ONTOLOGY REPORT - ANNOTATIONS

Term:amlodipine
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Accession:CHEBI:2668 term browser browse the term
Definition:A fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina.
Synonyms:exact_synonym: 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate;   Amlodipine Free Base;   C20H25ClN2O5;   CCOC(=O)C1=C(COCCN)NC(C)=C(C1c1ccccc1Cl)C(=O)OC;   InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3;   InChIKey=HTIQEAQVCYTUBX-UHFFFAOYSA-N;   amlodipino;   amlodipinum
 xref_casrn: 88150-42-9
 xref: Beilstein:3570229 "Beilstein Registry Number";   ChEMBL:518414 "ChEMBL COMPOUND";   ChemIDplus:88150-42-9 "CAS Registry Number";   CiteXplore:1532771 "PubMed citation";   CiteXplore:16422032 "PubMed citation";   CiteXplore:1834846 "PubMed citation";   CiteXplore:19450066 "PubMed citation";   CiteXplore:21591999 "PubMed citation";   CiteXplore:7522286 "PubMed citation";   CiteXplore:8310972 "PubMed citation";   CiteXplore:8310973 "PubMed citation";   CiteXplore:9156957 "PubMed citation";   DrugBank:88150-42-9 "CAS Registry Number";   DrugBank:DB00381 "DrugBank";   KEGG COMPOUND:88150-42-9 "CAS Registry Number";   KEGG COMPOUND:C06825 "KEGG COMPOUND";   KEGG DRUG:88150-42-9 "CAS Registry Number";   KEGG DRUG:D07450 "KEGG DRUG"
 xref_mesh: MESH:D017311
 xref: Patent:EP89167 "Patent";   Patent:US4572909 "Patent";   Reaxys:3570229 "Reaxys Registry Number";   Wikipedia:Amlodipine "Wikipedia"

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amlodipine term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 GBrowse link decreases expression EXP 10 95,361,338 95,381,455 RGD:6480464 CTD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link increases expression ISO 11 79,908,291 79,911,065 RGD:6480464 CTD
G Adipoq adiponectin, C1Q and collagen domain containing GBrowse link increases expression ISO 11 79,908,291 79,911,065 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link multiple interactions ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agtr1a angiotensin II receptor, type 1a GBrowse link decreases expression EXP 17 40,629,318 40,684,982 RGD:6480464 CTD
G Agtr2 angiotensin II receptor, type 2 decreases expression EXP RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions EXP 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions ISO 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions EXP 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bcl2 B-cell CLL/lymphoma 2 GBrowse link multiple interactions EXP 13 12,730,736 12,905,108 RGD:6480464 CTD
G Bdkrb2 bradykinin receptor B2 GBrowse link increases response to substance ISO 6 129,744,781 129,748,851 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link decreases cleavage EXP 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp7 caspase 7 GBrowse link multiple interactions ISO 1 262,689,300 262,721,591 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link decreases expression EXP 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccnd1 cyclin D1 GBrowse link multiple interactions ISO 1 205,357,235 205,366,757 RGD:6480464 CTD
G Ccne1 cyclin E1 GBrowse link decreases activity ISO 1 90,568,189 90,577,426 RGD:6480464 CTD
G Cdk2 cyclin dependent kinase 2 GBrowse link decreases activity ISO 7 2,000,196 2,007,682 RGD:6480464 CTD
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Col1a1 collagen, type I, alpha 1 GBrowse link decreases expression EXP 10 83,622,438 83,639,368 RGD:6480464 CTD
G Col1a2 collagen, type I, alpha 2 GBrowse link multiple interactions EXP 4 29,393,645 29,428,572 RGD:6480464 CTD
G Crp C-reactive protein, pentraxin-related GBrowse link multiple interactions ISO 13 88,702,243 88,703,153 RGD:6480464 CTD
G Ctsd cathepsin D GBrowse link multiple interactions EXP 1 202,619,669 202,631,545 RGD:6480464 CTD
G Ctsd cathepsin D GBrowse link multiple interactions EXP 1 202,619,669 202,631,545 RGD:6480464 CTD
G Ctsd cathepsin D GBrowse link multiple interactions EXP 1 202,619,669 202,631,545 RGD:6480464 CTD
G Cyba cytochrome b-245, alpha polypeptide GBrowse link multiple interactions EXP 19 52,713,150 52,721,609 RGD:6480464 CTD
G Cybb cytochrome b-245, beta polypeptide GBrowse link multiple interactions EXP X 25,514,572 25,547,181 RGD:6480464 CTD
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 GBrowse link decreases expression EXP 8 61,793,976 61,805,308 RGD:6480464 CTD
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 GBrowse link decreases activity ISO 8 61,462,207 61,468,237 RGD:6480464 CTD
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 GBrowse link decreases activity ISO 1 81,345,425 81,359,415 RGD:6480464 CTD
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 GBrowse link affects response to substance ISO 12 17,164,384 17,204,589 RGD:6480464 CTD
G Drd1 dopamine receptor D1 GBrowse link multiple interactions ISO 17 16,655,926 16,658,161 RGD:6480464 CTD
G Drd2 dopamine receptor D2 GBrowse link multiple interactions ISO 8 52,641,160 52,707,749 RGD:6480464 CTD
G Edn1 endothelin 1 GBrowse link affects expression ISO 17 28,303,886 28,309,775 RGD:6480464 CTD
G Gal galanin/GMAP prepropeptide GBrowse link multiple interactions EXP 1 205,936,352 205,941,215 RGD:6480464 CTD
G Gal galanin/GMAP prepropeptide GBrowse link multiple interactions EXP 1 205,936,352 205,941,215 RGD:6480464 CTD
G Gal galanin/GMAP prepropeptide GBrowse link multiple interactions EXP 1 205,936,352 205,941,215 RGD:6480464 CTD
G Gsr glutathione reductase GBrowse link decreases activity EXP 16 62,255,562 62,298,458 RGD:6480464 CTD
G Gusb glucuronidase, beta GBrowse link multiple interactions EXP 12 27,744,409 27,757,755 RGD:6480464 CTD
G Gusb glucuronidase, beta GBrowse link multiple interactions EXP 12 27,744,409 27,757,755 RGD:6480464 CTD
G Hspd1 heat shock protein 1 (chaperonin) GBrowse link multiple interactions EXP 9 53,884,193 53,895,043 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link multiple interactions EXP 8 20,040,177 20,051,939 RGD:6480464 CTD
G Icam1 intercellular adhesion molecule 1 GBrowse link decreases expression EXP 8 20,040,177 20,051,939 RGD:6480464 CTD
G Ins2 insulin 2 GBrowse link decreases expression ISO 1 202,935,548 202,936,379 RGD:6480464 CTD
G Jak2 Janus kinase 2 GBrowse link increases expression ISO 1 232,915,995 232,974,763 RGD:6480464 CTD
G Lep leptin GBrowse link decreases expression ISO 4 55,943,837 55,945,938 RGD:6480464 CTD
G Lep leptin GBrowse link decreases expression ISO 4 55,943,837 55,945,938 RGD:6480464 CTD
G Mt1a metallothionein 1a GBrowse link multiple interactions EXP 19 11,261,631 11,262,647 RGD:6480464 CTD
G Mtf1 metal-regulatory transcription factor 1 GBrowse link multiple interactions EXP 5 144,135,674 144,180,430 RGD:6480464 CTD
G Myh7 myosin, heavy chain 7, cardiac muscle, beta GBrowse link decreases expression EXP 15 33,072,928 33,094,595 RGD:6480464 CTD
G Nos3 nitric oxide synthase 3, endothelial cell GBrowse link increases expression EXP 4 6,158,847 6,179,441 RGD:6480464 CTD
G Nos3 nitric oxide synthase 3, endothelial cell GBrowse link increases expression EXP 4 6,158,847 6,179,441 RGD:6480464 CTD
G Nos3 nitric oxide synthase 3, endothelial cell GBrowse link increases expression EXP 4 6,158,847 6,179,441 RGD:6480464 CTD
G Nos3 nitric oxide synthase 3, endothelial cell GBrowse link increases expression EXP 4 6,158,847 6,179,441 RGD:6480464 CTD
G Nox1 NADPH oxidase 1 multiple interactions EXP RGD:6480464 CTD
G Nox4 NADPH oxidase 4 GBrowse link decreases expression EXP 1 143,415,816 143,603,554 RGD:6480464 CTD
G Nox4 NADPH oxidase 4 GBrowse link multiple interactions EXP 1 143,415,816 143,603,554 RGD:6480464 CTD
G Nppa natriuretic peptide A GBrowse link decreases expression EXP 5 165,074,518 165,075,827 RGD:6480464 CTD
G Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 GBrowse link multiple interactions ISO 4 166,747,228 166,769,340 RGD:6480464 CTD
G Ppbp pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) GBrowse link decreases expression ISO 14 18,816,434 18,817,238 RGD:6480464 CTD
G Rb1 retinoblastoma 1 GBrowse link decreases phosphorylation ISO 15 53,828,881 53,962,099 RGD:6480464 CTD
G Ren renin GBrowse link multiple interactions ISO 13 46,262,936 46,275,213 RGD:6480464 CTD
G Retn resistin GBrowse link decreases expression ISO 12 2,499,630 2,501,370 RGD:6480464 CTD
G Selp selectin P GBrowse link decreases expression ISO 13 79,886,614 79,922,180 RGD:6480464 CTD
G Smad2 SMAD family member 2 GBrowse link multiple interactions ISO 18 73,180,520 73,241,707 RGD:6480464 CTD
G Smad4 SMAD family member 4 GBrowse link multiple interactions ISO 18 70,432,705 70,461,541 RGD:6480464 CTD
G Sod1 superoxide dismutase 1, soluble GBrowse link multiple interactions EXP 11 29,810,766 29,816,342 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link increases expression ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link multiple interactions ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tgfb1 transforming growth factor, beta 1 GBrowse link decreases response to substance ISO 1 80,894,705 80,911,020 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Vcam1 vascular cell adhesion molecule 1 GBrowse link decreases expression EXP 2 212,277,654 212,297,376 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      application 245197
        pharmaceutical 174005
          drug 173802
            antihypertensive agent 5780
              amlodipine 78
                (R)-amlodipine 0
                (S)-amlodipine 0
                amlodipine benzenesulfonate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic molecule 359465
                              organic cyclic compound 298342
                                organic heterocyclic compound 154273
                                  organic heteromonocyclic compound 58845
                                    pyridines 8073
                                      dihydropyridine 229
                                        amlodipine 78
                                          (R)-amlodipine 0
                                          (S)-amlodipine 0
                                          amlodipine benzenesulfonate 0
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