|
.009 |
.008 |
.01 |
.004 |
.004 |
.001 |
.001 |
.001 |
.0 |
.04 |
.0 |
.002 |
.0 |
.034 |
.839 |
.001 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.897 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.001 |
.25 |
.003 |
.0 |
.026 |
.009 |
.001 |
.015 |
.031 |
.003 |
.001 |
.004 |
.002 |
.187 |
.102 |
.944 |
.011 |
.009 |
.022 |
.002 |
.106 |
-- |
-- |
.009 |
.948 |
1.0 |
.999 |
1.0 |
.998 |
.078 |
.031 |
.183 |
.019 |
.001 |
.001 |
.002 |
.014 |
.001 |
.0 |
.019 |
.002 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.0 |
.086 |
.008 |
.0 |
.082 |
.04 |
.02 |
.003 |
.16 |
.31 |
.059 |
.001 |
.0 |
.0 |
.166 |
.144 |
.02 |
.001 |
.005 |
.025 |
.005 |
.036 |
.024 |
.218 |
.101 |
.0 |
.0 |
-- |
-- |
-- |
.203 |
.0 |
-- |
-- |
-- |
-- |
-- |
-- |
.011 |
.096 |
.001 |
.003 |
.041 |
.004 |
.025 |
.079 |
.034 |
.032 |
.005 |
.001 |
.004 |
.013 |
.283 |
.001 |
.016 |
.028 |
-- |
.979 |
.098 |
.098 |
.0 |
.02 |
.023 |
.025 |
-- |
-- |
.0 |
.0 |
.018 |
.231 |
.002 |
.0 |
.002 |
.001 |
.025 |
.006 |
.03 |
.001 |
.461 |
.01 |
.001 |
.0 |
.14 |
.0 |
.266 |
.003 |
.869 |
.886 |
.008 |
.004 |
.001 |
.025 |
.042 |
.002 |
.01 |
.045 |
.007 |
.0 |
.005 |
.001 |
.0 |
.016 |
.011 |
.013 |
.052 |
.033 |
.001 |
.0 |
.046 |
.011 |
.0 |
.0 |
.0 |
.001 |
.0 |
.001 |
.0 |
.0 |
.001 |
.166 |
.0 |
.046 |
.087 |
.052 |
-- |
-- |
.071 |
.077 |
.0 |
.0 |
.0 |
.002 |
.03 |
.0 |
.827 |
.08 |
.01 |
.002 |
.008 |
.007 |
.17 |
.618 |
.53 |
.046 |
.018 |
.115 |
.092 |
.171 |
.029 |
.01 |
.002 |
.229 |
.006 |
.002 |
.0 |
.027 |
.001 |
.005 |
.103 |
.022 |
.034 |
.001 |
.006 |
.0 |
.0 |
.028 |
.001 |
.034 |
.207 |
.005 |
.001 |
.004 |
.176 |
.273 |
.292 |
.299 |
.295 |
.284 |
.001 |
.016 |
.087 |
.002 |
.055 |
.194 |
.183 |
.067 |
.332 |
.009 |
.008 |
.032 |
.08 |
.331 |
.143 |
.938 |
.295 |
.991 |
.514 |
.072 |
.042 |
.083 |
.152 |
.018 |
.415 |
.059 |
.002 |
.012 |
.002 |
.1 |
.404 |
.067 |
.004 |
.109 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.037 |
.001 |
.205 |
.265 |
.003 |
.12 |
.023 |
.519 |
.016 |
.0 |
.001 |
.0 |
.094 |
-- |
-- |
-- |
.102 |
.361 |
.214 |
-- |
-- |
.005 |
.31 |
.412 |
.001 |
.344 |
.29 |
.036 |
.007 |
.059 |
.816 |
.83 |
.001 |
.002 |
.073 |
.015 |
.004 |
.022 |
.218 |
.313 |
.169 |
.057 |
.057 |
-- |
.019 |
.021 |
.07 |
.004 |
.075 |
.009 |
.001 |
.016 |
-- |
-- |
.0 |
.022 |
.003 |
.813 |
.027 |
.692 |
.002 |
.041 |
.732 |
.769 |
.001 |
.026 |
.01 |
.058 |
.023 |
.187 |
.204 |
.224 |
.408 |
.021 |
.317 |
.003 |
.036 |
.272 |
.016 |
.442 |
-- |
.12 |
.217 |
-- |
-- |
-- |
-- |
-- |
.074 |
.12 |
.023 |
.0 |
.144 |
.003 |
-- |
.005 |
.001 |
.008 |
.134 |
.004 |
.031 |
.019 |
.0 |
.797 |
.004 |
.043 |
.008 |
.043 |
.011 |
.017 |
.006 |
.022 |
.001 |
.008 |
.004 |
.0 |
.096 |
.002 |
.379 |
.002 |
.033 |
.998 |
.972 |
.043 |
.601 |
.003 |
.01 |
.395 |
.014 |
.025 |
.111 |
.206 |
.313 |
1.0 |
.266 |
.0 |
.001 |
.001 |
.027 |
.0 |
.0 |
.002 |
.007 |
-- |
.005 |
.008 |
.002 |
.001 |
.001 |
.003 |
-- |
-- |
-- |
.017 |
.003 |
.008 |
.006 |
.0 |
.033 |
.0 |
.004 |
.034 |
.443 |
.525 |
.001 |
.007 |
.009 |
.053 |
.007 |
.004 |
.002 |
.473 |
.263 |
.118 |
1.0 |
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
Pcsk2
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
Wbp4-ps1
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
T |
C |
T |
C |
G |
C |
C |
G |
G |
A |
G |
G |
G |
A |
2 |
3 |
C |
A |
A |
T |
G |
T |
T |
T |
T |
T |
T |
C |
T |
G |
T |
G |
G |
G |
A |
C |
T |
G |
G |
A |
A |
C |
G |
T |
T |
G |
A |
A |
G |
T |
26 |
G |
C |
C |
G |
A |
A |
A |
G |
G |
C |
A |
A |
A |
C |
A |
A |
G |
C |
T |
A |
C |
G |
A |
A |
G |
A |
A |
C |
C |
A |
A |
G |
A |
A |
C |
T |
G |
115 |
G |
C |
T |
T |
C |
T |
A |
G |
G |
A |
C |
12 |
4 |
G |
G |
T |
G |
C |
A |
G |
8 |
4 |
C |
G |
T |
G |
T |
A |
C |
T |
C |
G |
C |
G |
T |
G |
G |
T |
T |
T |
G |
C |
C |
A |
T |
T |
C |
T |
A |
T |
T |
C |
C |
T |
T |
A |
C |
G |
2 |
A |
A |
G |
A |
A |
T |
4 |
10 |
T |
G |
T |
C |
T |
T |
G |
G |
A |
T |
A |
17 |
A |
T |
C |
A |
8 |
6 |
A |
A |
A |
C |
C |
C |
4 |
C |
C |
T |
11 |
G |
A |
T |
G |
A |
T |
G |
G |
G |
T |
G |
A |
G |
G |
G |
A |
C |
G |
C |
A |
C |
A |
5 |
A |
A |
T |
T |
3 |
2 |
C |
T |
G |
G |
C |
A |
T |
3 |
A |
G |
G |
A |
A |
2 |
11 |
C |
A |
A |
A |
T |
G |
G |
6 |
4 |
C |
A |
C |
C |
G |
G |
4 |
20 |
A |
A |
T |
G |
G |
G |
C |
A |
C |
T |
T |
T |
2 |
A |
2 |
16 |
14 |
12 |
2 |
2 |
G |
A |
T |
G |
14 |
A |
A |
G |
A |
G |
T |
T |
A |
G |
G |
A |
C |
C |
2 |
10 |
T |
C |
T |
A |
C |
A |
T |
G |
11 |
T |
C |
2 |
A |
G |
C |
A |
2 |
G |
C |
G |
A |
G |
G |
A |
T |
G |
C |
T |
A |
C |
A |
8 |
A |
T |
C |
T |
C |
A |
G |
18 |
A |
T |
G |
2 |
4 |
T |
T |
T |
T |
G |
A |
T |
A |
A |
C |
T |
G |
T |
G |
G |
A |
G |
C |
T |
C |
A |
T |
G |
A |
C |
T |
A |
C |
T |
T |
G |
C |
C |
A |
T |
A |
C |
T |
G |
T |
C |
T |
8 |
6 |
T |
T |
A |
T |
4 |
A |
C |
T |
2 |
116 |
T |
C |
C |
A |
A |
C |
G |
4 |
4 |
T |
A |
C |
A |
A |
A |
G |
6 |
A |
6 |
T |
T |
C |
A |
A |
G |
G |
C |
C |
C |
C |
G |
T |
T |
C |
C |
G |
G |
T |
T |
A |
A |
G |
G |
G |
T |
T |
T |
T |
T |
T |
A |
A |
C |
T |
T |
A |
A |
T |
A |
G |
T |
C |
C |
A |
C |
G |
G |
G |
T |
16 |
A |
T |
A |
G |
T |
T |
26 |
A |
4 |
T |
A |
C |
C |
T |
A |
T |
T |
A |
C |
T |
A |
G |
A |
20 |
G |
T |
A |
T |
A |
A |
G |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
T
|
C
|
G
|
T
|
G
|
T
|
C
|
A
|
-
|
C
|
C
|
2
|
-
|
-
|
-
|
A
|
G
|
G
|
3
|
A
|
G
|
-
|
C
|
A
|
-
|
C
|
T
|
C
|
A
|
C
|
A
|
A
|
-
|
G
|
A
|
C
|
A
|
T
|
T
|
C
|
T
|
T
|
C
|
C
|
A
|
G
|
C
|
A
|
5/3
|
-
|
C
|
T
|
2
|
4
|
G
|
T
|
-
|
A
|
-
|
2
|
2
|
C
|
G
|
T
|
2
|
G
|
A
|
T
|
C
|
C
|
G
|
A
|
G
|
G
|
T
|
G
|
G
|
A
|
G
|
C
|
C
|
C
|
-
|
2
|
T
|
A
|
A
|
-
|
A
|
2
|
C
|
C
|
T
|
C
|
T
|
A
|
A
|
G
|
T
|
-
|
-
|
C
|
2
|
G
|
4/3
|
G
|
G
|
A
|
8/-
|
-
|
2
|
T
|
15
|
2
|
2
|
C
|
T
|
C
|
T
|
A
|
-
|
A
|
89
|
A
|
A
|
-
|
3
|
2
|
2
|
T
|
A
|
T
|
2
|
-
|
-
|
-
|
4
|
-
|
3
|
T
|
-
|
2
|
C
|
G
|
7
|
A
|
2/-
|
A/-
|
-
|
A
|
G
|
T
|
C
|
-
|
10/-
|
-
|
A
|
C
|
G
|
C
|
A
|
A
|
A
|
-
|
G
|
T
|
17/-
|
-
|
C
|
3
|
G
|
8/-
|
6/-
|
T
|
G
|
G
|
C/13
|
C/11
|
2
|
-
|
4
|
13
|
A
|
-
|
A
|
G
|
G
|
A
|
T
|
-
|
T
|
C
|
C
|
A
|
C
|
C
|
A
|
C
|
C
|
C
|
A
|
C
|
T
|
T
|
T
|
-
|
-
|
G
|
A/-
|
T/C
|
T/C
|
3/-
|
-
|
A
|
A
|
T
|
19
|
23
|
C
|
A
|
-
|
G
|
A
|
C
|
G
|
T
|
-
|
11/-
|
A
|
C
|
C
|
C
|
2
|
T
|
C
|
-
|
-
|
T
|
G
|
13
|
A
|
A
|
A
|
-
|
-
|
G
|
G
|
A
|
A
|
A
|
A
|
T
|
G
|
T
|
G
|
2
|
43
|
2/-
|
3
|
-
|
16/-
|
14/-
|
12/-
|
2/-
|
-
|
A
|
G
|
A
|
4
|
-
|
G
|
G
|
A
|
G
|
A
|
3
|
C
|
-
|
A
|
T
|
G
|
9
|
T
|
-
|
-
|
C
|
G
|
G
|
G
|
T
|
5/7
|
C
|
T
|
-
|
C
|
T
|
-
|
G
|
A
|
3
|
2
|
-
|
-
|
-
|
-
|
-
|
T
|
T
|
-
|
9
|
9
|
T
|
-
|
2
|
T
|
G
|
-
|
7/9
|
C
|
T
|
C
|
T
|
G
|
A
|
-
|
G
|
C
|
A
|
-
|
-
|
C
|
C
|
-
|
A
|
A
|
6
|
25
|
G
|
G
|
-
|
2
|
A
|
-
|
A
|
A
|
C
|
C
|
T
|
C
|
T
|
C
|
C
|
A
|
C
|
G
|
C
|
G
|
3/4
|
C
|
G
|
T
|
A
|
C/2
|
-
|
C
|
G
|
T
|
G
|
C
|
C
|
A
|
C
|
8/-
|
6/-
|
2
|
C
|
G
|
A
|
-
|
G
|
T
|
-
|
-
|
116/-
|
C
|
A
|
T
|
G
|
G
|
A
|
A
|
-
|
-
|
G
|
-
|
G
|
T
|
2
|
-
|
26
|
-
|
G
|
-
|
A
|
5/3
|
T
|
G
|
T
|
A
|
A
|
T
|
T
|
T
|
G
|
A
|
C
|
C
|
A
|
T
|
A
|
T
|
C
|
A
|
G
|
T
|
A
|
A
|
A
|
-
|
C
|
3
|
C
|
4
|
G
|
22
|
5
|
A
|
C
|
C
|
-
|
G
|
C
|
6
|
A
|
C
|
T
|
T
|
2
|
19
|
T
|
A
|
A
|
2
|
16/-
|
G
|
G
|
T
|
T
|
A
|
G
|
-
|
2
|
-
|
C
|
T
|
A
|
T
|
C
|
G
|
C
|
G
|
G
|
T
|
-
|
G
|
A
|
G
|
-
|
A
|
C
|
C
|
2
|
A/-
|
A/-
|
A
|
|