ONTOLOGY REPORT - ANNOTATIONS

Term:auranofin
go back to main search page
Accession:CHEBI:2922 term browser browse the term
Definition:An S-glycosyl compound consisting of 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranose with the sufur atom coordinated to (triethylphosphoranylidene)gold. It is administered orally for the treatment of active progressive rheumatoid arthritis.
Synonyms:exact_synonym: (2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-kappaS(1))(triethylphosphine)gold;   (2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-kappaS(1))(triethylphosphoranylidene)gold
 related_synonym: (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate;   2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold;   C20H34AuO9PS;   CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O;   CC[P+](CC)(CC)[Au-]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O;   InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1;   InChIKey=AUJRCFUBUPVWSZ-XTZHGVARSA-M;   Ridaura;   Triethylphosphine gold;   auranofina;   auranofine;   auranofinum
 xref_casrn: 34031-32-8
 xref: Beilstein:8187029 "Beilstein Registry Number";   ChEMBL:408917 "ChEMBL COMPOUND";   ChemIDplus:34031-32-8 "CAS Registry Number";   CiteXplore:10796461 "PubMed citation";   CiteXplore:11071118 "PubMed citation";   CiteXplore:16036347 "PubMed citation";   CiteXplore:17645497 "PubMed citation";   CiteXplore:18409052 "PubMed citation";   CiteXplore:18789312 "PubMed citation";   CiteXplore:20127591 "PubMed citation";   CiteXplore:22610278 "PubMed citation";   CiteXplore:2656613 "PubMed citation";   CiteXplore:6426843 "PubMed citation";   CiteXplore:6426923 "PubMed citation";   CiteXplore:9189058 "PubMed citation";   DrugBank:34031-32-8 "CAS Registry Number";   DrugBank:DB00995 "DrugBank";   Gmelin:112479 "Gmelin Registry Number";   Gmelin:294107 "Gmelin Registry Number";   KEGG DRUG:34031-32-8 "CAS Registry Number";   KEGG DRUG:D00237 "KEGG DRUG"
 xref_mesh: MESH:D001310
 xref: Patent:DE2051495 "Patent";   Patent:US3635945 "Patent";   Reaxys:11644694 "Reaxys Registry Number";   Reaxys:14401468 "Reaxys Registry Number";   Wikipedia:Auranofin "Wikipedia"

  • Rat
  • Mouse
  • Human
  • All
  • show annotations for term's descendants
  •     Sort by:
auranofin term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Alb albumin GBrowse link affects binding ISO 14 19,126,935 19,142,214 RGD:6480464 CTD
G Bak1 BCL2-antagonist/killer 1 GBrowse link multiple interactions ISO 20 5,255,954 5,264,593 RGD:6480464 CTD
G Bak1 BCL2-antagonist/killer 1 GBrowse link increases response to substance ISO 20 5,255,954 5,264,593 RGD:6480464 CTD
G Bak1 BCL2-antagonist/killer 1 GBrowse link multiple interactions ISO 20 5,255,954 5,264,593 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases response to substance ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cebpe CCAAT/enhancer binding protein (C/EBP), epsilon GBrowse link multiple interactions ISO 15 32,787,946 32,789,344 RGD:6480464 CTD
G Chuk conserved helix-loop-helix ubiquitous kinase GBrowse link multiple interactions ISO 1 249,122,845 249,158,369 RGD:6480464 CTD
G Chuk conserved helix-loop-helix ubiquitous kinase GBrowse link multiple interactions ISO 1 249,122,845 249,158,369 RGD:6480464 CTD
G Gpx1 glutathione peroxidase 1 increases expression ISO RGD:6480464 CTD
G Gpx1 glutathione peroxidase 1 multiple interactions ISO RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link increases expression ISO 19 13,963,139 13,969,960 RGD:6480464 CTD
G Hmox1 heme oxygenase (decycling) 1 GBrowse link increases expression ISO 19 13,963,139 13,969,960 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions ISO 4 456,799 461,376 RGD:6480464 CTD
G Il6st interleukin 6 signal transducer GBrowse link multiple interactions ISO 2 43,806,301 43,842,365 RGD:6480464 CTD
G Irak1 interleukin-1 receptor-associated kinase 1 GBrowse link multiple interactions ISO X 159,960,184 159,969,180 RGD:6480464 CTD
G Irf3 interferon regulatory factor 3 GBrowse link multiple interactions ISO 1 95,470,284 95,475,078 RGD:6480464 CTD
G Itgam integrin, alpha M GBrowse link multiple interactions ISO 1 187,334,413 187,385,583 RGD:6480464 CTD
G Jak2 Janus kinase 2 GBrowse link multiple interactions ISO 1 232,915,995 232,974,763 RGD:6480464 CTD
G Mcl1 myeloid cell leukemia sequence 1 multiple interactions ISO RGD:6480464 CTD
G Mcl1 myeloid cell leukemia sequence 1 decreases expression ISO RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions ISO 6 75,729,302 75,732,475 RGD:6480464 CTD
G Nfkbib nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta GBrowse link multiple interactions ISO 1 83,865,440 83,873,010 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link decreases activity ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link increases cleavage ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Prdx3 peroxiredoxin 3 GBrowse link multiple interactions ISO 1 267,468,371 267,481,273 RGD:6480464 CTD
G Prdx3 peroxiredoxin 3 GBrowse link increases oxidation ISO 1 267,468,371 267,481,273 RGD:6480464 CTD
G Prdx3 peroxiredoxin 3 GBrowse link increases oxidation ISO 1 267,468,371 267,481,273 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link multiple interactions ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Rb1 retinoblastoma 1 GBrowse link decreases phosphorylation ISO 15 53,828,881 53,962,099 RGD:6480464 CTD
G RT1-Ba RT1 class II, locus Ba GBrowse link increases response to substance ISO 20 4,697,971 4,702,564 RGD:6480464 CTD
G RT1-Db1 RT1 class II, locus Db1 GBrowse link increases response to substance ISO 20 4,671,489 4,681,058 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link decreases expression ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) GBrowse link multiple interactions ISO 10 89,821,078 89,872,970 RGD:6480464 CTD
G Tbk1 TANK-binding kinase 1 GBrowse link multiple interactions ISO 7 60,863,099 60,896,131 RGD:6480464 CTD
G Tlr4 toll-like receptor 4 GBrowse link multiple interactions ISO 5 83,564,100 83,577,735 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link multiple interactions ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link increases expression ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link increases oxidation ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity EXP 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity ISO 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link multiple interactions EXP 7 23,055,544 23,093,815 RGD:6480464 CTD
G Txnrd2 thioredoxin reductase 2 GBrowse link decreases activity ISO 11 84,513,361 84,561,673 RGD:6480464 CTD
G Txnrd2 thioredoxin reductase 2 GBrowse link decreases activity ISO 11 84,513,361 84,561,673 RGD:6480464 CTD
G Txnrd2 thioredoxin reductase 2 GBrowse link multiple interactions ISO 11 84,513,361 84,561,673 RGD:6480464 CTD
G Txnrd2 thioredoxin reductase 2 GBrowse link decreases activity ISO 11 84,513,361 84,561,673 RGD:6480464 CTD
G Txnrd2 thioredoxin reductase 2 GBrowse link decreases activity EXP 11 84,513,361 84,561,673 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        immunomodulator 23525
          immunosuppressive agent 17518
            auranofin 69
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            heteroorganic entity 324767
                              organochalcogen compound 226950
                                organooxygen compound 213735
                                  carbohydrate 20809
                                    carbohydrate derivative 16368
                                      S-glycosyl compound 82
                                        auranofin 69
paths to the root

Contact Us |  About Us |  Jobs at RGD