ONTOLOGY REPORT - ANNOTATIONS

Term:busulfan
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Accession:CHEBI:28901 term browser browse the term
Definition:A methanesulfonate ester that is butane-1,4-diol in which the hydrogens of the hydroxy groups are replaced by methanesulfonyl groups. An alkylating antineoplastic agent, it is used for the treatment of chronic myeloid leukemia (although it has been largely replaced by newer drugs). It is also used as an insect sterilant.
Synonyms:exact_synonym: butane-1,4-diyl dimethanesulfonate
 related_synonym: 1,4-Bis(methanesulfonoxy)butane;   1,4-Butanediol dimethanesulfonate;   1,4-Dimesyloxybutane;   1,4-Dimethanesulfonoxybutane;   Bisulfex;   C6H14O6S2;   CS(=O)(=O)OCCCCOS(C)(=O)=O;   InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3;   InChIKey=COVZYZSDYWQREU-UHFFFAOYSA-N;   Leucosulfan;   Mablin;   Mielucin;   Misulban;   Mitostan;   Myeloleukon;   Myleran;   Myleran (TN);   Tetramethylene bis(methanesulfonate);   busulfano;   busulfanum
 alt_id: CHEBI:18936;   CHEBI:3225
 xref_casrn: 55-98-1
 xref: Beilstein:1791786 "Beilstein Registry Number";   ChEMBL:156644 "ChEMBL COMPOUND";   ChemIDplus:55-98-1 "CAS Registry Number";   CiteXplore:10523796 "PubMed citation";   CiteXplore:19361744 "PubMed citation";   CiteXplore:19611402 "PubMed citation";   DrugBank:DB01008 "DrugBank";   KEGG COMPOUND:C06862 "KEGG COMPOUND";   KEGG DRUG:55-98-1 "CAS Registry Number";   KEGG DRUG:D00248 "KEGG DRUG"
 xref_mesh: MESH:D002066
 xref: Patent:US2917432 "Patent";   Reaxys:1791786 "Reaxys Registry Number";   Wikipedia:Busulfan "Wikipedia"

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busulfan term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adrb2 adrenoceptor beta 2, surface GBrowse link decreases response to substance ISO 18 58,174,958 58,177,000 RGD:6480464 CTD
G Anp32b acidic (leucine-rich) nuclear phosphoprotein 32 family, member B GBrowse link multiple interactions ISO 5 63,044,718 63,058,038 RGD:6480464 CTD
G Apex1 APEX nuclease (multifunctional DNA repair enzyme) 1 GBrowse link increases response to substance ISO 15 26,904,124 26,906,224 RGD:6480464 CTD
G Ar androgen receptor GBrowse link multiple interactions ISO X 85,949,507 86,119,199 RGD:6480464 CTD
G Arhgdia Rho GDP dissociation inhibitor (GDI) alpha GBrowse link multiple interactions ISO 10 109,967,771 109,971,260 RGD:6480464 CTD
G Arhgdia Rho GDP dissociation inhibitor (GDI) alpha GBrowse link affects response to substance ISO 10 109,967,771 109,971,260 RGD:6480464 CTD
G Atm ataxia telangiectasia mutated GBrowse link multiple interactions ISO 8 56,894,746 56,996,565 RGD:6480464 CTD
G Bmp4 bone morphogenetic protein 4 GBrowse link decreases expression EXP 15 22,283,171 22,286,757 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link increases activity ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Cdc25b cell division cycle 25B GBrowse link multiple interactions ISO 3 118,893,716 118,903,516 RGD:6480464 CTD
G Cdk2 cyclin dependent kinase 2 GBrowse link decreases expression ISO 7 2,000,196 2,007,682 RGD:6480464 CTD
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO RGD:6480464 CTD
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link multiple interactions ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cdkn2a cyclin-dependent kinase inhibitor 2A GBrowse link increases expression ISO 5 108,908,749 108,916,380 RGD:6480464 CTD
G Chek1 checkpoint kinase 1 GBrowse link multiple interactions ISO 8 37,954,322 37,974,748 RGD:6480464 CTD
G Chek2 checkpoint kinase 2 GBrowse link multiple interactions ISO 12 45,933,900 45,965,427 RGD:6480464 CTD
G Col4a1 collagen, type IV, alpha 1 GBrowse link affects expression ISO 16 83,045,183 83,157,835 RGD:6480464 CTD
G Faslg Fas ligand (TNF superfamily, member 6) GBrowse link decreases expression ISO 13 77,472,950 77,480,210 RGD:6480464 CTD
G Fgf8 fibroblast growth factor 8 GBrowse link decreases expression EXP 1 250,951,023 250,956,730 RGD:6480464 CTD
G Gdnf glial cell derived neurotrophic factor GBrowse link affects expression ISO 2 57,399,312 57,424,030 RGD:6480464 CTD
G Gdnf glial cell derived neurotrophic factor GBrowse link increases expression ISO 2 57,399,312 57,424,030 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link affects metabolic processing ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link affects metabolic processing ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link multiple interactions ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link decreases response to substance ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link affects abundance ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link affects metabolic processing ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gsta1 glutathione S-transferase alpha 1 GBrowse link affects metabolic processing ISO 9 20,051,501 20,068,146 RGD:6480464 CTD
G Gstm1 glutathione S-transferase mu 1 GBrowse link affects response to substance ISO 2 203,575,444 203,580,821 RGD:6480464 CTD
G Gstm1 glutathione S-transferase mu 1 GBrowse link affects response to substance ISO 2 203,575,444 203,580,821 RGD:6480464 CTD
G Gstm1 glutathione S-transferase mu 1 GBrowse link affects metabolic processing ISO 2 203,575,444 203,580,821 RGD:6480464 CTD
G Gstm1 glutathione S-transferase mu 1 GBrowse link affects abundance ISO 2 203,575,444 203,580,821 RGD:6480464 CTD
G Gstm1 glutathione S-transferase mu 1 GBrowse link affects response to substance ISO 2 203,575,444 203,580,821 RGD:6480464 CTD
G Gstm1 glutathione S-transferase mu 1 GBrowse link multiple interactions ISO 2 203,575,444 203,580,821 RGD:6480464 CTD
G Gstp1 glutathione S-transferase pi 1 GBrowse link affects metabolic processing ISO 1 206,627,398 206,629,866 RGD:6480464 CTD
G Gstp1 glutathione S-transferase pi 1 GBrowse link affects abundance ISO 1 206,627,398 206,629,866 RGD:6480464 CTD
G Gstt1 glutathione S-transferase theta 1 GBrowse link multiple interactions ISO 20 13,604,355 13,621,456 RGD:6480464 CTD
G H2afx H2A histone family, member X GBrowse link increases phosphorylation ISO 8 47,312,609 47,313,938 RGD:6480464 CTD
G H2afx H2A histone family, member X GBrowse link multiple interactions ISO 8 47,312,609 47,313,938 RGD:6480464 CTD
G Inhba inhibin beta-A GBrowse link multiple interactions ISO 17 57,244,466 57,257,531 RGD:6480464 CTD
G Inhba inhibin beta-A GBrowse link increases expression ISO 17 57,244,466 57,257,531 RGD:6480464 CTD
G Inhba inhibin beta-A GBrowse link increases expression ISO 17 57,244,466 57,257,531 RGD:6480464 CTD
G Inhba inhibin beta-A GBrowse link increases expression ISO 17 57,244,466 57,257,531 RGD:6480464 CTD
G Kit v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog GBrowse link decreases expression ISO 14 34,906,043 34,984,819 RGD:6480464 CTD
G Lama1 laminin, alpha 1 GBrowse link affects expression ISO 9 106,855,708 106,980,651 RGD:6480464 CTD
G Lama4 laminin, alpha 4 GBrowse link affects expression ISO 20 43,077,612 43,203,519 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link increases activity ISO 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link increases activity ISO 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mgst2 microsomal glutathione S-transferase 2 GBrowse link decreases response to substance ISO 2 140,546,939 140,568,616 RGD:6480464 CTD
G Myc myelocytomatosis oncogene GBrowse link multiple interactions ISO 7 98,953,142 98,958,060 RGD:6480464 CTD
G Npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) GBrowse link multiple interactions ISO 10 18,051,990 18,062,714 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link increases cleavage ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Phb prohibitin affects expression ISO RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link increases expression ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Rad51 RAD51 homolog (S. cerevisiae) GBrowse link decreases expression ISO 3 105,625,265 105,650,392 RGD:6480464 CTD
G Rb1 retinoblastoma 1 GBrowse link decreases phosphorylation ISO 15 53,828,881 53,962,099 RGD:6480464 CTD
G Serpinc1 serpin peptidase inhibitor, clade C (antithrombin), member 1 GBrowse link affects expression ISO 13 76,548,456 76,562,724 RGD:6480464 CTD
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link increases expression ISO 12 20,931,996 20,942,374 RGD:6480464 CTD
G Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 GBrowse link multiple interactions ISO 12 20,931,996 20,942,374 RGD:6480464 CTD
G Smc1a structural maintenance of chromosomes 1A GBrowse link multiple interactions ISO X 41,503,393 41,547,830 RGD:6480464 CTD
G Smc3 structural maintenance of chromosomes 3 GBrowse link multiple interactions ISO 1 259,822,480 259,865,602 RGD:6480464 CTD
G Stra8 stimulated by retinoic acid 8 GBrowse link decreases expression ISO 4 62,321,565 62,336,954 RGD:6480464 CTD
G Tf transferrin GBrowse link increases expression ISO 8 108,217,774 108,244,487 RGD:6480464 CTD
G Tf transferrin GBrowse link increases expression ISO 8 108,217,774 108,244,487 RGD:6480464 CTD
G Tf transferrin GBrowse link increases expression ISO 8 108,217,774 108,244,487 RGD:6480464 CTD
G Tf transferrin GBrowse link multiple interactions ISO 8 108,217,774 108,244,487 RGD:6480464 CTD
G Tfpi tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) GBrowse link decreases expression ISO 3 67,654,389 67,697,178 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link increases expression ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Thbs1 thrombospondin 1 increases expression ISO RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link multiple interactions ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Txnrd1 thioredoxin reductase 1 GBrowse link decreases activity EXP 7 23,055,544 23,093,815 RGD:6480464 CTD
G Xiap X-linked inhibitor of apoptosis GBrowse link multiple interactions ISO X 3,011,520 3,047,798 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501881
    role 491510
      biological role 489686
        aetiopathogenetic role 110697
          carcinogenic agent 18435
            busulfan 84
Path 2
Term Annotations click to browse term
  CHEBI ontology 501881
    subatomic particle 500845
      composite particle 500845
        hadron 500845
          baryon 500845
            nucleon 500845
              atomic nucleus 500845
                atom 500845
                  main group element atom 470301
                    p-block element atom 467779
                      chalcogen 321400
                        oxygen atom 306060
                          oxygen molecular entity 306060
                            hydroxides 227260
                              oxoacid 145252
                                chalcogen oxoacid 15090
                                  sulfur oxoacid 13595
                                    sulfonic acid 5003
                                      sulfo group 1390
                                        organosulfonic acid 1390
                                          alkanesulfonic acid 202
                                            methanesulfonic acid 191
                                              methanesulfonates 191
                                                methanesulfonate ester 191
                                                  busulfan 84
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