imatinib - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	imatinib	go back to main search page
Accession:	CHEBI:45783	browse the term
Definition:	A N-methylpiperazine that has formula C29H31N7O.
Synonyms:	related_synonym:	4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE; 4-[(4-methylpiperazin-1-yl)methyl]-N-{4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl}benzamide; C29H31N7O; CN1CCN(CC1)Cc1ccc(cc1)C(=O)Nc1ccc(C)c(Nc2nccc(n2)-c2cccnc2)c1; InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34); InChIKey=KTUFNOKKBVMGRW-UHFFFAOYSA-N; STI 571; alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-toluidide
	alt_id:	CHEBI:305376; CHEBI:38918; CHEBI:45781
	xref_casrn:	152459-95-5
	xref:	Beilstein:7671333 "Beilstein Registry Number"; ChEMBL:188797 "ChEMBL COMPOUND"; ChEMBL:305376 "ChEMBL COMPOUND"; ChemIDplus:152459-95-5 "CAS Registry Number"; CiteXplore:17457302 "PubMed citation"; CiteXplore:18407734 "PubMed citation"; DrugBank:DB00619 "DrugBank"
	xref_mesh:	MESH:C097613
	xref:	PDBeChem:STI "PDBeChem"; Patent:EP564409 "Patent"; Patent:US5521184 "Patent"; Wikipedia:Imatinib "Wikipedia"

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imatinib
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Abcb11	ATP-binding cassette, subfamily B (MDR/TAP), member 11		decreases activity	ISO				RGD:6480464	CTD
G	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A		increases expression	ISO	4	21,709,855	21,796,628	RGD:6480464	CTD
G	Abcb1a	ATP-binding cassette, sub-family B (MDR/TAP), member 1A		multiple interactions	ISO	4	21,709,855	21,796,628	RGD:6480464	CTD
G	Abcc10	ATP-binding cassette, subfamily C (CFTR/MRP), member 10		multiple interactions	ISO	9	10,219,822	10,239,734	RGD:6480464	CTD
G	Abcg2	ATP-binding cassette, subfamily G (WHITE), member 2		increases expression	ISO	4	87,502,584	87,560,017	RGD:6480464	CTD
G	Abcg2	ATP-binding cassette, subfamily G (WHITE), member 2		multiple interactions	ISO	4	87,502,584	87,560,017	RGD:6480464	CTD
G	Abcg2	ATP-binding cassette, subfamily G (WHITE), member 2		multiple interactions	ISO	4	87,502,584	87,560,017	RGD:6480464	CTD
G	Abcg2	ATP-binding cassette, subfamily G (WHITE), member 2		increases export	ISO	4	87,502,584	87,560,017	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		multiple interactions	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		increases response to substance	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases response to substance	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		multiple interactions	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		multiple interactions	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases activity	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases phosphorylation	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		multiple interactions	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases phosphorylation	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases expression	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		multiple interactions	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases phosphorylation	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase		multiple interactions	ISO	3	10,804,594	10,907,162	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		multiple interactions	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		decreases phosphorylation	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		decreases expression	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		decreases expression	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		decreases phosphorylation	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		increases phosphorylation	ISO	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Aldh2	aldehyde dehydrogenase 2 family (mitochondrial)		multiple interactions	ISO	12	36,081,778	36,116,445	RGD:6480464	CTD
G	Aldh2	aldehyde dehydrogenase 2 family (mitochondrial)		decreases expression	ISO	12	36,081,778	36,116,445	RGD:6480464	CTD
G	Aldoc	aldolase C, fructose-bisphosphate		multiple interactions	ISO	10	64,308,826	64,312,415	RGD:6480464	CTD
G	Aldoc	aldolase C, fructose-bisphosphate		decreases expression	ISO	10	64,308,826	64,312,415	RGD:6480464	CTD
G	Atf3	activating transcription factor 3		increases expression	EXP	13	107,191,622	107,223,850	RGD:6480464	CTD
G	Bad	BCL2-associated agonist of cell death		multiple interactions	ISO	1	209,617,373	209,626,292	RGD:6480464	CTD
G	Bcl2l1	Bcl2-like 1		decreases expression	ISO	3	143,129,087	143,180,199	RGD:6480464	CTD
G	Bcl2l1	Bcl2-like 1		multiple interactions	ISO	3	143,129,087	143,180,199	RGD:6480464	CTD
G	Bcl2l1	Bcl2-like 1		decreases expression	ISO	3	143,129,087	143,180,199	RGD:6480464	CTD
G	Bcl2l11	BCL2-like 11 (apoptosis facilitator)		increases response to substance	ISO	3	115,692,323	115,722,701	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		multiple interactions	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		multiple interactions	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		decreases activity	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		decreases phosphorylation	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		multiple interactions	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		decreases activity	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		multiple interactions	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bcr	breakpoint cluster region		decreases phosphorylation	ISO	20	13,972,773	14,097,816	RGD:6480464	CTD
G	Bid	BH3 interacting domain death agonist		multiple interactions	ISO	4	157,296,383	157,318,481	RGD:6480464	CTD
G	Birc2	baculoviral IAP repeat-containing 2		multiple interactions	ISO	8	4,649,559	4,667,733	RGD:6480464	CTD
G	Birc5	baculoviral IAP repeat-containing 5		decreases expression	ISO				RGD:6480464	CTD
G	Birc5	baculoviral IAP repeat-containing 5		decreases response to substance	ISO				RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp8	caspase 8		multiple interactions	ISO	9	57,389,353	57,437,803	RGD:6480464	CTD
G	Casp8	caspase 8		multiple interactions	ISO	9	57,389,353	57,437,803	RGD:6480464	CTD
G	Cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase		multiple interactions	ISO	8	47,135,357	47,211,889	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccna2	cyclin A2		multiple interactions	ISO	2	123,062,752	123,069,085	RGD:6480464	CTD
G	Ccna2	cyclin A2		decreases expression	ISO	2	123,062,752	123,069,085	RGD:6480464	CTD
G	Ccnd3	cyclin D3		multiple interactions	ISO				RGD:6480464	CTD
G	Ccnd3	cyclin D3		decreases expression	ISO				RGD:6480464	CTD
G	Ccnd3	cyclin D3		decreases expression	ISO				RGD:6480464	CTD
G	Ccnd3	cyclin D3		multiple interactions	ISO				RGD:6480464	CTD
G	Cdc25a	cell division cycle 25A		multiple interactions	ISO	8	114,237,704	114,255,971	RGD:6480464	CTD
G	Cdk1	cyclin-dependent kinase 1		multiple interactions	ISO	20	20,018,044	20,044,030	RGD:6480464	CTD
G	Cdk1	cyclin-dependent kinase 1		decreases expression	ISO	20	20,018,044	20,044,030	RGD:6480464	CTD
G	Cdk1	cyclin-dependent kinase 1		decreases expression	ISO	20	20,018,044	20,044,030	RGD:6480464	CTD
G	Cdk2	cyclin dependent kinase 2		decreases expression	ISO	7	2,000,196	2,007,682	RGD:6480464	CTD
G	Cdk4	cyclin-dependent kinase 4		decreases expression	ISO				RGD:6480464	CTD
G	Cdk4	cyclin-dependent kinase 4		multiple interactions	ISO				RGD:6480464	CTD
G	Cdkn1b	cyclin-dependent kinase inhibitor 1B		multiple interactions	ISO	4	171,841,705	171,846,506	RGD:6480464	CTD
G	Cdkn1b	cyclin-dependent kinase inhibitor 1B		multiple interactions	ISO	4	171,841,705	171,846,506	RGD:6480464	CTD
G	Cebpb	CCAAT/enhancer binding protein (C/EBP), beta		increases expression	ISO	3	158,826,021	158,827,848	RGD:6480464	CTD
G	Cflar	CASP8 and FADD-like apoptosis regulator		multiple interactions	ISO	9	57,309,836	57,356,635	RGD:6480464	CTD
G	Col1a1	collagen, type I, alpha 1		multiple interactions	ISO	10	83,622,438	83,639,368	RGD:6480464	CTD
G	Col1a2	collagen, type I, alpha 2		multiple interactions	EXP	4	29,393,645	29,428,572	RGD:6480464	CTD
G	Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like		decreases phosphorylation	ISO	11	85,520,244	85,554,667	RGD:6480464	CTD
G	Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like		decreases phosphorylation	ISO	11	85,520,244	85,554,667	RGD:6480464	CTD
G	Crkl	v-crk sarcoma virus CT10 oncogene homolog (avian)-like		multiple interactions	ISO	11	85,520,244	85,554,667	RGD:6480464	CTD
G	Csf1r	colony stimulating factor 1 receptor		decreases expression	EXP	18	57,080,324	57,107,295	RGD:6480464	CTD
G	Cul1	cullin 1		multiple interactions	ISO	4	75,636,914	75,705,724	RGD:6480464	CTD
G	Cxcl10	chemokine (C-X-C motif) ligand 10		multiple interactions	ISO	14	17,265,986	17,268,183	RGD:6480464	CTD
G	Cxcl9	chemokine (C-X-C motif) ligand 9		multiple interactions	ISO	14	17,284,085	17,288,996	RGD:6480464	CTD
G	Ddit3	DNA-damage inducible transcript 3		increases expression	EXP	7	67,247,749	67,252,571	RGD:6480464	CTD
G	Diablo	diablo, IAP-binding mitochondrial protein		multiple interactions	ISO	12	34,196,347	34,209,633	RGD:6480464	CTD
G	Dok1	docking protein 1		decreases phosphorylation	ISO	4	117,242,746	117,245,209	RGD:6480464	CTD
G	Eif4b	eukaryotic translation initiation factor 4B		decreases expression	ISO	7	140,814,663	140,836,485	RGD:6480464	CTD
G	Eif4e	eukaryotic translation initiation factor 4E		decreases expression	ISO	2	236,072,748	236,104,714	RGD:6480464	CTD
G	Fadd	Fas (TNFRSF6)-associated via death domain		multiple interactions	ISO	1	205,010,363	205,012,768	RGD:6480464	CTD
G	Fbxo16	F-box protein 16		multiple interactions	ISO	15	44,690,042	44,736,309	RGD:6480464	CTD
G	Fgfr3	fibroblast growth factor receptor 3		decreases expression	ISO	14	82,683,191	82,697,229	RGD:6480464	CTD
G	Gck	glucokinase		multiple interactions	ISO	14	86,572,518	86,587,723	RGD:6480464	CTD
G	Gck	glucokinase		decreases expression	ISO	14	86,572,518	86,587,723	RGD:6480464	CTD
G	H2afx	H2A histone family, member X		increases expression	ISO	8	47,312,609	47,313,938	RGD:6480464	CTD
G	Hdc	histidine decarboxylase		multiple interactions	ISO	3	114,119,316	114,138,107	RGD:6480464	CTD
G	Hdc	histidine decarboxylase		decreases expression	ISO	3	114,119,316	114,138,107	RGD:6480464	CTD
G	Hmox1	heme oxygenase (decycling) 1		multiple interactions	ISO	19	13,963,139	13,969,960	RGD:6480464	CTD
G	Hsf1	heat shock transcription factor 1		increases expression	ISO	7	114,524,211	114,551,166	RGD:6480464	CTD
G	Hspb1	heat shock protein 1		increases expression	ISO	12	21,911,223	21,912,784	RGD:6480464	CTD
G	Icam1	intercellular adhesion molecule 1		increases expression	ISO	8	20,040,177	20,051,939	RGD:6480464	CTD
G	Ifng	interferon gamma		increases expression	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	ISO	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Igf1	insulin-like growth factor 1		multiple interactions	ISO	7	24,531,669	24,605,742	RGD:6480464	CTD
G	Igfbp4	insulin-like growth factor binding protein 4		increases expression	ISO	10	87,822,429	87,834,315	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		decreases expression	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il4r	interleukin 4 receptor		increases expression	ISO	1	184,612,903	184,637,863	RGD:6480464	CTD
G	Jun	jun proto-oncogene		multiple interactions	ISO	5	115,358,166	115,361,259	RGD:6480464	CTD
G	Kit	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog		multiple interactions	ISO	14	34,906,043	34,984,819	RGD:6480464	CTD
G	Kit	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog		decreases expression	ISO	14	34,906,043	34,984,819	RGD:6480464	CTD
G	Krt14	keratin 14		increases expression	ISO	10	89,144,357	89,148,415	RGD:6480464	CTD
G	Krt5	keratin 5		increases expression	ISO				RGD:6480464	CTD
G	Lck	lymphocyte-specific protein tyrosine kinase		decreases phosphorylation	ISO	5	148,707,505	148,718,296	RGD:6480464	CTD
G	LOC100360940	diablo-like		multiple interactions	ISO	5	148,562,065	148,563,619	RGD:6480464	CTD
G	Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog		decreases response to substance	ISO	5	16,933,111	17,054,564	RGD:6480464	CTD
G	Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog		multiple interactions	ISO	5	16,933,111	17,054,564	RGD:6480464	CTD
G	Lyn	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog		decreases response to substance	ISO	5	16,933,111	17,054,564	RGD:6480464	CTD
G	Mapk1	mitogen activated protein kinase 1		multiple interactions	ISO	11	85,968,732	86,030,387	RGD:6480464	CTD
G	Mapk1	mitogen activated protein kinase 1		decreases phosphorylation	ISO	11	85,968,732	86,030,387	RGD:6480464	CTD
G	Mapk14	mitogen activated protein kinase 14		multiple interactions	ISO	20	6,939,249	7,000,378	RGD:6480464	CTD
G	Mapk3	mitogen activated protein kinase 3		multiple interactions	ISO	1	185,935,044	185,941,245	RGD:6480464	CTD
G	Mapk3	mitogen activated protein kinase 3		decreases phosphorylation	ISO	1	185,935,044	185,941,245	RGD:6480464	CTD
G	Mcl1	myeloid cell leukemia sequence 1		multiple interactions	ISO				RGD:6480464	CTD
G	Mtor	mechanistic target of rapamycin (serine/threonine kinase)		multiple interactions	ISO	5	165,531,402	165,640,899	RGD:6480464	CTD
G	Mtor	mechanistic target of rapamycin (serine/threonine kinase)		decreases expression	ISO	5	165,531,402	165,640,899	RGD:6480464	CTD
G	Mtor	mechanistic target of rapamycin (serine/threonine kinase)		multiple interactions	ISO	5	165,531,402	165,640,899	RGD:6480464	CTD
G	Nab2	Ngfi-A binding protein 2		increases expression	ISO	7	67,642,321	67,648,713	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		multiple interactions	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		increases phosphorylation	ISO	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		multiple interactions	ISO	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Odc1	ornithine decarboxylase 1		increases expression	ISO	6	41,309,211	41,315,796	RGD:6480464	CTD
G	Pcna	proliferating cell nuclear antigen		multiple interactions	ISO	3	120,008,715	120,012,589	RGD:6480464	CTD
G	Pdgfb	platelet-derived growth factor beta polypeptide		decreases expression	ISO	7	118,244,385	118,262,021	RGD:6480464	CTD
G	Pdgfb	platelet-derived growth factor beta polypeptide		multiple interactions	EXP	7	118,244,385	118,262,021	RGD:6480464	CTD
G	Pdgfra	platelet derived growth factor receptor, alpha polypeptide		decreases expression	ISO	14	35,369,422	35,418,126	RGD:6480464	CTD
G	Pdgfra	platelet derived growth factor receptor, alpha polypeptide		decreases expression	ISO	14	35,369,422	35,418,126	RGD:6480464	CTD
G	Pdgfra	platelet derived growth factor receptor, alpha polypeptide		multiple interactions	ISO	14	35,369,422	35,418,126	RGD:6480464	CTD
G	Pdgfra	platelet derived growth factor receptor, alpha polypeptide		decreases expression	ISO	14	35,369,422	35,418,126	RGD:6480464	CTD
G	Pdgfra	platelet derived growth factor receptor, alpha polypeptide		decreases expression	EXP	14	35,369,422	35,418,126	RGD:6480464	CTD
G	Pdgfrb	platelet derived growth factor receptor, beta polypeptide		decreases expression	ISO	18	57,014,475	57,053,581	RGD:6480464	CTD
G	Pdgfrb	platelet derived growth factor receptor, beta polypeptide		decreases phosphorylation	ISO	18	57,014,475	57,053,581	RGD:6480464	CTD
G	Pdgfrb	platelet derived growth factor receptor, beta polypeptide		decreases expression	EXP	18	57,014,475	57,053,581	RGD:6480464	CTD
G	Pdgfrb	platelet derived growth factor receptor, beta polypeptide		decreases phosphorylation	ISO	18	57,014,475	57,053,581	RGD:6480464	CTD
G	Pdgfrb	platelet derived growth factor receptor, beta polypeptide		multiple interactions	EXP	18	57,014,475	57,053,581	RGD:6480464	CTD
G	Pdhb	pyruvate dehydrogenase (lipoamide) beta		decreases expression	ISO	15	18,737,449	18,743,391	RGD:6480464	CTD
G	Pdhb	pyruvate dehydrogenase (lipoamide) beta		multiple interactions	ISO	15	18,737,449	18,743,391	RGD:6480464	CTD
G	Pecam1	platelet/endothelial cell adhesion molecule 1		multiple interactions	ISO	10	96,056,220	96,057,232	RGD:6480464	CTD
G	Pik3r1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		decreases expression	ISO	2	32,602,673	32,675,350	RGD:6480464	CTD
G	Potef	POTE ankyrin domain family, member F		multiple interactions	EXP	18	24,420,779	24,422,284	RGD:6480464	CTD
G	Pparg	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	4	151,492,220	151,617,331	RGD:6480464	CTD
G	Ppp2ca	protein phosphatase 2, catalytic subunit, alpha isozyme		increases expression	ISO	10	37,621,256	37,641,008	RGD:6480464	CTD
G	Prkcd	protein kinase C, delta		multiple interactions	ISO	16	5,954,218	5,975,743	RGD:6480464	CTD
G	Pten	phosphatase and tensin homolog		multiple interactions	ISO	1	236,771,027	236,837,261	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		multiple interactions	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Ptgs2	prostaglandin-endoperoxide synthase 2		decreases expression	ISO	13	64,427,288	64,432,978	RGD:6480464	CTD
G	Rb1	retinoblastoma 1		multiple interactions	ISO	15	53,828,881	53,962,099	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		increases methylation	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		increases phosphorylation	ISO	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Ret	ret proto-oncogene		decreases phosphorylation	ISO	4	154,448,179	154,491,103	RGD:6480464	CTD
G	Rps6	ribosomal protein S6		multiple interactions	ISO	5	106,165,612	106,168,472	RGD:6480464	CTD
G	Rps6kb1	ribosomal protein S6 kinase, polypeptide 1		decreases expression	ISO	10	76,657,024	76,698,088	RGD:6480464	CTD
G	Sohlh1	spermatogenesis and oogenesis specific basic helix-loop-helix 1		decreases expression	ISO	3	4,015,651	4,019,668	RGD:6480464	CTD
G	Sqstm1	sequestosome 1		increases expression	EXP	10	35,751,300	35,762,630	RGD:6480464	CTD
G	Stat1	signal transducer and activator of transcription 1		multiple interactions	ISO	9	46,455,635	46,497,560	RGD:6480464	CTD
G	Stat5a	signal transducer and activator of transcription 5A		multiple interactions	ISO	10	89,795,404	89,819,732	RGD:6480464	CTD
G	Tank	TRAF family member-associated NFKB activator		increases expression	ISO	3	43,396,247	43,475,491	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		decreases expression	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnfrsf10b	tumor necrosis factor receptor superfamily, member 10b		increases expression	ISO	15	50,138,439	50,163,254	RGD:6480464	CTD
G	Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b		multiple interactions	ISO	5	163,666,541	163,697,484	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		decreases secretion	ISO	9	10,520,730	10,536,071	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		multiple interactions	ISO	9	10,520,730	10,536,071	RGD:6480464	CTD
G	Wt1	Wilms tumor 1		decreases expression	ISO	3	90,529,704	90,577,280	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	492507
role	482196
application	245130
pharmaceutical	173979
drug	173776
antineoplastic agent	62937
imatinib	173
imatinib methanesulfonate	0
linkable imatinib analogue	0
Path 2
Term	Annotations
CHEBI ontology	492507
subatomic particle	491470
composite particle	491470
hadron	491470
baryon	491470
nucleon	491470
atomic nucleus	491470
atom	491470
main group element atom	461139
p-block element atom	458635
carbon group element atom	410624
carbon atom	407181
organic molecular entity	407174
organic group	167657
organic divalent group	166492
organodiyl group	166492
carbonyl group	166182
carbonyl compound	166182
carboxylic acid	121381
carboacyl group	40896
univalent carboacyl group	40896
carbamoyl group	37115
carboxamide	37106
monocarboxylic acid amide	24326
arenecarboxamide	405
benzamides	405
benzamide	178
imatinib	173
imatinib methanesulfonate	0
linkable imatinib analogue	0