ONTOLOGY REPORT - ANNOTATIONS
| Term: | deoxycholic acid |
|
| Accession: | CHEBI:28834
|
browse the term
|
| Definition: | A dihydroxy-5beta-cholanic acid that has formula C24H40O4. |
| Synonyms: | exact_synonym: | 3alpha,12alpha-dihydroxy-5beta-cholan-24-oic acid |
| | related_synonym: | (3ALPHA,5ALPHA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID; (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oic acid; 3alpha,12alpha-Dihydroxy-5beta-cholanic acid; 7alpha-deoxycholic acid; C24H40O4; Desoxycholsaeure; InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1; InChIKey=KXGVEGMKQFWNSR-LLQZFEROSA-N; [H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2; desoxycholic acid |
| | alt_id: | CHEBI:1687; CHEBI:23616; CHEBI:42317 |
| | xref_casrn: | 83-44-3 |
| | xref: | ChEMBL:542077 "ChEMBL COMPOUND"; ChemIDplus:3219882 "Beilstein Registry Number"; ChemIDplus:83-44-3 "CAS Registry Number"; DrugBank:DB03619 "DrugBank"; Gmelin:670078 "Gmelin Registry Number"; KEGG COMPOUND:83-44-3 "CAS Registry Number"; KEGG COMPOUND:C04483 "KEGG COMPOUND"; LIPID MAPS:LMST04010040 "LIPID MAPS instance" |
| | xref_mesh: | MESH:D003840 |
| | xref: | PDBeChem:DXC "PDBeChem" |
| | cyclic_relationship: | is_conjugate_acid_of CHEBI:23614 |
|
|
deoxycholic acid
|
| G |
Abcb11 |
ATP-binding cassette, subfamily B (MDR/TAP), member 11 |
|
increases expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcb11 |
ATP-binding cassette, subfamily B (MDR/TAP), member 11 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcb11 |
ATP-binding cassette, subfamily B (MDR/TAP), member 11 |
|
decreases expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcb4 |
ATP-binding cassette, subfamily B (MDR/TAP), member 4 |
|
affects expression |
ISO |
4 |
21,946,274 |
22,004,328 |
RGD:6480464 |
CTD |
| G |
Abcb4 |
ATP-binding cassette, subfamily B (MDR/TAP), member 4 |
|
multiple interactions |
ISO |
4 |
21,946,274 |
22,004,328 |
RGD:6480464 |
CTD |
| G |
Abcc2 |
ATP-binding cassette, subfamily C (CFTR/MRP), member 2 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcc2 |
ATP-binding cassette, subfamily C (CFTR/MRP), member 2 |
|
affects expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcc3 |
ATP-binding cassette, subfamily C (CFTR/MRP), member 3 |
|
increases activity |
ISO |
10 |
82,986,552 |
83,030,799 |
RGD:6480464 |
CTD |
| G |
Abcc3 |
ATP-binding cassette, subfamily C (CFTR/MRP), member 3 |
|
affects expression |
ISO |
10 |
82,986,552 |
83,030,799 |
RGD:6480464 |
CTD |
| G |
Abcc3 |
ATP-binding cassette, subfamily C (CFTR/MRP), member 3 |
|
multiple interactions |
ISO |
10 |
82,986,552 |
83,030,799 |
RGD:6480464 |
CTD |
| G |
Abcg5 |
ATP-binding cassette, subfamily G (WHITE), member 5 |
|
increases expression |
ISO |
6 |
8,027,647 |
8,064,425 |
RGD:6480464 |
CTD |
| G |
Abcg5 |
ATP-binding cassette, subfamily G (WHITE), member 5 |
|
multiple interactions |
ISO |
6 |
8,027,647 |
8,064,425 |
RGD:6480464 |
CTD |
| G |
Abcg8 |
ATP-binding cassette, subfamily G (WHITE), member 8 |
|
increases expression |
ISO |
6 |
8,064,631 |
8,083,271 |
RGD:6480464 |
CTD |
| G |
Abcg8 |
ATP-binding cassette, subfamily G (WHITE), member 8 |
|
multiple interactions |
ISO |
6 |
8,064,631 |
8,083,271 |
RGD:6480464 |
CTD |
| G |
Adrbk1 |
adrenergic, beta, receptor kinase 1 |
|
multiple interactions |
EXP |
1 |
206,873,002 |
206,892,868 |
RGD:6480464 |
CTD |
| G |
Aldh1a2 |
aldehyde dehydrogenase 1 family, member A2 |
|
multiple interactions |
EXP |
8 |
75,692,099 |
75,771,159 |
RGD:6480464 |
CTD |
| G |
Areg |
amphiregulin |
|
increases secretion |
ISO |
14 |
18,466,313 |
18,475,571 |
RGD:6480464 |
CTD |
| G |
Arnt2 |
aryl hydrocarbon receptor nuclear translocator 2 |
|
multiple interactions |
EXP |
1 |
140,535,823 |
140,646,838 |
RGD:6480464 |
CTD |
| G |
Atp6v1f |
ATPase, H transporting, lysosomal V1 subunit F |
|
multiple interactions |
EXP |
4 |
56,347,184 |
56,350,085 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
increases expression |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
increases expression |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
multiple interactions |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
multiple interactions |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
multiple interactions |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
increases expression |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
increases expression |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
increases expression |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
multiple interactions |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
multiple interactions |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
increases expression |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bax |
Bcl2-associated X protein |
|
multiple interactions |
EXP |
1 |
95,933,023 |
95,938,176 |
RGD:6480464 |
CTD |
| G |
Bcl2 |
B-cell CLL/lymphoma 2 |
|
decreases response to substance |
ISO |
13 |
12,730,736 |
12,905,108 |
RGD:6480464 |
CTD |
| G |
Bnip3 |
BCL2/adenovirus E1B interacting protein 3 |
|
affects response to substance |
ISO |
1 |
198,683,009 |
198,700,075 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
affects response to substance |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
EXP |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
EXP |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases cleavage |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp6 |
caspase 6 |
|
affects response to substance |
ISO |
2 |
227,361,538 |
227,373,844 |
RGD:6480464 |
CTD |
| G |
Casp6 |
caspase 6 |
|
multiple interactions |
ISO |
2 |
227,361,538 |
227,373,844 |
RGD:6480464 |
CTD |
| G |
Casp6 |
caspase 6 |
|
increases activity |
ISO |
2 |
227,361,538 |
227,373,844 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
multiple interactions |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
increases activity |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
multiple interactions |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
increases cleavage |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Ccl2 |
chemokine (C-C motif) ligand 2 |
|
increases expression |
ISO |
10 |
70,256,263 |
70,258,061 |
RGD:6480464 |
CTD |
| G |
Ccl20 |
chemokine (C-C motif) ligand 20 |
|
increases expression |
ISO |
9 |
82,440,965 |
82,443,542 |
RGD:6480464 |
CTD |
| G |
Ccl5 |
chemokine (C-C motif) ligand 5 |
|
increases expression |
ISO |
10 |
71,605,791 |
71,610,330 |
RGD:6480464 |
CTD |
| G |
Ccl7 |
chemokine (C-C motif) ligand 7 |
|
increases expression |
ISO |
10 |
70,267,281 |
70,269,131 |
RGD:6480464 |
CTD |
| G |
Ccl7 |
chemokine (C-C motif) ligand 7 |
|
multiple interactions |
ISO |
10 |
70,267,281 |
70,269,131 |
RGD:6480464 |
CTD |
| G |
Ccnd1 |
cyclin D1 |
|
multiple interactions |
EXP |
1 |
205,357,235 |
205,366,757 |
RGD:6480464 |
CTD |
| G |
Ccnd1 |
cyclin D1 |
|
increases expression |
EXP |
1 |
205,357,235 |
205,366,757 |
RGD:6480464 |
CTD |
| G |
Cebpb |
CCAAT/enhancer binding protein (C/EBP), beta |
|
increases expression |
ISO |
3 |
158,826,021 |
158,827,848 |
RGD:6480464 |
CTD |
| G |
Cebpb |
CCAAT/enhancer binding protein (C/EBP), beta |
|
multiple interactions |
ISO |
3 |
158,826,021 |
158,827,848 |
RGD:6480464 |
CTD |
| G |
Csf1r |
colony stimulating factor 1 receptor |
|
multiple interactions |
EXP |
18 |
57,080,324 |
57,107,295 |
RGD:6480464 |
CTD |
| G |
Csf2 |
colony stimulating factor 2 (granulocyte-macrophage) |
|
multiple interactions |
ISO |
10 |
39,665,850 |
39,667,831 |
RGD:6480464 |
CTD |
| G |
Csf2 |
colony stimulating factor 2 (granulocyte-macrophage) |
|
increases expression |
ISO |
10 |
39,665,850 |
39,667,831 |
RGD:6480464 |
CTD |
| G |
Csf3 |
colony stimulating factor 3 (granulocyte) |
|
multiple interactions |
ISO |
10 |
87,473,990 |
87,476,365 |
RGD:6480464 |
CTD |
| G |
Csf3 |
colony stimulating factor 3 (granulocyte) |
|
increases expression |
ISO |
10 |
87,473,990 |
87,476,365 |
RGD:6480464 |
CTD |
| G |
Cxcl1 |
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
increases expression |
ISO |
14 |
18,690,339 |
18,692,118 |
RGD:6480464 |
CTD |
| G |
Cxcl1 |
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) |
|
multiple interactions |
ISO |
14 |
18,690,339 |
18,692,118 |
RGD:6480464 |
CTD |
| G |
Cxcl10 |
chemokine (C-X-C motif) ligand 10 |
|
increases expression |
ISO |
14 |
17,265,986 |
17,268,183 |
RGD:6480464 |
CTD |
| G |
Cxcl11 |
chemokine (C-X-C motif) ligand 11 |
|
increases expression |
ISO |
14 |
17,250,648 |
17,253,423 |
RGD:6480464 |
CTD |
| G |
Cxcl11 |
chemokine (C-X-C motif) ligand 11 |
|
increases expression |
ISO |
14 |
17,250,648 |
17,253,423 |
RGD:6480464 |
CTD |
| G |
Cxcl2 |
chemokine (C-X-C motif) ligand 2 |
|
multiple interactions |
ISO |
14 |
18,677,129 |
18,679,175 |
RGD:6480464 |
CTD |
| G |
Cxcl2 |
chemokine (C-X-C motif) ligand 2 |
|
increases expression |
ISO |
14 |
18,677,129 |
18,679,175 |
RGD:6480464 |
CTD |
| G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
|
decreases expression |
ISO |
9 |
74,039,204 |
74,068,648 |
RGD:6480464 |
CTD |
| G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
9 |
74,039,204 |
74,068,648 |
RGD:6480464 |
CTD |
| G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
|
multiple interactions |
EXP |
1 |
81,266,828 |
81,290,471 |
RGD:6480464 |
CTD |
| G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
|
decreases expression |
EXP |
1 |
243,281,320 |
243,320,945 |
RGD:6480464 |
CTD |
| G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
|
multiple interactions |
EXP |
1 |
243,281,320 |
243,320,945 |
RGD:6480464 |
CTD |
| G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
|
decreases expression |
EXP |
1 |
243,859,015 |
243,896,003 |
RGD:6480464 |
CTD |
| G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
|
multiple interactions |
EXP |
1 |
243,859,015 |
243,896,003 |
RGD:6480464 |
CTD |
| G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
|
multiple interactions |
EXP |
1 |
200,918,521 |
200,928,919 |
RGD:6480464 |
CTD |
| G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
|
affects metabolic processing |
ISO |
12 |
9,517,016 |
9,541,000 |
RGD:6480464 |
CTD |
| G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
|
multiple interactions |
EXP |
12 |
9,517,016 |
9,541,000 |
RGD:6480464 |
CTD |
| G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
|
decreases expression |
EXP |
12 |
9,517,016 |
9,541,000 |
RGD:6480464 |
CTD |
| G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
|
decreases expression |
EXP |
5 |
135,901,653 |
135,915,754 |
RGD:6480464 |
CTD |
| G |
Cyp4a1 |
cytochrome P450, family 4, subfamily a, polypeptide 1 |
|
multiple interactions |
EXP |
5 |
135,901,653 |
135,915,754 |
RGD:6480464 |
CTD |
| G |
Cyp4a8 |
cytochrome P450, family 4, subfamily a, polypeptide 8 |
|
multiple interactions |
EXP |
5 |
135,546,858 |
135,578,199 |
RGD:6480464 |
CTD |
| G |
Cyp7a1 |
cytochrome P450, family 7, subfamily a, polypeptide 1 |
|
decreases expression |
ISO |
5 |
19,707,159 |
19,716,856 |
RGD:6480464 |
CTD |
| G |
Cyp7a1 |
cytochrome P450, family 7, subfamily a, polypeptide 1 |
|
multiple interactions |
ISO |
5 |
19,707,159 |
19,716,856 |
RGD:6480464 |
CTD |
| G |
Cyp7a1 |
cytochrome P450, family 7, subfamily a, polypeptide 1 |
|
decreases expression |
ISO |
5 |
19,707,159 |
19,716,856 |
RGD:6480464 |
CTD |
| G |
Cyp7a1 |
cytochrome P450, family 7, subfamily a, polypeptide 1 |
|
decreases expression |
ISO |
5 |
19,707,159 |
19,716,856 |
RGD:6480464 |
CTD |
| G |
Cyp7b1 |
cytochrome P450, family 7, subfamily b, polypeptide 1 |
|
decreases expression |
ISO |
2 |
103,102,679 |
103,271,273 |
RGD:6480464 |
CTD |
| G |
Cyp7b1 |
cytochrome P450, family 7, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
2 |
103,102,679 |
103,271,273 |
RGD:6480464 |
CTD |
| G |
Cyp8b1 |
cytochrome P450, family 8, subfamily b, polypeptide 1 |
|
decreases expression |
ISO |
8 |
127,018,908 |
127,020,878 |
RGD:6480464 |
CTD |
| G |
Cyp8b1 |
cytochrome P450, family 8, subfamily b, polypeptide 1 |
|
multiple interactions |
ISO |
8 |
127,018,908 |
127,020,878 |
RGD:6480464 |
CTD |
| G |
Egfr |
epidermal growth factor receptor |
|
increases activity |
ISO |
14 |
97,617,358 |
97,788,211 |
RGD:6480464 |
CTD |
| G |
Egfr |
epidermal growth factor receptor |
|
increases phosphorylation |
ISO |
14 |
97,617,358 |
97,788,211 |
RGD:6480464 |
CTD |
| G |
Egfr |
epidermal growth factor receptor |
|
decreases response to substance |
ISO |
14 |
97,617,358 |
97,788,211 |
RGD:6480464 |
CTD |
| G |
Egfr |
epidermal growth factor receptor |
|
increases activity |
EXP |
14 |
97,617,358 |
97,788,211 |
RGD:6480464 |
CTD |
| G |
Egfr |
epidermal growth factor receptor |
|
multiple interactions |
ISO |
14 |
97,617,358 |
97,788,211 |
RGD:6480464 |
CTD |
| G |
Egr1 |
early growth response 1 |
|
increases expression |
ISO |
18 |
27,343,919 |
27,346,117 |
RGD:6480464 |
CTD |
| G |
Egr1 |
early growth response 1 |
|
multiple interactions |
ISO |
18 |
27,343,919 |
27,346,117 |
RGD:6480464 |
CTD |
| G |
Egr1 |
early growth response 1 |
|
increases expression |
ISO |
18 |
27,343,919 |
27,346,117 |
RGD:6480464 |
CTD |
| G |
Egr1 |
early growth response 1 |
|
multiple interactions |
ISO |
18 |
27,343,919 |
27,346,117 |
RGD:6480464 |
CTD |
| G |
Fabp6 |
fatty acid binding protein 6, ileal |
|
increases expression |
ISO |
10 |
28,694,773 |
28,699,442 |
RGD:6480464 |
CTD |
| G |
Fgf19 |
fibroblast growth factor 19 |
|
increases expression |
ISO |
1 |
205,324,890 |
205,328,178 |
RGD:6480464 |
CTD |
| G |
Gstp1 |
glutathione S-transferase pi 1 |
|
affects binding |
ISO |
1 |
206,627,398 |
206,629,866 |
RGD:6480464 |
CTD |
| G |
Gstp1 |
glutathione S-transferase pi 1 |
|
multiple interactions |
ISO |
1 |
206,627,398 |
206,629,866 |
RGD:6480464 |
CTD |
| G |
Gstp1 |
glutathione S-transferase pi 1 |
|
increases response to substance |
ISO |
1 |
206,627,398 |
206,629,866 |
RGD:6480464 |
CTD |
| G |
Guca1a |
guanylate cyclase activator 1a (retina) |
|
decreases response to substance |
ISO |
9 |
9,046,617 |
9,056,984 |
RGD:6480464 |
CTD |
| G |
Hgf |
hepatocyte growth factor |
|
multiple interactions |
ISO |
4 |
14,864,357 |
14,932,513 |
RGD:6480464 |
CTD |
| G |
Hmox1 |
heme oxygenase (decycling) 1 |
|
decreases response to substance |
ISO |
19 |
13,963,139 |
13,969,960 |
RGD:6480464 |
CTD |
| G |
Hoxa1 |
homeo box A1 |
|
multiple interactions |
EXP |
4 |
80,456,728 |
80,458,388 |
RGD:6480464 |
CTD |
| G |
Hras |
Harvey rat sarcoma virus oncogene |
|
increases activity |
ISO |
1 |
201,385,705 |
201,388,987 |
RGD:6480464 |
CTD |
| G |
Hspa5 |
heat shock protein 5 |
|
decreases response to substance |
ISO |
3 |
13,783,825 |
13,788,022 |
RGD:6480464 |
CTD |
| G |
Htra1 |
HtrA serine peptidase 1 |
|
affects response to substance |
ISO |
1 |
190,257,899 |
190,308,325 |
RGD:6480464 |
CTD |
| G |
Icam1 |
intercellular adhesion molecule 1 |
|
increases expression |
ISO |
8 |
20,040,177 |
20,051,939 |
RGD:6480464 |
CTD |
| G |
Icam1 |
intercellular adhesion molecule 1 |
|
multiple interactions |
ISO |
8 |
20,040,177 |
20,051,939 |
RGD:6480464 |
CTD |
| G |
Ifng |
interferon gamma |
|
multiple interactions |
EXP |
7 |
57,621,756 |
57,625,792 |
RGD:6480464 |
CTD |
| G |
Kcnc1 |
potassium voltage gated channel, Shaw-related subfamily, member 1 |
|
multiple interactions |
EXP |
1 |
96,928,275 |
96,970,062 |
RGD:6480464 |
CTD |
| G |
Lmna |
lamin A/C |
|
increases cleavage |
ISO |
2 |
180,595,724 |
180,616,354 |
RGD:6480464 |
CTD |
| G |
Lmna |
lamin A/C |
|
multiple interactions |
ISO |
2 |
180,595,724 |
180,616,354 |
RGD:6480464 |
CTD |
| G |
Lpl |
lipoprotein lipase |
|
multiple interactions |
EXP |
16 |
22,533,105 |
22,556,905 |
RGD:6480464 |
CTD |
| G |
Mapk1 |
mitogen activated protein kinase 1 |
|
multiple interactions |
ISO |
11 |
85,968,732 |
86,030,387 |
RGD:6480464 |
CTD |
| G |
Mapk1 |
mitogen activated protein kinase 1 |
|
increases phosphorylation |
ISO |
11 |
85,968,732 |
86,030,387 |
RGD:6480464 |
CTD |
| G |
Mapk1 |
mitogen activated protein kinase 1 |
|
multiple interactions |
ISO |
11 |
85,968,732 |
86,030,387 |
RGD:6480464 |
CTD |
| G |
Mapk3 |
mitogen activated protein kinase 3 |
|
multiple interactions |
ISO |
1 |
185,935,044 |
185,941,245 |
RGD:6480464 |
CTD |
| G |
Mapk3 |
mitogen activated protein kinase 3 |
|
multiple interactions |
ISO |
1 |
185,935,044 |
185,941,245 |
RGD:6480464 |
CTD |
| G |
Mapk3 |
mitogen activated protein kinase 3 |
|
increases phosphorylation |
ISO |
1 |
185,935,044 |
185,941,245 |
RGD:6480464 |
CTD |
| G |
Mdh1 |
malate dehydrogenase 1, NAD (soluble) |
|
multiple interactions |
EXP |
14 |
102,259,130 |
102,273,788 |
RGD:6480464 |
CTD |
| G |
Mdh2 |
malate dehydrogenase 2, NAD (mitochondrial) |
|
multiple interactions |
EXP |
12 |
22,021,302 |
22,034,257 |
RGD:6480464 |
CTD |
| G |
Nfkb1 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
|
decreases response to substance |
ISO |
2 |
233,091,013 |
233,187,501 |
RGD:6480464 |
CTD |
| G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
multiple interactions |
ISO |
6 |
75,729,302 |
75,732,475 |
RGD:6480464 |
CTD |
| G |
Nfkbia |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
|
increases phosphorylation |
ISO |
6 |
75,729,302 |
75,732,475 |
RGD:6480464 |
CTD |
| G |
Nr1d2 |
nuclear receptor subfamily 1, group D, member 2 |
|
multiple interactions |
EXP |
|
|
|
RGD:6480464 |
CTD |
| G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
|
increases expression |
ISO |
7 |
26,189,759 |
26,307,061 |
RGD:6480464 |
CTD |
| G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
|
increases activity |
ISO |
7 |
26,189,759 |
26,307,061 |
RGD:6480464 |
CTD |
| G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
|
increases expression |
ISO |
13 |
87,104,241 |
87,108,563 |
RGD:6480464 |
CTD |
| G |
Nras |
neuroblastoma ras oncogene |
|
multiple interactions |
ISO |
2 |
198,292,650 |
198,300,286 |
RGD:6480464 |
CTD |
| G |
Pak1 |
p21 protein (Cdc42/Rac)-activated kinase 1 |
|
multiple interactions |
EXP |
1 |
155,057,622 |
155,174,714 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
increases cleavage |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
multiple interactions |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
multiple interactions |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
increases cleavage |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
|
increases cleavage |
ISO |
13 |
96,309,670 |
96,341,486 |
RGD:6480464 |
CTD |
| G |
Pgap2 |
post-GPI attachment to proteins 2 |
|
multiple interactions |
EXP |
1 |
159,696,924 |
159,722,582 |
RGD:6480464 |
CTD |
| G |
Pip5k1c |
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma |
|
decreases response to substance |
ISO |
7 |
9,881,767 |
9,909,651 |
RGD:6480464 |
CTD |
| G |
Plaur |
plasminogen activator, urokinase receptor |
|
increases expression |
ISO |
1 |
79,708,646 |
79,712,881 |
RGD:6480464 |
CTD |
| G |
Prdx2 |
peroxiredoxin 2 |
|
decreases response to substance |
ISO |
19 |
24,836,199 |
24,841,390 |
RGD:6480464 |
CTD |
| G |
Prdx4 |
peroxiredoxin 4 |
|
decreases response to substance |
ISO |
X |
61,501,206 |
61,516,286 |
RGD:6480464 |
CTD |
| G |
Prkab1 |
protein kinase, AMP-activated, beta 1 non-catalytic subunit |
|
decreases response to substance |
ISO |
12 |
41,840,866 |
41,851,241 |
RGD:6480464 |
CTD |
| G |
Prkar1a |
protein kinase, cAMP-dependent, regulatory, type I, alpha |
|
multiple interactions |
EXP |
10 |
148,642,200 |
148,642,454 |
RGD:6480464 |
CTD |
| G |
Prkca |
protein kinase C, alpha |
|
multiple interactions |
EXP |
10 |
97,367,196 |
97,638,910 |
RGD:6480464 |
CTD |
| G |
Prkcb |
protein kinase C, beta |
|
multiple interactions |
ISO |
1 |
181,117,512 |
181,459,856 |
RGD:6480464 |
CTD |
| G |
Prkcb |
protein kinase C, beta |
|
increases expression |
ISO |
1 |
181,117,512 |
181,459,856 |
RGD:6480464 |
CTD |
| G |
Prkce |
protein kinase C, epsilon |
|
multiple interactions |
ISO |
6 |
9,631,234 |
10,097,311 |
RGD:6480464 |
CTD |
| G |
Prkce |
protein kinase C, epsilon |
|
increases cleavage |
ISO |
6 |
9,631,234 |
10,097,311 |
RGD:6480464 |
CTD |
| G |
Prkcz |
protein kinase C, zeta |
|
decreases response to substance |
ISO |
5 |
172,061,825 |
172,172,793 |
RGD:6480464 |
CTD |
| G |
Ptges |
prostaglandin E synthase |
|
multiple interactions |
EXP |
3 |
9,946,194 |
9,957,538 |
RGD:6480464 |
CTD |
| G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
increases expression |
ISO |
13 |
64,427,288 |
64,432,978 |
RGD:6480464 |
CTD |
| G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
multiple interactions |
ISO |
13 |
64,427,288 |
64,432,978 |
RGD:6480464 |
CTD |
| G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
|
increases expression |
ISO |
13 |
64,427,288 |
64,432,978 |
RGD:6480464 |
CTD |
| G |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
|
multiple interactions |
EXP |
18 |
64,205,920 |
64,271,288 |
RGD:6480464 |
CTD |
| G |
Raf1 |
v-raf-leukemia viral oncogene 1 |
|
multiple interactions |
ISO |
4 |
151,752,583 |
151,775,609 |
RGD:6480464 |
CTD |
| G |
Rara |
retinoic acid receptor, alpha |
|
multiple interactions |
EXP |
10 |
87,740,479 |
87,753,265 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
decreases response to substance |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
multiple interactions |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
increases expression |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rela |
v-rel reticuloendotheliosis viral oncogene homolog A (avian) |
|
increases localization |
ISO |
1 |
208,262,669 |
208,273,148 |
RGD:6480464 |
CTD |
| G |
Rxrg |
retinoid X receptor gamma |
|
multiple interactions |
EXP |
13 |
83,256,823 |
83,298,724 |
RGD:6480464 |
CTD |
| G |
Sema6c |
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C |
|
multiple interactions |
EXP |
2 |
190,069,489 |
190,078,845 |
RGD:6480464 |
CTD |
| G |
Serpinb5 |
serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
|
decreases response to substance |
ISO |
13 |
13,037,587 |
13,057,785 |
RGD:6480464 |
CTD |
| G |
Serpine1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
multiple interactions |
ISO |
12 |
20,931,996 |
20,942,374 |
RGD:6480464 |
CTD |
| G |
Serpine1 |
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
|
increases expression |
ISO |
12 |
20,931,996 |
20,942,374 |
RGD:6480464 |
CTD |
| G |
Sirpa |
signal-regulatory protein alpha |
|
multiple interactions |
EXP |
3 |
117,210,116 |
117,247,840 |
RGD:6480464 |
CTD |
| G |
Slc10a1 |
solute carrier family 10 (sodium/bile acid cotransporter family), member 1 |
|
increases expression |
ISO |
6 |
104,735,839 |
104,749,464 |
RGD:6480464 |
CTD |
| G |
Slc15a2 |
solute carrier family 15 (H+/peptide transporter), member 2 |
|
multiple interactions |
EXP |
11 |
65,819,551 |
65,849,924 |
RGD:6480464 |
CTD |
| G |
Slc22a1 |
solute carrier family 22 (organic cation transporter), member 1 |
|
decreases expression |
ISO |
1 |
42,351,239 |
42,378,295 |
RGD:6480464 |
CTD |
| G |
Slc22a7 |
solute carrier family 22 (organic anion transporter), member 7 |
|
affects expression |
ISO |
9 |
9,934,309 |
9,940,107 |
RGD:6480464 |
CTD |
| G |
Slc22a7 |
solute carrier family 22 (organic anion transporter), member 7 |
|
multiple interactions |
ISO |
9 |
9,934,309 |
9,940,107 |
RGD:6480464 |
CTD |
| G |
Slc22a8 |
solute carrier family 22 (organic anion transporter), member 8 |
|
multiple interactions |
EXP |
1 |
211,269,366 |
211,287,596 |
RGD:6480464 |
CTD |
| G |
Slc51a |
solute carrier family 51, alpha subunit |
|
decreases expression |
ISO |
11 |
70,115,430 |
70,129,828 |
RGD:6480464 |
CTD |
| G |
Slc51a |
solute carrier family 51, alpha subunit |
|
multiple interactions |
ISO |
11 |
70,115,430 |
70,129,828 |
RGD:6480464 |
CTD |
| G |
Slc51a |
solute carrier family 51, alpha subunit |
|
increases expression |
ISO |
11 |
70,115,430 |
70,129,828 |
RGD:6480464 |
CTD |
| G |
Slc51b |
solute carrier family 51, beta subunit |
|
increases expression |
ISO |
8 |
69,661,815 |
69,669,889 |
RGD:6480464 |
CTD |
| G |
Slc51b |
solute carrier family 51, beta subunit |
|
multiple interactions |
ISO |
8 |
69,661,815 |
69,669,889 |
RGD:6480464 |
CTD |
| G |
Slc51b |
solute carrier family 51, beta subunit |
|
increases expression |
ISO |
8 |
69,661,815 |
69,669,889 |
RGD:6480464 |
CTD |
| G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
|
increases expression |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Sstr3 |
somatostatin receptor 3 |
|
multiple interactions |
EXP |
7 |
116,495,750 |
116,502,948 |
RGD:6480464 |
CTD |
| G |
Tp53 |
tumor protein p53 |
|
increases expression |
EXP |
10 |
56,399,721 |
56,411,150 |
RGD:6480464 |
CTD |
| G |
Tp53 |
tumor protein p53 |
|
multiple interactions |
EXP |
10 |
56,399,721 |
56,411,150 |
RGD:6480464 |
CTD |
| G |
Tp53 |
tumor protein p53 |
|
multiple interactions |
EXP |
10 |
56,399,721 |
56,411,150 |
RGD:6480464 |
CTD |
| G |
Traf2 |
Tnf receptor-associated factor 2 |
|
decreases response to substance |
ISO |
3 |
3,692,740 |
3,717,332 |
RGD:6480464 |
CTD |
| G |
Ube2i |
ubiquitin-conjugating enzyme E2I |
|
multiple interactions |
EXP |
10 |
14,509,948 |
14,524,551 |
RGD:6480464 |
CTD |
| G |
Vamp2 |
vesicle-associated membrane protein 2 |
|
multiple interactions |
EXP |
10 |
55,848,264 |
55,852,132 |
RGD:6480464 |
CTD |
| G |
Vax2 |
ventral anterior homeobox 2 |
|
multiple interactions |
EXP |
4 |
117,903,748 |
117,927,411 |
RGD:6480464 |
CTD |
| G |
Vcam1 |
vascular cell adhesion molecule 1 |
|
increases expression |
ISO |
2 |
212,277,654 |
212,297,376 |
RGD:6480464 |
CTD |
glycodeoxycholic acid
|
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
EXP |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
|
increases activity |
ISO |
7 |
26,189,759 |
26,307,061 |
RGD:6480464 |
CTD |
| G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
taurodeoxycholic acid
|
| G |
Abcb11 |
ATP-binding cassette, subfamily B (MDR/TAP), member 11 |
|
multiple interactions |
EXP |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcb11 |
ATP-binding cassette, subfamily B (MDR/TAP), member 11 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Abcb11 |
ATP-binding cassette, subfamily B (MDR/TAP), member 11 |
|
increases abundance |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
increases activity |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp3 |
caspase 3 |
|
multiple interactions |
ISO |
16 |
48,944,226 |
48,962,420 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
increases activity |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Casp9 |
caspase 9, apoptosis-related cysteine peptidase |
|
multiple interactions |
ISO |
5 |
160,704,234 |
160,721,796 |
RGD:6480464 |
CTD |
| G |
Cyp7b1 |
cytochrome P450, family 7, subfamily b, polypeptide 1 |
|
decreases activity |
EXP |
2 |
103,102,679 |
103,271,273 |
RGD:6480464 |
CTD |
| G |
Cyp7b1 |
cytochrome P450, family 7, subfamily b, polypeptide 1 |
|
decreases expression |
EXP |
2 |
103,102,679 |
103,271,273 |
RGD:6480464 |
CTD |
| G |
Mapk14 |
mitogen activated protein kinase 14 |
|
increases activity |
ISO |
20 |
6,939,249 |
7,000,378 |
RGD:6480464 |
CTD |
| G |
Nr1h4 |
nuclear receptor subfamily 1, group H, member 4 |
|
increases activity |
ISO |
7 |
26,189,759 |
26,307,061 |
RGD:6480464 |
CTD |
| G |
Pnlip |
pancreatic lipase |
|
affects folding |
ISO |
1 |
265,107,812 |
265,120,969 |
RGD:6480464 |
CTD |
| G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
|
affects abundance |
ISO |
|
|
|
RGD:6480464 |
CTD |
| G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
|
multiple interactions |
ISO |
|
|
|
RGD:6480464 |
CTD |
Term paths to the root
|