ONTOLOGY REPORT - ANNOTATIONS

Term:amiloride
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Accession:CHEBI:2639 term browser browse the term
Definition:A pyrazine that has formula C6H8ClN7O.
Synonyms:exact_synonym: 3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
 related_synonym: C6H8ClN7O;   InChI=1S/C6H8ClN7O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11/h(H4,8,9,13)(H4,10,11,14,15);   InChIKey=XSDQTOBWRPYKKA-UHFFFAOYSA-N;   N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide;   NC(=N)NC(=O)c1nc(Cl)c(N)nc1N;   amilorida;   amiloridum
 xref_casrn: 2609-46-3
 xref: Beilstein:616612 "Beilstein Registry Number";   ChEMBL:189526 "ChEMBL COMPOUND";   ChemIDplus:2609-46-3 "CAS Registry Number";   DrugBank:DB00594 "DrugBank";   KEGG COMPOUND:2609-46-3 "CAS Registry Number";   KEGG COMPOUND:C06821 "KEGG COMPOUND";   KEGG DRUG:D07447 "KEGG DRUG"
 xref_mesh: MESH:D000584
 xref: Patent:BE639386 "Patent";   Patent:US3313813 "Patent";   Wikipedia:Amiloride "Wikipedia"

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amiloride term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abp1 amiloride binding protein 1 (amine oxidase, copper-containing) GBrowse link affects binding ISO 4 76,957,477 76,977,643 RGD:6480464 CTD
G Abp1 amiloride binding protein 1 (amine oxidase, copper-containing) GBrowse link decreases activity ISO 4 76,957,477 76,977,643 RGD:6480464 CTD
G Abp1 amiloride binding protein 1 (amine oxidase, copper-containing) GBrowse link multiple interactions ISO 4 76,957,477 76,977,643 RGD:6480464 CTD
G Acan aggrecan GBrowse link affects expression EXP 1 134,787,341 134,848,992 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link multiple interactions EXP 19 54,738,556 54,750,349 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link increases expression ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Akt1 v-akt murine thymoma viral oncogene homolog 1 GBrowse link multiple interactions ISO 6 137,640,482 137,657,552 RGD:6480464 CTD
G Alb albumin GBrowse link multiple interactions EXP 14 19,126,935 19,142,214 RGD:6480464 CTD
G Asic3 acid-sensing (proton-gated) ion channel 3 GBrowse link affects response to substance ISO 4 6,125,614 6,129,660 RGD:6480464 CTD
G Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide GBrowse link multiple interactions EXP 2 196,657,749 196,687,242 RGD:6480464 CTD
G Atp6v1b1 ATPase, H transporting, lysosomal V1 subunit B1 GBrowse link multiple interactions EXP 4 117,931,972 117,950,626 RGD:6480464 CTD
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit GBrowse link multiple interactions ISO 10 14,621,372 14,679,051 RGD:6480464 CTD
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit GBrowse link multiple interactions ISO 10 14,621,372 14,679,051 RGD:6480464 CTD
G Calca calcitonin-related polypeptide alpha GBrowse link multiple interactions ISO 1 172,686,168 172,691,061 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp8 caspase 8 GBrowse link multiple interactions ISO 9 57,389,353 57,437,803 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link multiple interactions ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions ISO 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link decreases expression EXP 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions EXP 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link multiple interactions ISO 10 71,744,559 71,746,109 RGD:6480464 CTD
G Ccnb1 cyclin B1 GBrowse link decreases expression ISO 2 31,574,600 31,581,784 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link increases activity ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Col2a1 collagen, type II, alpha 1 GBrowse link affects expression EXP 7 136,679,219 136,707,976 RGD:6480464 CTD
G Cxcl2 chemokine (C-X-C motif) ligand 2 GBrowse link multiple interactions ISO 14 18,677,129 18,679,175 RGD:6480464 CTD
G Cycs cytochrome c, somatic GBrowse link multiple interactions ISO 4 78,825,878 78,827,978 RGD:6480464 CTD
G Ddit3 DNA-damage inducible transcript 3 GBrowse link multiple interactions ISO 7 67,247,749 67,252,571 RGD:6480464 CTD
G Dysf dysferlin GBrowse link decreases expression ISO 4 118,213,435 118,371,283 RGD:6480464 CTD
G Eif2a eukaryotic translation initiation factor 2A GBrowse link increases phosphorylation ISO 2 147,870,265 147,903,411 RGD:6480464 CTD
G Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) GBrowse link decreases phosphorylation ISO 10 87,219,157 87,242,919 RGD:6480464 CTD
G Ern1 endoplasmic reticulum to nucleus signaling 1 GBrowse link multiple interactions ISO 10 95,794,488 95,855,895 RGD:6480464 CTD
G Fos FBJ osteosarcoma oncogene GBrowse link increases expression ISO 6 109,559,135 109,562,001 RGD:6480464 CTD
G Fos FBJ osteosarcoma oncogene GBrowse link multiple interactions ISO 6 109,559,135 109,562,001 RGD:6480464 CTD
G Hspa5 heat shock protein 5 GBrowse link multiple interactions ISO 3 13,783,825 13,788,022 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link multiple interactions ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Ifng interferon gamma GBrowse link multiple interactions ISO 7 57,621,756 57,625,792 RGD:6480464 CTD
G Il12b interleukin 12B GBrowse link multiple interactions ISO 10 29,558,955 29,568,331 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Itgal integrin, alpha L GBrowse link multiple interactions ISO 1 186,561,795 186,598,908 RGD:6480464 CTD
G Klk1 kallikrein 1 GBrowse link increases response to substance ISO 1 94,624,828 94,628,822 RGD:6480464 CTD
G Klk1 kallikrein 1 GBrowse link multiple interactions ISO 1 94,624,828 94,628,822 RGD:6480464 CTD
G Mapk1 mitogen activated protein kinase 1 GBrowse link multiple interactions ISO 11 85,968,732 86,030,387 RGD:6480464 CTD
G Mapk3 mitogen activated protein kinase 3 GBrowse link multiple interactions ISO 1 185,935,044 185,941,245 RGD:6480464 CTD
G Mapk8 mitogen-activated protein kinase 8 GBrowse link multiple interactions ISO 16 8,925,133 9,004,897 RGD:6480464 CTD
G Mapk9 mitogen-activated protein kinase 9 GBrowse link multiple interactions ISO 10 35,353,486 35,384,319 RGD:6480464 CTD
G Myf5 myogenic factor 5 GBrowse link increases expression ISO 7 46,189,256 46,192,487 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link multiple interactions ISO 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 GBrowse link multiple interactions ISO 2 233,091,013 233,187,501 RGD:6480464 CTD
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha GBrowse link multiple interactions ISO 6 75,729,302 75,732,475 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Parp1 poly (ADP-ribose) polymerase 1 GBrowse link multiple interactions ISO 13 96,309,670 96,341,486 RGD:6480464 CTD
G Pdpk1 3-phosphoinositide dependent protein kinase-1 GBrowse link decreases phosphorylation ISO 10 13,329,708 13,394,080 RGD:6480464 CTD
G Pdx1 pancreatic and duodenal homeobox 1 decreases uptake ISO RGD:6480464 CTD
G Pkd2 polycystic kidney disease 2 (autosomal dominant) GBrowse link multiple interactions ISO 14 6,349,519 6,392,988 RGD:6480464 CTD
G Plau plasminogen activator, urokinase GBrowse link decreases activity ISO 15 3,680,072 3,686,232 RGD:6480464 CTD
G Plau plasminogen activator, urokinase GBrowse link multiple interactions ISO 15 3,680,072 3,686,232 RGD:6480464 CTD
G Plau plasminogen activator, urokinase GBrowse link decreases activity ISO 15 3,680,072 3,686,232 RGD:6480464 CTD
G Plau plasminogen activator, urokinase GBrowse link decreases activity ISO 15 3,680,072 3,686,232 RGD:6480464 CTD
G Plau plasminogen activator, urokinase GBrowse link decreases activity ISO 15 3,680,072 3,686,232 RGD:6480464 CTD
G Plaur plasminogen activator, urokinase receptor GBrowse link multiple interactions ISO 1 79,708,646 79,712,881 RGD:6480464 CTD
G Plg plasminogen GBrowse link multiple interactions ISO 1 42,782,464 42,825,149 RGD:6480464 CTD
G Ppp1ca protein phosphatase 1, catalytic subunit, alpha isozyme GBrowse link decreases phosphorylation ISO 1 206,774,719 206,778,336 RGD:6480464 CTD
G Ppp1ca protein phosphatase 1, catalytic subunit, alpha isozyme GBrowse link multiple interactions ISO 1 206,774,719 206,778,336 RGD:6480464 CTD
G Ptgs2 prostaglandin-endoperoxide synthase 2 GBrowse link multiple interactions ISO 13 64,427,288 64,432,978 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) GBrowse link multiple interactions ISO 1 208,262,669 208,273,148 RGD:6480464 CTD
G Scnn1a sodium channel, nonvoltage-gated 1 alpha GBrowse link multiple interactions ISO 4 161,445,936 161,469,267 RGD:6480464 CTD
G Scnn1a sodium channel, nonvoltage-gated 1 alpha GBrowse link multiple interactions ISO 4 161,445,936 161,469,267 RGD:6480464 CTD
G Scnn1a sodium channel, nonvoltage-gated 1 alpha GBrowse link multiple interactions ISO 4 161,445,936 161,469,267 RGD:6480464 CTD
G Scnn1a sodium channel, nonvoltage-gated 1 alpha GBrowse link affects activity ISO 4 161,445,936 161,469,267 RGD:6480464 CTD
G Scnn1a sodium channel, nonvoltage-gated 1 alpha GBrowse link multiple interactions EXP 4 161,445,936 161,469,267 RGD:6480464 CTD
G Scnn1a sodium channel, nonvoltage-gated 1 alpha GBrowse link multiple interactions ISO 4 161,445,936 161,469,267 RGD:6480464 CTD
G Scnn1b sodium channel, nonvoltage-gated 1, beta GBrowse link multiple interactions ISO 1 180,682,622 180,748,068 RGD:6480464 CTD
G Scnn1b sodium channel, nonvoltage-gated 1, beta GBrowse link multiple interactions ISO 1 180,682,622 180,748,068 RGD:6480464 CTD
G Scnn1b sodium channel, nonvoltage-gated 1, beta GBrowse link multiple interactions ISO 1 180,682,622 180,748,068 RGD:6480464 CTD
G Scnn1b sodium channel, nonvoltage-gated 1, beta GBrowse link affects activity ISO 1 180,682,622 180,748,068 RGD:6480464 CTD
G Scnn1b sodium channel, nonvoltage-gated 1, beta GBrowse link multiple interactions ISO 1 180,682,622 180,748,068 RGD:6480464 CTD
G Scnn1g sodium channel, nonvoltage-gated 1, gamma GBrowse link affects activity ISO 1 180,555,660 180,589,534 RGD:6480464 CTD
G Scnn1g sodium channel, nonvoltage-gated 1, gamma GBrowse link multiple interactions ISO 1 180,555,660 180,589,534 RGD:6480464 CTD
G Scnn1g sodium channel, nonvoltage-gated 1, gamma GBrowse link multiple interactions ISO 1 180,555,660 180,589,534 RGD:6480464 CTD
G Scnn1g sodium channel, nonvoltage-gated 1, gamma GBrowse link multiple interactions ISO 1 180,555,660 180,589,534 RGD:6480464 CTD
G Scnn1g sodium channel, nonvoltage-gated 1, gamma GBrowse link multiple interactions ISO 1 180,555,660 180,589,534 RGD:6480464 CTD
G Sele selectin E GBrowse link multiple interactions ISO 13 79,813,455 79,822,845 RGD:6480464 CTD
G Slc12a4 solute carrier family 12 (potassium/chloride transporters), member 4 GBrowse link multiple interactions ISO 19 35,785,181 35,807,024 RGD:6480464 CTD
G Slc26a4 solute carrier family 26, member 4 GBrowse link multiple interactions EXP 6 49,389,212 49,427,000 RGD:6480464 CTD
G Slc31a1 solute carrier family 31 (copper transporters), member 1 GBrowse link multiple interactions ISO 5 79,359,420 79,385,988 RGD:6480464 CTD
G Slc47a1 solute carrier family 47, member 1 GBrowse link decreases activity ISO 10 47,514,258 47,548,353 RGD:6480464 CTD
G Slc52a3 solute carrier family 52, riboflavin transporter, member 3 GBrowse link multiple interactions EXP 3 142,360,661 142,365,285 RGD:6480464 CTD
G Slc9a2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 GBrowse link multiple interactions EXP 9 39,832,184 39,916,242 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 GBrowse link multiple interactions ISO 2 113,204,303 113,221,550 RGD:6480464 CTD
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 GBrowse link multiple interactions ISO 2 113,204,303 113,221,550 RGD:6480464 CTD
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 GBrowse link multiple interactions ISO 2 113,204,303 113,221,550 RGD:6480464 CTD
G Tnfsf10 tumor necrosis factor (ligand) superfamily, member 10 GBrowse link multiple interactions ISO 2 113,204,303 113,221,550 RGD:6480464 CTD
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 GBrowse link multiple interactions ISO 5 3,531,163 3,584,401 RGD:6480464 CTD
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 GBrowse link multiple interactions ISO 8 100,770,833 100,821,420 RGD:6480464 CTD
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 GBrowse link decreases activity ISO 8 5,472,515 5,577,537 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link decreases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Xbp1 X-box binding protein 1 GBrowse link multiple interactions ISO 14 86,151,910 86,156,975 RGD:6480464 CTD
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      application 245197
        pharmaceutical 174005
          drug 173802
            diuretic 2330
              amiloride 105
                amiloride hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic group 167766
                              organic divalent group 166601
                                organodiyl group 166601
                                  carbonyl group 166291
                                    carbonyl compound 166291
                                      carboxylic acid 121484
                                        carboacyl group 40976
                                          univalent carboacyl group 40976
                                            carbamoyl group 37195
                                              carboxamide 37186
                                                amiloride 105
                                                  amiloride hydrochloride 0
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