daunorubicin - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	daunorubicin	go back to main search page
Accession:	CHEBI:41977	browse the term
Definition:	A natural product found in Actinomadura roseola.
Synonyms:	exact_synonym:	(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
	related_synonym:	(8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; C27H29NO10; COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(C)=O; Daunomycin; InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1; InChIKey=STQGQHZAVUOBTE-VGBVRHCVSA-N; acetyladriamycin; daunorubicinum; leukaemomycin C
	alt_id:	CHEBI:23560; CHEBI:41970; CHEBI:4330; CHEBI:65723
	xref_casrn:	20830-81-3
	xref:	ChEMBL:436913 "ChEMBL COMPOUND"; ChemIDplus:1445583 "Beilstein Registry Number"; ChemIDplus:20830-81-3 "CAS Registry Number"; DrugBank:DB00694 "DrugBank"; KEGG COMPOUND:20830-81-3 "CAS Registry Number"; KEGG COMPOUND:C01907 "KEGG COMPOUND"; LIPID MAPS:LMPK13050002 "LIPID MAPS instance"
	xref_mesh:	MESH:D003630
	xref:	PDBeChem:DM1 "PDBeChem"; Wikipedia:Daunorubicin "Wikipedia"
	cyclic_relationship:	is_conjugate_base_of CHEBI:64677

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daunorubicin
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		affects response to substance	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		increases response to substance	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		decreases uptake	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		increases transport	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		increases export	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		decreases expression	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		affects transport	ISO	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	ISO	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		multiple interactions	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1		increases transport	EXP	7	87,133,179	87,342,639	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		affects response to substance	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		affects export	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		decreases response to substance	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		increases secretion	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		affects response to substance	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		multiple interactions	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		decreases response to substance	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		multiple interactions	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		multiple interactions	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		multiple interactions	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		multiple interactions	ISO	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		decreases uptake	ISO	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		affects response to substance	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		affects response to substance	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		increases secretion	EXP	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1		decreases response to substance	ISO	16	16,043,434	16,236,931	RGD:6480464	CTD
G	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2		affects response to substance	EXP	10	101,542,463	101,611,662	RGD:6480464	CTD
G	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2		multiple interactions	EXP	4	89,011,416	89,152,474	RGD:6480464	CTD
G	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2		increases expression	EXP	4	89,011,416	89,152,474	RGD:6480464	CTD
G	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase		decreases response to substance	EXP	9	133,589,268	133,763,062	RGD:6480464	CTD
G	AGRN	agrin		increases expression	EXP	1	955,503	991,499	RGD:6480464	CTD
G	AGTR1	angiotensin II receptor, type 1		increases expression	ISO	3	148,415,658	148,460,790	RGD:6480464	CTD
G	AGTR1	angiotensin II receptor, type 1		multiple interactions	ISO	3	148,415,658	148,460,790	RGD:6480464	CTD
G	AGTR1	angiotensin II receptor, type 1		multiple interactions	ISO	3	148,415,658	148,460,790	RGD:6480464	CTD
G	AGTR1	angiotensin II receptor, type 1		increases expression	ISO	3	148,415,658	148,460,790	RGD:6480464	CTD
G	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)		increases reduction	EXP	1	46,016,455	46,035,723	RGD:6480464	CTD
G	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)		increases metabolic processing	EXP	1	46,016,455	46,035,723	RGD:6480464	CTD
G	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)		multiple interactions	EXP	1	46,016,455	46,035,723	RGD:6480464	CTD
G	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)		affects metabolic processing	EXP	1	46,016,455	46,035,723	RGD:6480464	CTD
G	AKR1B1	aldo-keto reductase family 1, member B1 (aldose reductase)		increases reduction	EXP	7	134,127,107	134,143,888	RGD:6480464	CTD
G	AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)		decreases response to substance	EXP	7	134,212,344	134,226,166	RGD:6480464	CTD
G	AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)		multiple interactions	EXP	7	134,212,344	134,226,166	RGD:6480464	CTD
G	AKR1B10	aldo-keto reductase family 1, member B10 (aldose reductase)		increases reduction	EXP	7	134,212,344	134,226,166	RGD:6480464	CTD
G	AKR1C3	aldo-keto reductase family 1, member C3		increases metabolic processing	EXP	10	5,090,958	5,149,878	RGD:6480464	CTD
G	AKT1	v-akt murine thymoma viral oncogene homolog 1		decreases response to substance	EXP	14	105,235,686	105,262,080	RGD:6480464	CTD
G	ANGPT1	angiopoietin 1		decreases expression	ISO	8	108,261,710	108,510,254	RGD:6480464	CTD
G	ANGPT2	angiopoietin 2		increases expression	ISO	8	6,357,172	6,420,784	RGD:6480464	CTD
G	ANKRD1	ankyrin repeat domain 1 (cardiac muscle)		decreases expression	ISO	10	92,671,857	92,681,032	RGD:6480464	CTD
G	ANO3	anoctamin 3		affects response to substance	EXP	11	26,353,678	26,684,836	RGD:6480464	CTD
G	ANXA2	annexin A2		decreases expression	EXP	15	60,639,350	60,690,185	RGD:6480464	CTD
G	ANXA4	annexin A4		increases expression	EXP	2	69,969,127	70,053,596	RGD:6480464	CTD
G	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1		multiple interactions	EXP	14	20,923,290	20,925,931	RGD:6480464	CTD
G	APOB	apolipoprotein B (including Ag(x) antigen)		increases expression	ISO	2	21,224,301	21,266,945	RGD:6480464	CTD
G	APOC3	apolipoprotein C-III		increases expression	ISO	11	116,700,624	116,703,787	RGD:6480464	CTD
G	ATM	ataxia telangiectasia mutated		increases expression	EXP	11	108,093,559	108,239,826	RGD:6480464	CTD
G	BARD1	BRCA1 associated RING domain 1		affects expression	EXP	2	215,593,262	215,674,428	RGD:6480464	CTD
G	BAX	BCL2-associated X protein		multiple interactions	EXP	19	49,458,117	49,465,055	RGD:6480464	CTD
G	BAX	BCL2-associated X protein		multiple interactions	EXP	19	49,458,117	49,465,055	RGD:6480464	CTD
G	BAX	BCL2-associated X protein		multiple interactions	EXP	19	49,458,117	49,465,055	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		multiple interactions	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		decreases response to substance	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		multiple interactions	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		multiple interactions	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		decreases expression	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BCL2	B-cell CLL/lymphoma 2		multiple interactions	EXP	18	60,790,579	60,986,613	RGD:6480464	CTD
G	BID	BH3 interacting domain death agonist		multiple interactions	EXP	22	18,216,906	18,257,431	RGD:6480464	CTD
G	BIRC5	baculoviral IAP repeat containing 5		multiple interactions	EXP	17	76,210,277	76,221,716	RGD:6480464	CTD
G	BIRC5	baculoviral IAP repeat containing 5		multiple interactions	EXP	17	76,210,277	76,221,716	RGD:6480464	CTD
G	C4orf45	chromosome 4 open reading frame 45		affects response to substance	EXP	4	159,814,684	159,956,333	RGD:6480464	CTD
G	CAB39	calcium binding protein 39		decreases expression	EXP	2	231,577,557	231,685,790	RGD:6480464	CTD
G	CACNA1S	calcium channel, voltage-dependent, L type, alpha 1S subunit		affects response to substance	EXP	1	201,008,640	201,081,694	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		increases activity	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		multiple interactions	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		increases activity	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		increases activity	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP3	caspase 3, apoptosis-related cysteine peptidase		increases activity	EXP	4	185,548,850	185,570,629	RGD:6480464	CTD
G	CASP8	caspase 8, apoptosis-related cysteine peptidase		multiple interactions	EXP	2	202,098,166	202,152,434	RGD:6480464	CTD
G	CAT	catalase		affects response to substance	EXP	11	34,460,472	34,493,607	RGD:6480464	CTD
G	CBR1	carbonyl reductase 1		increases metabolic processing	EXP	21	37,442,285	37,445,462	RGD:6480464	CTD
G	CBR1	carbonyl reductase 1		multiple interactions	EXP	21	37,442,285	37,445,462	RGD:6480464	CTD
G	CBR1	carbonyl reductase 1		decreases metabolic processing	EXP	21	37,442,285	37,445,462	RGD:6480464	CTD
G	CBR1	carbonyl reductase 1		increases reduction	EXP	21	37,442,285	37,445,462	RGD:6480464	CTD
G	CBR3	carbonyl reductase 3		affects response to substance	EXP	21	37,507,263	37,518,860	RGD:6480464	CTD
G	CBR3	carbonyl reductase 3		affects metabolic processing	EXP	21	37,507,263	37,518,860	RGD:6480464	CTD
G	CCL2	chemokine (C-C motif) ligand 2		decreases expression	EXP	17	32,582,296	32,584,222	RGD:6480464	CTD
G	CCL4	chemokine (C-C motif) ligand 4		decreases expression	EXP	17	34,431,220	34,433,014	RGD:6480464	CTD
G	CCND3	cyclin D3		increases expression	EXP	6	41,902,671	42,016,610	RGD:6480464	CTD
G	CCNE1	cyclin E1		affects expression	EXP	19	30,302,901	30,315,215	RGD:6480464	CTD
G	CCNG2	cyclin G2		increases expression	EXP	4	78,078,357	78,091,213	RGD:6480464	CTD
G	CDC25A	cell division cycle 25A		increases expression	EXP	3	48,198,668	48,229,801	RGD:6480464	CTD
G	CDH13	cadherin 13, H-cadherin (heart)		affects response to substance	EXP	16	82,660,399	83,830,215	RGD:6480464	CTD
G	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)		increases expression	EXP	6	36,644,237	36,655,116	RGD:6480464	CTD
G	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)		increases expression	EXP	6	36,644,237	36,655,116	RGD:6480464	CTD
G	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)		multiple interactions	ISO	12	12,870,302	12,875,305	RGD:6480464	CTD
G	CDKN1B	cyclin-dependent kinase inhibitor 1B (p27, Kip1)		affects expression	ISO	12	12,870,302	12,875,305	RGD:6480464	CTD
G	CDKN2A	cyclin-dependent kinase inhibitor 2A		affects expression	EXP	9	21,967,751	21,994,490	RGD:6480464	CTD
G	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)		increases expression	EXP	9	22,002,902	22,009,312	RGD:6480464	CTD
G	CEACAM1	carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)		increases expression	EXP	19	43,011,458	43,032,661	RGD:6480464	CTD
G	CEBPZ	CCAAT/enhancer binding protein (C/EBP), zeta		decreases expression	EXP	2	37,428,772	37,458,740	RGD:6480464	CTD
G	CLK2	CDC-like kinase 2		increases expression	EXP	1	155,232,659	155,243,281	RGD:6480464	CTD
G	CLYBL	citrate lyase beta like		affects response to substance	EXP	13	100,258,919	100,549,388	RGD:6480464	CTD
G	CMC2	COX assembly mitochondrial protein 2 homolog (S. cerevisiae)		affects response to substance	EXP	16	81,009,699	81,040,502	RGD:6480464	CTD
G	CMIP	c-Maf inducing protein		affects response to substance	EXP	16	81,478,775	81,745,367	RGD:6480464	CTD
G	CWC27	CWC27 spliceosome-associated protein homolog (S. cerevisiae)		affects response to substance	EXP	5	64,064,755	64,314,590	RGD:6480464	CTD
G	CYBA	cytochrome b-245, alpha polypeptide		multiple interactions	ISO	16	88,709,697	88,717,492	RGD:6480464	CTD
G	CYBA	cytochrome b-245, alpha polypeptide		increases expression	ISO	16	88,709,697	88,717,492	RGD:6480464	CTD
G	CYP1B1	cytochrome P450, family 1, subfamily B, polypeptide 1		affects response to substance	EXP	2	38,294,746	38,303,323	RGD:6480464	CTD
G	DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide		increases degradation	EXP	1	10,520,588	10,532,613	RGD:6480464	CTD
G	E2F5	E2F transcription factor 5, p130-binding		increases expression	EXP	8	86,089,619	86,126,753	RGD:6480464	CTD
G	EDN1	endothelin 1		increases expression	ISO	6	12,290,529	12,297,427	RGD:6480464	CTD
G	EDN1	endothelin 1		multiple interactions	ISO	6	12,290,529	12,297,427	RGD:6480464	CTD
G	EDNRA	endothelin receptor type A		increases expression	ISO	4	148,402,069	148,466,106	RGD:6480464	CTD
G	EDNRA	endothelin receptor type A		multiple interactions	ISO	4	148,402,069	148,466,106	RGD:6480464	CTD
G	EDNRB	endothelin receptor type B		increases expression	ISO	13 13	78,469,616 78,513,393	78,549,664 78,549,674	RGD:6480464	CTD
G	EDNRB	endothelin receptor type B		multiple interactions	ISO	13 13	78,469,616 78,513,393	78,549,664 78,549,674	RGD:6480464	CTD
G	EGF	epidermal growth factor		multiple interactions	EXP	4	110,834,040	110,934,118	RGD:6480464	CTD
G	EI24	etoposide induced 2.4		increases expression	EXP	11	125,439,298	125,454,575	RGD:6480464	CTD
G	EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1		increases phosphorylation	EXP	8	37,888,020	37,917,883	RGD:6480464	CTD
G	EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1		multiple interactions	EXP	8	37,888,020	37,917,883	RGD:6480464	CTD
G	EPM2AIP1	EPM2A (laforin) interacting protein 1		increases expression	EXP	3	37,027,357	37,034,795	RGD:6480464	CTD
G	FASLG	Fas ligand (TNF superfamily, member 6)		multiple interactions	ISO	1	172,628,185	172,636,013	RGD:6480464	CTD
G	FASLG	Fas ligand (TNF superfamily, member 6)		increases expression	ISO	1	172,628,185	172,636,013	RGD:6480464	CTD
G	FDXR	ferredoxin reductase		increases expression	EXP	17	72,858,619	72,869,156	RGD:6480464	CTD
G	GAPT	GRB2-binding adaptor protein, transmembrane		affects response to substance	EXP	5	57,787,330	57,792,185	RGD:6480464	CTD
G	GPC5	glypican 5		affects response to substance	EXP	13	92,050,935	93,519,490	RGD:6480464	CTD
G	GSTM1	glutathione S-transferase mu 1		affects response to substance	EXP	1	110,230,418	110,236,367	RGD:6480464	CTD
G	HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)		affects response to substance	EXP	4	83,274,467	83,295,149	RGD:6480464	CTD
G	ICAM1	intercellular adhesion molecule 1		increases expression	ISO	19	10,381,517	10,397,291	RGD:6480464	CTD
G	ICAM1	intercellular adhesion molecule 1		multiple interactions	ISO	19	10,381,517	10,397,291	RGD:6480464	CTD
G	IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon		affects response to substance	EXP	1	206,643,586	206,670,223	RGD:6480464	CTD
G	IL6R	interleukin 6 receptor		decreases expression	EXP	1	154,377,669	154,441,926	RGD:6480464	CTD
G	IL8	interleukin 8		decreases expression	EXP	4	74,606,223	74,609,433	RGD:6480464	CTD
G	ILKAP	integrin-linked kinase-associated serine/threonine phosphatase		affects response to substance	EXP	2	239,079,043	239,112,324	RGD:6480464	CTD
G	INPP4B	inositol polyphosphate-4-phosphatase, type II, 105kDa		affects response to substance	EXP	4	142,949,181	143,767,604	RGD:6480464	CTD
G	KIF1A	kinesin family member 1A		affects response to substance	EXP	2	241,653,181	241,759,725	RGD:6480464	CTD
G	KRT19	keratin 19		increases expression	ISO	17	39,679,869	39,684,641	RGD:6480464	CTD
G	KRT8	keratin 8		increases expression	ISO	12	53,290,971	53,343,650	RGD:6480464	CTD
G	LSAMP	limbic system-associated membrane protein		affects response to substance	EXP	3	115,521,210	116,164,385	RGD:6480464	CTD
G	LUZP2	leucine zipper protein 2		affects response to substance	EXP	11	24,518,516	25,104,186	RGD:6480464	CTD
G	MAP1B	microtubule-associated protein 1B		affects response to substance	EXP	5	71,403,118	71,505,397	RGD:6480464	CTD
G	MAP2K3	mitogen-activated protein kinase kinase 3		increases expression	EXP	17	21,187,968	21,218,552	RGD:6480464	CTD
G	MAP3K5	mitogen-activated protein kinase kinase kinase 5		decreases expression	EXP	6	136,878,187	137,113,656	RGD:6480464	CTD
G	MAPT	microtubule-associated protein tau		decreases expression	EXP	17	43,971,748	44,105,700	RGD:6480464	CTD
G	MDM4	Mdm4 p53 binding protein homolog (mouse)		decreases expression	EXP	1	204,485,507	204,527,248	RGD:6480464	CTD
G	MIR21	microRNA 21		decreases response to substance	EXP	17	57,918,627	57,918,698	RGD:6480464	CTD
G	MT1A	metallothionein 1A		increases expression	ISO	16	56,672,578	56,673,999	RGD:6480464	CTD
G	MT1A	metallothionein 1A		multiple interactions	ISO	16	56,672,578	56,673,999	RGD:6480464	CTD
G	MTOR	mechanistic target of rapamycin (serine/threonine kinase)		increases phosphorylation	EXP	1	11,166,588	11,322,608	RGD:6480464	CTD
G	MTOR	mechanistic target of rapamycin (serine/threonine kinase)		multiple interactions	EXP	1	11,166,588	11,322,608	RGD:6480464	CTD
G	NCF1	neutrophil cytosolic factor 1		multiple interactions	ISO	7	74,188,309	74,203,659	RGD:6480464	CTD
G	NCF1	neutrophil cytosolic factor 1		increases expression	ISO	7	74,188,309	74,203,659	RGD:6480464	CTD
G	NCF2	neutrophil cytosolic factor 2		increases expression	ISO	1	183,524,697	183,560,056	RGD:6480464	CTD
G	NCF2	neutrophil cytosolic factor 2		multiple interactions	ISO	1	183,524,697	183,560,056	RGD:6480464	CTD
G	NCK2	NCK adaptor protein 2		decreases expression	EXP	2	106,361,520	106,510,730	RGD:6480464	CTD
G	NGEF	neuronal guanine nucleotide exchange factor		affects response to substance	EXP	2	233,743,396	233,877,951	RGD:6480464	CTD
G	NOX4	NADPH oxidase 4		increases expression	ISO	11	89,057,521	89,322,779	RGD:6480464	CTD
G	NOX4	NADPH oxidase 4		multiple interactions	ISO	11	89,057,521	89,322,779	RGD:6480464	CTD
G	NPC1	Niemann-Pick disease, type C1		increases secretion	EXP	18	21,111,463	21,166,581	RGD:6480464	CTD
G	NPC1	Niemann-Pick disease, type C1		multiple interactions	EXP	18	21,111,463	21,166,581	RGD:6480464	CTD
G	NPC1	Niemann-Pick disease, type C1		affects response to substance	EXP	18	21,111,463	21,166,581	RGD:6480464	CTD
G	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)		decreases expression	ISO	19	36,316,274	36,342,895	RGD:6480464	CTD
G	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)		multiple interactions	ISO	19	36,316,274	36,342,895	RGD:6480464	CTD
G	NPPB	natriuretic peptide B		decreases expression	ISO	1	11,917,521	11,918,992	RGD:6480464	CTD
G	NPPB	natriuretic peptide B		increases expression	EXP	1	11,917,521	11,918,992	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		decreases expression	EXP	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		increases activity	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		increases activity	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		increases activity	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		increases activity	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NQO1	NAD(P)H dehydrogenase, quinone 1		increases activity	ISO	16	69,743,304	69,760,533	RGD:6480464	CTD
G	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)		decreases activity	EXP	5	142,657,496	142,815,077	RGD:6480464	CTD
G	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog		increases expression	EXP	1	115,247,085	115,259,515	RGD:6480464	CTD
G	PARP1	poly (ADP-ribose) polymerase 1		multiple interactions	EXP	1	226,548,392	226,595,801	RGD:6480464	CTD
G	PARP1	poly (ADP-ribose) polymerase 1		increases cleavage	EXP	1	226,548,392	226,595,801	RGD:6480464	CTD
G	PARP1	poly (ADP-ribose) polymerase 1		increases cleavage	EXP	1	226,548,392	226,595,801	RGD:6480464	CTD
G	PFKM	phosphofructokinase, muscle		decreases expression	ISO	12	48,499,656	48,540,187	RGD:6480464	CTD
G	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)		affects response to substance	EXP	5	67,511,584	67,597,649	RGD:6480464	CTD
G	PLAT	plasminogen activator, tissue		multiple interactions	EXP	8	42,032,236	42,065,194	RGD:6480464	CTD
G	PLK3	polo-like kinase 3		increases expression	EXP	1	45,266,036	45,271,667	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		multiple interactions	ISO	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPARG	peroxisome proliferator-activated receptor gamma		increases expression	ISO	3	12,329,349	12,475,855	RGD:6480464	CTD
G	PPP1R13L	protein phosphatase 1, regulatory subunit 13 like		decreases response to substance	EXP	19	45,882,892	45,909,607	RGD:6480464	CTD
G	PRC1	protein regulator of cytokinesis 1		decreases expression	EXP	15	91,509,268	91,537,881	RGD:6480464	CTD
G	PRKCD	protein kinase C, delta		increases cleavage	EXP	3	53,195,223	53,226,733	RGD:6480464	CTD
G	PSME2P3	proteasome activator subunit 2 pseudogene 3		affects response to substance	EXP	4	159,928,240	159,929,029	RGD:6480464	CTD
G	PTEN	phosphatase and tensin homolog		increases response to substance	EXP	10	89,623,195	89,728,532	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		increases expression	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)		multiple interactions	ISO	1	186,640,944	186,649,559	RGD:6480464	CTD
G	RANBP17	RAN binding protein 17		affects response to substance	EXP	5	170,288,896	170,727,019	RGD:6480464	CTD
G	RB1	retinoblastoma 1		increases expression	EXP	13	48,877,883	49,056,026	RGD:6480464	CTD
G	RBBP5	retinoblastoma binding protein 5		affects expression	EXP	1	205,055,270	205,091,150	RGD:6480464	CTD
G	RBBP6	retinoblastoma binding protein 6		increases expression	EXP	16	24,550,908	24,584,184	RGD:6480464	CTD
G	RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	EXP	11	65,421,067	65,430,443	RGD:6480464	CTD
G	ROCK1	Rho-associated, coiled-coil containing protein kinase 1		affects expression	ISO	18	18,529,701	18,691,812	RGD:6480464	CTD
G	ROCK1	Rho-associated, coiled-coil containing protein kinase 1		multiple interactions	ISO	18	18,529,701	18,691,812	RGD:6480464	CTD
G	RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1		increases phosphorylation	EXP	17	57,970,443	58,027,787	RGD:6480464	CTD
G	RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1		multiple interactions	EXP	17	57,970,443	58,027,787	RGD:6480464	CTD
G	RYR2	ryanodine receptor 2 (cardiac)		multiple interactions	ISO	1	237,205,702	237,997,288	RGD:6480464	CTD
G	RYR2	ryanodine receptor 2 (cardiac)		decreases expression	ISO	1	237,205,702	237,997,288	RGD:6480464	CTD
G	RYR2	ryanodine receptor 2 (cardiac)		multiple interactions	ISO	1	237,205,702	237,997,288	RGD:6480464	CTD
G	RYR2	ryanodine receptor 2 (cardiac)		decreases expression	ISO	1	237,205,702	237,997,288	RGD:6480464	CTD
G	SDC1	syndecan 1		increases expression	EXP	2	20,400,558	20,425,194	RGD:6480464	CTD
G	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1		decreases expression	EXP	7	100,770,370	100,782,547	RGD:6480464	CTD
G	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1		multiple interactions	EXP	7	100,770,370	100,782,547	RGD:6480464	CTD
G	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1		multiple interactions	EXP	7	100,770,370	100,782,547	RGD:6480464	CTD
G	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1		decreases secretion	ISO	7	100,770,370	100,782,547	RGD:6480464	CTD
G	SLC22A16	solute carrier family 22 (organic cation/carnitine transporter), member 16		multiple interactions	EXP	6	110,745,890	110,797,844	RGD:6480464	CTD
G	SLC25A4	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4		decreases expression	ISO	4	186,064,417	186,071,538	RGD:6480464	CTD
G	SLIT3	slit homolog 3 (Drosophila)		affects response to substance	EXP	5	168,093,071	168,728,133	RGD:6480464	CTD
G	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal		increases expression	EXP	11	6,411,644	6,416,228	RGD:6480464	CTD
G	SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal		increases activity	EXP	11	6,411,644	6,416,228	RGD:6480464	CTD
G	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)		increases expression	EXP	16	68,392,230	68,482,409	RGD:6480464	CTD
G	SMPD3	sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)		increases response to substance	EXP	16	68,392,230	68,482,409	RGD:6480464	CTD
G	SOD2	superoxide dismutase 2, mitochondrial		decreases secretion	ISO	6	160,100,148	160,114,353	RGD:6480464	CTD
G	SOD2	superoxide dismutase 2, mitochondrial		multiple interactions	ISO	6	160,100,148	160,114,353	RGD:6480464	CTD
G	SP110	SP110 nuclear body protein		affects response to substance	EXP	2	231,033,634	231,090,444	RGD:6480464	CTD
G	SP3	Sp3 transcription factor		increases expression	EXP	2	174,771,187	174,830,430	RGD:6480464	CTD
G	TAGLN3	transgelin 3		affects response to substance	EXP	3	111,717,586	111,732,735	RGD:6480464	CTD
G	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)		increases expression	EXP	6	32,812,986	32,821,748	RGD:6480464	CTD
G	TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)		affects response to substance	EXP	6	32,789,610	32,806,547	RGD:6480464	CTD
G	TAX1BP3	Tax1 (human T-cell leukemia virus type I) binding protein 3		increases expression	EXP	17	3,566,187	3,571,973	RGD:6480464	CTD
G	TGFB1	transforming growth factor, beta 1		multiple interactions	ISO	19	41,836,812	41,859,831	RGD:6480464	CTD
G	TGFB1	transforming growth factor, beta 1		increases expression	ISO	19	41,836,812	41,859,831	RGD:6480464	CTD
G	TLR4	toll-like receptor 4		decreases response to substance	ISO	9	120,466,453	120,479,769	RGD:6480464	CTD
G	TM4SF20	transmembrane 4 L six family member 20		affects response to substance	EXP	2	228,226,872	228,244,022	RGD:6480464	CTD
G	TNF	tumor necrosis factor		increases expression	ISO	6	31,543,344	31,546,113	RGD:6480464	CTD
G	TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a		multiple interactions	EXP	8	23,048,970	23,082,680	RGD:6480464	CTD
G	TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b		multiple interactions	EXP	8	22,877,646	22,926,700	RGD:6480464	CTD
G	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10		multiple interactions	EXP	3	172,223,298	172,241,297	RGD:6480464	CTD
G	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10		multiple interactions	EXP	3	172,223,298	172,241,297	RGD:6480464	CTD
G	TNFSF9	tumor necrosis factor (ligand) superfamily, member 9		increases expression	EXP	19	6,531,010	6,535,939	RGD:6480464	CTD
G	TNNT2	troponin T type 2 (cardiac)		multiple interactions	ISO	1	201,328,142	201,346,805	RGD:6480464	CTD
G	TNNT2	troponin T type 2 (cardiac)		increases secretion	ISO	1	201,328,142	201,346,805	RGD:6480464	CTD
G	TP53	tumor protein p53		multiple interactions	EXP	17	7,571,720	7,590,868	RGD:6480464	CTD
G	TP53	tumor protein p53		increases expression	EXP	17	7,571,720	7,590,868	RGD:6480464	CTD
G	TP53	tumor protein p53		increases activity	EXP	17	7,571,720	7,590,868	RGD:6480464	CTD
G	TP53I3	tumor protein p53 inducible protein 3		increases expression	EXP	2	24,300,303	24,308,085	RGD:6480464	CTD
G	TP53TG1	TP53 target 1 (non-protein coding)		increases expression	EXP	7	86,954,663	86,974,808	RGD:6480464	CTD
G	TYMS	thymidylate synthetase		affects response to substance	EXP	18	657,604	673,499	RGD:6480464	CTD
G	UQCRFS1	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1		decreases expression	ISO	19	29,698,167	29,704,136	RGD:6480464	CTD
G	VCAM1	vascular cell adhesion molecule 1		increases expression	ISO	1	101,185,196	101,204,601	RGD:6480464	CTD
G	VCAM1	vascular cell adhesion molecule 1		multiple interactions	ISO	1	101,185,196	101,204,601	RGD:6480464	CTD
G	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor		affects response to substance	EXP	12	48,235,320	48,298,814	RGD:6480464	CTD
G	VEGFA	vascular endothelial growth factor A		decreases expression	EXP	6	43,737,946	43,754,224	RGD:6480464	CTD
G	VIM	vimentin		increases expression	ISO	10	17,270,258	17,279,592	RGD:6480464	CTD
G	ZBTB20	zinc finger and BTB domain containing 20		affects response to substance	EXP	3	114,056,941	114,866,127	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	513696
role	503218
biological role	501391
antimicrobial agent	47908
antibiotic	12843
carbohydrate-containing antibiotic	330
aminoglycoside antibiotic	312
daunorubicin	255
Path 2
Term	Annotations
CHEBI ontology	513696
subatomic particle	512589
composite particle	512589
hadron	512589
baryon	512589
nucleon	512589
atomic nucleus	512589
atom	512589
main group element atom	480600
main group molecular entity	475252
s-block molecular entity	323761
hydrogen molecular entity	320957
hydrides	200522
organic hydride	123080
organic fundamental parent	123080
hydrocarbon	73803
cyclic hydrocarbon	38698
arene	38022
polycyclic arene	34560
ortho-fused polycyclic arene	7838
acene	4624
tetracene	4595
daunorubicin	255