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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid
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Accession:CHEBI:4286 term browser browse the term
Definition:A 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid that has formula C16H10N2O6S4.
Synonyms:exact_synonym: 5,5'-diisothiocyanato-2,2'-[(1E)-ethene-1,2-diyl]dibenzenesulfonic acid
 related_synonym: 2,2'-(E)-ethene-1,2-diylbis(5-isothiocyanatobenzenesulfonic acid);   4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid;   DIDS;   Formula=C16H10N2O6S4;   InChI=1S/C16H10N2O6S4/c19-27(20,21)15-7-13(17-9-25)5-3-11(15)1-2-12-4-6-14(18-10-26)8-16(12)28(22,23)24/h1-8H,(H,19,20,21)(H,22,23,24)/b2-1+;   InChIKey=YSCNMFDFYJUPEF-OWOJBTEDSA-N;   SMILES=OS(=O)(=O)c1cc(ccc1\\C=C\\c1ccc(cc1S(O)(=O)=O)N=C=S)N=C=S
 xref: Beilstein:5385887;   CAS:53005-05-3;   KEGG:C11591
 xref_mesh: MESH:D017878


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4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase increases response to substance
multiple interactions		 ISO AICDA results in increased susceptibility to 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of RAD51 protein] which results in increased activity of AICDA protein		 CTD PMID:23589568 NCBI chr 4:155,774,132...155,783,972
Ensembl chr 4:155,774,132...155,783,972 		JBrowse link
G Alb albumin decreases uptake ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased uptake of ALB protein CTD PMID:16313995 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ano6 anoctamin 6 decreases activity ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of ANO6 protein CTD PMID:24478309 NCBI chr 7:126,933,919...127,113,588
Ensembl chr 7:126,933,936...127,113,589 		JBrowse link
G Atf4 activating transcription factor 4 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein] CTD PMID:27638049 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [quinocetone results in increased cleavage of CASP3 protein]; [Carmustine co-treated with 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid] results in increased activity of CASP3 protein CTD PMID:18590702 PMID:28343033 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Asbestos, Amosite results in increased activity of CASP9 protein]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [quinocetone results in increased cleavage of CASP9 protein] CTD PMID:14766669 PMID:28343033 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity		 ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Colforsin results in increased activity of CFTR protein]
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of CFTR protein		 CTD PMID:15131065 PMID:16038730 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 decreases activity ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of CLCN3 protein CTD PMID:17699636 NCBI chr16:29,127,152...29,200,133
Ensembl chr16:29,127,419...29,200,119 		JBrowse link
G Clcnka chloride voltage-gated channel Ka decreases activity EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid analog results in decreased activity of CLCNKA protein CTD PMID:15167890 NCBI chr 5:153,691,208...153,706,295
Ensembl chr 5:153,691,209...153,706,148 		JBrowse link
G Clcnkb chloride voltage-gated channel Kb decreases activity EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid analog results in decreased activity of CLCNKB protein CTD PMID:15167890 NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153 		JBrowse link
G Clic1 chloride intracellular channel 1 multiple interactions ISO [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of CLIC1 protein] which results in increased susceptibility to Carmustine CTD PMID:18590702 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of DDIT3 protein]
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of DDIT3 protein]		 CTD PMID:27638049 PMID:29421517 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of EIF2AK3 protein modified form] CTD PMID:27638049 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased phosphorylation of EIF2S1 protein] CTD PMID:27638049 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of HSPA5 protein] CTD PMID:29421517 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Ifng interferon gamma multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta affects secretion
multiple interactions		 ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid affects the secretion of IL1B protein
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in decreased expression of IL1B mRNA]		 CTD PMID:15578659 PMID:27461142 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased expression of ITPR1 protein modified form] CTD PMID:27638049 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK8 protein] CTD PMID:19815690 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [azaspiracid results in increased phosphorylation of and affects the localization of MAPK9 protein] CTD PMID:19815690 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Panx1 Pannexin 1 decreases activity ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of PANX1 protein CTD PMID:19023039 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [quinocetone results in increased expression of PARP1 protein modified form] CTD PMID:28343033 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in decreased expression of PDCD6IP protein] CTD PMID:29421517 NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773 		JBrowse link
G Rad51 RAD51 recombinase decreases activity
multiple interactions		 ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of RAD51 protein
[4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of RAD51 protein] which results in increased activity of AICDA protein		 CTD PMID:23589568 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035 		JBrowse link
G Rara retinoic acid receptor, alpha multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in increased degradation of RARA protein] CTD PMID:17018029 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142 		JBrowse link
G Sct secretin decreases activity ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SCT protein CTD PMID:10880878 NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658 		JBrowse link
G Slc12a7 solute carrier family 12 member 7 decreases activity ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC12A7 protein CTD PMID:10913127 NCBI chr 1:29,472,692...29,554,246
Ensembl chr 1:29,472,692...29,554,302 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions ISO [4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC19A1 protein] which results in decreased uptake of Folic Acid CTD PMID:17034785 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid] CTD PMID:12472777 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173 		JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity		 ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC46A1 protein		 CTD PMID:17475902 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions
affects binding		 ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides]
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid binds to SLC4A1 protein		 CTD PMID:2511191 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [SLC4A2 protein results in increased uptake of Benzoic Acid] CTD PMID:9563070 NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 decreases activity EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid results in decreased activity of SLC4A4 protein CTD PMID:17325238 NCBI chr14:18,841,289...19,293,297
Ensembl chr14:18,845,159...19,272,883 		JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of SQSTM1 protein] CTD PMID:29421517 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [arsenic trioxide results in decreased expression of TGFB1 mRNA] CTD PMID:27461142 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein] CTD PMID:10951577 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP
ISO		 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Staurosporine promotes the reaction [VDAC1 protein binds to VDAC1 protein]]
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [quinocetone promotes the reaction [VDAC1 protein binds to VDAC1 protein]]		 CTD PMID:20937774 PMID:28343033 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640 		JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions ISO 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [quinocetone promotes the reaction [VDAC2 protein binds to VDAC2 protein]] CTD PMID:29229420 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    chemical entity 19840
      group 19768
        inorganic group 19361
          sulfo group 9917
            organosulfonic acid 9917
              arenesulfonic acid 689
                4,4'-diisothiocyanostilbene-2,2'-disulfonic acid 40
                  4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid 40
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      chalcogen 19515
                        oxygen atom 19520
                          oxygen molecular entity 19490
                            hydroxides 19300
                              oxoacid 18725
                                chalcogen oxoacid 13752
                                  sulfur oxoacid 13540
                                    sulfonic acid 11576
                                      sulfo group 9917
                                        organosulfonic acid 9917
                                          arenesulfonic acid 689
                                            4,4'-diisothiocyanostilbene-2,2'-disulfonic acid 40
                                              4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid 40
paths to the root