hydroxyurea - Ontology Report - Rat Genome Database

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Term:	hydroxyurea	go back to main search page
Accession:	CHEBI:44423	browse the term
Definition:	An urea that has formula CH4N2O2.
Synonyms:	related_synonym:	CH4N2O2; Hydroxycarbamid; Hydroxycarbamide; Hydroxyharnstoff; InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4); InChIKey=VSNHCAURESNICA-UHFFFAOYSA-N; N-HYDROXYUREA; N-carbamoylhydroxylamine; NC(=O)NO; carbamohydroxamic acid; carbamohydroximic acid; carbamoyl oxime; carbamyl hydroxamate; hydrea; oxyurea
	alt_id:	CHEBI:44420; CHEBI:5816
	xref_casrn:	127-07-1
	xref:	ChEMBL:104730 "ChEMBL COMPOUND"; ChemIDplus:127-07-1 "CAS Registry Number"; ChemIDplus:1741548 "Beilstein Registry Number"; DrugBank:DB01005 "DrugBank"; Gmelin:130423 "Gmelin Registry Number"; KEGG COMPOUND:127-07-1 "CAS Registry Number"; KEGG COMPOUND:C07044 "KEGG COMPOUND"
	xref_mesh:	MESH:D006918
	xref:	PDBeChem:NHY "PDBeChem"; Wikipedia:Hydroxyurea "Wikipedia"

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hydroxyurea
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Aldoa	aldolase A, fructose-bisphosphate		multiple interactions	ISO	1	185,970,658	185,974,615	RGD:6480464	CTD
G	Alox5	arachidonate 5-lipoxygenase		multiple interactions	ISO	4	152,610,283	152,657,891	RGD:6480464	CTD
G	Atp6v1f	ATPase, H transporting, lysosomal V1 subunit F		increases mutagenesis	ISO	4	56,347,184	56,350,085	RGD:6480464	CTD
G	Atr	ataxia telangiectasia and Rad3 related		multiple interactions	ISO	8	100,936,342	101,014,881	RGD:6480464	CTD
G	Atr	ataxia telangiectasia and Rad3 related		multiple interactions	ISO	8	100,936,342	101,014,881	RGD:6480464	CTD
G	Bax	Bcl2-associated X protein		increases expression	ISO	1	95,933,023	95,938,176	RGD:6480464	CTD
G	Bax	Bcl2-associated X protein		increases expression	ISO	1	95,933,023	95,938,176	RGD:6480464	CTD
G	Bcl2l1	Bcl2-like 1		decreases response to substance	EXP	3	143,129,087	143,180,199	RGD:6480464	CTD
G	Blm	Bloom syndrome, RecQ helicase-like		increases expression	ISO	1	136,271,573	136,358,077	RGD:6480464	CTD
G	Bmi1	Bmi1 polycomb ring finger oncogene		decreases expression	ISO	17	92,784,216	92,787,947	RGD:6480464	CTD
G	Bora	bora, aurora kinase A activator		decreases expression	ISO	15	82,829,209	82,852,061	RGD:6480464	CTD
G	Bpnt1	3'(2'), 5'-bisphosphate nucleotidase 1		increases mutagenesis	ISO	13	101,340,544	101,367,549	RGD:6480464	CTD
G	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)		increases expression	ISO	1	211,509,675	211,518,963	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases activity	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp3	caspase 3		increases cleavage	ISO	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Ccna2	cyclin A2		increases expression	ISO	2	123,062,752	123,069,085	RGD:6480464	CTD
G	Ccnb1	cyclin B1		increases expression	ISO	2	31,574,600	31,581,784	RGD:6480464	CTD
G	Ccnb1	cyclin B1		decreases expression	ISO	2	31,574,600	31,581,784	RGD:6480464	CTD
G	Ccnd1	cyclin D1		increases expression	ISO	1	205,357,235	205,366,757	RGD:6480464	CTD
G	Ccnd1	cyclin D1		decreases expression	ISO	1	205,357,235	205,366,757	RGD:6480464	CTD
G	Ccnd2	cyclin D2		increases expression	ISO	4	163,523,817	163,546,501	RGD:6480464	CTD
G	Ccnd3	cyclin D3		increases expression	ISO				RGD:6480464	CTD
G	Ccne1	cyclin E1		increases expression	ISO	1	90,568,189	90,577,426	RGD:6480464	CTD
G	Ccne2	cyclin E2		decreases expression	ISO	5	25,032,748	25,044,509	RGD:6480464	CTD
G	Ccng1	cyclin G1		increases expression	ISO	10	25,776,380	25,782,754	RGD:6480464	CTD
G	Ccng2	cyclin G2		increases expression	ISO	14	16,338,132	16,346,628	RGD:6480464	CTD
G	Cdc25a	cell division cycle 25A		increases expression	ISO	8	114,237,704	114,255,971	RGD:6480464	CTD
G	Cdca8	cell division cycle associated 8		decreases expression	ISO	5	144,251,164	144,276,352	RGD:6480464	CTD
G	Cdk4	cyclin-dependent kinase 4		decreases expression	ISO				RGD:6480464	CTD
G	Cdk4	cyclin-dependent kinase 4		decreases expression	ISO				RGD:6480464	CTD
G	Cdk5rap1	CDK5 regulatory subunit associated protein 1		increases mutagenesis	ISO	3	144,803,213	144,840,056	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		multiple interactions	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	EXP	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1a	cyclin-dependent kinase inhibitor 1A		increases expression	ISO	20	7,376,325	7,386,778	RGD:6480464	CTD
G	Cdkn1b	cyclin-dependent kinase inhibitor 1B		increases expression	ISO	4	171,841,705	171,846,506	RGD:6480464	CTD
G	Cdkn1b	cyclin-dependent kinase inhibitor 1B		multiple interactions	ISO	4	171,841,705	171,846,506	RGD:6480464	CTD
G	Cdkn1c	cyclin-dependent kinase inhibitor 1C		increases expression	ISO	1	203,835,215	203,837,844	RGD:6480464	CTD
G	Cdkn2a	cyclin-dependent kinase inhibitor 2A		multiple interactions	ISO	5	108,908,749	108,916,380	RGD:6480464	CTD
G	Cdkn2a	cyclin-dependent kinase inhibitor 2A		increases expression	ISO	5	108,908,749	108,916,380	RGD:6480464	CTD
G	Chchd3	coiled-coil-helix-coiled-coil-helix domain containing 3		decreases expression	ISO	4	59,891,615	60,170,903	RGD:6480464	CTD
G	Chek1	checkpoint kinase 1		multiple interactions	ISO	8	37,954,322	37,974,748	RGD:6480464	CTD
G	Chek1	checkpoint kinase 1		decreases expression	ISO	8	37,954,322	37,974,748	RGD:6480464	CTD
G	Cideb	cell death-inducing DFFA-like effector b		decreases expression	ISO	15	33,916,472	33,920,872	RGD:6480464	CTD
G	Cks2	CDC28 protein kinase regulatory subunit 2		decreases expression	ISO	17	19,423,502	19,429,451	RGD:6480464	CTD
G	Cpb2	carboxypeptidase B2 (plasma)		decreases expression	ISO	15	56,104,920	56,154,321	RGD:6480464	CTD
G	Cradd	CASP2 and RIPK1 domain containing adaptor with death domain		increases mutagenesis	ISO	7	32,504,279	32,517,581	RGD:6480464	CTD
G	Cxcr1	chemokine (C-X-C motif) receptor 1		increases mutagenesis	ISO	9	73,510,488	73,511,537	RGD:6480464	CTD
G	Dclre1c	DNA cross-link repair 1C		increases response to substance	ISO	17	85,896,581	85,928,644	RGD:6480464	CTD
G	Ddb2	damage specific DNA binding protein 2		increases expression	ISO	3	75,568,487	75,591,428	RGD:6480464	CTD
G	Dlgap1	discs, large (Drosophila) homolog-associated protein 1		increases mutagenesis	ISO	9	109,455,911	110,018,738	RGD:6480464	CTD
G	Dnmt1	DNA (cytosine-5-)-methyltransferase 1		affects response to substance	ISO	8	19,926,995	19,973,256	RGD:6480464	CTD
G	Dym	dymeclin		increases mutagenesis	ISO	18	71,889,053	72,188,251	RGD:6480464	CTD
G	Ech1	enoyl CoA hydratase 1, peroxisomal		increases mutagenesis	ISO	1	83,932,720	83,938,918	RGD:6480464	CTD
G	Edn3	endothelin 3		decreases expression	ISO	3	166,491,368	166,514,051	RGD:6480464	CTD
G	Epo	erythropoietin		increases expression	ISO	12	19,551,768	19,555,208	RGD:6480464	CTD
G	Ercc5	excision repair cross-complementing rodent repair deficiency, complementation group 5		increases expression	ISO	9	43,248,023	43,293,196	RGD:6480464	CTD
G	Fas	Fas (TNF receptor superfamily, member 6)		increases expression	ISO	1	238,259,443	238,274,745	RGD:6480464	CTD
G	Fas	Fas (TNF receptor superfamily, member 6)		increases expression	ISO	1	238,259,443	238,274,745	RGD:6480464	CTD
G	Faslg	Fas ligand (TNF superfamily, member 6)		increases expression	ISO	13	77,472,950	77,480,210	RGD:6480464	CTD
G	Fkbp3	FK506 binding protein 3		increases expression	ISO	6	86,410,859	86,422,588	RGD:6480464	CTD
G	Fos	FBJ osteosarcoma oncogene		multiple interactions	ISO	6	109,559,135	109,562,001	RGD:6480464	CTD
G	Gadd45a	growth arrest and DNA-damage-inducible, alpha		increases expression	ISO	4	96,649,941	96,652,243	RGD:6480464	CTD
G	Galnt16	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16		increases mutagenesis	ISO	6	104,285,081	104,366,257	RGD:6480464	CTD
G	Gapdh	glyceraldehyde-3-phosphate dehydrogenase		multiple interactions	ISO	4	161,282,215	161,286,090	RGD:6480464	CTD
G	Gapdh	glyceraldehyde-3-phosphate dehydrogenase		affects localization	ISO	4	161,282,215	161,286,090	RGD:6480464	CTD
G	Gapdh	glyceraldehyde-3-phosphate dehydrogenase		decreases activity	ISO	4	161,282,215	161,286,090	RGD:6480464	CTD
G	Got2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)		multiple interactions	ISO	19	9,629,687	9,655,336	RGD:6480464	CTD
G	Grb14	growth factor receptor bound protein 14		increases mutagenesis	ISO	3	46,832,380	46,952,670	RGD:6480464	CTD
G	Hdac2	histone deacetylase 2		multiple interactions	ISO	20	41,162,093	41,186,492	RGD:6480464	CTD
G	Hesx1	HESX homeobox 1		increases mutagenesis	ISO	16	2,255,128	2,257,233	RGD:6480464	CTD
G	Hspa8	heat shock 70kDa protein 8		increases expression	ISO	8	43,784,035	43,787,760	RGD:6480464	CTD
G	Ier3	immediate early response 3		increases expression	ISO	20	3,076,568	3,077,772	RGD:6480464	CTD
G	Il13	interleukin 13		affects expression	ISO	10	39,093,512	39,096,069	RGD:6480464	CTD
G	Kif3b	kinesin family member 3B		increases mutagenesis	ISO	3	143,642,175	143,681,902	RGD:6480464	CTD
G	Kpna2	karyopherin alpha 2		decreases expression	ISO	10	96,342,214	96,352,613	RGD:6480464	CTD
G	Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog		decreases expression	ISO	4	182,869,242	182,895,106	RGD:6480464	CTD
G	LOC100359600	karyopherin alpha 2-like		decreases expression	ISO	6	10,523,393	10,524,982	RGD:6480464	CTD
G	Mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast)		decreases expression	ISO	4	96,380,039	96,386,042	RGD:6480464	CTD
G	Mapk1	mitogen activated protein kinase 1		decreases phosphorylation	EXP	11	85,968,732	86,030,387	RGD:6480464	CTD
G	Mapk3	mitogen activated protein kinase 3		decreases phosphorylation	EXP	1	185,935,044	185,941,245	RGD:6480464	CTD
G	Mapk8	mitogen-activated protein kinase 8		decreases phosphorylation	EXP	16	8,925,133	9,004,897	RGD:6480464	CTD
G	Mdm2	p53 E3 ubiquitin protein ligase		increases expression	ISO	7	56,996,694	57,020,926	RGD:6480464	CTD
G	Mdm2	p53 E3 ubiquitin protein ligase		affects expression	ISO	7	56,996,694	57,020,926	RGD:6480464	CTD
G	Mdm2	p53 E3 ubiquitin protein ligase		increases expression	ISO	7	56,996,694	57,020,926	RGD:6480464	CTD
G	Mecom	MDS1 and EVI1 complex locus		increases expression	ISO	2	114,814,409	114,882,676	RGD:6480464	CTD
G	Mgmt	O-6-methylguanine-DNA methyltransferase		increases expression	ISO	1	196,629,366	196,866,937	RGD:6480464	CTD
G	Mpg	N-methylpurine-DNA glycosylase		increases expression	ISO	10	15,643,334	15,649,561	RGD:6480464	CTD
G	Nampt	nicotinamide phosphoribosyltransferase		decreases expression	ISO	6	51,129,160	51,166,514	RGD:6480464	CTD
G	Nek3	NIMA-related kinase 3		decreases expression	ISO	16	74,524,839	74,547,785	RGD:6480464	CTD
G	Neurod4	neuronal differentiation 4		decreases expression	ISO	7	8,534,957	8,547,130	RGD:6480464	CTD
G	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1		increases expression	ISO	2	233,091,013	233,187,501	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		increases expression	ISO	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Nudt12	nudix (nucleoside diphosphate linked moiety X)-type motif 12		increases expression	ISO	9	97,551,943	97,565,919	RGD:6480464	CTD
G	Nus1	nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae)		decreases expression	ISO	20	31,143,886	31,170,668	RGD:6480464	CTD
G	Pcna	proliferating cell nuclear antigen		increases expression	ISO	3	120,008,715	120,012,589	RGD:6480464	CTD
G	Pklr	pyruvate kinase, liver and RBC		decreases expression	ISO	2	181,214,853	181,223,505	RGD:6480464	CTD
G	Ppp1r12a	protein phosphatase 1, regulatory subunit 12A		decreases expression	ISO	7	46,876,552	46,986,022	RGD:6480464	CTD
G	Prc1	protein regulator of cytokinesis 1		decreases expression	ISO	1	136,112,674	136,133,720	RGD:6480464	CTD
G	Prl2b1	Prolactin family 2, subfamily b, member 1		increases expression	ISO	17	44,180,979	44,188,002	RGD:6480464	CTD
G	Prune	prune exopolyphosphatase		increases mutagenesis	ISO	2	190,165,356	190,192,807	RGD:6480464	CTD
G	Psip1	PC4 and SFRS1 interacting protein 1		decreases expression	ISO	5	102,304,948	102,336,608	RGD:6480464	CTD
G	Psrc1	proline/serine-rich coiled-coil 1		decreases expression	ISO	2	203,952,299	203,956,742	RGD:6480464	CTD
G	Rab34	RAB34, member RAS oncogene family		increases expression	ISO	10	64,443,111	64,447,315	RGD:6480464	CTD
G	Rad23a	RAD23 homolog A (S. cerevisiae)		decreases expression	ISO	19	24,971,070	24,976,901	RGD:6480464	CTD
G	Ran	RAN, member RAS oncogene family		decreases expression	ISO	12	28,736,786	28,739,921	RGD:6480464	CTD
G	Rara	retinoic acid receptor, alpha		increases mutagenesis	ISO	10	87,740,479	87,753,265	RGD:6480464	CTD
G	Rbm4	RNA binding motif protein 4		increases mutagenesis	ISO	1	207,394,470	207,403,393	RGD:6480464	CTD
G	Rfx4	regulatory factor X, 4 (influences HLA class II expression)		increases mutagenesis	ISO	7	20,976,369	21,052,088	RGD:6480464	CTD
G	Rnf19a	ring finger protein 19A, E3 ubiquitin protein ligase		decreases expression	ISO	7	71,763,837	71,803,435	RGD:6480464	CTD
G	Rpl22l1	ribosomal protein L22 like 1		decreases expression	ISO	2	116,168,790	116,170,726	RGD:6480464	CTD
G	Rras	related RAS viral (r-ras) oncogene homolog		increases expression	ISO	1	95,490,730	95,495,462	RGD:6480464	CTD
G	Rrm2b	ribonucleotide reductase M2 B (TP53 inducible)		increases expression	ISO	7	73,432,161	73,459,541	RGD:6480464	CTD
G	Runx1	runt-related transcription factor 1		increases expression	ISO	11	32,623,461	32,725,404	RGD:6480464	CTD
G	Sgk1	serum/glucocorticoid regulated kinase 1		increases expression	ISO	1	23,501,257	23,506,651	RGD:6480464	CTD
G	Slc14a1	solute carrier family 14 (urea transporter), member 1		affects transport	ISO	18	75,024,200	75,048,481	RGD:6480464	CTD
G	Slc16a12	solute carrier family 16, member 12 (monocarboxylic acid transporter 12)		increases mutagenesis	ISO	1	238,643,040	238,665,699	RGD:6480464	CTD
G	Snca	synuclein, alpha (non A4 component of amyloid precursor)		multiple interactions	ISO	4	89,613,731	89,722,807	RGD:6480464	CTD
G	Spink4	serine peptidase inhibitor, Kazal type 4		increases mutagenesis	ISO	5	58,314,305	58,325,973	RGD:6480464	CTD
G	Srxn1	sulfiredoxin 1		increases expression	ISO	3	142,457,352	142,462,725	RGD:6480464	CTD
G	Tbpl1	TBP-like 1		affects localization	ISO	1	23,295,515	23,320,298	RGD:6480464	CTD
G	Tmem69	transmembrane protein 69		increases mutagenesis	ISO	5	136,831,040	136,834,619	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		increases secretion	ISO	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnfrsf10b	tumor necrosis factor receptor superfamily, member 10b		increases expression	ISO	15	50,138,439	50,163,254	RGD:6480464	CTD
G	Top1	topoisomerase (DNA) I		decreases expression	ISO	3	151,428,931	151,512,884	RGD:6480464	CTD
G	Tp53	tumor protein p53		increases expression	ISO	10	56,399,721	56,411,150	RGD:6480464	CTD
G	Tp53	tumor protein p53		multiple interactions	ISO	10	56,399,721	56,411,150	RGD:6480464	CTD
G	Tp53	tumor protein p53		increases expression	ISO	10	56,399,721	56,411,150	RGD:6480464	CTD
G	Tpp2	tripeptidyl peptidase II		affects localization	ISO	9	42,984,834	43,066,195	RGD:6480464	CTD
G	Tpp2	tripeptidyl peptidase II		affects localization	ISO	9	42,984,834	43,066,195	RGD:6480464	CTD
G	Tradd	TNFRSF1A-associated via death domain		multiple interactions	ISO	19	35,073,150	35,075,251	RGD:6480464	CTD
G	Trg	T cell receptor gamma locus		increases mutagenesis	ISO	17	53,496,412	53,528,047	RGD:6480464	CTD
G	Triap1	TP53 regulated inhibitor of apoptosis 1		increases expression	ISO	12	42,535,655	42,538,148	RGD:6480464	CTD
G	Ubac2	UBA domain containing 2		increases mutagenesis	ISO	15	107,009,509	107,125,419	RGD:6480464	CTD
G	Ube2c	ubiquitin-conjugating enzyme E2C		decreases expression	ISO	3	155,800,357	155,802,757	RGD:6480464	CTD
G	Xpc	xeroderma pigmentosum, complementation group C		increases expression	ISO	4	125,672,674	125,699,925	RGD:6480464	CTD
G	Xrcc4	X-ray repair complementing defective repair in Chinese hamster cells 4		decreases response to substance	ISO	2	19,904,490	20,158,358	RGD:6480464	CTD
G	Xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5		decreases expression	ISO	9	71,472,459	71,581,936	RGD:6480464	CTD
G	Xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5		increases mutagenesis	ISO	9	71,472,459	71,581,936	RGD:6480464	CTD
G	Zfp385a	zinc finger protein 385A		increases expression	ISO	7	142,222,824	142,250,176	RGD:6480464	CTD
G	Zfp52	zinc finger protein 52		decreases expression	ISO	1	59,540,774	59,568,607	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	492507
role	482196
application	245130
food additive	24032
flour treatment agent	3865
urea	2916
ureas	2889
hydroxyurea	145
Path 2
Term	Annotations
CHEBI ontology	492507
subatomic particle	491470
composite particle	491470
hadron	491470
baryon	491470
nucleon	491470
atomic nucleus	491470
atom	491470
main group element atom	461139
p-block element atom	458635
carbon group element atom	410624
carbon atom	407181
organic molecular entity	407174
organic group	167657
organic divalent group	166492
organodiyl group	166492
carbonyl group	166182
carbonyl compound	166182
carboxylic acid	121381
carboacyl group	40896
univalent carboacyl group	40896
carbamoyl group	37115
carboxamide	37106
monocarboxylic acid amide	24326
urea	2916
ureas	2889
hydroxyurea	145