ONTOLOGY REPORT - ANNOTATIONS

Term:mechlorethamine
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Accession:CHEBI:28925 term browser browse the term
Definition:A nitrogen mustard that has formula C5H11Cl2N.
Synonyms:exact_synonym: 2-chloro-N-(2-chloroethyl)-N-methylethanamine
 related_synonym: 2,2'-dichloro-N-methyldiethylamine;   C5H11Cl2N;   CN(CCCl)CCCl;   InChI=1S/C5H11Cl2N/c1-8(4-2-6)5-3-7/h2-5H2,1H3;   InChIKey=HAWPXGHAZFHHAD-UHFFFAOYSA-N;   N-methyl-bis(2-chloroethyl)amine;   N-methyl-bis(beta-chloroethyl)amine;   beta,beta'-dichlorodiethyl-N-methylamine;   bis(2-chloroethyl)methylamine;   bis(beta-chloroethyl)methylamine;   chlormethine;   methylbis(2-chloroethyl)amine;   methylbis(beta-chloroethyl)amine;   nitrogen mustard
 alt_id: CHEBI:25557;   CHEBI:6708
 xref_casrn: 51-75-2
 xref: ChEMBL:101470 "ChEMBL COMPOUND";   ChemIDplus:51-75-2 "CAS Registry Number";   DrugBank:DB00888 "DrugBank";   KEGG COMPOUND:51-75-2 "CAS Registry Number";   KEGG COMPOUND:C07115 "KEGG COMPOUND"
 xref_mesh: MESH:D008466
 xref: NIST Chemistry WebBook:51-75-2 "CAS Registry Number";   Wikipedia:Mechlorethamine "Wikipedia"

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mechlorethamine term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 GBrowse link increases expression ISO X 134,868,878 134,908,166 RGD:6480464 CTD
G Ampd3 adenosine monophosphate deaminase 3 GBrowse link increases expression ISO 1 168,519,462 168,568,291 RGD:6480464 CTD
G Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide GBrowse link decreases expression ISO 13 88,258,993 88,283,918 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link decreases expression ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Calm3 calmodulin 3 GBrowse link decreases expression ISO 1 77,245,609 77,252,717 RGD:6480464 CTD
G Casp2 caspase 2 GBrowse link increases activity ISO 4 70,029,728 70,047,164 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Ccna2 cyclin A2 GBrowse link multiple interactions ISO 2 123,062,752 123,069,085 RGD:6480464 CTD
G Ccna2 cyclin A2 GBrowse link increases stability ISO 2 123,062,752 123,069,085 RGD:6480464 CTD
G Ccnb1 cyclin B1 GBrowse link decreases activity ISO 2 31,574,600 31,581,784 RGD:6480464 CTD
G Ccnb1 cyclin B1 GBrowse link multiple interactions ISO 2 31,574,600 31,581,784 RGD:6480464 CTD
G Cdk1 cyclin-dependent kinase 1 GBrowse link multiple interactions ISO 20 20,018,044 20,044,030 RGD:6480464 CTD
G Cdk1 cyclin-dependent kinase 1 GBrowse link decreases activity ISO 20 20,018,044 20,044,030 RGD:6480464 CTD
G Cdk1 cyclin-dependent kinase 1 GBrowse link increases stability ISO 20 20,018,044 20,044,030 RGD:6480464 CTD
G Cdk2 cyclin dependent kinase 2 GBrowse link multiple interactions ISO 7 2,000,196 2,007,682 RGD:6480464 CTD
G Cdk2 cyclin dependent kinase 2 GBrowse link increases activity ISO 7 2,000,196 2,007,682 RGD:6480464 CTD
G Ctgf connective tissue growth factor GBrowse link increases expression EXP 1 21,327,099 21,330,215 RGD:6480464 CTD
G Cxcr2 chemokine (C-X-C motif) receptor 2 GBrowse link affects response to substance ISO 9 73,470,943 73,477,315 RGD:6480464 CTD
G Cxcr4 chemokine (C-X-C motif) receptor 4 GBrowse link increases expression ISO 13 41,308,286 41,312,190 RGD:6480464 CTD
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link decreases expression ISO 10 87,219,157 87,242,919 RGD:6480464 CTD
G Gdf9 growth differentiation factor 9 GBrowse link increases expression ISO 10 38,899,125 38,903,073 RGD:6480464 CTD
G Gsta2 glutathione S-transferase alpha 2 GBrowse link decreases response to substance ISO 8 83,299,249 83,312,958 RGD:6480464 CTD
G Gsta2 glutathione S-transferase alpha 2 GBrowse link increases expression ISO 8 83,299,249 83,312,958 RGD:6480464 CTD
G Gsta3 glutathione S-transferase alpha 3 GBrowse link decreases response to substance EXP 9 20,005,570 20,032,031 RGD:6480464 CTD
G Gsta3 glutathione S-transferase alpha 3 GBrowse link decreases response to substance EXP 9 20,005,570 20,032,031 RGD:6480464 CTD
G Jag1 jagged 1 GBrowse link increases expression ISO 3 125,181,063 125,216,481 RGD:6480464 CTD
G Lamc2 laminin, gamma 2 GBrowse link decreases expression ISO 13 68,151,074 68,211,117 RGD:6480464 CTD
G Lamc2 laminin, gamma 2 GBrowse link increases degradation ISO 13 68,151,074 68,211,117 RGD:6480464 CTD
G Mmp9 matrix metallopeptidase 9 GBrowse link increases expression EXP 3 155,985,473 155,993,433 RGD:6480464 CTD
G Mobp myelin-associated oligodendrocyte basic protein GBrowse link decreases expression ISO 8 125,118,618 125,144,099 RGD:6480464 CTD
G Msh2 mutS homolog 2 (E. coli) GBrowse link affects response to substance ISO 6 11,199,906 11,258,350 RGD:6480464 CTD
G Nckap1 NCK-associated protein 1 GBrowse link decreases expression ISO 3 63,191,700 63,274,021 RGD:6480464 CTD
G Ndrg2 NDRG family member 2 GBrowse link decreases expression ISO 15 27,338,552 27,347,196 RGD:6480464 CTD
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 GBrowse link decreases response to substance ISO 3 58,366,693 58,394,116 RGD:6480464 CTD
G Nmu neuromedin U GBrowse link increases expression ISO 14 34,115,472 34,143,662 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link increases expression EXP 10 65,036,884 65,072,453 RGD:6480464 CTD
G Pdcd4 programmed cell death 4 GBrowse link increases expression ISO 1 260,183,648 260,202,032 RGD:6480464 CTD
G Plp1 proteolipid protein 1 GBrowse link decreases expression ISO X 124,488,627 124,503,639 RGD:6480464 CTD
G Polr2j polymerase (RNA) II (DNA directed) polypeptide J GBrowse link decreases expression ISO 12 21,658,406 21,663,958 RGD:6480464 CTD
G Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 GBrowse link increases expression ISO 10 68,664,950 68,710,616 RGD:6480464 CTD
G Psmd7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 GBrowse link increases expression ISO 19 37,452,152 37,459,440 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link increases expression EXP 13 64,427,288 64,432,978 RGD:6480464 CTD
G Shfm1 split hand/foot malformation (ectrodactyly) type 1 GBrowse link increases expression ISO 4 31,316,084 31,336,240 RGD:6480464 CTD
G Stk11 serine/threonine kinase 11 GBrowse link increases expression ISO 7 11,086,760 11,103,522 RGD:6480464 CTD
G Tnfrsf12a tumor necrosis factor receptor superfamily, member 12a GBrowse link decreases expression ISO 10 12,940,334 12,942,343 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link affects response to substance ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Ube2k ubiquitin-conjugating enzyme E2K GBrowse link increases expression ISO 14 45,349,287 45,411,823 RGD:6480464 CTD
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  CHEBI ontology 501881
    role 491510
      biological role 489686
        aetiopathogenetic role 110697
          mutagen 18604
            alkylating agent 5304
              mechlorethamine 49
                mechlorethamine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 501881
    subatomic particle 500845
      composite particle 500845
        hadron 500845
          baryon 500845
            nucleon 500845
              atomic nucleus 500845
                atom 500845
                  main group element atom 470301
                    p-block element atom 467779
                      carbon group element atom 419149
                        carbon atom 415667
                          organic molecular entity 415660
                            heteroorganic entity 332309
                              organohalogen compound 91627
                                organochlorine compound 78365
                                  mechlorethamine 49
                                    mechlorethamine hydrochloride 0
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