ONTOLOGY REPORT - ANNOTATIONS

Term:bromocriptine
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Accession:CHEBI:3181 term browser browse the term
Definition:An indole alkaloid that has formula C32H40BrN5O5.
Synonyms:exact_synonym: (5'alpha)-2-bromo-12'-hydroxy-5'-(2-methylpropyl)-2'-(propan-2-yl)-3',6',18-trioxoergotaman
 related_synonym: (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-3',6',18-trioxoergotaman;   (5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione;   (5'alpha)-2-bromo-12'-hydroxy-5'-isobutyl-2'-isopropyl-3',6',18-trioxoergotaman;   2-bromo-alpha-ergocryptine;   2-bromo-alpha-ergokryptin;   2-bromo-alpha-ergokryptine;   C32H40BrN5O5;   InChI=1S/C32H40BrN5O5/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39)/t18-,23-,24+,25+,31-,32+/m1/s1;   InChIKey=OZVBMTJYIDMWIL-AYFBDAFISA-N;   [H][C@@]12Cc3c(Br)[nH]c4cccc(C1=C[C@H](CN2C)C(=O)N[C@@]1(O[C@]2(O)N([C@@H](CC(C)C)C(=O)N5CCC[C@@]25[H])C1=O)C(C)C)c34;   bromocriptinum;   bromocryptine;   bromoergocriptine
 xref_casrn: 25614-03-3
 xref: Beilstein:741357 "Beilstein Registry Number";   ChEMBL:107065 "ChEMBL COMPOUND";   ChemIDplus:25614-03-3 "CAS Registry Number";   DrugBank:DB01200 "DrugBank";   KEGG COMPOUND:25614-03-3 "CAS Registry Number";   KEGG COMPOUND:C06856 "KEGG COMPOUND";   KEGG DRUG:D03165 "KEGG DRUG"
 xref_mesh: MESH:D001971
 xref: Patent:DE1926045 "Patent";   Patent:US3752814 "Patent";   Wikipedia:Bromocriptine "Wikipedia"

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bromocriptine term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link increases expression EXP 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1a ATP-binding cassette, sub-family B (MDR/TAP), member 1A GBrowse link multiple interactions EXP 4 21,709,855 21,796,628 RGD:6480464 CTD
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B GBrowse link increases activity EXP 4 21,829,489 21,912,239 RGD:6480464 CTD
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B GBrowse link increases expression EXP 4 21,829,489 21,912,239 RGD:6480464 CTD
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B GBrowse link multiple interactions EXP 4 21,829,489 21,912,239 RGD:6480464 CTD
G Akr1c3 aldo-keto reductase family 1, member C3 GBrowse link increases expression EXP 17 77,269,626 77,286,521 RGD:6480464 CTD
G Akr1c3 aldo-keto reductase family 1, member C3 GBrowse link multiple interactions EXP 17 77,269,626 77,286,521 RGD:6480464 CTD
G Atf3 activating transcription factor 3 GBrowse link increases expression ISO 13 107,191,622 107,223,850 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bdnf brain-derived neurotrophic factor decreases secretion ISO RGD:6480464 CTD
G Ctnnb1 catenin (cadherin associated protein), beta 1 GBrowse link multiple interactions ISO 8 125,978,161 125,987,670 RGD:6480464 CTD
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link multiple interactions EXP 8 61,793,976 61,805,308 RGD:6480464 CTD
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link decreases expression EXP 8 61,793,976 61,805,308 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link affects binding ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link affects metabolic processing ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) GBrowse link decreases activity ISO 3 6,052,706 6,069,826 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link decreases expression EXP 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link multiple interactions EXP 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link multiple interactions EXP 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link affects response to substance EXP 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link affects expression ISO 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link increases response to substance ISO 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link decreases expression ISO 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link increases expression ISO 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link multiple interactions ISO 8 52,641,160 52,707,749 RGD:6480464 CTD
G Drd3 dopamine receptor D3 GBrowse link multiple interactions EXP 11 58,446,901 58,520,589 RGD:6480464 CTD
G Drd3 dopamine receptor D3 GBrowse link decreases expression EXP 11 58,446,901 58,520,589 RGD:6480464 CTD
G Esr1 estrogen receptor 1 GBrowse link multiple interactions ISO 1 35,523,680 35,759,891 RGD:6480464 CTD
G Fshb follicle stimulating hormone, beta polypeptide GBrowse link increases expression ISO 3 92,569,344 92,571,254 RGD:6480464 CTD
G Gdnf glial cell derived neurotrophic factor GBrowse link decreases expression ISO 2 57,399,312 57,424,030 RGD:6480464 CTD
G Gdnf glial cell derived neurotrophic factor GBrowse link decreases secretion ISO 2 57,399,312 57,424,030 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link increases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Gh1 growth hormone 1 GBrowse link decreases expression ISO 10 95,692,240 95,694,117 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link increases expression ISO 19 13,963,139 13,969,960 RGD:6480464 CTD
G Ins2 insulin 2 GBrowse link decreases expression ISO 1 202,935,548 202,936,379 RGD:6480464 CTD
G Lhb luteinizing hormone beta GBrowse link increases expression ISO 1 95,892,999 95,893,988 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link multiple interactions EXP 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link multiple interactions EXP 1 185,935,044 185,941,245 RGD:6480464 CTD
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 GBrowse link increases localization ISO 3 58,366,693 58,394,116 RGD:6480464 CTD
G Ngf nerve growth factor (beta polypeptide) GBrowse link increases secretion ISO 2 197,621,726 197,632,960 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link multiple interactions ISO 10 65,036,884 65,072,453 RGD:6480464 CTD
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 GBrowse link multiple interactions EXP 13 49,931,592 50,048,756 RGD:6480464 CTD
G Pcna proliferating cell nuclear antigen GBrowse link multiple interactions EXP 3 120,008,715 120,012,589 RGD:6480464 CTD
G Pomc proopiomelanocortin GBrowse link decreases expression EXP 6 26,931,969 26,937,789 RGD:6480464 CTD
G Pomc proopiomelanocortin GBrowse link multiple interactions EXP 6 26,931,969 26,937,789 RGD:6480464 CTD
G Pomc proopiomelanocortin GBrowse link increases expression ISO 6 26,931,969 26,937,789 RGD:6480464 CTD
G Prkcd protein kinase C, delta GBrowse link multiple interactions EXP 16 5,954,218 5,975,743 RGD:6480464 CTD
G Prkcd protein kinase C, delta GBrowse link affects localization EXP 16 5,954,218 5,975,743 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link multiple interactions EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases secretion EXP 17 44,699,101 44,709,162 RGD:6480464 CTD
G Prl prolactin GBrowse link decreases expression ISO 17 44,699,101 44,709,162 RGD:6480464 CTD
G Scarb1 scavenger receptor class B, member 1 GBrowse link multiple interactions EXP 12 32,390,183 32,457,661 RGD:6480464 CTD
G Sod1 superoxide dismutase 1, soluble GBrowse link multiple interactions ISO 11 29,810,766 29,816,342 RGD:6480464 CTD
G Star steroidogenic acute regulatory protein GBrowse link decreases expression EXP 16 70,642,580 70,647,203 RGD:6480464 CTD
G Stat5a signal transducer and activator of transcription 5A GBrowse link affects localization ISO 10 89,795,404 89,819,732 RGD:6480464 CTD
G Tgfa transforming growth factor alpha GBrowse link multiple interactions EXP 4 120,355,649 120,437,772 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions EXP 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link multiple interactions EXP 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vip vasoactive intestinal peptide GBrowse link multiple interactions ISO 1 36,361,513 36,369,594 RGD:6480464 CTD
G Vip vasoactive intestinal peptide GBrowse link multiple interactions EXP 1 36,361,513 36,369,594 RGD:6480464 CTD
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  CHEBI ontology 501881
    role 491510
      biological role 489686
        pharmacological role 129710
          antagonist 30773
            hormone antagonist 10795
              bromocriptine 103
                bromocriptine methanesulfonate 0
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  CHEBI ontology 501881
    subatomic particle 500845
      composite particle 500845
        hadron 500845
          baryon 500845
            nucleon 500845
              atomic nucleus 500845
                atom 500845
                  main group element atom 470301
                    main group molecular entity 465185
                      s-block molecular entity 315220
                        hydrogen molecular entity 312457
                          hydrides 195649
                            organic hydride 120792
                              organic fundamental parent 120792
                                natural product fundamental parent 40935
                                  alkaloid fundamental parent 2109
                                    indole alkaloid fundamental parent 834
                                      ergotaman 106
                                        bromocriptine 103
                                          bromocriptine methanesulfonate 0
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