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Term:4-phenylbutyric acid
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Accession:CHEBI:41500 term browser browse the term
Definition:A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Synonyms:exact_synonym: 4-phenylbutanoic acid
 related_synonym: 4-PHENYL-BUTANOIC ACID;   4-Phenyl-n-butyric acid;   Benzenebutyric acid;   C10H12O2;   InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12);   InChIKey=OBKXEAXTFZPCHS-UHFFFAOYSA-N;   OC(=O)CCCc1ccccc1;   PBA;   gamma-Phenyl-n-butyric acid;   gamma-phenylbutyric acid;   omega-Phenylbutanoic acid;   omega-phenylbutyric acid
 alt_id: CHEBI:64058
 xref_casrn: 1821-12-1
 xref: ChEMBL:497873 "ChEMBL COMPOUND";   ChemIDplus:1821-12-1 "CAS Registry Number";   CiteXplore:19918981 "PubMed citation";   CiteXplore:20399799 "PubMed citation";   CiteXplore:21237159 "PubMed citation";   CiteXplore:21726539 "PubMed citation";   CiteXplore:21887297 "PubMed citation";   CiteXplore:21894430 "PubMed citation";   CiteXplore:22101259 "PubMed citation";   CiteXplore:22359472 "PubMed citation"
 xref_mesh: MESH:C075773
 xref: NIST Chemistry WebBook:1821-12-1 "CAS Registry Number";   PDBeChem:CLT "PDBeChem";   Reaxys:638180 "Reaxys Registry Number"

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4-phenylbutyric acid term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Aars alanyl-tRNA synthetase GBrowse link decreases expression ISO 19 40,952,408 40,974,425 RGD:6480464 CTD
G Aars alanyl-tRNA synthetase GBrowse link increases expression ISO 19 40,952,408 40,974,425 RGD:6480464 CTD
G Ajuba ajuba LIM protein GBrowse link decreases expression ISO 15 32,627,633 32,637,861 RGD:6480464 CTD
G Akr1c1 aldo-keto reductase family 1, member C1 GBrowse link increases expression ISO 17 77,084,306 77,112,994 RGD:6480464 CTD
G App amyloid beta (A4) precursor protein GBrowse link affects activity EXP 11 24,457,855 24,693,851 RGD:6480464 CTD
G Atf6 activating transcription factor 6 GBrowse link multiple interactions ISO 13 86,543,773 86,718,970 RGD:6480464 CTD
G Atf6 activating transcription factor 6 GBrowse link multiple interactions EXP 13 86,543,773 86,718,970 RGD:6480464 CTD
G Bcl6 B-cell CLL/lymphoma 6 GBrowse link increases expression ISO 11 79,006,123 79,030,555 RGD:6480464 CTD
G Cars cysteinyl-tRNA synthetase GBrowse link decreases expression ISO 1 203,934,812 203,977,042 RGD:6480464 CTD
G Cars cysteinyl-tRNA synthetase GBrowse link increases expression ISO 1 203,934,812 203,977,042 RGD:6480464 CTD
G Casp12 caspase 12 GBrowse link multiple interactions ISO 8 2,082,933 2,110,511 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link multiple interactions ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link multiple interactions ISO 5 108,908,749 108,916,380 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link multiple interactions ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link multiple interactions ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link increases activity ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Cirh1a cirrhosis, autosomal recessive 1A (cirhin) GBrowse link decreases expression ISO 19 36,742,206 36,770,285 RGD:6480464 CTD
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 GBrowse link decreases expression ISO 1 12,721,500 12,723,943 RGD:6480464 CTD
G Cldn1 claudin 1 GBrowse link decreases expression ISO 11 76,473,654 76,488,809 RGD:6480464 CTD
G Cmss1 cms1 ribosomal small subunit homolog (yeast) GBrowse link decreases expression ISO 11 43,763,988 44,068,609 RGD:6480464 CTD
G Cnih4 cornichon homolog 4 (Drosophila) GBrowse link decreases expression ISO 13 96,921,481 96,940,409 RGD:6480464 CTD
G Cnot2 CCR4-NOT transcription complex, subunit 2 GBrowse link decreases expression ISO 7 55,823,982 55,880,812 RGD:6480464 CTD
G Col5a1 collagen, type V, alpha 1 GBrowse link increases expression ISO 3 6,826,169 6,971,054 RGD:6480464 CTD
G Csde1 cold shock domain containing E1, RNA binding decreases expression ISO RGD:6480464 CTD
G Cspg5 chondroitin sulfate proteoglycan 5 (neuroglycan C) GBrowse link increases expression ISO 8 114,621,534 114,635,336 RGD:6480464 CTD
G Ddx55 DEAD (Asp-Glu-Ala-Asp) box polypeptide 55 GBrowse link decreases expression ISO 12 33,147,211 33,162,925 RGD:6480464 CTD
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 GBrowse link decreases expression ISO 17 32,217,424 32,228,130 RGD:6480464 CTD
G Eftud2 elongation factor Tu GTP binding domain containing 2 GBrowse link decreases expression ISO 10 92,012,161 92,053,043 RGD:6480464 CTD
G Egfl7 EGF-like-domain, multiple 7 GBrowse link increases expression ISO 3 4,760,574 4,769,909 RGD:6480464 CTD
G Egfl7 EGF-like-domain, multiple 7 GBrowse link multiple interactions ISO 3 4,760,574 4,769,909 RGD:6480464 CTD
G Ehd3 EH-domain containing 3 GBrowse link increases expression ISO 6 21,638,705 21,686,023 RGD:6480464 CTD
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha GBrowse link multiple interactions ISO 6 101,495,444 101,520,113 RGD:6480464 CTD
G Ern1 endoplasmic reticulum to nucleus signaling 1 GBrowse link multiple interactions EXP 10 95,794,488 95,855,895 RGD:6480464 CTD
G Faah fatty acid amide hydrolase GBrowse link increases expression ISO 5 136,310,965 136,329,817 RGD:6480464 CTD
G Farsb phenylalanyl-tRNA synthetase, beta subunit GBrowse link decreases expression ISO 9 77,806,573 77,865,757 RGD:6480464 CTD
G Fbln1 fibulin 1 GBrowse link increases expression ISO 7 123,208,154 123,287,289 RGD:6480464 CTD
G Fgf2 fibroblast growth factor 2 GBrowse link decreases expression ISO 2 123,893,314 123,947,136 RGD:6480464 CTD
G Gas6 growth arrest specific 6 GBrowse link decreases expression ISO 16 80,900,159 80,930,929 RGD:6480464 CTD
G Gpx3 glutathione peroxidase 3 GBrowse link increases expression ISO 10 40,311,094 40,319,382 RGD:6480464 CTD
G Grb10 growth factor receptor bound protein 10 GBrowse link increases expression ISO 14 92,814,797 92,911,442 RGD:6480464 CTD
G Gsta4 glutathione S-transferase alpha 4 GBrowse link increases expression ISO 8 83,165,139 83,183,055 RGD:6480464 CTD
G Hdac1 histone deacetylase 1 GBrowse link multiple interactions ISO 5 148,672,515 148,699,810 RGD:6480464 CTD
G Hmga1 high mobility group AT-hook 1 GBrowse link decreases expression ISO 20 5,769,052 5,772,269 RGD:6480464 CTD
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 GBrowse link decreases expression ISO 4 79,700,327 79,704,116 RGD:6480464 CTD
G Hspa1a heat shock protein 1A GBrowse link increases expression ISO 20 3,945,716 3,959,552 RGD:6480464 CTD
G Hspa2 heat shock protein 2 GBrowse link increases expression ISO 6 99,000,541 99,003,041 RGD:6480464 CTD
G Hspa4l heat shock protein 4-like GBrowse link increases expression ISO 2 127,697,504 127,751,085 RGD:6480464 CTD
G Hspa5 heat shock protein 5 GBrowse link multiple interactions EXP 3 13,783,825 13,788,022 RGD:6480464 CTD
G Hspa5 heat shock protein 5 GBrowse link multiple interactions ISO 3 13,783,825 13,788,022 RGD:6480464 CTD
G Hspa5 heat shock protein 5 GBrowse link multiple interactions ISO 3 13,783,825 13,788,022 RGD:6480464 CTD
G Hsph1 heat shock 105/110 protein 1 GBrowse link increases expression ISO 12 5,794,645 5,811,453 RGD:6480464 CTD
G Id1 inhibitor of DNA binding 1 GBrowse link decreases expression ISO 3 143,086,162 143,087,289 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions ISO 4 456,799 461,376 RGD:6480464 CTD
G Ins1 insulin 1 GBrowse link multiple interactions EXP 1 258,001,134 258,001,688 RGD:6480464 CTD
G Ins2 insulin 2 GBrowse link multiple interactions ISO 1 202,935,548 202,936,379 RGD:6480464 CTD
G Ipo11 importin 11 GBrowse link decreases expression ISO 2 38,006,409 38,054,430 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link multiple interactions EXP 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link multiple interactions EXP 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mapk8 mitogen-activated protein kinase 8 GBrowse link multiple interactions EXP 16 8,925,133 9,004,897 RGD:6480464 CTD
G Mapk9 mitogen-activated protein kinase 9 GBrowse link multiple interactions EXP 10 35,353,486 35,384,319 RGD:6480464 CTD
G Mat2a methionine adenosyltransferase II, alpha GBrowse link decreases expression ISO 4 105,739,943 105,745,472 RGD:6480464 CTD
G Mecp2 methyl CpG binding protein 2 GBrowse link multiple interactions ISO X 159,980,599 160,035,260 RGD:6480464 CTD
G Mef2a myocyte enhancer factor 2a multiple interactions ISO RGD:6480464 CTD
G Mef2a myocyte enhancer factor 2a multiple interactions EXP RGD:6480464 CTD
G Mki67ip Mki67 (FHA domain) interacting nucleolar phosphoprotein GBrowse link decreases expression ISO 13 30,944,169 30,953,973 RGD:6480464 CTD
G Mrps18c mitochondrial ribosomal protein S18C GBrowse link decreases expression ISO 14 10,096,209 10,102,427 RGD:6480464 CTD
G Nde1 nudE nuclear distribution E homolog 1 (A. nidulans) GBrowse link decreases expression ISO 10 777,877 814,260 RGD:6480464 CTD
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 GBrowse link multiple interactions EXP 3 58,366,693 58,394,116 RGD:6480464 CTD
G Nln neurolysin (metallopeptidase M3 family) GBrowse link decreases expression ISO 2 34,915,111 35,031,566 RGD:6480464 CTD
G Nolc1 nucleolar and coiled-body phosphoprotein 1 GBrowse link decreases expression ISO 1 251,297,417 251,308,127 RGD:6480464 CTD
G Nr1d2 nuclear receptor subfamily 1, group D, member 2 increases expression ISO RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link increases expression EXP 5 168,050,149 168,061,616 RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link increases expression ISO 5 168,050,149 168,061,616 RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link multiple interactions EXP 5 168,050,149 168,061,616 RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link increases expression ISO 5 168,050,149 168,061,616 RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link multiple interactions ISO 5 168,050,149 168,061,616 RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link multiple interactions ISO 5 168,050,149 168,061,616 RGD:6480464 CTD
G Pawr PRKC, apoptosis, WT1, regulator GBrowse link decreases expression ISO 7 47,040,162 47,119,613 RGD:6480464 CTD
G Pdcd2l programmed cell death 2-like GBrowse link decreases expression ISO 1 86,640,488 86,653,181 RGD:6480464 CTD
G Pole4 polymerase (DNA-directed), epsilon 4, accessory subunit GBrowse link decreases expression ISO 4 116,856,445 116,862,256 RGD:6480464 CTD
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A GBrowse link increases expression ISO 10 56,552,872 56,579,172 RGD:6480464 CTD
G Polr2a polymerase (RNA) II (DNA directed) polypeptide A GBrowse link decreases expression ISO 10 56,552,872 56,579,172 RGD:6480464 CTD
G Ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha GBrowse link multiple interactions ISO 14 64,278,115 64,370,912 RGD:6480464 CTD
G Ppargc1a peroxisome proliferator-activated receptor gamma, coactivator 1 alpha GBrowse link multiple interactions EXP 14 64,278,115 64,370,912 RGD:6480464 CTD
G Ppil1 peptidylprolyl isomerase (cyclophilin)-like 1 GBrowse link decreases expression ISO 20 7,548,896 7,565,640 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link multiple interactions ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Rbm8a RNA binding motif protein 8A GBrowse link decreases expression ISO 2 191,429,805 191,432,261 RGD:6480464 CTD
G Rpl7a ribosomal protein L7a GBrowse link decreases expression ISO 18 5,807,901 5,810,543 RGD:6480464 CTD
G RT1-S3 RT1 class Ib, locus S3 GBrowse link increases expression ISO 20 2,815,943 2,820,644 RGD:6480464 CTD
G Slc22a18 solute carrier family 22, member 18 GBrowse link increases expression ISO 1 203,852,313 203,876,165 RGD:6480464 CTD
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 GBrowse link multiple interactions ISO 10 56,786,705 56,792,209 RGD:6480464 CTD
G Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 GBrowse link multiple interactions EXP 10 56,786,705 56,792,209 RGD:6480464 CTD
G Slc38a2 solute carrier family 38, member 2 GBrowse link multiple interactions ISO 7 135,365,172 135,377,341 RGD:6480464 CTD
G Slu7 SLU7 splicing factor homolog (S. cerevisiae) GBrowse link decreases expression ISO 10 28,536,630 28,551,427 RGD:6480464 CTD
G Smcr7l Smith-Magenis syndrome chromosome region, candidate 7-like GBrowse link decreases expression ISO 7 118,526,138 118,531,814 RGD:6480464 CTD
G Snca synuclein, alpha (non A4 component of amyloid precursor) GBrowse link multiple interactions ISO 4 89,613,731 89,722,807 RGD:6480464 CTD
G Snca synuclein, alpha (non A4 component of amyloid precursor) GBrowse link multiple interactions ISO 4 89,613,731 89,722,807 RGD:6480464 CTD
G Snx5 sorting nexin 5 GBrowse link decreases expression ISO 3 132,778,470 132,797,964 RGD:6480464 CTD
G Sox4 SRY (sex determining region Y)-box 4 GBrowse link decreases expression ISO 17 42,172,863 42,177,590 RGD:6480464 CTD
G Srsf10 serine/arginine-rich splicing factor 10 GBrowse link decreases expression ISO 5 154,637,426 154,645,826 RGD:6480464 CTD
G Suv420h1 suppressor of variegation 4-20 homolog 1 (Drosophila) GBrowse link decreases expression ISO 1 206,285,303 206,341,955 RGD:6480464 CTD
G Syvn1 synovial apoptosis inhibitor 1, synoviolin GBrowse link decreases expression ISO 1 208,684,460 208,690,978 RGD:6480464 CTD
G Tax1bp1 Tax1 (human T-cell leukemia virus type I) binding protein 1 GBrowse link decreases expression ISO 4 81,021,495 81,081,478 RGD:6480464 CTD
G Th tyrosine hydroxylase GBrowse link increases expression ISO 1 203,164,253 203,171,506 RGD:6480464 CTD
G Timm50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) GBrowse link decreases expression ISO 1 83,399,403 83,400,789 RGD:6480464 CTD
G Tmed5 transmembrane emp24 protein transport domain containing 5 GBrowse link increases expression ISO 14 2,155,594 2,167,280 RGD:6480464 CTD
G Tmed5 transmembrane emp24 protein transport domain containing 5 GBrowse link decreases expression ISO 14 2,155,594 2,167,280 RGD:6480464 CTD
G Tmpo thymopoietin GBrowse link decreases expression ISO 7 28,086,576 28,111,800 RGD:6480464 CTD
G Tra2a transformer 2 alpha homolog (Drosophila) GBrowse link decreases expression ISO 4 77,372,546 77,391,417 RGD:6480464 CTD
G Tsc2 tuberous sclerosis 2 GBrowse link increases expression ISO 10 13,848,210 13,883,189 RGD:6480464 CTD
G Tsr1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) GBrowse link decreases expression ISO 10 62,207,449 62,218,861 RGD:6480464 CTD
G Tubb3 tubulin, beta 3 class III GBrowse link multiple interactions ISO 19 53,742,652 53,751,706 RGD:6480464 CTD
G Tubb3 tubulin, beta 3 class III GBrowse link affects expression ISO 19 53,742,652 53,751,706 RGD:6480464 CTD
G Uba6 ubiquitin-like modifier activating enzyme 6 GBrowse link decreases expression ISO 14 23,666,102 23,729,920 RGD:6480464 CTD
G Ube2w ubiquitin-conjugating enzyme E2W decreases expression ISO RGD:6480464 CTD
G Ube2wl ubiquitin-conjugating enzyme E2W-like GBrowse link decreases expression ISO X 29,818,682 29,824,530 RGD:6480464 CTD
G Wdr4 WD repeat domain 4 GBrowse link decreases expression ISO 20 9,925,854 9,942,051 RGD:6480464 CTD
G Wwtr1 WW domain containing transcription regulator 1 GBrowse link decreases expression ISO 2 146,713,977 146,831,603 RGD:6480464 CTD
G Xbp1 X-box binding protein 1 GBrowse link multiple interactions ISO 14 86,151,910 86,156,975 RGD:6480464 CTD
G Xbp1 X-box binding protein 1 GBrowse link multiple interactions EXP 14 86,151,910 86,156,975 RGD:6480464 CTD
G Xpo5 exportin 5 GBrowse link decreases expression ISO 9 10,302,751 10,341,791 RGD:6480464 CTD
G Ythdf2 YTH domain family, member 2 GBrowse link decreases expression ISO 5 151,063,958 151,089,250 RGD:6480464 CTD
G Zbtb2 zinc finger and BTB domain containing 2 GBrowse link decreases expression ISO 1 35,076,357 35,083,932 RGD:6480464 CTD
G Znrd1 zinc ribbon domain containing 1 GBrowse link decreases expression ISO 20 1,687,673 1,691,591 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492507
    role 482196
      biological role 480389
        biochemical role 193500
          apoptosis inducer 170
            4-phenylbutyric acid 125
Path 2
Term Annotations click to browse term
  CHEBI ontology 492507
    subatomic particle 491470
      composite particle 491470
        hadron 491470
          baryon 491470
            nucleon 491470
              atomic nucleus 491470
                atom 491470
                  main group element atom 461139
                    p-block element atom 458635
                      carbon group element atom 410624
                        carbon atom 407181
                          organic molecular entity 407174
                            organic group 167657
                              organic divalent group 166492
                                organodiyl group 166492
                                  carbonyl group 166182
                                    carbonyl compound 166182
                                      carboxylic acid 121381
                                        monocarboxylic acid 70480
                                          fatty acid 25061
                                            saturated fatty acid 21695
                                              straight-chain saturated fatty acid 14375
                                                butyric acid 4097
                                                  4-phenylbutyric acid 125
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