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Term:5-formyltetrahydrofolic acid
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Accession:CHEBI:15640 term browser browse the term
Definition:A formyltetrahydrofolic acid in which the formyl group is located at position 5.
Synonyms:exact_synonym: N-[4-({[2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
 related_synonym: (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate;   10-Formyl-7,8-dihydrofolic acid;   5-Formyl-5,6,7,8-tetrahydrofolic acid;   5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid;   5-Formyltetrahydrofolate;   Acide folinique;   C20H23N7O7;   Folinic acid;   InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1;   InChIKey=VVIAGPKUTFNRDU-ABLWVSNPSA-N;   L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid;   Leucovorin;   Leucovorinum;   N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid;   N5-Formyl-5,6,7,8-tetrahydrofolic acid;   N5-Formyltetrahydrofolic acid;   [H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12;   folinate
 alt_id: CHEBI:12127;   CHEBI:18607;   CHEBI:2057
 xref_casrn: 58-05-9
 xref: ChEMBL:610462 "ChEMBL COMPOUND";   ChemIDplus:58-05-9 "CAS Registry Number";   DrugBank:DB03256 "DrugBank";   KEGG COMPOUND:58-05-9 "CAS Registry Number";   KEGG COMPOUND:C03479 "KEGG COMPOUND";   KEGG DRUG:D07986 "KEGG DRUG"
 xref_mesh: MESH:D002955
 xref: Reaxys:101688 "Reaxys Registry Number";   Wikipedia:Folinic_acid "Wikipedia"
 cyclic_relationship: is_conjugate_acid_of CHEBI:65340

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5-formyltetrahydrofolic acid term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Abcc2 ATP-binding cassette, subfamily C (CFTR/MRP), member 2 multiple interactions EXP RGD:6480464 CTD
G Alb albumin GBrowse link multiple interactions ISO 14 19,126,935 19,142,214 RGD:6480464 CTD
G Angptl2 angiopoietin-like 2 GBrowse link multiple interactions ISO 3 12,226,515 12,256,396 RGD:6480464 CTD
G Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit GBrowse link multiple interactions ISO 11 31,914,320 31,920,632 RGD:6480464 CTD
G Boll bol, boule-like (Drosophila) GBrowse link multiple interactions ISO 9 54,105,735 54,165,888 RGD:6480464 CTD
G Casp3 caspase 3 GBrowse link multiple interactions ISO 16 48,944,226 48,962,420 RGD:6480464 CTD
G Ccne1 cyclin E1 GBrowse link multiple interactions ISO 1 90,568,189 90,577,426 RGD:6480464 CTD
G Cdc45 cell division cycle 45 multiple interactions ISO RGD:6480464 CTD
G Cdc6 cell division cycle 6 GBrowse link multiple interactions ISO 10 87,684,493 87,697,865 RGD:6480464 CTD
G Cdk1 cyclin-dependent kinase 1 GBrowse link multiple interactions ISO 20 20,018,044 20,044,030 RGD:6480464 CTD
G Cdk2 cyclin dependent kinase 2 GBrowse link multiple interactions ISO 7 2,000,196 2,007,682 RGD:6480464 CTD
G Cdkn1a cyclin-dependent kinase inhibitor 1A GBrowse link multiple interactions ISO 20 7,376,325 7,386,778 RGD:6480464 CTD
G Dhfr dihydrofolate reductase GBrowse link multiple interactions ISO 2 22,607,093 22,828,487 RGD:6480464 CTD
G Dhfr dihydrofolate reductase GBrowse link increases expression ISO 2 22,607,093 22,828,487 RGD:6480464 CTD
G Dpyd dihydropyrimidine dehydrogenase GBrowse link multiple interactions ISO 2 214,931,901 215,818,809 RGD:6480464 CTD
G Drd5 dopamine receptor D5 GBrowse link multiple interactions ISO 14 77,768,060 77,769,487 RGD:6480464 CTD
G Edn1 endothelin 1 GBrowse link increases expression ISO 17 28,303,886 28,309,775 RGD:6480464 CTD
G Eml2 echinoderm microtubule associated protein like 2 GBrowse link multiple interactions ISO 1 78,539,321 78,570,125 RGD:6480464 CTD
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 GBrowse link multiple interactions ISO 1 78,711,249 78,722,474 RGD:6480464 CTD
G Ercc2 excision repair cross-complementing rodent repair deficiency, complementation group 2 multiple interactions ISO RGD:6480464 CTD
G F8 coagulation factor VIII, procoagulant component GBrowse link multiple interactions ISO 18 121,134 162,008 RGD:6480464 CTD
G Hand2 heart and neural crest derivatives expressed 2 GBrowse link increases expression ISO 16 36,324,327 36,348,104 RGD:6480464 CTD
G Hspb1 heat shock protein 1 GBrowse link multiple interactions ISO 12 21,911,223 21,912,784 RGD:6480464 CTD
G Lgals8 lectin, galactoside-binding, soluble, 8 GBrowse link multiple interactions ISO 17 68,589,595 68,614,014 RGD:6480464 CTD
G Mthfr methylenetetrahydrofolate reductase (NAD(P)H) GBrowse link multiple interactions ISO 5 165,112,850 165,126,885 RGD:6480464 CTD
G Serpine2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 GBrowse link multiple interactions ISO 9 79,091,414 79,166,330 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link multiple interactions EXP 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a6 solute carrier family 22 (organic anion transporter), member 6 GBrowse link increases uptake ISO 1 211,294,178 211,302,398 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link multiple interactions EXP 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc22a8 solute carrier family 22 (organic anion transporter), member 8 GBrowse link increases uptake ISO 1 211,269,366 211,287,596 RGD:6480464 CTD
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link decreases activity ISO 10 64,576,068 64,582,504 RGD:6480464 CTD
G Slc46a1 solute carrier family 46 (folate transporter), member 1 GBrowse link multiple interactions ISO 10 64,576,068 64,582,504 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Tyms thymidylate synthetase GBrowse link multiple interactions ISO 9 112,604,912 112,617,706 RGD:6480464 CTD
G Zrsr2 zinc finger (CCCH type), RNA binding motif and serine/arginine rich 2 GBrowse link multiple interactions ISO X 51,304,090 51,327,172 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      biological role 480454
        aetiopathogenetic role 109798
          neurotoxin 82102
            ammonia 74849
              organic amino compound 74788
                amino acid 49829
                  modified amino acid 8436
                    glutamic acid derivative 3550
                      folic acids 3529
                        tetrahydrofolic acid 55
                          formyltetrahydrofolic acid 40
                            5-formyltetrahydrofolic acid 39
                              (6S)-5-formyltetrahydrofolic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic group 167766
                              organic divalent group 166601
                                organodiyl group 166601
                                  carbonyl group 166291
                                    carbonyl compound 166291
                                      carboxylic acid 121484
                                        amino acid 49829
                                          modified amino acid 8436
                                            glutamic acid derivative 3550
                                              folic acids 3529
                                                tetrahydrofolic acid 55
                                                  formyltetrahydrofolic acid 40
                                                    5-formyltetrahydrofolic acid 39
                                                      (6S)-5-formyltetrahydrofolic acid 0
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