|
.021 |
.001 |
.054 |
.007 |
.001 |
.018 |
.022 |
-- |
-- |
.914 |
.0 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
.004 |
-- |
-- |
-- |
.016 |
.298 |
.085 |
.189 |
.04 |
.005 |
.008 |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.0 |
.001 |
.003 |
.001 |
.002 |
.456 |
-- |
-- |
.026 |
.041 |
.021 |
.035 |
.008 |
.019 |
.047 |
.007 |
.017 |
-- |
-- |
-- |
-- |
.119 |
.082 |
.658 |
.006 |
.062 |
.08 |
.042 |
.671 |
.021 |
.002 |
.001 |
.003 |
.006 |
.002 |
.018 |
.016 |
.002 |
.533 |
.044 |
.003 |
.03 |
.012 |
.002 |
.049 |
.29 |
.241 |
.0 |
.001 |
.0 |
.008 |
.009 |
.01 |
.04 |
-- |
.044 |
.029 |
.003 |
.003 |
.044 |
.003 |
.019 |
.168 |
.025 |
.468 |
.01 |
.009 |
.002 |
.001 |
.001 |
.0 |
.436 |
.013 |
.026 |
.022 |
.02 |
.001 |
.057 |
.145 |
.195 |
.253 |
.179 |
-- |
.033 |
.121 |
.098 |
.083 |
.007 |
.013 |
.009 |
-- |
.05 |
.264 |
.04 |
.097 |
.219 |
.023 |
.006 |
.432 |
.002 |
.0 |
.1 |
.004 |
.001 |
.001 |
.001 |
.122 |
.037 |
.082 |
.002 |
.028 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.027 |
.09 |
.142 |
.165 |
.62 |
.861 |
.837 |
.827 |
.89 |
.893 |
.902 |
.903 |
.851 |
.892 |
.738 |
.776 |
.673 |
.024 |
.018 |
.004 |
.269 |
.046 |
.792 |
.03 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.045 |
.009 |
.479 |
-- |
-- |
.111 |
.144 |
.006 |
-- |
-- |
.023 |
.019 |
-- |
-- |
.566 |
-- |
-- |
.049 |
.036 |
.079 |
.037 |
.637 |
.005 |
.117 |
.304 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.056 |
.001 |
.004 |
.001 |
.004 |
.105 |
.601 |
.001 |
.258 |
.023 |
.014 |
.216 |
.045 |
.026 |
.029 |
.003 |
.003 |
.104 |
.116 |
.191 |
.008 |
.999 |
.998 |
.063 |
.001 |
.0 |
-- |
-- |
-- |
-- |
-- |
-- |
.055 |
.011 |
.011 |
.035 |
.068 |
.011 |
.006 |
.746 |
.783 |
.586 |
.001 |
.997 |
.0 |
.115 |
.014 |
.001 |
.003 |
.006 |
.002 |
.131 |
.242 |
.001 |
.002 |
.466 |
.5 |
.728 |
-- |
-- |
.903 |
.745 |
.863 |
.958 |
.889 |
.268 |
-- |
-- |
.001 |
.095 |
-- |
.028 |
.098 |
.01 |
.004 |
.005 |
.005 |
.004 |
.001 |
.01 |
.007 |
.04 |
.001 |
.001 |
.002 |
.0 |
.001 |
.0 |
.005 |
.004 |
.939 |
.057 |
.003 |
.009 |
.007 |
.008 |
.025 |
.023 |
.011 |
.054 |
.061 |
.887 |
.868 |
.008 |
.004 |
.094 |
.083 |
.034 |
.08 |
.019 |
.033 |
.003 |
.005 |
.008 |
.039 |
.001 |
.168 |
.001 |
.078 |
.006 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.1 |
.111 |
.074 |
.578 |
.231 |
.34 |
.0 |
.007 |
.016 |
.0 |
.0 |
.001 |
.001 |
.993 |
1.0 |
.001 |
.2 |
.475 |
.269 |
.383 |
.835 |
.382 |
.232 |
.198 |
.238 |
.0 |
.047 |
.129 |
.0 |
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
Prkar1b
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
G |
A |
G |
C |
A |
G |
T |
T |
G |
A |
G |
G |
A |
G |
C |
C |
T |
A |
T |
T |
C |
G |
A |
A |
T |
T |
C |
G |
G |
T |
A |
A |
G |
3 |
T |
C |
T |
C |
A |
T |
G |
C |
A |
G |
8 |
G |
G |
A |
T |
T |
G |
C |
A |
C |
T |
G |
A |
T |
C |
2 |
T |
2 |
C |
A |
G |
T |
A |
T |
T |
A |
A |
C |
A |
C |
T |
G |
6 |
C |
A |
C |
A |
G |
3 |
A |
G |
A |
G |
G |
G |
T |
A |
2 |
A |
G |
C |
T |
T |
G |
G |
T |
T |
T |
T |
T |
G |
A |
T |
G |
A |
A |
T |
G |
T |
G |
14 |
G |
G |
G |
G |
T |
C |
A |
G |
T |
C |
C |
5 |
A |
C |
T |
G |
C |
T |
T |
A |
A |
T |
T |
C |
C |
A |
C |
C |
A |
G |
C |
4 |
A |
C |
T |
G |
T |
T |
G |
T |
T |
C |
G |
T |
G |
A |
A |
C |
G |
T |
G |
C |
G |
A |
A |
C |
C |
A |
G |
A |
A |
A |
C |
T |
C |
C |
A |
T |
C |
A |
G |
T |
T |
C |
T |
C |
G |
G |
G |
A |
T |
G |
10 |
5 |
G |
A |
G |
C |
C |
T |
C |
3 |
2 |
T |
C |
G |
G |
T |
A |
C |
T |
G |
C |
G |
C |
G |
T |
G |
A |
3 |
G |
T |
T |
T |
T |
T |
T |
A |
A |
G |
A |
A |
G |
C |
G |
A |
C |
T |
T |
T |
C |
A |
T |
G |
C |
G |
G |
C |
T |
G |
T |
G |
C |
G |
T |
G |
T |
4 |
C |
C |
4 |
G |
C |
C |
A |
C |
G |
C |
T |
C |
G |
A |
A |
C |
T |
A |
C |
G |
G |
T |
A |
A |
C |
A |
G |
G |
5 |
18 |
A |
A |
2 |
A |
C |
T |
G |
C |
A |
G |
G |
G |
C |
3 |
G |
T |
4 |
A |
A |
A |
A |
T |
G |
A |
G |
T |
T |
T |
G |
C |
T |
G |
A |
G |
A |
A |
4 |
2 |
G |
2 |
2 |
G |
A |
G |
G |
T |
A |
A |
A |
T |
T |
T |
A |
2 |
C |
A |
A |
C |
A |
T |
G |
G |
G |
T |
G |
G |
T |
T |
T |
C |
C |
T |
3 |
C |
12 |
3 |
T |
C |
A |
T |
C |
G |
C |
C |
A |
C |
T |
G |
A |
G |
T |
C |
4 |
8 |
G |
C |
T |
C |
A |
A |
A |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
G
|
A
|
T
|
G
|
A
|
C
|
-
|
T
|
G
|
A
|
A
|
G
|
G/T
|
C/T
|
C/G
|
T/C
|
G
|
C
|
C
|
T
|
4
|
G
|
G
|
A
|
-
|
T
|
A
|
A
|
T/4
|
A/C
|
2
|
A
|
-
|
C
|
T
|
C
|
-
|
A/C
|
C
|
A
|
T
|
A/2
|
G/A
|
-
|
A
|
A
|
G
|
C
|
C
|
A
|
G
|
G
|
C/G
|
T/C
|
G/T
|
A/T
|
11
|
C/G
|
-
|
5
|
-
|
5
|
G
|
A
|
G
|
T
|
T/C
|
T/C
|
C
|
-
|
T
|
G
|
T
|
G
|
A
|
-
|
T
|
G
|
T
|
G
|
A
|
-
|
G
|
A
|
G
|
A
|
A
|
6
|
T/C
|
T
|
-
|
G
|
A
|
3
|
C
|
C
|
A
|
-
|
C
|
C
|
C
|
A
|
A
|
C
|
5
|
A
|
A
|
A/3
|
A/G
|
T/C
|
G/A
|
C
|
8
|
-
|
G/C
|
G/C
|
C/3
|
A
|
2
|
T
|
G
|
A
|
A
|
A
|
T
|
5/-
|
A/G
|
T
|
C
|
A
|
T
|
A
|
2
|
C
|
G
|
C
|
C
|
T
|
T
|
G
|
-
|
A
|
G
|
A
|
T
|
-
|
C
|
5
|
C
|
A
|
C
|
C
|
T
|
C
|
T/C
|
C/T
|
G/A
|
T/C
|
G/T
|
A/G
|
A/G
|
C/T
|
G/A
|
T/C
|
T/GC
|
C/A
|
G/T
|
A/C
|
A/G
|
C/T
|
C/A
|
A/C
|
G/-
|
A/C
|
A/G
|
C
|
C/2
|
A
|
G
|
T
|
G
|
T/2
|
A
|
G
|
A
|
2
|
G
|
T
|
4
|
A
|
T
|
T
|
A
|
G
|
G
|
A
|
-
|
-
|
T
|
G
|
A
|
T
|
G
|
C
|
T
|
3/-
|
-
|
A
|
T
|
A
|
T
|
C
|
G
|
T
|
C
|
T
|
T
|
-
|
A
|
A
|
C
|
C
|
G
|
-
|
T
|
G
|
C
|
C
|
A
|
2
|
A
|
G
|
3
|
C
|
G
|
2
|
G/A
|
T
|
2
|
G
|
T
|
5
|
C
|
C
|
T
|
22/-
|
C
|
C
|
G
|
A
|
14
|
C/-
|
-
|
A
|
G
|
A
|
T
|
A
|
G
|
2
|
A
|
-
|
T
|
T
|
4/-
|
G/A
|
A
|
T
|
C
|
G
|
A
|
A
|
2
|
T
|
A
|
G
|
7
|
G
|
C
|
G
|
T
|
9
|
C
|
C
|
G
|
G
|
4
|
G
|
A
|
A
|
5/-
|
18/-
|
A/2
|
A/G
|
-
|
A/2
|
C/-
|
T/2
|
-
|
T
|
G
|
G/-
|
G/A
|
C
|
2
|
3/-
|
A
|
5
|
-
|
C
|
C
|
G
|
G
|
C
|
A
|
G
|
T
|
C
|
C
|
A
|
T
|
T
|
C
|
A
|
G
|
A
|
9
|
A/-
|
4/-
|
2/-
|
G/A
|
2/-
|
2/-
|
G/T
|
A/T
|
A
|
C
|
-
|
G
|
T
|
G
|
C
|
G
|
C
|
G
|
-
|
T
|
G
|
G
|
-
|
G
|
C
|
A
|
A
|
A
|
2
|
C
|
A
|
C
|
T/3
|
TC/C
|
T
|
C/-
|
4
|
-
|
C/T
|
-
|
3/-
|
C
|
G
|
G
|
C
|
T
|
A
|
T
|
T
|
G
|
-
|
C
|
A
|
G
|
A
|
A
|
T
|
-
|
-
|
3
|
T
|
C
|
T
|
G
|
C
|
G
|
T
|
|