|
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.011 |
.0 |
.001 |
.007 |
.051 |
.566 |
.035 |
.021 |
.015 |
.446 |
.023 |
.114 |
.0 |
.012 |
.324 |
.0 |
.001 |
.003 |
.013 |
.003 |
.0 |
.006 |
.0 |
.0 |
.001 |
.0 |
.056 |
.015 |
.001 |
.012 |
.064 |
.017 |
.191 |
.056 |
.206 |
.041 |
-- |
.515 |
.044 |
.0 |
-- |
.05 |
.718 |
.025 |
.002 |
.009 |
.0 |
.001 |
.276 |
.348 |
.399 |
.0 |
.021 |
.125 |
.118 |
.0 |
.008 |
.026 |
.001 |
.001 |
.277 |
.084 |
.288 |
.143 |
.02 |
.06 |
.05 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.181 |
-- |
-- |
-- |
-- |
-- |
-- |
.051 |
.014 |
.005 |
.001 |
.811 |
.047 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.018 |
.012 |
.057 |
.022 |
.242 |
.128 |
-- |
-- |
-- |
-- |
-- |
-- |
.023 |
.283 |
.006 |
.07 |
.076 |
.01 |
.002 |
.001 |
.0 |
.014 |
.007 |
.001 |
.056 |
.002 |
.013 |
.129 |
.063 |
.637 |
.026 |
.018 |
.002 |
.006 |
.024 |
.006 |
.009 |
-- |
-- |
.002 |
.048 |
.002 |
.005 |
.001 |
.564 |
.003 |
.003 |
.0 |
.006 |
.004 |
.0 |
.014 |
.0 |
.16 |
.012 |
.031 |
.0 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.01 |
.008 |
.0 |
.009 |
.015 |
.01 |
.017 |
.015 |
.047 |
.022 |
.229 |
.227 |
.605 |
.19 |
.994 |
.998 |
.897 |
.111 |
.0 |
.0 |
.009 |
.001 |
.002 |
.021 |
.023 |
.024 |
.016 |
.002 |
.0 |
.0 |
.0 |
.003 |
.353 |
.001 |
.004 |
.007 |
.003 |
.002 |
.017 |
.173 |
.008 |
.185 |
.011 |
.001 |
.001 |
.196 |
.945 |
.864 |
.062 |
.032 |
.02 |
.009 |
.026 |
.025 |
.006 |
.002 |
.139 |
.59 |
.098 |
.387 |
.025 |
.0 |
.011 |
.003 |
.114 |
-- |
.003 |
.51 |
.289 |
.612 |
.24 |
.365 |
.609 |
.984 |
.298 |
.227 |
.002 |
.043 |
.308 |
1.0 |
.038 |
.004 |
.147 |
.0 |
.037 |
.021 |
.063 |
.047 |
.007 |
.228 |
.022 |
.012 |
.001 |
.03 |
.044 |
.006 |
.012 |
.014 |
.643 |
.006 |
.003 |
.016 |
.0 |
.002 |
.0 |
.0 |
.002 |
.047 |
.297 |
.002 |
.799 |
.005 |
.001 |
.001 |
.005 |
.001 |
.0 |
.001 |
.041 |
.038 |
.165 |
.017 |
.244 |
.024 |
.012 |
.168 |
.198 |
.01 |
.075 |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.028 |
.009 |
.0 |
.004 |
.055 |
.002 |
.006 |
.0 |
.011 |
.031 |
.358 |
.013 |
.015 |
.057 |
.061 |
.001 |
.007 |
-- |
.0 |
.002 |
.09 |
.003 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.056 |
.718 |
.135 |
.137 |
.008 |
.004 |
.001 |
.003 |
.007 |
.017 |
.0 |
-- |
.005 |
.021 |
.97 |
.998 |
.032 |
.002 |
.031 |
.0 |
.001 |
.018 |
.001 |
.992 |
.001 |
.001 |
.007 |
.994 |
.231 |
.079 |
.079 |
.594 |
.0 |
.453 |
.007 |
.0 |
.001 |
.009 |
.013 |
.001 |
.018 |
.011 |
.001 |
.411 |
.005 |
-- |
-- |
-- |
-- |
-- |
.018 |
.0 |
.003 |
.043 |
.162 |
.071 |
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
Cftr
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
T |
A |
C |
C |
G |
G |
T |
C |
A |
A |
G |
C |
G |
G |
A |
G |
T |
G |
G |
A |
G |
C |
G |
A |
C |
T |
T |
T |
A |
C |
G |
G |
T |
T |
T |
A |
A |
G |
10 |
8 |
C |
C |
G |
T |
A |
A |
3 |
T |
T |
C |
G |
C |
T |
G |
A |
C |
G |
C |
T |
A |
A |
G |
G |
T |
C |
G |
C |
G |
C |
A |
A |
G |
T |
A |
G |
T |
A |
18 |
A |
T |
C |
C |
G |
6 |
A |
T |
A |
G |
C |
A |
T |
A |
A |
2 |
G |
A |
T |
C |
A |
C |
A |
A |
G |
C |
T |
A |
G |
A |
T |
A |
C |
A |
6 |
2 |
2 |
C |
C |
6 |
T |
A |
A |
G |
T |
T |
C |
T |
C |
2 |
T |
T |
G |
A |
T |
G |
T |
A |
T |
G |
A |
T |
G |
A |
T |
T |
G |
T |
A |
T |
T |
A |
T |
G |
G |
G |
T |
C |
A |
G |
A |
A |
C |
T |
G |
T |
G |
T |
A |
C |
A |
C |
T |
21 |
C |
G |
T |
T |
T |
G |
A |
C |
A |
C |
C |
G |
G |
G |
G |
T |
G |
T |
C |
T |
A |
T |
T |
A |
G |
A |
C |
A |
G |
A |
G |
A |
T |
A |
A |
3 |
11 |
T |
G |
C |
G |
A |
C |
A |
A |
3 |
A |
A |
C |
T |
C |
C |
A |
A |
C |
C |
A |
T |
T |
C |
T |
14 |
A |
C |
A |
G |
T |
T |
T |
G |
G |
C |
A |
A |
G |
6 |
T |
A |
A |
C |
G |
2 |
G |
A |
T |
G |
C |
G |
T |
G |
5 |
G |
G |
T |
A |
A |
C |
A |
G |
C |
A |
2 |
2 |
2 |
15 |
A |
C |
28 |
T |
A |
T |
T |
T |
A |
A |
G |
C |
A |
C |
A |
T |
A |
C |
T |
A |
G |
T |
C |
T |
T |
T |
T |
T |
G |
C |
A |
G |
4 |
A |
T |
T |
A |
T |
C |
C |
T |
A |
G |
T |
G |
2 |
T |
A |
A |
A |
C |
4 |
2 |
G |
T |
A |
T |
C |
C |
T |
T |
T |
A |
119 |
G |
G |
A |
C |
12 |
A |
A |
A |
10 |
A |
A |
G |
C |
A |
A |
C |
T |
16 |
T |
C |
G |
G |
11 |
A |
T |
A |
T |
A |
G |
C |
T |
T |
T |
G |
G |
C |
A |
C |
T |
A |
G |
G |
3 |
A |
4 |
A |
A |
C |
2 |
A |
4 |
T |
T |
A |
T |
T |
C |
T |
C |
A |
A |
T |
G |
G |
T |
A |
C |
C |
T |
A |
T |
T |
C |
G |
A |
G |
C |
T |
G |
C |
A |
G |
A |
C |
2 |
G |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
2
|
G
|
8
|
T
|
T
|
G/3
|
G
|
T
|
T
|
A/2
|
A
|
C/A
|
C
|
T
|
C
|
A
|
G
|
A
|
T
|
G
|
T
|
G
|
C
|
T
|
T
|
C
|
A
|
C
|
T
|
T
|
A
|
A
|
G
|
T/C
|
2
|
-
|
G
|
A
|
10/-
|
-
|
T
|
T
|
C
|
C
|
C
|
G
|
-
|
-
|
3
|
G
|
A
|
T
|
C
|
2
|
G
|
A
|
T
|
T
|
T/C
|
G
|
G
|
13
|
A
|
C
|
5
|
A
|
A
|
9
|
T
|
T
|
4
|
A
|
C
|
T
|
A
|
G
|
G
|
-
|
-
|
C
|
T
|
G
|
T
|
6/-
|
T
|
C
|
G
|
2
|
T
|
T
|
C
|
5
|
3
|
-
|
C
|
G
|
G
|
T
|
-
|
A
|
G
|
T
|
C
|
T
|
A
|
G
|
A
|
G
|
2
|
T
|
A
|
G
|
-
|
-
|
-
|
2
|
G
|
-
|
C
|
G
|
G
|
A
|
A
|
C
|
T
|
-
|
T
|
-
|
2
|
G
|
A
|
G
|
C
|
A
|
G
|
G
|
C
|
A
|
G
|
C
|
A
|
2
|
C
|
2
|
T
|
-
|
G
|
-
|
C
|
C
|
C
|
T
|
A
|
T
|
C
|
G
|
C
|
11
|
C
|
G
|
G
|
C
|
C
|
-
|
T
|
C
|
7/13
|
G
|
G
|
3
|
C
|
-
|
A
|
2
|
A
|
A
|
C
|
A
|
G
|
A
|
G
|
T
|
T
|
T
|
2
|
A
|
T
|
C
|
A
|
A
|
G
|
C
|
G
|
A
|
3
|
G
|
T
|
G
|
T
|
G
|
A
|
G
|
T
|
T
|
C
|
C
|
G
|
-
|
-
|
-
|
A
|
5
|
A
|
T
|
T
|
T
|
G
|
-
|
-
|
T
|
A
|
A
|
T
|
T
|
T
|
T
|
3
|
A
|
G
|
G
|
G
|
A
|
A
|
-
|
G
|
T
|
G
|
-
|
C
|
G
|
C
|
A
|
A
|
T
|
2
|
G
|
T
|
-
|
10
|
G
|
T
|
T
|
4
|
-
|
C
|
2
|
A
|
A
|
T
|
C
|
-
|
-
|
-
|
A
|
A
|
C
|
G
|
G
|
G
|
2
|
A
|
T
|
2
|
-
|
2/-
|
2/-
|
-
|
G
|
A
|
-
|
C
|
3
|
C
|
C
|
-
|
2
|
-
|
T
|
A
|
A/21
|
T
|
G
|
C
|
G
|
G
|
C
|
T
|
2
|
C
|
G
|
A
|
C
|
A
|
-
|
G
|
A
|
A
|
T
|
T
|
-
|
G
|
T/G
|
G
|
-
|
-
|
T
|
4
|
C
|
T
|
C
|
G
|
A
|
-
|
C
|
C
|
-
|
G
|
T
|
-
|
2/-
|
2
|
C
|
T
|
5
|
T
|
A
|
2
|
T/17
|
A
|
C
|
-
|
-
|
A
|
T
|
T
|
-
|
C
|
C
|
C
|
10/-
|
C
|
G
|
A
|
T
|
-
|
G
|
-
|
C
|
-
|
A
|
T
|
A
|
T
|
-
|
G
|
-
|
11
|
G
|
G
|
A
|
T
|
G
|
G
|
A
|
T
|
T
|
2
|
-
|
A
|
A
|
G
|
A
|
-
|
-
|
-
|
-
|
3
|
T
|
A
|
-
|
G
|
-
|
C
|
C
|
G
|
G
|
A
|
T
|
A
|
C/3
|
G
|
C
|
G
|
2
|
A
|
C
|
2
|
A
|
T
|
C
|
C
|
A
|
C
|
T
|
3/13
|
G
|
A
|
G
|
A
|
A
|
-
|
G
|
5
|
G
|
T
|
2/-
|
T
|
|