|
.535 |
.0 |
.0 |
.766 |
.293 |
.001 |
.003 |
.004 |
.005 |
.024 |
.001 |
.0 |
.001 |
.001 |
.297 |
.0 |
.002 |
.02 |
.038 |
.015 |
.981 |
.023 |
.012 |
.658 |
.007 |
.001 |
.076 |
.012 |
.013 |
.002 |
.002 |
.005 |
.006 |
.004 |
.012 |
.009 |
.007 |
.158 |
.0 |
.047 |
.64 |
.006 |
.001 |
.001 |
.0 |
.046 |
.135 |
.032 |
.024 |
.172 |
-- |
.006 |
-- |
.047 |
.06 |
.501 |
.001 |
.074 |
.007 |
.001 |
.836 |
.005 |
-- |
.001 |
.508 |
.231 |
.467 |
.006 |
.063 |
.001 |
.034 |
.04 |
.214 |
-- |
.004 |
.032 |
.03 |
.021 |
.0 |
.0 |
.097 |
.015 |
.144 |
.371 |
-- |
-- |
.0 |
.278 |
.006 |
.0 |
.001 |
.001 |
.002 |
.0 |
.0 |
.001 |
.032 |
.002 |
.268 |
.643 |
.164 |
.001 |
.094 |
.001 |
.037 |
-- |
.362 |
.021 |
.002 |
.025 |
.124 |
.036 |
.611 |
.218 |
.025 |
.025 |
.304 |
-- |
-- |
-- |
-- |
-- |
-- |
.038 |
.001 |
.042 |
.015 |
.06 |
.014 |
.041 |
.002 |
-- |
.016 |
.0 |
.004 |
.21 |
.229 |
.063 |
.07 |
.0 |
.02 |
.012 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.281 |
.202 |
.004 |
.0 |
.001 |
.027 |
.003 |
.005 |
.002 |
.005 |
.94 |
.001 |
.005 |
.506 |
.507 |
.108 |
.662 |
.011 |
.001 |
.002 |
.011 |
.001 |
.0 |
.001 |
.001 |
.998 |
-- |
-- |
.014 |
.0 |
.0 |
.397 |
.012 |
.018 |
.004 |
.006 |
.001 |
.0 |
.223 |
.0 |
.0 |
.0 |
.023 |
.004 |
.993 |
.999 |
.0 |
.004 |
-- |
.022 |
.011 |
.028 |
.873 |
.0 |
.01 |
.0 |
.0 |
.012 |
.001 |
.0 |
.001 |
.015 |
.017 |
.0 |
.0 |
.005 |
.007 |
.028 |
.007 |
.085 |
.0 |
.995 |
.004 |
.326 |
.002 |
.059 |
.0 |
.023 |
.004 |
.001 |
-- |
.963 |
-- |
.0 |
.073 |
.111 |
.096 |
.002 |
.0 |
.002 |
.001 |
.007 |
.014 |
.007 |
.001 |
.049 |
.007 |
.101 |
.102 |
-- |
.004 |
.005 |
.005 |
.002 |
.005 |
.001 |
.001 |
.0 |
.0 |
.016 |
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
--
|
--
|
--
|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
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|
--
|
--
|
--
|
--
|
--
|
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|
--
|
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|
--
|
--
|
--
|
--
|
--
|
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|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
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|
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|
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|
--
|
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|
--
|
--
|
--
|
--
|
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
|
A |
A |
C |
T |
A |
A |
G |
T |
T |
G |
C |
A |
A |
6 |
T |
A |
10 |
C |
G |
T |
T |
2 |
A |
G |
A |
A |
A |
34 |
32 |
G |
G |
G |
A |
C |
T |
A |
T |
C |
C |
G |
C |
T |
8 |
C |
A |
C |
C |
G |
G |
5 |
T |
T |
2 |
C |
C |
G |
2 |
C |
A |
A |
G |
G |
A |
C |
C |
T |
T |
G |
T |
T |
T |
G |
C |
10 |
A |
A |
A |
T |
G |
T |
T |
A |
A |
C |
C |
A |
T |
T |
G |
A |
A |
G |
5 |
C |
T |
A |
G |
C |
G |
A |
C |
A |
A |
8 |
C |
G |
A |
C |
A |
G |
T |
C |
6 |
T |
C |
G |
C |
G |
G |
2 |
G |
G |
G |
G |
A |
A |
A |
A |
C |
A |
T |
A |
A |
C |
A |
C |
C |
A |
G |
3 |
A |
C |
144 |
2 |
G |
G |
3 |
6 |
T |
T |
G |
C |
T |
A |
C |
G |
T |
A |
T |
A |
C |
T |
T |
C |
C |
4 |
24 |
G |
C |
A |
T |
C |
G |
A |
G |
C |
C |
A |
A |
A |
T |
A |
A |
G |
A |
G |
C |
C |
A |
A |
T |
C |
C |
G |
G |
C |
T |
2 |
C |
A |
T |
A |
G |
C |
C |
G |
T |
G |
G |
A |
A |
G |
C |
C |
A |
G |
T |
C |
A |
C |
G |
C |
G |
C |
6 |
C |
A |
A |
A |
T |
G |
C |
5 |
C |
G |
G |
2 |
A |
G |
G |
A |
6 |
A |
A |
T |
T |
10 |
6 |
G |
A |
4 |
T |
11 |
C |
A |
A |
T |
T |
T |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
G
|
T
|
C
|
2
|
3
|
A
|
C
|
C
|
A
|
T
|
G
|
G
|
-
|
C
|
G
|
-
|
T
|
C
|
C
|
C
|
2/-
|
G
|
C
|
G
|
G
|
G
|
-
|
32/-
|
A
|
A
|
A
|
T
|
2
|
8
|
C
|
G
|
5/3
|
-
|
A
|
T
|
-
|
-
|
T
|
G
|
T
|
T
|
2
|
T
|
-
|
A
|
C
|
-
|
-
|
G
|
A
|
-
|
T
|
G
|
-
|
5
|
A
|
G
|
3
|
5
|
C
|
G
|
2
|
G
|
C
|
4
|
-
|
9
|
10/-
|
G
|
G
|
G
|
2
|
9
|
C
|
C
|
2
|
A/3
|
13
|
2
|
A/4
|
C
|
T/-
|
A
|
T
|
T
|
-
|
-
|
T
|
29
|
G
|
A
|
T
|
C
|
G
|
T
|
G
|
C
|
-
|
T
|
C
|
G
|
T
|
G
|
A
|
-
|
T
|
-
|
C
|
T
|
A
|
7
|
-
|
A
|
-
|
25
|
C
|
C
|
8
|
G
|
C
|
G
|
G
|
T
|
G
|
3
|
C
|
5
|
-
|
-
|
C/26
|
C/3
|
G
|
T
|
-
|
C
|
A
|
-
|
-
|
A
|
T
|
-
|
-
|
106
|
C
|
A
|
T
|
-
|
G
|
T
|
A
|
C
|
G
|
C
|
G
|
T
|
G
|
C
|
2
|
A
|
-
|
-
|
A
|
T
|
G
|
C
|
A
|
A
|
C
|
A
|
A
|
3
|
G
|
G
|
G
|
C
|
3
|
G
|
5
|
T
|
A
|
T
|
T
|
7
|
G
|
C
|
T
|
A
|
A
|
A
|
T
|
G
|
2/-
|
T
|
G
|
2
|
C
|
A
|
T
|
4
|
3
|
A
|
A
|
T
|
G
|
G
|
A
|
A
|
T
|
C
|
T
|
C
|
T
|
2
|
T
|
A
|
T
|
A
|
A
|
-
|
T
|
G
|
G
|
T
|
C
|
6
|
3
|
-
|
T
|
A
|
A
|
2/-
|
A/-
|
G/-
|
A
|
C
|
-
|
3
|
T
|
C
|
C
|
-
|
-
|
A
|
G
|
4/-
|
C
|
11/-
|
T
|
G
|
9
|
A
|
C
|
C
|
C
|
|