GBrowse link multiple interactions EXP 6 136,172,834 136,516,709 RGD:6480464 CTD
G PDE7B phosphodiesterase 7B GBrowse link multiple interactions ISO 6 136,172,834 136,516,709 RGD:6480464 CTD
G PDE7B phosphodiesterase 7B GBrowse link multiple interactions EXP 6 136,172,834 136,516,709 RGD:6480464 CTD
G PDE7B phosphodiesterase 7B GBrowse link multiple interactions ISO 6 136,172,834 136,516,709 RGD:6480464 CTD
G PDE8A phosphodiesterase 8A GBrowse link multiple interactions EXP 15 85,523,744 85,682,376 RGD:6480464 CTD
G PDE8A phosphodiesterase 8A GBrowse link multiple interactions ISO 15 85,523,744 85,682,376 RGD:6480464 CTD
G PDE8B phosphodiesterase 8B GBrowse link multiple interactions EXP 5 76,506,706 76,724,081 RGD:6480464 CTD
G PDE8B phosphodiesterase 8B GBrowse link multiple interactions EXP 5 76,506,706 76,724,081 RGD:6480464 CTD
G PLAT plasminogen activator, tissue GBrowse link multiple interactions EXP 8 42,032,236 42,065,194 RGD:6480464 CTD
G PLAT plasminogen activator, tissue GBrowse link increases secretion EXP 8 42,032,236 42,065,194 RGD:6480464 CTD
G PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) GBrowse link multiple interactions ISO 1 186,640,944 186,649,559 RGD:6480464 CTD
G PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) GBrowse link multiple interactions ISO 1 186,640,944 186,649,559 RGD:6480464 CTD
G RCAN1 regulator of calcineurin 1 GBrowse link affects binding EXP 21 35,888,782 35,987,382 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link multiple interactions EXP 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link multiple interactions EXP 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link decreases activity EXP 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link multiple interactions ISO 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link multiple interactions ISO 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link multiple interactions ISO 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A1 solute carrier family 29 (nucleoside transporters), member 1 GBrowse link multiple interactions EXP 6 44,187,242 44,201,888 RGD:6480464 CTD
G SLC29A2 solute carrier family 29 (nucleoside transporters), member 2 GBrowse link multiple interactions EXP 11 66,129,992 66,139,291 RGD:6480464 CTD
G SLC29A2 solute carrier family 29 (nucleoside transporters), member 2 GBrowse link multiple interactions ISO 11 66,129,992 66,139,291 RGD:6480464 CTD
G SLC4A1 solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) GBrowse link multiple interactions EXP 17 42,325,758 42,345,502 RGD:6480464 CTD
G SPP1 secreted phosphoprotein 1 GBrowse link multiple interactions ISO 4 88,896,802 88,904,563 RGD:6480464 CTD
G SPP1 secreted phosphoprotein 1 GBrowse link multiple interactions ISO 4 88,896,802 88,904,563 RGD:6480464 CTD
G TGFB1 transforming growth factor, beta 1 GBrowse link multiple interactions EXP 19 41,836,812 41,859,831 RGD:6480464 CTD
G TH tyrosine hydroxylase GBrowse link decreases expression ISO 11 2,185,159 2,193,035 RGD:6480464 CTD
G TNF tumor necrosis factor GBrowse link decreases expression ISO 6 31,543,344 31,546,113 RGD:6480464 CTD
G TXN thioredoxin GBrowse link multiple interactions ISO 9 113,006,092 113,018,920 RGD:6480464 CTD
G VCAM1 vascular cell adhesion molecule 1 GBrowse link decreases expression ISO 1 101,185,196 101,204,601 RGD:6480464 CTD
G VEGFA vascular endothelial growth factor A GBrowse link increases secretion EXP 6 43,737,946 43,754,224 RGD:6480464 CTD
G VEGFA vascular endothelial growth factor A GBrowse link multiple interactions EXP 6 43,737,946 43,754,224 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 513708
    role 503229
      chemical role 217197
        inhibitor 76988
          enzyme inhibitor 72394
            adenosine deaminase inhibitor 86
              dipyridamole 86
Path 2
Term Annotations click to browse term
  CHEBI ontology 513708
    subatomic particle 512601
      composite particle 512601
        hadron 512601
          baryon 512601
            nucleon 512601
              atomic nucleus 512601
                atom 512601
                  main group element atom 480609
                    main group molecular entity 475261
                      s-block molecular entity 323985
                        hydrogen molecular entity 321181
                          hydrides 200531
                            inorganic hydride 85569
                              pnictogen hydride 83946
                                nitrogen hydride 83941
                                  azane 78331
                                    ammonia 78135
                                      organic amino compound 78072
                                        tertiary amino compound 5917
                                          tertiary amine 959
                                            dipyridamole 86
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