edaravone - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:	edaravone	go back to main search page
Accession:	CHEBI:31530	browse the term
Definition:	A ring assembly that has formula C10H10N2O.
Synonyms:	related_synonym:	1-phenyl-3-methyl-5-oxo-2-pyrazoline; 2,4-dihydro-5-methyl-2-phenyl-3H-pyrazol-3-one; 3-methyl-1-phenyl-2-pyrazolin-5-one; 3-methyl-1-phenyl-5-pyrazolone; 3-methyl-1-phenylpyrazol-5-one; C.I. developer 1; C10H10N2O; CC1=NN(C(=O)C1)c1ccccc1; InChI=1S/C10H10N2O/c1-8-7-10(13)12(11-8)9-5-3-2-4-6-9/h2-6H,7H2,1H3; InChIKey=QELUYTUMUWHWMC-UHFFFAOYSA-N; Radicut; developer Z; methylphenylpyrazolone; norphenazone; phenyl methyl pyrazolone; phenylmethylpyrazolone
	xref_casrn:	89-25-8
	xref:	Beilstein:609575 "Beilstein Registry Number"; ChEMBL:160371 "ChEMBL COMPOUND"; ChemIDplus:89-25-8 "CAS Registry Number"; Gmelin:241147 "Gmelin Registry Number"; KEGG COMPOUND:89-25-8 "CAS Registry Number"; KEGG COMPOUND:C13008 "KEGG COMPOUND"; KEGG DRUG:D01552 "KEGG DRUG"
	xref_mesh:	MESH:C005435
	xref:	NIST Chemistry WebBook:89-25-8 "CAS Registry Number"

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edaravone
	Symbol	Object Name	GBrowse	Qualifiers	Evidence	Chr	Start	Stop	Reference	Source
G	Agtr1a	angiotensin II receptor, type 1a		multiple interactions	EXP	17	40,629,318	40,684,982	RGD:6480464	CTD
G	Agtr2	angiotensin II receptor, type 2		multiple interactions	EXP				RGD:6480464	CTD
G	Akt1	v-akt murine thymoma viral oncogene homolog 1		multiple interactions	EXP	6	137,640,482	137,657,552	RGD:6480464	CTD
G	Alox5	arachidonate 5-lipoxygenase		multiple interactions	EXP	4	152,610,283	152,657,891	RGD:6480464	CTD
G	Casp12	caspase 12		multiple interactions	EXP	8	2,082,933	2,110,511	RGD:6480464	CTD
G	Casp3	caspase 3		multiple interactions	EXP	16	48,944,226	48,962,420	RGD:6480464	CTD
G	Casp8	caspase 8		decreases expression	EXP	9	57,389,353	57,437,803	RGD:6480464	CTD
G	Ccl12	chemokine (C-C motif) ligand 12		multiple interactions	EXP	10	70,321,036	70,322,586	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	EXP	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		multiple interactions	EXP	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		decreases expression	EXP	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl2	chemokine (C-C motif) ligand 2		decreases expression	EXP	10	70,256,263	70,258,061	RGD:6480464	CTD
G	Ccl3	chemokine (C-C motif) ligand 3		decreases expression	EXP	10	71,744,559	71,746,109	RGD:6480464	CTD
G	Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)		decreases expression	EXP	14	18,690,339	18,692,118	RGD:6480464	CTD
G	Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)		multiple interactions	EXP	14	18,690,339	18,692,118	RGD:6480464	CTD
G	Cxcl12	chemokine (C-X-C motif) ligand 12		multiple interactions	EXP	4	153,503,576	153,516,423	RGD:6480464	CTD
G	Cxcl2	chemokine (C-X-C motif) ligand 2		multiple interactions	EXP	14	18,677,129	18,679,175	RGD:6480464	CTD
G	Cxcl2	chemokine (C-X-C motif) ligand 2		decreases expression	EXP	14	18,677,129	18,679,175	RGD:6480464	CTD
G	Cxcl3	chemokine (C-X-C motif) ligand 3		decreases expression	EXP	14	18,767,306	18,787,340	RGD:6480464	CTD
G	Cybb	cytochrome b-245, beta polypeptide		multiple interactions	EXP	X	25,514,572	25,547,181	RGD:6480464	CTD
G	Daxx	death-domain associated protein		decreases expression	EXP	20	5,121,854	5,127,601	RGD:6480464	CTD
G	Ern1	endoplasmic reticulum to nucleus signaling 1		increases expression	EXP	10	95,794,488	95,855,895	RGD:6480464	CTD
G	Fadd	Fas (TNFRSF6)-associated via death domain		decreases expression	EXP	1	205,010,363	205,012,768	RGD:6480464	CTD
G	Hif1a	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)		multiple interactions	ISO	6	96,419,024	96,463,891	RGD:6480464	CTD
G	Hspa1a	heat shock protein 1A		decreases expression	EXP	20	3,945,716	3,959,552	RGD:6480464	CTD
G	Hspa1a	heat shock protein 1A		decreases expression	EXP	20	3,945,716	3,959,552	RGD:6480464	CTD
G	Icam1	intercellular adhesion molecule 1		decreases expression	EXP	8	20,040,177	20,051,939	RGD:6480464	CTD
G	Icam1	intercellular adhesion molecule 1		decreases expression	EXP	8	20,040,177	20,051,939	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	EXP	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Ifng	interferon gamma		multiple interactions	EXP	7	57,621,756	57,625,792	RGD:6480464	CTD
G	Il10	interleukin 10		multiple interactions	EXP	13	43,953,900	43,957,766	RGD:6480464	CTD
G	Il10	interleukin 10		multiple interactions	EXP	13	43,953,900	43,957,766	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		decreases activity	ISO	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		multiple interactions	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1b	interleukin 1 beta		decreases expression	EXP	3	116,964,422	116,970,867	RGD:6480464	CTD
G	Il1r1	interleukin 1 receptor, type I		multiple interactions	EXP	9	39,434,910	39,473,552	RGD:6480464	CTD
G	Il4	interleukin 4		multiple interactions	EXP	10	39,074,582	39,080,134	RGD:6480464	CTD
G	Il6	interleukin 6		affects activity	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		decreases expression	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Il6	interleukin 6		multiple interactions	EXP	4	456,799	461,376	RGD:6480464	CTD
G	Ins1	insulin 1		multiple interactions	ISO	1	258,001,134	258,001,688	RGD:6480464	CTD
G	Map3k5	mitogen-activated protein kinase kinase kinase 5		decreases activity	ISO	1	15,205,361	15,346,422	RGD:6480464	CTD
G	Map3k5	mitogen-activated protein kinase kinase kinase 5		decreases activity	ISO	1	15,205,361	15,346,422	RGD:6480464	CTD
G	Mapk8	mitogen-activated protein kinase 8		increases phosphorylation	ISO	16	8,925,133	9,004,897	RGD:6480464	CTD
G	Mapk8	mitogen-activated protein kinase 8		decreases phosphorylation	ISO	16	8,925,133	9,004,897	RGD:6480464	CTD
G	Mmp2	matrix metallopeptidase 2		decreases expression	EXP	19	15,246,036	15,275,061	RGD:6480464	CTD
G	Mmp2	matrix metallopeptidase 2		multiple interactions	EXP	19	15,246,036	15,275,061	RGD:6480464	CTD
G	Mmp9	matrix metallopeptidase 9		multiple interactions	EXP	3	155,985,473	155,993,433	RGD:6480464	CTD
G	Mpo	myeloperoxidase		affects expression	EXP	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		decreases expression	EXP	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		multiple interactions	EXP	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Mpo	myeloperoxidase		decreases activity	EXP	10	76,085,872	76,097,012	RGD:6480464	CTD
G	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha		increases expression	EXP	6	75,729,302	75,732,475	RGD:6480464	CTD
G	Ngf	nerve growth factor (beta polypeptide)		increases expression	ISO	2	197,621,726	197,632,960	RGD:6480464	CTD
G	Ngf	nerve growth factor (beta polypeptide)		multiple interactions	ISO	2	197,621,726	197,632,960	RGD:6480464	CTD
G	Nos1	nitric oxide synthase 1, neuronal		multiple interactions	EXP	12	39,812,500	39,869,484	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	ISO	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		multiple interactions	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		decreases expression	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos2	nitric oxide synthase 2, inducible		increases degradation	EXP	10	65,036,884	65,072,453	RGD:6480464	CTD
G	Nos3	nitric oxide synthase 3, endothelial cell		increases expression	EXP	4	6,158,847	6,179,441	RGD:6480464	CTD
G	Nos3	nitric oxide synthase 3, endothelial cell		decreases degradation	ISO	4	6,158,847	6,179,441	RGD:6480464	CTD
G	Nppa	natriuretic peptide A		decreases expression	ISO	5	165,074,518	165,075,827	RGD:6480464	CTD
G	Plat	plasminogen activator, tissue		multiple interactions	EXP	16	73,711,323	73,736,328	RGD:6480464	CTD
G	Prnp	prion protein		multiple interactions	EXP	3	119,676,137	119,691,507	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		decreases expression	EXP	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	EXP	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)		multiple interactions	EXP	1	208,262,669	208,273,148	RGD:6480464	CTD
G	Sdc2	syndecan 2		multiple interactions	EXP	7	68,290,558	68,405,183	RGD:6480464	CTD
G	Sele	selectin E		decreases expression	EXP	13	79,813,455	79,822,845	RGD:6480464	CTD
G	Sod1	superoxide dismutase 1, soluble		multiple interactions	EXP	11	29,810,766	29,816,342	RGD:6480464	CTD
G	Sod2	superoxide dismutase 2, mitochondrial		multiple interactions	EXP	1	41,862,997	41,870,327	RGD:6480464	CTD
G	Tgfb1	transforming growth factor, beta 1		multiple interactions	EXP	1	80,894,705	80,911,020	RGD:6480464	CTD
G	Timp1	TIMP metallopeptidase inhibitor 1		multiple interactions	EXP	X	12,542,496	12,547,094	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		decreases expression	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		decreases expression	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		decreases expression	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Tnf	tumor necrosis factor		multiple interactions	EXP	20	3,661,000	3,663,618	RGD:6480464	CTD
G	Ucp2	uncoupling protein 2 (mitochondrial, proton carrier)		multiple interactions	EXP	1	157,925,514	157,928,222	RGD:6480464	CTD
G	Vcam1	vascular cell adhesion molecule 1		decreases expression	EXP	2	212,277,654	212,297,376	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		multiple interactions	ISO	9	10,520,730	10,536,071	RGD:6480464	CTD
G	Vegfa	vascular endothelial growth factor A		multiple interactions	ISO	9	10,520,730	10,536,071	RGD:6480464	CTD

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	501881
role	491510
chemical role	210371
antioxidant	26278
radical scavenger	1735
edaravone	95
Path 2
Term	Annotations
CHEBI ontology	501881
subatomic particle	500845
composite particle	500845
hadron	500845
baryon	500845
nucleon	500845
atomic nucleus	500845
atom	500845
group	456662
polyatomic entity	451021
molecule	371155
cyclic compound	306410
ring assembly	5641
edaravone	95