ONTOLOGY REPORT - ANNOTATIONS

Term:rolipram
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Accession:CHEBI:104872 term browser browse the term
Definition:Pyrrolidin-2-one bearing a 3-(cyclopentyloxy)-4-methoxyphenyl substituent at the 4-position. It is a type IV-specific phosphodiesterase (PDE4) inhibitor.
Synonyms:exact_synonym: 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
 related_synonym: 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone;   C16H21NO3;   COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1;   InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18);   InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N;   ZK 62711;   rolipramum
 alt_id: CHEBI:32104
 xref_casrn: 61413-54-5
 xref: Beilstein:1588548 "Beilstein Registry Number";   ChEMBL:104872 "ChEMBL COMPOUND";   ChemIDplus:61413-54-5 "CAS Registry Number";   CiteXplore:11163637 "PubMed citation";   CiteXplore:11239354 "PubMed citation";   CiteXplore:11408555 "PubMed citation";   CiteXplore:11555183 "PubMed citation";   CiteXplore:11737051 "PubMed citation";   CiteXplore:11739553 "PubMed citation";   CiteXplore:11959789 "PubMed citation";   CiteXplore:11978843 "PubMed citation";   CiteXplore:11992650 "PubMed citation";   CiteXplore:12003795 "PubMed citation";   CiteXplore:12065724 "PubMed citation";   CiteXplore:12191588 "PubMed citation";   CiteXplore:12447004 "PubMed citation";   CiteXplore:12508846 "PubMed citation";   CiteXplore:15114341 "PubMed citation";   CiteXplore:15277469 "PubMed citation";   CiteXplore:15374348 "PubMed citation";   CiteXplore:15646801 "PubMed citation";   CiteXplore:15744818 "PubMed citation";   CiteXplore:15790951 "PubMed citation";   CiteXplore:15839805 "PubMed citation";   CiteXplore:15986861 "PubMed citation";   CiteXplore:16010295 "PubMed citation";   CiteXplore:16022866 "PubMed citation";   CiteXplore:16077397 "PubMed citation";   CiteXplore:16129118 "PubMed citation";   CiteXplore:16190900 "PubMed citation";   CiteXplore:16242629 "PubMed citation";   CiteXplore:16250839 "PubMed citation";   CiteXplore:16253125 "PubMed citation";   CiteXplore:16254133 "PubMed citation";   CiteXplore:16442096 "PubMed citation";   CiteXplore:16455619 "PubMed citation";   CiteXplore:16962789 "PubMed citation";   CiteXplore:16968783 "PubMed citation";   CiteXplore:17081698 "PubMed citation";   CiteXplore:17097801 "PubMed citation";   CiteXplore:17390056 "PubMed citation";   CiteXplore:17489366 "PubMed citation";   CiteXplore:18311187 "PubMed citation";   CiteXplore:18347080 "PubMed citation";   CiteXplore:18424161 "PubMed citation";   CiteXplore:18437099 "PubMed citation";   CiteXplore:18554698 "PubMed citation";   CiteXplore:19554392 "PubMed citation";   CiteXplore:19569465 "PubMed citation";   DrugBank:DB01954 "DrugBank";   KEGG DRUG:D01783 "KEGG DRUG"
 xref_mesh: MESH:D020889
 xref: Patent:US4193926 "Patent";   Patent:US6337325 "Patent";   Patent:WO2011143607 "Patent";   Reaxys:1588548 "Reaxys Registry Number";   Wikipedia:Rolipram "Wikipedia"

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rolipram term browser
Symbol Object Name GBrowse Qualifiers Evidence Chr Start Stop Reference Source
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions ISO RGD:6480464 CTD
G Areg amphiregulin GBrowse link increases expression ISO 14 18,466,313 18,475,571 RGD:6480464 CTD
G Bdnf brain-derived neurotrophic factor multiple interactions EXP RGD:6480464 CTD
G Bdnf brain-derived neurotrophic factor increases expression EXP RGD:6480464 CTD
G Ccl2 chemokine (C-C motif) ligand 2 GBrowse link multiple interactions EXP 10 70,256,263 70,258,061 RGD:6480464 CTD
G Ccl3 chemokine (C-C motif) ligand 3 GBrowse link multiple interactions ISO 10 71,744,559 71,746,109 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link multiple interactions ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link decreases activity ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Cftr cystic fibrosis transmembrane conductance regulator GBrowse link increases activity ISO 4 43,874,852 44,041,870 RGD:6480464 CTD
G Creb1 cAMP responsive element binding protein 1 GBrowse link multiple interactions EXP 9 63,170,785 63,234,727 RGD:6480464 CTD
G Creb1 cAMP responsive element binding protein 1 GBrowse link increases expression EXP 9 63,170,785 63,234,727 RGD:6480464 CTD
G Edn1 endothelin 1 GBrowse link increases activity EXP 17 28,303,886 28,309,775 RGD:6480464 CTD
G Il13 interleukin 13 GBrowse link decreases expression ISO 10 39,093,512 39,096,069 RGD:6480464 CTD
G Il13 interleukin 13 GBrowse link decreases secretion ISO 10 39,093,512 39,096,069 RGD:6480464 CTD
G Il18 interleukin 18 GBrowse link multiple interactions ISO 8 53,936,584 53,943,228 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions EXP 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il1b interleukin 1 beta GBrowse link multiple interactions ISO 3 116,964,422 116,970,867 RGD:6480464 CTD
G Il4 interleukin 4 GBrowse link multiple interactions ISO 10 39,074,582 39,080,134 RGD:6480464 CTD
G Il6 interleukin 6 GBrowse link multiple interactions ISO 4 456,799 461,376 RGD:6480464 CTD
G Ltc4s leukotriene C4 synthase GBrowse link decreases secretion ISO 10 35,786,877 35,788,838 RGD:6480464 CTD
G Mpo myeloperoxidase GBrowse link multiple interactions ISO 10 76,085,872 76,097,012 RGD:6480464 CTD
G Mpo myeloperoxidase GBrowse link multiple interactions EXP 10 76,085,872 76,097,012 RGD:6480464 CTD
G Mpo myeloperoxidase GBrowse link multiple interactions EXP 10 76,085,872 76,097,012 RGD:6480464 CTD
G Nos2 nitric oxide synthase 2, inducible GBrowse link multiple interactions EXP 10 65,036,884 65,072,453 RGD:6480464 CTD
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 GBrowse link increases expression EXP 17 11,494,463 11,811,654 RGD:6480464 CTD
G Pde4a phosphodiesterase 4A, cAMP-specific GBrowse link multiple interactions ISO 8 20,192,677 20,241,557 RGD:6480464 CTD
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link multiple interactions ISO 5 123,158,156 123,533,877 RGD:6480464 CTD
G Pde4b phosphodiesterase 4B, cAMP specific GBrowse link multiple interactions ISO 5 123,158,156 123,533,877 RGD:6480464 CTD
G Sele selectin E GBrowse link multiple interactions ISO 13 79,813,455 79,822,845 RGD:6480464 CTD
G Spp1 secreted phosphoprotein 1 multiple interactions EXP RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions ISO 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link multiple interactions EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
G Tnf tumor necrosis factor GBrowse link decreases expression EXP 20 3,661,000 3,663,618 RGD:6480464 CTD
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 492574
    role 482262
      chemical role 208077
        inhibitor 73170
          enzyme inhibitor 68950
            phosphodiesterase inhibitor 1435
              rolipram 35
                (+)-rolipram 0
                (-)-rolipram 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 492574
    subatomic particle 491537
      composite particle 491537
        hadron 491537
          baryon 491537
            nucleon 491537
              atomic nucleus 491537
                atom 491537
                  main group element atom 461203
                    p-block element atom 458699
                      carbon group element atom 410677
                        carbon atom 407233
                          organic molecular entity 407226
                            organic molecule 359465
                              organic cyclic compound 298342
                                organic heterocyclic compound 154273
                                  organic heteromonocyclic compound 58845
                                    pyrrolidines 1958
                                      pyrrolidinone 84
                                        rolipram 35
                                          (+)-rolipram 0
                                          (-)-rolipram 0
paths to the root

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