nimesulide - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	nimesulide	go back to main search page
Accession:	CHEBI:44445	browse the term
Definition:	An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Synonyms:	exact_synonym:	N-(4-nitro-2-phenoxyphenyl)methanesulfonamide
	related_synonym:	4-NITRO-2-PHENOXYMETHANESULFONANILIDE; C13H12N2O5S; CS(=O)(=O)Nc1ccc(cc1Oc1ccccc1)[N+]([O-])=O; InChI=1S/C13H12N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h2-9,14H,1H3; InChIKey=HYWYRSMBCFDLJT-UHFFFAOYSA-N
	alt_id:	CHEBI:44440; CHEBI:7574
	xref_casrn:	51803-78-2
	xref:	Beilstein:2421175 "Beilstein Registry Number"; ChEMBL:185553 "ChEMBL COMPOUND"; ChemIDplus:51803-78-2 "CAS Registry Number"; DrugBank:DB04743 "DrugBank"; KEGG DRUG:D01049 "KEGG DRUG"
	xref_mesh:	MESH:C012655
	xref:	PDBeChem:NIM "PDBeChem"; Wikipedia:Nimesulide "Wikipedia"

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nimesulide
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		decreases expression	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		increases expression	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		increases expression	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2		decreases activity	EXP	4	89,011,416	89,152,474	RGD:6480464	CTD
G	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2		decreases expression	EXP	4	89,011,416	89,152,474	RGD:6480464	CTD
G	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)		decreases activity	ISO	1	230,838,269	230,850,336	RGD:6480464	CTD
G	ANGPTL4	angiopoietin-like 4		increases expression	EXP	19	8,429,011	8,439,257	RGD:6480464	CTD
G	APOE	apolipoprotein E		multiple interactions	ISO	19	45,409,039	45,412,650	RGD:6480464	CTD
G	AREG	amphiregulin		multiple interactions	EXP	4	75,310,853	75,320,726	RGD:6480464	CTD
G	BAK1	BCL2-antagonist/killer 1		multiple interactions	EXP	6	33,540,323	33,548,070	RGD:6480464	CTD
G	BAK1	BCL2-antagonist/killer 1		decreases response to substance	ISO	6	33,540,323	33,548,070	RGD:6480464	CTD
G	BAX	BCL2-associated X protein		multiple interactions	EXP	19	49,458,117	49,465,055	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		decreases expression	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		affects localization	ISO	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		decreases expression	ISO	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BID	BH3 interacting domain death agonist		multiple interactions	EXP	22	18,216,906	18,257,431	RGD:6480464	CTD
G	BIRC5	baculoviral IAP repeat containing 5		decreases expression	EXP	17	76,210,277	76,221,716	RGD:6480464	CTD
G	C1QB	complement component 1, q subcomponent, B chain		multiple interactions	EXP	1	22,979,682	22,988,029	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		increases expression	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	ISO	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		increases activity	ISO	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP8	caspase 8, apoptosis-related cysteine peptidase		multiple interactions	EXP	2	202,098,166	202,152,434	RGD:6480464	CTD
G	CASP8	caspase 8, apoptosis-related cysteine peptidase		multiple interactions	EXP	2	202,098,166	202,152,434	RGD:6480464	CTD
G	CASP9	caspase 9, apoptosis-related cysteine peptidase		multiple interactions	EXP	1	15,818,769	15,851,285	RGD:6480464	CTD
G	CASP9	caspase 9, apoptosis-related cysteine peptidase		multiple interactions	EXP	1	15,818,769	15,851,285	RGD:6480464	CTD
G	CASP9	caspase 9, apoptosis-related cysteine peptidase		increases activity	ISO	1	15,818,769	15,851,285	RGD:6480464	CTD
G	CAT	catalase		decreases activity	ISO	11	34,460,472	34,493,607	RGD:6480464	CTD
G	CAT	catalase		decreases expression	EXP	11	34,460,472	34,493,607	RGD:6480464	CTD
G	CAT	catalase		decreases activity	ISO	11	34,460,472	34,493,607	RGD:6480464	CTD
G	CAT	catalase		multiple interactions	ISO	11	34,460,472	34,493,607	RGD:6480464	CTD
G	CAV1	caveolin 1, caveolae protein, 22kDa		increases expression	EXP	7	116,164,839	116,201,239	RGD:6480464	CTD
G	CCL2	chemokine (C-C motif) ligand 2		decreases expression	EXP	17	32,582,296	32,584,222	RGD:6480464	CTD
G	CCL2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	17	32,582,296	32,584,222	RGD:6480464	CTD
G	CCL2	chemokine (C-C motif) ligand 2		multiple interactions	ISO	17	32,582,296	32,584,222	RGD:6480464	CTD
G	CCNA2	cyclin A2		multiple interactions	ISO	4	122,737,599	122,745,088	RGD:6480464	CTD
G	CCND1	cyclin D1		multiple interactions	EXP	11	69,455,873	69,469,242	RGD:6480464	CTD
G	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)		increases expression	EXP	6	36,644,237	36,655,116	RGD:6480464	CTD
G	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)		increases expression	EXP	6	36,644,237	36,655,116	RGD:6480464	CTD
G	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)		multiple interactions	EXP	6	36,644,237	36,655,116	RGD:6480464	CTD
G	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)		increases expression	EXP	12	12,870,302	12,875,305	RGD:6480464	CTD
G	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)		increases expression	EXP	12	12,870,302	12,875,305	RGD:6480464	CTD
G	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)		multiple interactions	EXP	1	51,434,367	51,440,309	RGD:6480464	CTD
G	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha		multiple interactions	ISO	19	33,790,840	33,793,430	RGD:6480464	CTD
G	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha		multiple interactions	ISO	19	33,790,840	33,793,430	RGD:6480464	CTD
G	CNR1	cannabinoid receptor 1 (brain)		multiple interactions	ISO	6	88,849,583	88,875,767	RGD:6480464	CTD
G	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa		affects localization	EXP	3	41,240,942	41,281,939	RGD:6480464	CTD
G	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa		decreases expression	ISO	3	41,240,942	41,281,939	RGD:6480464	CTD
G	CXCL10	chemokine (C-X-C motif) ligand 10		multiple interactions	ISO	4	76,942,269	76,944,689	RGD:6480464	CTD
G	CXCL11	chemokine (C-X-C motif) ligand 11		multiple interactions	ISO	4	76,954,835	76,957,350	RGD:6480464	CTD
G	CXCL11	chemokine (C-X-C motif) ligand 11		multiple interactions	ISO	4	76,954,835	76,957,350	RGD:6480464	CTD
G	CXCL9	chemokine (C-X-C motif) ligand 9		multiple interactions	ISO	4	76,922,623	76,928,641	RGD:6480464	CTD
G	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1		decreases activity	EXP	15	51,500,254	51,630,795	RGD:6480464	CTD
G	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1		multiple interactions	EXP	15	51,500,254	51,630,795	RGD:6480464	CTD
G	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1		decreases activity	EXP	15	51,500,254	51,630,795	RGD:6480464	CTD
G	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1		decreases expression	EXP	15	51,500,254	51,630,795	RGD:6480464	CTD
G	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1		decreases activity	EXP	15	51,500,254	51,630,795	RGD:6480464	CTD
G	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1		decreases expression	EXP	15	51,500,254	51,630,795	RGD:6480464	CTD
G	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4		multiple interactions	ISO	7	99,354,583	99,381,811	RGD:6480464	CTD
G	DDIT3	DNA-damage-inducible transcript 3		multiple interactions	ISO	12	57,910,371	57,914,300	RGD:6480464	CTD
G	EDN1	endothelin 1		multiple interactions	ISO	6	12,290,529	12,297,427	RGD:6480464	CTD
G	EDNRB	endothelin receptor type B		multiple interactions	EXP	13 13	78,469,616 78,513,393	78,549,664 78,549,674	RGD:6480464	CTD
G	EREG	epiregulin		multiple interactions	EXP	4	75,230,860	75,254,477	RGD:6480464	CTD
G	F2	coagulation factor II (thrombin)		decreases activity	EXP	11	46,740,743	46,761,056	RGD:6480464	CTD
G	F2	coagulation factor II (thrombin)		multiple interactions	ISO	11	46,740,743	46,761,056	RGD:6480464	CTD
G	FAAH	fatty acid amide hydrolase		multiple interactions	ISO	1	46,859,939	46,879,520	RGD:6480464	CTD
G	GPX1	glutathione peroxidase 1		decreases expression	EXP	3	49,394,609	49,395,791	RGD:6480464	CTD
G	GSK3B	glycogen synthase kinase 3 beta		decreases activity	EXP	3	119,540,800	119,813,264	RGD:6480464	CTD
G	H2AFX	H2A histone family, member X		multiple interactions	EXP	11	118,964,584	118,966,177	RGD:6480464	CTD
G	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog		multiple interactions	EXP	11	532,242	535,550	RGD:6480464	CTD
G	ICAM1	intercellular adhesion molecule 1		multiple interactions	EXP	19	10,381,517	10,397,291	RGD:6480464	CTD
G	IFNG	interferon, gamma		multiple interactions	ISO	12	68,548,550	68,553,521	RGD:6480464	CTD
G	IFNG	interferon, gamma		multiple interactions	EXP	12	68,548,550	68,553,521	RGD:6480464	CTD
G	IFNG	interferon, gamma		multiple interactions	ISO	12	68,548,550	68,553,521	RGD:6480464	CTD
G	IGF1	insulin-like growth factor 1 (somatomedin C)		decreases expression	ISO	12	102,789,645	102,874,378	RGD:6480464	CTD
G	IL10	interleukin 10		multiple interactions	EXP	1	206,940,948	206,945,839	RGD:6480464	CTD
G	IL1A	interleukin 1, alpha		multiple interactions	EXP	2	113,531,492	113,542,971	RGD:6480464	CTD
G	IL1B	interleukin 1, beta		multiple interactions	EXP	2	113,587,337	113,594,356	RGD:6480464	CTD
G	IL1B	interleukin 1, beta		multiple interactions	EXP	2	113,587,337	113,594,356	RGD:6480464	CTD
G	IL1B	interleukin 1, beta		multiple interactions	EXP	2	113,587,337	113,594,356	RGD:6480464	CTD
G	IL1B	interleukin 1, beta		multiple interactions	ISO	2	113,587,337	113,594,356	RGD:6480464	CTD
G	IL23A	interleukin 23, alpha subunit p19		multiple interactions	ISO	12	56,732,663	56,734,194	RGD:6480464	CTD
G	IL6	interleukin 6 (interferon, beta 2)		multiple interactions	EXP	7	22,766,766	22,771,621	RGD:6480464	CTD
G	IL6	interleukin 6 (interferon, beta 2)		multiple interactions	ISO	7	22,766,766	22,771,621	RGD:6480464	CTD
G	IL6	interleukin 6 (interferon, beta 2)		multiple interactions	ISO	7	22,766,766	22,771,621	RGD:6480464	CTD
G	IL8	interleukin 8		affects expression	EXP	4	74,606,223	74,609,433	RGD:6480464	CTD
G	IL8	interleukin 8		multiple interactions	EXP	4	74,606,223	74,609,433	RGD:6480464	CTD
G	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)		multiple interactions	EXP	12	54,789,045	54,813,050	RGD:6480464	CTD
G	ITGA5	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)		decreases expression	EXP	12	54,789,045	54,813,050	RGD:6480464	CTD
G	JUN	jun proto-oncogene		decreases expression	EXP	1	59,246,463	59,249,785	RGD:6480464	CTD
G	KNG1	kininogen 1		multiple interactions	ISO	3	186,435,098	186,462,199	RGD:6480464	CTD
G	KRT10	keratin 10		multiple interactions	ISO	17	38,974,369	38,978,863	RGD:6480464	CTD
G	LCT	lactase		affects activity	ISO	2	136,545,415	136,594,750	RGD:6480464	CTD
G	LCT	lactase		decreases activity	ISO	2	136,545,415	136,594,750	RGD:6480464	CTD
G	LCT	lactase		multiple interactions	ISO	2	136,545,415	136,594,750	RGD:6480464	CTD
G	LCT	lactase		increases activity	ISO	2	136,545,415	136,594,750	RGD:6480464	CTD
G	LCT	lactase		increases activity	ISO	2	136,545,415	136,594,750	RGD:6480464	CTD
G	LHB	luteinizing hormone beta polypeptide		multiple interactions	EXP	19	49,519,237	49,520,347	RGD:6480464	CTD
G	MAPK1	mitogen-activated protein kinase 1		multiple interactions	EXP	22	22,113,946	22,221,970	RGD:6480464	CTD
G	MAPK1	mitogen-activated protein kinase 1		increases phosphorylation	EXP	22	22,113,946	22,221,970	RGD:6480464	CTD
G	MAPK1	mitogen-activated protein kinase 1		multiple interactions	EXP	22	22,113,946	22,221,970	RGD:6480464	CTD
G	MAPK1	mitogen-activated protein kinase 1		increases phosphorylation	EXP	22	22,113,946	22,221,970	RGD:6480464	CTD
G	MAPK3	mitogen-activated protein kinase 3		increases phosphorylation	EXP	16	30,125,426	30,134,630	RGD:6480464	CTD
G	MAPK3	mitogen-activated protein kinase 3		multiple interactions	EXP	16	30,125,426	30,134,630	RGD:6480464	CTD
G	MAPK3	mitogen-activated protein kinase 3		multiple interactions	EXP	16	30,125,426	30,134,630	RGD:6480464	CTD
G	MAPK3	mitogen-activated protein kinase 3		increases phosphorylation	EXP	16	30,125,426	30,134,630	RGD:6480464	CTD
G	MAPK9	mitogen-activated protein kinase 9		decreases phosphorylation	EXP	5	179,660,594	179,719,071	RGD:6480464	CTD
G	MKI67	antigen identified by monoclonal antibody Ki-67		multiple interactions	ISO	10	129,894,923	129,924,468	RGD:6480464	CTD
G	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)		decreases expression	EXP	20	44,637,547	44,645,200	RGD:6480464	CTD
G	MPO	myeloperoxidase		decreases activity	ISO	17	56,347,217	56,358,296	RGD:6480464	CTD
G	MPO	myeloperoxidase		multiple interactions	EXP	17	56,347,217	56,358,296	RGD:6480464	CTD
G	NFE2L2	nuclear factor (erythroid-derived 2)-like 2		multiple interactions	EXP	2	178,095,031	178,129,859	RGD:6480464	CTD
G	NFE2L2	nuclear factor (erythroid-derived 2)-like 2		affects localization	EXP	2	178,095,031	178,129,859	RGD:6480464	CTD
G	NFE2L2	nuclear factor (erythroid-derived 2)-like 2		multiple interactions	ISO	2	178,095,031	178,129,859	RGD:6480464	CTD
G	NFE2L2	nuclear factor (erythroid-derived 2)-like 2		affects localization	ISO	2	178,095,031	178,129,859	RGD:6480464	CTD
G	NGF	nerve growth factor (beta polypeptide)		multiple interactions	ISO	1	115,828,537	115,880,857	RGD:6480464	CTD
G	NOS2	nitric oxide synthase 2, inducible		multiple interactions	ISO	17	26,083,792	26,127,555	RGD:6480464	CTD
G	NOS2	nitric oxide synthase 2, inducible		multiple interactions	ISO	17	26,083,792	26,127,555	RGD:6480464	CTD
G	NOS2	nitric oxide synthase 2, inducible		decreases expression	ISO	17	26,083,792	26,127,555	RGD:6480464	CTD
G	NOS2	nitric oxide synthase 2, inducible		increases expression	ISO	17	26,083,792	26,127,555	RGD:6480464	CTD
G	NOS2	nitric oxide synthase 2, inducible		multiple interactions	ISO	17	26,083,792	26,127,555	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		multiple interactions	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		increases expression	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	PARP1	poly (ADP-ribose) polymerase 1		increases cleavage	EXP	1	226,548,392	226,595,801	RGD:6480464	CTD
G	PAWR	PRKC, apoptosis, WT1, regulator		increases expression	EXP	12	79,985,745	80,084,790	RGD:6480464	CTD
G	PLIN2	perilipin 2		increases expression	EXP	9	19,115,759	19,127,604	RGD:6480464	CTD
G	PPARA	peroxisome proliferator-activated receptor alpha		multiple interactions	EXP	22	46,546,499	46,639,653	RGD:6480464	CTD
G	PPARA	peroxisome proliferator-activated receptor alpha		decreases expression	EXP	22	46,546,499	46,639,653	RGD:6480464	CTD
G	PPARA	peroxisome proliferator-activated receptor alpha		increases expression	EXP	22	46,546,499	46,639,653	RGD:6480464	CTD
G	PPARD	peroxisome proliferator-activated receptor delta		increases expression	EXP	6	35,310,335	35,395,968	RGD:6480464	CTD
G	PPARD	peroxisome proliferator-activated receptor delta		multiple interactions	ISO	6	35,310,335	35,395,968	RGD:6480464	CTD
G	PPARD	peroxisome proliferator-activated receptor delta		multiple interactions	ISO	6	35,310,335	35,395,968	RGD:6480464	CTD
G	PPARD	peroxisome proliferator-activated receptor delta		increases response to substance	ISO	6	35,310,335	35,395,968	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	EXP	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	EXP	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	EXP	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		decreases expression	EXP	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		increases expression	EXP	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		increases expression	ISO	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	EXP	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PRKCE	protein kinase C, epsilon		multiple interactions	ISO	2	45,879,043	46,415,129	RGD:6480464	CTD
G	PSEN2	presenilin 2 (Alzheimer disease 4)		decreases activity	EXP	1	227,058,273	227,083,804	RGD:6480464	CTD
G	PTGES	prostaglandin E synthase		decreases expression	ISO	9	132,500,615	132,515,344	RGD:6480464	CTD
G	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)		increases expression	EXP	9	125,132,809	125,157,982	RGD:6480464	CTD
G	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	9	125,132,809	125,157,982	RGD:6480464	CTD
G	PTGS1	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	9	125,132,809	125,157,982	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		affects expression	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		increases expression	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		increases expression	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	EXP	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		decreases activity	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	ISO	11	65,421,067	65,430,443	RGD:6480464	CTD
G	SELE	selectin E		multiple interactions	EXP	1	169,691,781	169,703,220	RGD:6480464	CTD
G	SELL	selectin L		decreases expression	EXP	1	169,659,806	169,680,843	RGD:6480464	CTD
G	SI	sucrase-isomaltase (alpha-glucosidase)		affects activity	ISO	3	164,696,686	164,796,283	RGD:6480464	CTD
G	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1		multiple interactions	ISO	1	43,391,046	43,424,847	RGD:6480464	CTD
G	SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4		increases expression	ISO	17	7,185,054	7,191,367	RGD:6480464	CTD
G	SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4		multiple interactions	ISO	17	7,185,054	7,191,367	RGD:6480464	CTD
G	SOD2	superoxide dismutase 2, mitochondrial		decreases expression	EXP	6	160,100,148	160,114,353	RGD:6480464	CTD
G	SOD2	superoxide dismutase 2, mitochondrial		decreases expression	EXP	6	160,100,148	160,114,353	RGD:6480464	CTD
G	SP1	Sp1 transcription factor		increases expression	EXP	12	53,773,979	53,810,230	RGD:6480464	CTD
G	SULT1A1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1		decreases activity	EXP	16	28,616,908	28,634,907	RGD:6480464	CTD
G	TAC1	tachykinin, precursor 1		multiple interactions	ISO	7	97,361,271	97,369,784	RGD:6480464	CTD
G	TAC1	tachykinin, precursor 1		decreases expression	ISO	7	97,361,271	97,369,784	RGD:6480464	CTD
G	TBXA2R	thromboxane A2 receptor		increases response to substance	ISO	19	3,594,504	3,606,831	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	EXP	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		decreases expression	EXP	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		decreases activity	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		increases expression	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	EXP	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNF	tumor necrosis factor		multiple interactions	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11		multiple interactions	ISO	13	43,136,872	43,182,149	RGD:6480464	CTD
G	TYR	tyrosinase		decreases expression	ISO	11	88,911,040	89,028,927	RGD:6480464	CTD
G	VCAM1	vascular cell adhesion molecule 1		multiple interactions	EXP	1	101,185,196	101,204,601	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		affects secretion	EXP	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		multiple interactions	EXP	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		decreases expression	EXP	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		increases expression	EXP	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		decreases expression	ISO	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		multiple interactions	ISO	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VEGFC	vascular endothelial growth factor C		decreases expression	EXP	4	177,604,691	177,713,895	RGD:6480464	CTD
G	XCL1	chemokine (C motif) ligand 1		multiple interactions	ISO	1	168,545,711	168,551,315	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	513708
role	503229
application	255100
anti-inflammatory agent	36083
anti-inflammatory drug	22967
non-steroidal anti-inflammatory drug	18456
nimesulide	231
Path 2
Term	Annotations
CHEBI ontology	513708
subatomic particle	512601
composite particle	512601
hadron	512601
baryon	512601
nucleon	512601
atomic nucleus	512601
atom	512601
main group element atom	480609
p-block element atom	478027
carbon group element atom	427614
carbon atom	424022
organic molecular entity	424015
organic molecule	375005
organic cyclic compound	311241
carbocyclic compound	75621
benzenoid aromatic compound	42695
benzenes	26058
nitrobenzenes	2086
nitrobenzene	617
nimesulide	231