ONTOLOGY REPORT - ANNOTATIONS

Term:4-hydroperoxycyclophosphamide
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Accession:CHEBI:196991 term browser browse the term
Definition:The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties.
Synonyms:exact_synonym: 2-[bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-yl hydroperoxide
 related_synonym: 2-(Bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine;   2-(bis(2-chloroethyl)amino)tetrahydro-2-oxideo-2H-1,3,2-oxazaphosphorin-4-yl hydroperoxide;   4-Hydroperoxycyclofosfamide;   4-OOH Cyclophosphamide;   C7H15Cl2N2O4P;   InChI=1S/C7H15Cl2N2O4P/c8-2-4-11(5-3-9)16(13)10-7(15-12)1-6-14-16/h7,12H,1-6H2,(H,10,13);   InChIKey=VPAWVRUHMJVRHU-UHFFFAOYSA-N;   OOC1CCOP(=O)(N1)N(CCCl)CCCl;   Perfosfamide (unspecified)
 xref_casrn: 39800-16-3
 xref: Beilstein:531579 "Beilstein Registry Number";   ChEMBL:196991 "ChEMBL COMPOUND";   ChemIDplus:39800-16-3 "CAS Registry Number";   CiteXplore:8024619 "PubMed citation"
 xref_mesh: MESH:C011272
 xref: Patent:NL7208895 "Patent";   Patent:US3808297 "Patent"

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4-hydroperoxycyclophosphamide term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abl1 c-abl oncogene 1, non-receptor tyrosine kinase GBrowse link increases expression ISO 3 10,804,594 10,907,162 RGD:6480464 CTD
G Actb actin, beta GBrowse link decreases expression ISO 12 12,047,070 12,050,040 RGD:6480464 CTD
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) GBrowse link decreases response to substance ISO 19 54,738,556 54,750,349 RGD:6480464 CTD
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 GBrowse link multiple interactions ISO X 134,868,878 134,908,166 RGD:6480464 CTD
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 GBrowse link increases response to substance ISO X 134,868,878 134,908,166 RGD:6480464 CTD
G Akr1b10 aldo-keto reductase family 1, member B10 (aldose reductase) GBrowse link affects response to substance ISO 4 61,755,871 61,771,264 RGD:6480464 CTD
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 GBrowse link decreases response to substance ISO 1 223,731,675 223,773,285 RGD:6480464 CTD
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 GBrowse link decreases response to substance ISO 1 223,731,675 223,773,285 RGD:6480464 CTD
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 GBrowse link decreases response to substance ISO 8 75,692,099 75,771,159 RGD:6480464 CTD
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 GBrowse link affects response to substance ISO 5 62,311,268 62,316,276 RGD:6480464 CTD
G Aldh2 aldehyde dehydrogenase 2 family (mitochondrial) GBrowse link decreases response to substance ISO 12 36,081,778 36,116,445 RGD:6480464 CTD
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 GBrowse link decreases response to substance ISO 10 47,365,195 47,374,880 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link multiple interactions ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link increases expression ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bax Bcl2-associated X protein GBrowse link affects folding ISO 1 95,933,023 95,938,176 RGD:6480464 CTD
G Bbc3 Bcl-2 binding component 3 increases expression ISO RGD:6480464 CTD
G Bmpr1b bone morphogenetic protein receptor, type IB GBrowse link decreases expression ISO 2 239,727,569 239,767,802 RGD:6480464 CTD
G C1d C1D nuclear receptor co-repressor GBrowse link increases expression ISO 14 98,153,633 98,166,585 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link increases activity ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Casp9 caspase 9, apoptosis-related cysteine peptidase GBrowse link increases activity ISO 5 160,704,234 160,721,796 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link increases expression ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Cxcl9 chemokine (C-X-C motif) ligand 9 GBrowse link decreases expression ISO 14 17,284,085 17,288,996 RGD:6480464 CTD
G E2f1 E2F transcription factor 1 GBrowse link increases expression ISO 3 145,032,489 145,043,729 RGD:6480464 CTD
G Egr1 early growth response 1 GBrowse link decreases expression ISO 18 27,343,919 27,346,117 RGD:6480464 CTD
G Endog endonuclease G GBrowse link increases response to substance ISO 3 9,184,023 9,187,524 RGD:6480464 CTD
G Endog endonuclease G GBrowse link multiple interactions ISO 3 9,184,023 9,187,524 RGD:6480464 CTD
G Epas1 endothelial PAS domain protein 1 GBrowse link increases expression ISO 6 10,203,108 10,297,215 RGD:6480464 CTD
G Epha6 Eph receptor A6 GBrowse link decreases expression ISO 11 40,551,554 41,458,539 RGD:6480464 CTD
G Eya1 eyes absent homolog 1 (Drosophila) GBrowse link decreases expression ISO 5 4,132,825 4,276,837 RGD:6480464 CTD
G Faslg Fas ligand (TNF superfamily, member 6) GBrowse link increases expression ISO 13 77,472,950 77,480,210 RGD:6480464 CTD
G Gjc1 gap junction protein, gamma 1 increases expression ISO RGD:6480464 CTD
G Gjc1 gap junction protein, gamma 1 increases expression ISO RGD:6480464 CTD
G Gli2 GLI family zinc finger 2 GBrowse link decreases expression ISO 13 31,551,089 31,607,264 RGD:6480464 CTD
G Hes1 hairy and enhancer of split 1 (Drosophila) GBrowse link increases expression ISO 11 72,603,482 72,605,673 RGD:6480464 CTD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link increases expression ISO 6 96,419,024 96,463,891 RGD:6480464 CTD
G Hif1a hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) GBrowse link increases expression ISO 6 96,419,024 96,463,891 RGD:6480464 CTD
G Hoxa11 homeobox A11 GBrowse link decreases expression ISO 4 80,542,417 80,546,079 RGD:6480464 CTD
G Hoxa13 homeo box A13 GBrowse link increases expression ISO 4 80,558,841 80,561,053 RGD:6480464 CTD
G Hoxd10 homeo box D10 GBrowse link increases expression ISO 3 57,306,064 57,309,273 RGD:6480464 CTD
G Hras Harvey rat sarcoma virus oncogene GBrowse link decreases expression ISO 1 201,385,705 201,388,987 RGD:6480464 CTD
G Kl Klotho GBrowse link decreases expression ISO 12 3,732,712 3,772,371 RGD:6480464 CTD
G Mdm2 p53 E3 ubiquitin protein ligase GBrowse link increases expression ISO 7 56,996,694 57,020,926 RGD:6480464 CTD
G Myo1b myosin Ib GBrowse link increases expression ISO 9 46,756,678 46,917,169 RGD:6480464 CTD
G Myog myogenin GBrowse link increases expression ISO 13 47,243,712 47,246,301 RGD:6480464 CTD
G Ndn necdin, melanoma antigen (MAGE) family member GBrowse link increases expression ISO 1 116,594,603 116,596,202 RGD:6480464 CTD
G Odc1 ornithine decarboxylase 1 GBrowse link decreases expression ISO 6 41,309,211 41,315,796 RGD:6480464 CTD
G Pea15 phosphoprotein enriched in astrocytes 15 GBrowse link decreases expression ISO 13 88,187,674 88,197,296 RGD:6480464 CTD
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 GBrowse link increases expression ISO 18 62,914,845 62,918,832 RGD:6480464 CTD
G Pold1 polymerase (DNA directed), delta 1, catalytic subunit GBrowse link decreases expression ISO 1 95,010,719 95,021,686 RGD:6480464 CTD
G Rad21 RAD21 homolog (S. pombe) GBrowse link decreases expression ISO 7 88,267,648 88,294,703 RGD:6480464 CTD
G Sdf4 stromal cell derived factor 4 GBrowse link decreases expression ISO 5 172,836,094 172,853,044 RGD:6480464 CTD
G Sfrp2 secreted frizzled-related protein 2 GBrowse link decreases expression ISO 2 175,479,320 175,486,865 RGD:6480464 CTD
G Slc30a4 solute carrier family 30 (zinc transporter), member 4 GBrowse link decreases expression ISO 3 109,643,714 109,665,750 RGD:6480464 CTD
G Smad1 SMAD family member 1 GBrowse link decreases expression ISO 19 30,348,886 30,409,345 RGD:6480464 CTD
G Tap1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) GBrowse link affects response to substance ISO 20 4,790,363 4,800,730 RGD:6480464 CTD
G Tcf12 transcription factor 12 GBrowse link increases expression ISO 8 76,311,327 76,498,091 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link multiple interactions ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link increases expression ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Tp53 tumor protein p53 GBrowse link multiple interactions ISO 10 56,399,721 56,411,150 RGD:6480464 CTD
G Trim27 tripartite motif-containing 27 GBrowse link decreases expression ISO 17 51,192,286 51,204,942 RGD:6480464 CTD
G Ttf1 transcription termination factor, RNA polymerase I GBrowse link decreases expression ISO 3 8,067,017 8,086,185 RGD:6480464 CTD
G Ubb ubiquitin B GBrowse link decreases expression ISO 10 139,578,694 139,579,068 RGD:6480464 CTD
G Vegfa vascular endothelial growth factor A GBrowse link increases expression ISO 9 10,520,730 10,536,071 RGD:6480464 CTD
G Vim vimentin GBrowse link decreases expression ISO 17 87,847,280 87,855,763 RGD:6480464 CTD
G Wnt11 wingless-type MMTV integration site family, member 11 GBrowse link increases expression ISO 1 156,125,969 156,142,065 RGD:6480464 CTD
G Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide GBrowse link decreases expression ISO 7 72,283,825 72,306,126 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 501881
    role 491510
      biological role 489686
        biochemical role 195456
          metabolite 176736
            4-hydroperoxycyclophosphamide 70
Path 2
Term Annotations click to browse term
  CHEBI ontology 501881
    subatomic particle 500845
      composite particle 500845
        hadron 500845
          baryon 500845
            nucleon 500845
              atomic nucleus 500845
                atom 500845
                  main group element atom 470301
                    p-block element atom 467779
                      chalcogen 321400
                        oxygen atom 306060
                          oxygen molecular entity 306060
                            hydroxides 227260
                              oxoacid 145252
                                pnictogen oxoacid 8557
                                  phosphorus oxoacid 7757
                                    phosphoric acids 7621
                                      phosphoric acid 7621
                                        phosphoramide 1102
                                          phosphorodiamide 1025
                                            4-hydroperoxycyclophosphamide 70
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