ONTOLOGY REPORT - ANNOTATIONS

Term:amphotericin B
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Accession:CHEBI:2682 term browser browse the term
Definition:A macrolide antibiotic used to treat potentially life-threatening fungal infections.
Synonyms:exact_synonym: (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
 related_synonym: AMPH-B;   Amphotericine B;   C47H73NO17;   InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1;   InChIKey=APKFDSVGJQXUKY-INPOYWNPSA-N;   Liposomal Amphotericin B;   [H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2;   amfotericina B;   amphotericinum B
 alt_id: CHEBI:106303;   CHEBI:566395
 xref_casrn: 1397-89-3
 xref: Beilstein:4645978 "Beilstein Registry Number";   ChEMBL:106303 "ChEMBL COMPOUND";   ChEMBL:108873 "ChEMBL COMPOUND";   ChEMBL:1732516 "PubMed citation";   ChEMBL:17507115 "PubMed citation";   ChEMBL:566395 "ChEMBL COMPOUND";   ChemIDplus:1397-89-3 "CAS Registry Number";   DrugBank:1397-89-3 "CAS Registry Number";   DrugBank:DB00681 "DrugBank";   KEGG COMPOUND:1397-89-3 "CAS Registry Number";   KEGG COMPOUND:C06573 "KEGG COMPOUND";   KEGG DRUG:1397-89-3 "CAS Registry Number";   KEGG DRUG:D00203 "KEGG DRUG";   LIPID MAPS:LMPK06000002 "LIPID MAPS instance"
 xref_mesh: MESH:D000666
 xref: Patent:US2908611 "Patent";   Reaxys:4645978 "Reaxys Registry Number"

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amphotericin B term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Arhgef26 Rho guanine nucleotide exchange factor (GEF) 26 GBrowse link increases expression ISO 2 151,998,907 152,114,966 RGD:6480464 CTD
G Arnt aryl hydrocarbon receptor nuclear translocator GBrowse link multiple interactions ISO 2 190,333,978 190,391,015 RGD:6480464 CTD
G Atg3 autophagy related 3 GBrowse link decreases expression ISO 11 57,162,205 57,190,568 RGD:6480464 CTD
G Cat catalase GBrowse link decreases expression EXP 3 88,654,077 88,686,212 RGD:6480464 CTD
G Ccr2 chemokine (C-C motif) receptor 2 GBrowse link decreases expression EXP 8 128,892,784 128,893,905 RGD:6480464 CTD
G Clu clusterin GBrowse link affects expression EXP 15 45,365,779 45,405,314 RGD:6480464 CTD
G Ednrb endothelin receptor type B GBrowse link increases expression ISO 15 87,893,141 87,898,700 RGD:6480464 CTD
G Eno1 enolase 1, (alpha) GBrowse link multiple interactions ISO 5 167,394,131 167,405,516 RGD:6480464 CTD
G Ep300 E1A binding protein p300 GBrowse link multiple interactions ISO 7 119,938,507 120,008,886 RGD:6480464 CTD
G Epo erythropoietin GBrowse link multiple interactions ISO 12 19,551,768 19,555,208 RGD:6480464 CTD
G Epo erythropoietin GBrowse link decreases expression ISO 12 19,551,768 19,555,208 RGD:6480464 CTD
G Epo erythropoietin GBrowse link multiple interactions EXP 12 19,551,768 19,555,208 RGD:6480464 CTD
G Epo erythropoietin GBrowse link decreases expression ISO 12 19,551,768 19,555,208 RGD:6480464 CTD
G Glod4 glyoxalase domain containing 4 GBrowse link decreases expression ISO 10 63,575,440 63,600,076 RGD:6480464 CTD
G Gpr20 G protein-coupled receptor 20 GBrowse link increases expression ISO 7 111,405,379 111,406,441 RGD:6480464 CTD
G Gstp1 glutathione S-transferase pi 1 GBrowse link decreases expression EXP 1 206,627,398 206,629,866 RGD:6480464 CTD
G Gstt1 glutathione S-transferase theta 1 GBrowse link decreases expression EXP 20 13,604,355 13,621,456 RGD:6480464 CTD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link multiple interactions ISO 6 96,419,024 96,463,891 RGD:6480464 CTD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link decreases activity ISO 6 96,419,024 96,463,891 RGD:6480464 CTD
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor GBrowse link multiple interactions ISO 1 249,607,945 249,618,000 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link multiple interactions ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifngr1 interferon gamma receptor 1 GBrowse link increases expression ISO 1 14,846,369 14,864,804 RGD:6480464 CTD
G Igfbp5 insulin-like growth factor binding protein 5 GBrowse link decreases expression ISO 9 72,003,637 72,016,263 RGD:6480464 CTD
G Il10 interleukin 10 GBrowse link multiple interactions ISO 13 43,953,900 43,957,766 RGD:6480464 CTD
G Kcnq4 potassium voltage-gated channel, KQT-like subfamily, member 4 GBrowse link decreases expression ISO 5 141,289,211 141,339,803 RGD:6480464 CTD
G Lsg1 large subunit GTPase 1 homolog (S. cerevisiae) GBrowse link decreases expression ISO 11 72,026,815 72,051,401 RGD:6480464 CTD
G Nprl2 nitrogen permease regulator-like 2 (S. cerevisiae) GBrowse link decreases expression ISO 8 112,789,664 112,792,837 RGD:6480464 CTD
G Nt5c2 5'-nucleotidase, cytosolic II GBrowse link increases expression ISO 1 252,204,106 252,329,479 RGD:6480464 CTD
G Paip1 poly(A) binding protein interacting protein 1 GBrowse link decreases expression ISO 2 51,610,582 51,637,190 RGD:6480464 CTD
G Pard3 par-3 (partitioning defective 3) homolog (C. elegans) GBrowse link decreases expression ISO 19 57,015,742 57,603,133 RGD:6480464 CTD
G Pgk1 phosphoglycerate kinase 1 GBrowse link multiple interactions ISO X 94,324,219 94,340,193 RGD:6480464 CTD
G Polm polymerase (DNA directed), mu GBrowse link increases expression ISO 14 86,491,716 86,501,294 RGD:6480464 CTD
G Runx3 runt-related transcription factor 3 GBrowse link decreases expression ISO 5 153,950,116 153,973,141 RGD:6480464 CTD
G Slit1 slit homolog 1 (Drosophila) GBrowse link decreases expression ISO 1 246,813,909 246,964,408 RGD:6480464 CTD
G Spp1 secreted phosphoprotein 1 affects expression EXP RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link increases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Ugt1a8 UDP glycosyltransferase 1 family, polypeptide A8 GBrowse link affects expression EXP 9 87,017,029 87,098,362 RGD:6480464 CTD
G Ugt1a9 UDP glucuronosyltransferase 1 family, polypeptide A9 GBrowse link affects expression EXP 9 86,986,915 87,098,362 RGD:6480464 CTD
G Usp36 ubiquitin specific peptidase 36 GBrowse link increases expression ISO 10 108,264,874 108,296,384 RGD:6480464 CTD
amphotericin B methyl ester term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Havcr1 hepatitis A virus cellular receptor 1 GBrowse link increases expression ISO 10 31,834,519 31,858,019 RGD:6480464 CTD
G Lcn2 lipocalin 2 GBrowse link increases expression ISO 3 11,511,402 11,514,747 RGD:6480464 CTD
G Spp1 secreted phosphoprotein 1 increases expression ISO RGD:6480464 CTD
G Timp1 TIMP metallopeptidase inhibitor 1 GBrowse link increases expression ISO X 12,542,496 12,547,094 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492507
    role 482196
      biological role 480389
        antimicrobial agent 45708
          antifungal agent 9495
            amphotericin B 44
              amphotericin B methyl ester 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 492507
    subatomic particle 491470
      composite particle 491470
        hadron 491470
          baryon 491470
            nucleon 491470
              atomic nucleus 491470
                atom 491470
                  main group element atom 461139
                    p-block element atom 458635
                      carbon group element atom 410624
                        carbon atom 407181
                          organic molecular entity 407174
                            organic group 167657
                              organic divalent group 166492
                                organodiyl group 166492
                                  carbonyl group 166182
                                    carbonyl compound 166182
                                      carboxylic ester 33791
                                        lactone 8941
                                          macrocyclic lactone 1807
                                            macrolide 1761
                                              macrolide antibiotic 261
                                                amphotericin B 44
                                                  amphotericin B methyl ester 4
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