ONTOLOGY REPORT - ANNOTATIONS

Term:astemizole
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Accession:CHEBI:2896 term browser browse the term
Definition:A piperidine compound having a 2-(4-methoxyphenyl)ethyl group at the 1-position and an N-[(4-fluorobenzyl)benzimidazol-2-yl]amino group at the 4-position.
Synonyms:exact_synonym: 1-(4-fluorobenzyl)-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
 related_synonym: 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole;   1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole;   Astemison;   C28H31FN4O;   COc1ccc(CCN2CCC(CC2)Nc2nc3ccccc3n2Cc2ccc(F)cc2)cc1;   InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31);   InChIKey=GXDALQBWZGODGZ-UHFFFAOYSA-N;   astemizol;   astemizolum
 xref_casrn: 68844-77-9
 xref: Beilstein:4830190 "Beilstein Registry Number";   ChEMBL:165605 "ChEMBL COMPOUND";   ChemIDplus:68844-77-9 "CAS Registry Number";   DrugBank:68844-77-9 "CAS Registry Number";   DrugBank:DB00637 "DrugBank";   KEGG COMPOUND:68844-77-9 "CAS Registry Number";   KEGG COMPOUND:C06832 "KEGG COMPOUND";   KEGG DRUG:68844-77-9 "CAS Registry Number";   KEGG DRUG:D00234 "KEGG DRUG"
 xref_mesh: MESH:D016589
 xref: Patent:EP5318 "Patent";   Patent:US4219559 "Patent"

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astemizole term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Ak3 adenylate kinase 3 GBrowse link increases expression EXP 1 232,658,879 232,684,083 RGD:6480464 CTD
G Alas2 aminolevulinate, delta-, synthase 2 increases expression EXP RGD:6480464 CTD
G Angpt2 angiopoietin 2 GBrowse link increases expression EXP 16 75,891,757 75,942,255 RGD:6480464 CTD
G Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide GBrowse link increases expression EXP 13 80,214,056 80,234,576 RGD:6480464 CTD
G Atp1b2 ATPase, Na+/K+ transporting, beta 2 polypeptide GBrowse link decreases expression EXP 10 56,418,323 56,424,465 RGD:6480464 CTD
G Atp5e ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit increases expression EXP RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression EXP 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bmp1 bone morphogenetic protein 1 GBrowse link decreases expression EXP 15 50,878,144 50,922,313 RGD:6480464 CTD
G Camk2d calcium/calmodulin-dependent protein kinase II delta GBrowse link decreases expression EXP 2 223,840,650 224,108,082 RGD:6480464 CTD
G Cat catalase GBrowse link increases expression EXP 3 88,654,077 88,686,212 RGD:6480464 CTD
G Ccl7 chemokine (C-C motif) ligand 7 GBrowse link decreases expression EXP 10 70,267,281 70,269,131 RGD:6480464 CTD
G Cebpb CCAAT/enhancer binding protein (C/EBP), beta GBrowse link increases expression EXP 3 158,826,021 158,827,848 RGD:6480464 CTD
G Cebpg CCAAT/enhancer binding protein (C/EBP), gamma GBrowse link decreases expression EXP 1 87,552,695 87,559,447 RGD:6480464 CTD
G Cfh complement factor H GBrowse link decreases expression EXP 13 53,252,249 53,355,987 RGD:6480464 CTD
G Colec12 collectin sub-family member 12 GBrowse link decreases expression EXP 18 996,297 1,188,288 RGD:6480464 CTD
G Cox6c-ps1 cytochrome c oxidase subunit VIc, pseudogene GBrowse link increases expression EXP 19 54,397,944 54,398,802 RGD:6480464 CTD
G Crh corticotropin releasing hormone GBrowse link multiple interactions EXP 2 104,764,023 104,765,887 RGD:6480464 CTD
G Cxcl3 chemokine (C-X-C motif) ligand 3 GBrowse link decreases expression EXP 14 18,767,306 18,787,340 RGD:6480464 CTD
G Cxcl9 chemokine (C-X-C motif) ligand 9 GBrowse link decreases expression EXP 14 17,284,085 17,288,996 RGD:6480464 CTD
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 GBrowse link multiple interactions ISO 5 116,702,370 116,729,722 RGD:6480464 CTD
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 GBrowse link decreases methylation ISO 5 116,702,370 116,729,722 RGD:6480464 CTD
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 GBrowse link increases metabolic processing ISO 5 116,702,370 116,729,722 RGD:6480464 CTD
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 GBrowse link decreases methylation ISO 5 116,702,370 116,729,722 RGD:6480464 CTD
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 GBrowse link increases degradation ISO 12 9,517,016 9,541,000 RGD:6480464 CTD
G Eaf1 ELL associated factor 1 GBrowse link increases expression EXP 16 6,938,938 6,953,687 RGD:6480464 CTD
G Egln1 EGL nine homolog 1 (C. elegans) GBrowse link increases expression EXP 19 55,080,670 55,118,226 RGD:6480464 CTD
G Eif4a1 eukaryotic translation initiation factor 4A1 GBrowse link increases expression EXP 10 56,484,232 56,489,739 RGD:6480464 CTD
G Errfi1 ERBB receptor feedback inhibitor 1 GBrowse link decreases expression EXP 5 168,012,683 168,025,963 RGD:6480464 CTD
G Etv5 ets variant 5 GBrowse link decreases expression EXP 11 80,846,286 80,904,013 RGD:6480464 CTD
G Fcer1a Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide GBrowse link multiple interactions EXP 13 89,429,982 89,436,507 RGD:6480464 CTD
G Gdf10 growth differentiation factor 10 GBrowse link increases expression EXP 16 9,558,781 9,570,656 RGD:6480464 CTD
G Gimap1 GTPase, IMAP family member 1 GBrowse link increases expression EXP 4 76,829,536 76,833,423 RGD:6480464 CTD
G Gpm6b glycoprotein m6b GBrowse link increases expression EXP X 48,746,584 48,788,414 RGD:6480464 CTD
G Gpx4 glutathione peroxidase 4 GBrowse link increases expression EXP 7 11,162,521 11,165,318 RGD:6480464 CTD
G Hexb hexosaminidase B GBrowse link increases secretion EXP 2 27,649,188 27,672,231 RGD:6480464 CTD
G Hexb hexosaminidase B GBrowse link multiple interactions EXP 2 27,649,188 27,672,231 RGD:6480464 CTD
G Hrh1 histamine receptor H 1 GBrowse link multiple interactions ISO 4 150,431,239 150,432,699 RGD:6480464 CTD
G Hrh1 histamine receptor H 1 GBrowse link multiple interactions ISO 4 150,431,239 150,432,699 RGD:6480464 CTD
G Hspa8 heat shock 70kDa protein 8 GBrowse link increases expression EXP 8 43,784,035 43,787,760 RGD:6480464 CTD
G Hspb8 heat shock protein B8 GBrowse link increases expression EXP 12 41,407,166 41,421,565 RGD:6480464 CTD
G Hsph1 heat shock 105/110 protein 1 GBrowse link decreases expression EXP 12 5,794,645 5,811,453 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link multiple interactions ISO 8 20,040,177 20,051,939 RGD:6480464 CTD
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 GBrowse link decreases expression EXP 1 238,571,300 238,576,443 RGD:6480464 CTD
G Igf1 insulin-like growth factor 1 GBrowse link multiple interactions ISO 7 24,531,669 24,605,742 RGD:6480464 CTD
G Igsf6 immunoglobulin superfamily, member 6 GBrowse link decreases expression EXP 1 179,911,684 179,922,158 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il36rn interleukin 36 receptor antagonist GBrowse link increases expression EXP 3 2,530,402 2,536,999 RGD:6480464 CTD
G Il7r interleukin 7 receptor GBrowse link decreases expression EXP 2 59,103,992 59,128,004 RGD:6480464 CTD
G Itga8 integrin, alpha 8 GBrowse link increases expression EXP 17 86,427,191 86,649,268 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link decreases activity ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link multiple interactions ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link affects binding ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link decreases activity ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link multiple interactions ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link decreases activity ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link decreases activity ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh1 potassium voltage-gated channel, subfamily H (eag-related), member 1 GBrowse link decreases activity ISO 13 108,129,617 108,407,815 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link affects binding ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link affects localization ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link affects binding ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link affects binding ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity EXP 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link affects localization ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link multiple interactions ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnh2 potassium voltage-gated channel, subfamily H (eag-related), member 2 GBrowse link decreases activity ISO 4 6,192,644 6,224,285 RGD:6480464 CTD
G Kcnq2 potassium voltage-gated channel, KQT-like subfamily, member 2 GBrowse link multiple interactions ISO 3 170,227,938 170,282,887 RGD:6480464 CTD
G Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 GBrowse link multiple interactions ISO 7 103,325,185 103,627,045 RGD:6480464 CTD
G LOC100362888 rCG52099-like GBrowse link increases expression EXP 15 41,841,298 41,844,727 RGD:6480464 CTD
G Maoa monoamine oxidase A GBrowse link decreases expression EXP X 17,678,960 17,745,908 RGD:6480464 CTD
G Mapt microtubule-associated protein tau GBrowse link affects binding ISO 10 93,411,098 93,508,762 RGD:6480464 CTD
G Mmp2 matrix metallopeptidase 2 GBrowse link decreases expression EXP 19 15,246,036 15,275,061 RGD:6480464 CTD
G Ms4a6a membrane-spanning 4-domains, subfamily A, member 6A GBrowse link decreases expression EXP 1 214,046,885 214,057,578 RGD:6480464 CTD
G Mtus1 microtubule associated tumor suppressor 1 GBrowse link decreases expression EXP 16 54,611,502 54,664,075 RGD:6480464 CTD
G Myh6 myosin, heavy chain 6, cardiac muscle, alpha GBrowse link increases expression EXP 15 33,044,506 33,068,098 RGD:6480464 CTD
G Ndufs7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 GBrowse link increases expression EXP 7 10,963,916 10,971,188 RGD:6480464 CTD
G Ndufv2 NADH dehydrogenase (ubiquinone) flavoprotein 2 GBrowse link increases expression EXP 9 104,852,714 104,873,325 RGD:6480464 CTD
G Necab1 N-terminal EF-hand calcium binding protein 1 GBrowse link decreases expression EXP 5 29,427,273 29,664,037 RGD:6480464 CTD
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 GBrowse link increases expression EXP 5 64,713,468 64,753,311 RGD:6480464 CTD
G Oasl 2'-5'-oligoadenylate synthetase-like GBrowse link decreases expression EXP 12 42,956,466 42,969,826 RGD:6480464 CTD
G Osbpl3 oxysterol binding protein-like 3 GBrowse link increases expression EXP 4 78,521,743 78,600,559 RGD:6480464 CTD
G Osgepl1 O-sialoglycoprotein endopeptidase-like 1 GBrowse link increases expression EXP 9 45,164,778 45,178,715 RGD:6480464 CTD
G Park7 parkinson protein 7 GBrowse link increases expression EXP 5 168,050,149 168,061,616 RGD:6480464 CTD
G Pcdh17 protocadherin 17 GBrowse link decreases expression EXP 15 66,391,901 66,482,530 RGD:6480464 CTD
G Peli2 pellino E3 ubiquitin protein ligase family member 2 GBrowse link increases expression EXP 15 24,227,734 24,371,242 RGD:6480464 CTD
G Prl8a3 prolactin family 8, subfamily a, member 3 decreases expression EXP RGD:6480464 CTD
G Psmb5 proteasome (prosome, macropain) subunit, beta type 5 GBrowse link increases expression EXP 15 32,689,859 32,694,364 RGD:6480464 CTD
G Ptgs1 prostaglandin-endoperoxide synthase 1 GBrowse link decreases expression EXP 3 15,343,832 15,365,412 RGD:6480464 CTD
G Pycrl pyrroline-5-carboxylate reductase-like GBrowse link increases expression EXP 7 113,895,788 113,926,200 RGD:6480464 CTD
G Pygm phosphorylase, glycogen, muscle GBrowse link increases expression EXP 1 209,166,701 209,181,588 RGD:6480464 CTD
G RGD1561089 RGD1561089 increases expression EXP RGD:6480464 CTD
G S100a8 S100 calcium binding protein A8 GBrowse link increases expression EXP 2 182,961,994 182,962,513 RGD:6480464 CTD
G S100b S100 calcium binding protein B GBrowse link decreases expression EXP 20 12,791,440 12,824,508 RGD:6480464 CTD
G Sik1 salt-inducible kinase 1 GBrowse link decreases expression EXP 20 10,282,203 10,291,735 RGD:6480464 CTD
G Slc1a1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 GBrowse link increases expression EXP 1 232,469,746 232,549,584 RGD:6480464 CTD
G Sod2 superoxide dismutase 2, mitochondrial GBrowse link increases expression EXP 1 41,862,997 41,870,327 RGD:6480464 CTD
G Sqstm1 sequestosome 1 GBrowse link increases expression EXP 10 35,751,300 35,762,630 RGD:6480464 CTD
G Tf transferrin GBrowse link decreases expression EXP 8 108,217,774 108,244,487 RGD:6480464 CTD
G Tgfb2 transforming growth factor, beta 2 GBrowse link increases expression EXP 13 102,718,703 102,818,768 RGD:6480464 CTD
G Tlr2 toll-like receptor 2 GBrowse link decreases expression EXP 2 175,607,990 175,613,992 RGD:6480464 CTD
G Tlr7 toll-like receptor 7 GBrowse link decreases expression EXP X 47,330,737 47,356,841 RGD:6480464 CTD
G Tmod1 tropomodulin 1 GBrowse link increases expression EXP 5 62,578,142 62,668,760 RGD:6480464 CTD
G Vcam1 vascular cell adhesion molecule 1 GBrowse link multiple interactions ISO 2 212,277,654 212,297,376 RGD:6480464 CTD
G Vcan versican GBrowse link decreases expression EXP 2 19,712,629 19,801,443 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      application 245197
        pharmaceutical 174005
          drug 173802
            anti-allergic agent 736
              astemizole 118
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic molecule 359465
                              organic cyclic compound 298342
                                organic heterocyclic compound 154273
                                  organic heteropolycyclic compound 95654
                                    organic heterobicyclic compound 57928
                                      benzimidazoles 1080
                                        astemizole 118
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