ONTOLOGY REPORT - ANNOTATIONS
Term: beta-carotene
Accession: CHEBI:17579
browse the term
Definition: A cyclic carotene obtained by dimerisation of all-trans-retinol. A strongly-coloured red-orange pigment abundant in plants and fruit and the most active and important provitamin A carotenoid.
Synonyms: related_synonym: 1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene); C40H56; CC(\\C=C\\C=C(C)\\C=C\\C1=C(C)CCCC1(C)C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C; InChI=1S/C40H56/c1-31(19-13-21-33(3)25-27-37-35(5)23-15-29-39(37,7)8)17-11-12-18-32(2)20-14-22-34(4)26-28-38-36(6)24-16-30-40(38,9)10/h11-14,17-22,25-28H,15-16,23-24,29-30H2,1-10H3/b12-11+,19-13+,20-14+,27-25+,28-26+,31-17+,32-18+,33-21+,34-22+; InChIKey=OENHQHLEOONYIE-JLTXGRSLSA-N; all-trans-beta-carotene; beta-Karotin
alt_id: CHEBI:10355; CHEBI:12392; CHEBI:22834; CHEBI:40987
xref_casrn: 7235-40-7
xref: Beilstein:1917416 "Beilstein Registry Number"; COMe:MOL000093 "COMe"; ChEMBL:355373 "ChEMBL COMPOUND"; ChemIDplus:7235-40-7 "CAS Registry Number"; CiteXplore:11171227 "PubMed citation"; CiteXplore:11182771 "PubMed citation"; CiteXplore:11332447 "PubMed citation"; CiteXplore:11359610 "PubMed citation"; CiteXplore:11382814 "PubMed citation"; CiteXplore:11567548 "PubMed citation"; CiteXplore:11677037 "PubMed citation"; CiteXplore:11714348 "PubMed citation"; CiteXplore:11962062 "PubMed citation"; CiteXplore:12081834 "PubMed citation"; CiteXplore:12891827 "PubMed citation"; CiteXplore:14658721 "PubMed citation"; CiteXplore:14764912 "PubMed citation"; CiteXplore:14976384 "PubMed citation"; CiteXplore:14997360 "PubMed citation"; CiteXplore:15113067 "PubMed citation"; CiteXplore:15333155 "PubMed citation"; CiteXplore:15695449 "PubMed citation"; CiteXplore:15789045 "PubMed citation"; CiteXplore:15909543 "PubMed citation"; CiteXplore:15949680 "PubMed citation"; CiteXplore:15949683 "PubMed citation"; CiteXplore:16036331 "PubMed citation"; CiteXplore:16087476 "PubMed citation"; CiteXplore:16338959 "PubMed citation"; CiteXplore:16563447 "PubMed citation"; CiteXplore:17004738 "PubMed citation"; CiteXplore:17625873 "PubMed citation"; CiteXplore:17708644 "PubMed citation"; CiteXplore:17851775 "PubMed citation"; CiteXplore:18429004 "PubMed citation"; CiteXplore:18766464 "PubMed citation"; CiteXplore:18767554 "PubMed citation"; CiteXplore:18794175 "PubMed citation"; CiteXplore:19480350 "PubMed citation"; CiteXplore:19574250 "PubMed citation"; CiteXplore:19669835 "PubMed citation"; CiteXplore:19703237 "PubMed citation"; CiteXplore:19852884 "PubMed citation"; CiteXplore:19888275 "PubMed citation"; CiteXplore:19896667 "PubMed citation"; CiteXplore:19937581 "PubMed citation"; CiteXplore:20074992 "PubMed citation"; CiteXplore:20515074 "PubMed citation"; CiteXplore:22079732 "PubMed citation"; CiteXplore:22309480 "PubMed citation"; CiteXplore:22428124 "PubMed citation"; CiteXplore:22489215 "PubMed citation"; CiteXplore:22534340 "PubMed citation"; CiteXplore:22575730 "PubMed citation"; HMDB:HMDB00561 "HMDB"; KEGG COMPOUND:7235-40-7 "CAS Registry Number"; KEGG COMPOUND:C02094 "KEGG COMPOUND"; KEGG DRUG:D03101 "KEGG DRUG"; LIPID MAPS:LMPR01070000 "LIPID MAPS instance"; LIPID MAPS:LMPR01070001 "LIPID MAPS instance"
xref_mesh: MESH:D019207
xref: MetaCyc:CPD1F-129 "MetaCyc"; NIST Chemistry WebBook:7235-40-7 "CAS Registry Number"; PDBeChem:BCR "PDBeChem"; Reaxys:1917416 "Reaxys Registry Number"; Wikipedia:Beta_Carotene "Wikipedia"
beta-carotene
G
Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
increases expression
ISO
2
235,979,108
235,991,515
RGD:6480464
CTD
G
Adipoq
adiponectin, C1Q and collagen domain containing
decreases expression
ISO
11
79,908,291
79,911,065
RGD:6480464
CTD
G
Aldh3b1
aldehyde dehydrogenase 3 family, member B1
decreases expression
ISO
1
206,438,325
206,455,477
RGD:6480464
CTD
G
Aldh4a1
aldehyde dehydrogenase 4 family, member A1
decreases expression
ISO
5
158,437,691
158,453,827
RGD:6480464
CTD
G
Ank2
ankyrin 2, neuronal
increases expression
ISO
2
224,182,431
224,501,751
RGD:6480464
CTD
G
Ank3
ankyrin 3, node of Ranvier (ankyrin G)
increases expression
ISO
20
19,328,684
19,828,196
RGD:6480464
CTD
G
Asah1
N-acylsphingosine amidohydrolase (acid ceramidase) 1
increases expression
ISO
16
54,279,253
54,311,084
RGD:6480464
CTD
G
Asb1
ankyrin repeat and SOCS box-containing 1
increases expression
ISO
9
90,758,693
90,774,541
RGD:6480464
CTD
G
Asb9
ankyrin repeat and SOCS box-containing 9
increases expression
ISO
X
50,712,265
50,748,863
RGD:6480464
CTD
G
Bag3
Bcl2-associated athanogene 3
decreases expression
ISO
1
187,781,147
187,804,835
RGD:6480464
CTD
G
Bag4
BCL2-associated athanogene 4
decreases expression
ISO
16
70,663,821
70,680,671
RGD:6480464
CTD
G
Bag5
BCL2-associated athanogene 5
decreases expression
ISO
6
136,491,438
136,495,093
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
decreases expression
ISO
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bax
Bcl2-associated X protein
increases expression
ISO
1
95,933,023
95,938,176
RGD:6480464
CTD
G
Bcmo1
beta-carotene 15,15'-monooxygenase 1
multiple interactions
ISO
19
47,202,955
47,239,225
RGD:6480464
CTD
G
Bcmo1
beta-carotene 15,15'-monooxygenase 1
multiple interactions
EXP
19
47,202,955
47,239,225
RGD:6480464
CTD
G
Bcmo1
beta-carotene 15,15'-monooxygenase 1
increases expression
ISO
19
47,202,955
47,239,225
RGD:6480464
CTD
G
Bcmo1
beta-carotene 15,15'-monooxygenase 1
increases oxidation
EXP
19
47,202,955
47,239,225
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
multiple interactions
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
increases metabolic processing
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Casp3
caspase 3
multiple interactions
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Casp3
caspase 3
increases activity
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Cat
catalase
multiple interactions
EXP
3
88,654,077
88,686,212
RGD:6480464
CTD
G
Cat
catalase
multiple interactions
EXP
3
88,654,077
88,686,212
RGD:6480464
CTD
G
Cdh1
cadherin 1
increases expression
ISO
19
36,442,693
36,512,091
RGD:6480464
CTD
G
Cebpa
CCAAT/enhancer binding protein (C/EBP), alpha
decreases expression
ISO
1
87,626,111
87,627,499
RGD:6480464
CTD
G
Cflar
CASP8 and FADD-like apoptosis regulator
increases expression
ISO
9
57,309,836
57,356,635
RGD:6480464
CTD
G
Cldn10
claudin 10
increases expression
ISO
15
103,699,243
103,793,405
RGD:6480464
CTD
G
Cldn18
claudin 18
increases expression
ISO
8
104,560,892
104,578,313
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
decreases expression
ISO
10
83,622,438
83,639,368
RGD:6480464
CTD
G
Col4a1
collagen, type IV, alpha 1
decreases expression
ISO
16
83,045,183
83,157,835
RGD:6480464
CTD
G
Col4a2
collagen, type IV, alpha 2
decreases expression
ISO
16
82,899,206
83,045,102
RGD:6480464
CTD
G
Cpt1b
carnitine palmitoyltransferase 1b, muscle
decreases expression
ISO
7
127,737,129
127,746,179
RGD:6480464
CTD
G
Cradd
CASP2 and RIPK1 domain containing adaptor with death domain
increases expression
ISO
7
32,504,279
32,517,581
RGD:6480464
CTD
G
Ctsb
cathepsin B
decreases expression
ISO
15
42,402,829
42,423,701
RGD:6480464
CTD
G
Cxcl12
chemokine (C-X-C motif) ligand 12
increases expression
ISO
4
153,503,576
153,516,423
RGD:6480464
CTD
G
Cxcl9
chemokine (C-X-C motif) ligand 9
increases expression
ISO
14
17,284,085
17,288,996
RGD:6480464
CTD
G
Cxcr4
chemokine (C-X-C motif) receptor 4
increases expression
ISO
13
41,308,286
41,312,190
RGD:6480464
CTD
G
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
increases expression
ISO
1
241,945,472
241,949,220
RGD:6480464
CTD
G
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
increases expression
ISO
1
241,945,472
241,949,220
RGD:6480464
CTD
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases expression
ISO
1
243,281,320
243,320,945
RGD:6480464
CTD
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
12
9,517,016
9,541,000
RGD:6480464
CTD
G
Dlx2
distal-less homeobox 2
increases expression
ISO
3
53,852,209
53,854,092
RGD:6480464
CTD
G
Dlx4
distal-less homeobox 4
increases expression
ISO
10
83,822,815
83,828,210
RGD:6480464
CTD
G
Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
decreases expression
ISO
RGD:6480464
CTD
G
Esr1
estrogen receptor 1
multiple interactions
ISO
1
35,523,680
35,759,891
RGD:6480464
CTD
G
Esr1
estrogen receptor 1
multiple interactions
ISO
1
35,523,680
35,759,891
RGD:6480464
CTD
G
Esr2
estrogen receptor 2 (ER beta)
multiple interactions
ISO
6
98,691,167
98,775,299
RGD:6480464
CTD
G
Fabp4
fatty acid binding protein 4, adipocyte
decreases expression
ISO
2
93,536,133
93,540,734
RGD:6480464
CTD
G
Faim2
Fas apoptotic inhibitory molecule 2
increases expression
ISO
7
138,246,372
138,272,190
RGD:6480464
CTD
G
Fas
Fas (TNF receptor superfamily, member 6)
increases expression
ISO
1
238,259,443
238,274,745
RGD:6480464
CTD
G
Fosl1
fos-like antigen 1
increases expression
ISO
1
208,090,612
208,099,118
RGD:6480464
CTD
G
Foxa1
forkhead box A1
increases expression
ISO
6
77,976,384
78,009,176
RGD:6480464
CTD
G
Gata6
GATA binding protein 6
increases expression
ISO
18
2,504,264
2,534,648
RGD:6480464
CTD
G
Gbp1
guanylate binding protein 1, interferon-inducible
increases expression
ISO
2
240,715,506
240,739,741
RGD:6480464
CTD
G
Gja1
gap junction protein, alpha 1
multiple interactions
ISO
20
35,409,815
35,422,262
RGD:6480464
CTD
G
Gja1
gap junction protein, alpha 1
increases expression
ISO
20
35,409,815
35,422,262
RGD:6480464
CTD
G
Gstk1
glutathione S-transferase kappa 1
decreases expression
ISO
4
69,999,767
70,004,086
RGD:6480464
CTD
G
Gstm2
glutathione S-transferase mu 2
increases expression
ISO
2
203,549,022
203,553,380
RGD:6480464
CTD
G
Gstm4
glutathione S-transferase mu 4
decreases expression
ISO
2
203,605,593
203,610,817
RGD:6480464
CTD
G
Gstz1
glutathione S-transferase zeta 1
decreases expression
ISO
RGD:6480464
CTD
G
Hoxa7
homeobox A7
increases expression
ISO
4
80,515,622
80,517,521
RGD:6480464
CTD
G
Hoxb6
homeo box B6
increases expression
ISO
10
85,030,558
85,033,604
RGD:6480464
CTD
G
Hoxc10
homeo box C10
increases expression
ISO
7
141,717,910
141,734,613
RGD:6480464
CTD
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
multiple interactions
EXP
X
139,929,647
139,961,616
RGD:6480464
CTD
G
Ifna16l1
interferon, alpha 16-like 1
increases expression
ISO
5
108,070,121
108,070,696
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
multiple interactions
ISO
3
116,964,422
116,970,867
RGD:6480464
CTD
G
Irf8
interferon regulatory factor 8
increases expression
ISO
19
51,100,088
51,116,730
RGD:6480464
CTD
G
Irx4
iroquois homeobox 4
decreases expression
ISO
17
106,225
116,183
RGD:6480464
CTD
G
Itgb1
integrin, beta 1
decreases expression
ISO
19
58,600,095
58,647,531
RGD:6480464
CTD
G
Itgb4
integrin, beta 4
decreases expression
ISO
10
106,080,452
106,116,632
RGD:6480464
CTD
G
Ivl
involucrin
increases expression
ISO
2
185,556,271
185,558,310
RGD:6480464
CTD
G
Jun
jun proto-oncogene
increases expression
ISO
5
115,358,166
115,361,259
RGD:6480464
CTD
G
Krt18
keratin 18
increases expression
ISO
RGD:6480464
CTD
G
Krt19
keratin 19
increases expression
ISO
10
89,080,953
89,085,670
RGD:6480464
CTD
G
Krt2
keratin 2
increases expression
ISO
7
140,500,902
140,507,590
RGD:6480464
CTD
G
Krt7
keratin 7
affects expression
ISO
7
140,160,829
140,226,474
RGD:6480464
CTD
G
Krt8
keratin 8
decreases expression
ISO
7
140,713,902
140,721,199
RGD:6480464
CTD
G
Lhx3
LIM homeobox 3
increases expression
ISO
3
4,381,890
4,389,132
RGD:6480464
CTD
G
Lpl
lipoprotein lipase
decreases expression
ISO
16
22,533,105
22,556,905
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
G
Mbl2
mannose-binding lectin (protein C) 2
multiple interactions
ISO
1
233,978,931
233,983,824
RGD:6480464
CTD
G
Mcl1
myeloid cell leukemia sequence 1
affects expression
ISO
RGD:6480464
CTD
G
Meis2
Meis homeobox 2
increases expression
ISO
3
101,915,966
102,117,215
RGD:6480464
CTD
G
Meox1
mesenchyme homeobox 1
increases expression
ISO
10
90,921,589
90,942,298
RGD:6480464
CTD
G
Mgmt
O-6-methylguanine-DNA methyltransferase
affects response to substance
ISO
1
196,629,366
196,866,937
RGD:6480464
CTD
G
Msh5
mutS homolog 5 (E. coli)
increases expression
ISO
20
3,845,731
3,862,011
RGD:6480464
CTD
G
Muc5ac
mucin 5AC, oligomeric mucus/gel-forming
increases expression
ISO
RGD:6480464
CTD
G
Nos1
nitric oxide synthase 1, neuronal
increases expression
ISO
12
39,812,500
39,869,484
RGD:6480464
CTD
G
Nos2
nitric oxide synthase 2, inducible
multiple interactions
EXP
10
65,036,884
65,072,453
RGD:6480464
CTD
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
11
64,239,918
64,276,702
RGD:6480464
CTD
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
11
64,239,918
64,276,702
RGD:6480464
CTD
G
Olr1
oxidized low density lipoprotein (lectin-like) receptor 1
increases expression
ISO
4
166,747,228
166,769,340
RGD:6480464
CTD
G
Pcdhgc3
protocadherin gamma subfamily C, 3
increases expression
ISO
18
30,714,544
30,754,205
RGD:6480464
CTD
G
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
increases expression
ISO
10
55,227,872
55,248,301
RGD:6480464
CTD
G
Plscr1
phospholipid scramblase 1
increases expression
ISO
8
97,206,388
97,226,725
RGD:6480464
CTD
G
Plscr3
phospholipid scramblase 3
increases expression
ISO
10
56,687,086
56,691,601
RGD:6480464
CTD
G
Plscr4
phospholipid scramblase 4
increases expression
ISO
8
97,428,403
97,466,096
RGD:6480464
CTD
G
Ppara
peroxisome proliferator activated receptor alpha
decreases expression
ISO
7
123,729,774
123,807,090
RGD:6480464
CTD
G
Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
ISO
4
151,492,220
151,617,331
RGD:6480464
CTD
G
Rad51ap1
RAD51 associated protein 1
decreases expression
ISO
4
163,308,788
163,321,854
RGD:6480464
CTD
G
Rad51d
RAD51 homolog D (S. cerevisiae)
increases expression
ISO
10
71,092,798
71,107,418
RGD:6480464
CTD
G
Rara
retinoic acid receptor, alpha
decreases expression
ISO
10
87,740,479
87,753,265
RGD:6480464
CTD
G
Rarb
retinoic acid receptor, beta
increases expression
ISO
RGD:6480464
CTD
G
Rarres1
retinoic acid receptor responder (tazarotene induced) 1
increases expression
ISO
2
157,332,213
157,367,137
RGD:6480464
CTD
G
Rbp4
retinol binding protein 4, plasma
multiple interactions
ISO
1
242,443,795
242,450,997
RGD:6480464
CTD
G
Rbp4
retinol binding protein 4, plasma
multiple interactions
ISO
1
242,443,795
242,450,997
RGD:6480464
CTD
G
Rxra
retinoid X receptor alpha
multiple interactions
ISO
3
6,605,782
6,689,224
RGD:6480464
CTD
G
Scarb1
scavenger receptor class B, member 1
increases transport
ISO
12
32,390,183
32,457,661
RGD:6480464
CTD
G
Six6
SIX homeobox 6
increases expression
ISO
6
95,358,546
95,363,526
RGD:6480464
CTD
G
Slc2a4
solute carrier family 2 (facilitated glucose transporter), member 4
decreases expression
ISO
10
56,786,705
56,792,209
RGD:6480464
CTD
G
Sod1
superoxide dismutase 1, soluble
decreases expression
ISO
11
29,810,766
29,816,342
RGD:6480464
CTD
G
Sod2
superoxide dismutase 2, mitochondrial
multiple interactions
EXP
1
41,862,997
41,870,327
RGD:6480464
CTD
G
Sptlc2
serine palmitoyltransferase, long chain base subunit 2
affects expression
ISO
6
111,546,037
111,622,959
RGD:6480464
CTD
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
ISO
10
46,461,684
46,483,646
RGD:6480464
CTD
G
Tgm2
transglutaminase 2, C polypeptide
increases expression
ISO
3
148,832,866
148,862,385
RGD:6480464
CTD
G
Tgm4
transglutaminase 4 (prostate)
increases expression
ISO
8
127,782,460
127,819,491
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
multiple interactions
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
increases expression
ISO
5
168,071,159
168,099,501
RGD:6480464
CTD
G
Tnfsf10
tumor necrosis factor (ligand) superfamily, member 10
increases expression
ISO
2
113,204,303
113,221,550
RGD:6480464
CTD
G
Txndc9
thioredoxin domain containing 9
increases expression
ISO
9
36,926,559
36,936,470
RGD:6480464
CTD
G
Xrcc3
X-ray repair complementing defective repair in Chinese hamster cells 3
increases expression
ISO
6
136,594,276
136,602,069
RGD:6480464
CTD
astaxanthin
G
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1
multiple interactions
ISO
X
134,868,878
134,908,166
RGD:6480464
CTD
G
App
amyloid beta (A4) precursor protein
multiple interactions
ISO
11
24,457,855
24,693,851
RGD:6480464
CTD
G
C1qa
complement component 1, q subcomponent, A chain
decreases expression
ISO
5
155,662,333
155,665,180
RGD:6480464
CTD
G
Cat
catalase
multiple interactions
ISO
3
88,654,077
88,686,212
RGD:6480464
CTD
G
Cntd1
cyclin N-terminal domain containing 1
multiple interactions
ISO
10
90,308,109
90,316,974
RGD:6480464
CTD
G
Cox15
cytochrome c oxidase assembly homolog 15 (yeast)
multiple interactions
ISO
1
247,077,102
247,093,757
RGD:6480464
CTD
G
Cox5a
cytochrome c oxidase, subunit Va
multiple interactions
ISO
8
61,264,971
61,276,380
RGD:6480464
CTD
G
Cox5b
cytochrome c oxidase subunit Vb
multiple interactions
ISO
9
35,625,478
35,627,304
RGD:6480464
CTD
G
Cox6b1
cytochrome c oxidase subunit VIb polypeptide 1
multiple interactions
ISO
1
85,669,891
85,677,195
RGD:6480464
CTD
G
Cox6c
cytochrome c oxidase, subunit VIc
multiple interactions
ISO
7
71,465,790
71,478,524
RGD:6480464
CTD
G
Ctss
cathepsin S
decreases expression
ISO
2
190,425,290
190,466,877
RGD:6480464
CTD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
EXP
8
61,462,207
61,468,237
RGD:6480464
CTD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
8
61,462,207
61,468,237
RGD:6480464
CTD
G
Gfap
glial fibrillary acidic protein
decreases expression
ISO
10
92,059,881
92,068,555
RGD:6480464
CTD
G
Gja1
gap junction protein, alpha 1
increases expression
ISO
20
35,409,815
35,422,262
RGD:6480464
CTD
G
Gja1
gap junction protein, alpha 1
multiple interactions
ISO
20
35,409,815
35,422,262
RGD:6480464
CTD
G
Gna13
guanine nucleotide binding protein (G protein), alpha 13
multiple interactions
ISO
10
98,933,205
98,965,819
RGD:6480464
CTD
G
Gpx3
glutathione peroxidase 3
multiple interactions
ISO
10
40,311,094
40,319,382
RGD:6480464
CTD
G
Grn
granulin
multiple interactions
ISO
10
91,536,135
91,542,239
RGD:6480464
CTD
G
Hmgb1
high mobility group box 1
multiple interactions
ISO
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
multiple interactions
EXP
19
13,963,139
13,969,960
RGD:6480464
CTD
G
Hmox1
heme oxygenase (decycling) 1
increases expression
EXP
19
13,963,139
13,969,960
RGD:6480464
CTD
G
Hoxa7
homeobox A7
multiple interactions
ISO
4
80,515,622
80,517,521
RGD:6480464
CTD
G
Hoxa9
homeobox A9
multiple interactions
ISO
4
80,524,246
80,526,491
RGD:6480464
CTD
G
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
multiple interactions
ISO
9
63,769,401
63,790,622
RGD:6480464
CTD
G
Il1b
interleukin 1 beta
decreases expression
ISO
3
116,964,422
116,970,867
RGD:6480464
CTD
G
Il6
interleukin 6
decreases expression
ISO
4
456,799
461,376
RGD:6480464
CTD
G
Lepr
leptin receptor
multiple interactions
ISO
5
122,320,075
122,503,449
RGD:6480464
CTD
G
Mt-nd6
mitochondrially encoded NADH dehydrogenase 6
multiple interactions
ISO
MT
13,543
14,061
RGD:6480464
CTD
G
Ndufa1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
multiple interactions
ISO
X
7,726,163
7,730,110
RGD:6480464
CTD
G
Ndufa5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5
multiple interactions
ISO
4
50,649,500
50,657,858
RGD:6480464
CTD
G
Ndufc2
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2
multiple interactions
ISO
1
154,635,889
154,642,112
RGD:6480464
CTD
G
Ndufv2
NADH dehydrogenase (ubiquinone) flavoprotein 2
multiple interactions
ISO
9
104,852,714
104,873,325
RGD:6480464
CTD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
multiple interactions
EXP
3
58,366,693
58,394,116
RGD:6480464
CTD
G
Nfe2l2
nuclear factor, erythroid derived 2, like 2
increases expression
EXP
3
58,366,693
58,394,116
RGD:6480464
CTD
G
Nme2
NME/NM23 nucleoside diphosphate kinase 2
multiple interactions
ISO
10
82,582,766
82,588,269
RGD:6480464
CTD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
multiple interactions
EXP
19
37,251,147
37,266,040
RGD:6480464
CTD
G
Nqo1
NAD(P)H dehydrogenase, quinone 1
increases expression
EXP
19
37,251,147
37,266,040
RGD:6480464
CTD
G
Pah
phenylalanine hydroxylase
decreases expression
ISO
7
24,175,898
24,243,592
RGD:6480464
CTD
G
Por
P450 (cytochrome) oxidoreductase
increases expression
EXP
12
22,078,629
22,097,301
RGD:6480464
CTD
G
Por
P450 (cytochrome) oxidoreductase
decreases activity
EXP
12
22,078,629
22,097,301
RGD:6480464
CTD
G
Ppp1cb
protein phosphatase 1, catalytic subunit, beta isozyme
multiple interactions
ISO
6
24,067,544
24,099,280
RGD:6480464
CTD
G
Prdx1
peroxiredoxin 1
multiple interactions
ISO
5
136,975,780
136,991,630
RGD:6480464
CTD
G
Prdx1
peroxiredoxin 1
multiple interactions
ISO
5
136,975,780
136,991,630
RGD:6480464
CTD
G
Prdx1l1
peroxiredoxin 1-like 1
multiple interactions
ISO
2
201,373,420
201,374,019
RGD:6480464
CTD
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
13
64,427,288
64,432,978
RGD:6480464
CTD
G
Rps2
ribosomal protein S2
multiple interactions
ISO
10
13,975,350
13,977,199
RGD:6480464
CTD
G
Skap2
src kinase associated phosphoprotein 2
decreases expression
ISO
4
80,149,846
80,300,111
RGD:6480464
CTD
G
Sod1
superoxide dismutase 1, soluble
multiple interactions
ISO
11
29,810,766
29,816,342
RGD:6480464
CTD
G
Spp1
secreted phosphoprotein 1
multiple interactions
ISO
RGD:6480464
CTD
G
Tgm2
transglutaminase 2, C polypeptide
multiple interactions
ISO
3
148,832,866
148,862,385
RGD:6480464
CTD
G
Tkt
transketolase
multiple interactions
ISO
16
5,908,759
5,933,695
RGD:6480464
CTD
G
Tnf
tumor necrosis factor
decreases expression
ISO
20
3,661,000
3,663,618
RGD:6480464
CTD
G
Tp53
tumor protein p53
multiple interactions
EXP
10
56,399,721
56,411,150
RGD:6480464
CTD
G
Ubb
ubiquitin B
multiple interactions
ISO
10
139,578,694
139,579,068
RGD:6480464
CTD
G
Uqcrb
ubiquinol-cytochrome c reductase binding protein
multiple interactions
ISO
7
67,958,363
67,963,730
RGD:6480464
CTD
G
Uqcrb-ps1
ubiquinol-cytochrome c reductase binding protein, pseudogene 1
multiple interactions
ISO
1
90,807,565
90,807,900
RGD:6480464
CTD
G
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
multiple interactions
ISO
1
179,459,817
179,490,381
RGD:6480464
CTD
beta-cryptoxanthin
G
Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
ISO
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
multiple interactions
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
increases metabolic processing
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Casp3
caspase 3
multiple interactions
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Casp3
caspase 3
increases expression
ISO
16
48,944,226
48,962,420
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
multiple interactions
ISO
10
83,622,438
83,639,368
RGD:6480464
CTD
G
Col1a1
collagen, type I, alpha 1
increases expression
ISO
10
83,622,438
83,639,368
RGD:6480464
CTD
G
Csf1
colony stimulating factor 1 (macrophage)
multiple interactions
ISO
2
203,292,765
203,307,968
RGD:6480464
CTD
G
Ctsk
cathepsin K
multiple interactions
ISO
2
190,394,854
190,405,668
RGD:6480464
CTD
G
Nfatc1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
multiple interactions
ISO
18
77,498,654
77,581,231
RGD:6480464
CTD
G
Runx2
runt-related transcription factor 2
multiple interactions
ISO
9
11,869,234
12,025,219
RGD:6480464
CTD
G
Runx2
runt-related transcription factor 2
increases expression
ISO
9
11,869,234
12,025,219
RGD:6480464
CTD
G
Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
multiple interactions
ISO
15
59,397,837
59,428,014
RGD:6480464
CTD
canthaxanthin
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
8
61,462,207
61,468,237
RGD:6480464
CTD
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
8
61,462,207
61,468,237
RGD:6480464
CTD
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
8
61,439,062
61,447,861
RGD:6480464
CTD
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO
8
61,439,062
61,447,861
RGD:6480464
CTD
zeaxanthin
G
Bco2
beta-carotene oxygenase 2
multiple interactions
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
affects metabolic processing
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
increases metabolic processing
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Bco2
beta-carotene oxygenase 2
increases expression
ISO
8
53,892,017
53,917,522
RGD:6480464
CTD
G
Gstp1
glutathione S-transferase pi 1
affects binding
ISO
1
206,627,398
206,629,866
RGD:6480464
CTD
G
Gstp1
glutathione S-transferase pi 1
affects binding
ISO
1
206,627,398
206,629,866
RGD:6480464
CTD
G
Hif1a
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
multiple interactions
ISO
6
96,419,024
96,463,891
RGD:6480464
CTD
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
11
85,968,732
86,030,387
RGD:6480464
CTD
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
1
185,935,044
185,941,245
RGD:6480464
CTD
Term paths to the root one longest all shortest one shortest all one shortest and longest all longest