|
.009 |
.0 |
.032 |
.077 |
.002 |
.0 |
.012 |
.014 |
.002 |
.218 |
.021 |
.0 |
.001 |
.089 |
.002 |
.029 |
.001 |
.005 |
.024 |
.014 |
-- |
-- |
-- |
-- |
.001 |
.001 |
.001 |
.0 |
.03 |
.008 |
.01 |
.022 |
.05 |
.145 |
.002 |
-- |
-- |
-- |
.058 |
.023 |
.019 |
.008 |
.058 |
.048 |
.003 |
-- |
.034 |
.009 |
.004 |
.028 |
.023 |
.01 |
.141 |
.022 |
.101 |
.017 |
.017 |
.048 |
.439 |
.112 |
.191 |
.032 |
.017 |
-- |
-- |
-- |
-- |
.282 |
.397 |
-- |
-- |
.01 |
.032 |
.301 |
-- |
-- |
-- |
.016 |
.041 |
.005 |
.002 |
.244 |
.001 |
-- |
-- |
.005 |
.171 |
.004 |
-- |
-- |
.026 |
.018 |
.009 |
.004 |
.0 |
.261 |
.002 |
.002 |
.0 |
.001 |
.0 |
.003 |
.027 |
.032 |
.002 |
.002 |
-- |
-- |
-- |
.703 |
.012 |
.119 |
.302 |
.012 |
.003 |
.002 |
.003 |
.008 |
.064 |
.001 |
.0 |
.001 |
.001 |
.197 |
.0 |
.793 |
.671 |
.0 |
.064 |
.003 |
.017 |
.013 |
.0 |
.001 |
.004 |
.04 |
.015 |
.065 |
.545 |
.047 |
.053 |
-- |
.006 |
.003 |
.001 |
-- |
.019 |
.0 |
.008 |
.025 |
.01 |
.046 |
.008 |
1.0 |
1.0 |
.001 |
.002 |
.001 |
.001 |
.003 |
.002 |
.284 |
.066 |
.006 |
.004 |
.031 |
.007 |
.059 |
.027 |
.06 |
.121 |
.205 |
.0 |
-- |
.03 |
.47 |
.352 |
.008 |
.001 |
.021 |
.007 |
.117 |
.109 |
.0 |
.73 |
.003 |
-- |
-- |
-- |
-- |
.006 |
.035 |
.12 |
.007 |
.12 |
.417 |
.0 |
.0 |
.018 |
.024 |
.075 |
.001 |
.001 |
.001 |
.224 |
.001 |
.005 |
.007 |
.145 |
.015 |
.029 |
.021 |
.006 |
.027 |
.037 |
.027 |
.012 |
.004 |
.005 |
.005 |
.005 |
.0 |
.001 |
.01 |
.0 |
.004 |
.529 |
.159 |
.0 |
.003 |
.005 |
.0 |
.204 |
.205 |
.945 |
.07 |
.005 |
.371 |
.012 |
.472 |
.031 |
.024 |
.002 |
.002 |
.001 |
.0 |
.001 |
.046 |
.008 |
.017 |
.023 |
.011 |
.004 |
.514 |
.007 |
.0 |
.188 |
-- |
-- |
.024 |
.061 |
.764 |
.018 |
.014 |
.0 |
-- |
.263 |
.44 |
.0 |
.0 |
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
Trpm1
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
T |
A |
G |
T |
G |
G |
G |
A |
A |
T |
C |
G |
A |
C |
T |
C |
T |
G |
A |
G |
C |
G |
T |
T |
A |
C |
C |
C |
G |
A |
C |
A |
C |
10 |
C |
A |
A |
C |
T |
A |
T |
C |
G |
A |
T |
T |
T |
T |
3 |
G |
C |
C |
C |
T |
C |
A |
T |
T |
G |
T |
C |
C |
T |
C |
A |
G |
G |
G |
A |
T |
T |
C |
C |
T |
C |
G |
T |
C |
C |
G |
A |
T |
59 |
T |
G |
G |
T |
T |
T |
T |
G |
G |
A |
G |
C |
2 |
G |
A |
G |
C |
T |
T |
C |
T |
T |
G |
C |
A |
A |
G |
G |
G |
A |
C |
A |
C |
G |
A |
C |
A |
T |
T |
C |
C |
T |
C |
C |
T |
A |
C |
T |
A |
G |
A |
G |
G |
C |
A |
G |
G |
G |
G |
A |
G |
C |
6 |
A |
G |
T |
C |
3 |
A |
C |
A |
C |
G |
A |
T |
G |
C |
C |
C |
T |
T |
T |
A |
T |
T |
C |
2 |
T |
T |
G |
C |
C |
T |
A |
C |
A |
A |
G |
C |
T |
A |
T |
T |
A |
4 |
G |
G |
2 |
A |
A |
T |
4 |
T |
A |
A |
3 |
A |
G |
T |
T |
G |
A |
A |
C |
A |
G |
G |
G |
C |
C |
A |
A |
T |
G |
G |
C |
5 |
G |
G |
A |
A |
G |
A |
3 |
C |
C |
T |
A |
C |
T |
A |
G |
G |
G |
A |
T |
A |
A |
G |
A |
T |
A |
G |
T |
C |
A |
A |
T |
G |
C |
T |
T |
T |
3 |
A |
G |
C |
G |
2 |
C |
G |
A |
T |
A |
T |
C |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
T
|
C
|
A/G
|
T
|
2
|
A
|
2
|
G/3
|
G
|
G
|
C
|
C/A
|
C
|
G
|
A
|
C
|
T
|
C
|
A
|
G
|
2
|
T
|
A
|
G
|
T/C
|
G
|
T
|
T
|
A
|
A
|
G
|
C/G
|
G
|
T
|
10/-
|
T
|
G
|
18
|
T
|
A
|
-
|
C
|
T
|
A
|
G
|
C
|
-
|
2
|
T/G
|
3/-
|
G/A
|
C/T
|
T
|
G
|
C
|
C/T
|
C
|
C
|
C
|
6
|
A
|
T
|
T
|
C
|
G
|
G
|
A
|
A
|
A
|
G
|
C
|
T/-
|
2
|
-
|
C
|
T
|
A
|
C
|
G
|
T
|
2
|
G
|
C
|
-
|
C
|
A
|
A
|
C
|
2
|
4
|
C
|
A
|
A
|
G
|
A
|
C/T
|
2/-
|
G/2
|
C
|
A
|
C/T
|
-
|
A
|
T
|
C
|
T/C
|
12
|
C/T
|
G
|
C
|
2
|
A
|
A
|
G
|
T
|
T
|
G
|
G/A
|
G
|
A
|
G
|
C
|
C
|
T
|
3
|
C
|
T
|
T
|
T/C
|
G
|
T
|
-
|
T
|
A
|
A/G
|
A
|
T
|
T
|
A/G
|
A
|
A
|
T
|
A
|
C
|
A
|
3
|
6/-
|
G
|
G/A
|
C
|
T
|
-
|
-
|
A
|
G
|
T
|
A
|
T
|
2
|
A
|
T
|
T
|
T
|
T/-
|
T/3
|
T/G
|
2
|
C
|
T/13
|
2
|
2/-
|
C
|
C
|
A
|
T
|
T
|
T/-
|
G
|
G
|
A/G
|
C
|
A
|
T
|
C
|
G
|
C
|
2
|
G
|
4/-
|
G/C
|
G/A
|
2/-
|
G
|
G
|
T/C
|
-
|
G
|
G
|
G
|
3/-
|
T
|
G/A
|
C
|
C
|
A
|
G
|
C
|
A
|
A/G
|
A
|
T
|
T
|
G
|
T
|
T
|
G
|
C
|
G/A
|
G/T
|
T
|
-
|
C
|
A
|
G
|
G
|
A
|
G
|
3/-
|
T
|
T
|
C
|
5
|
T
|
2
|
G
|
A
|
A
|
A
|
G
|
T/C
|
G
|
G
|
A
|
G
|
C
|
C
|
T
|
C
|
T
|
G
|
C
|
C
|
A
|
2
|
C
|
G
|
T/A
|
-
|
3
|
A
|
C/T
|
A
|
2/-
|
C/-
|
C
|
-
|
C
|
C
|
C
|
T
|
|