|
.535 |
.0 |
.293 |
.772 |
.0 |
.003 |
.004 |
.005 |
.089 |
.0 |
.001 |
.0 |
.0 |
.001 |
.297 |
.0 |
.002 |
.001 |
.002 |
.076 |
.02 |
.153 |
.009 |
.015 |
.981 |
.006 |
.023 |
.012 |
.658 |
.007 |
.0 |
.001 |
.076 |
.094 |
.288 |
.014 |
.006 |
.012 |
.009 |
.007 |
.0 |
.158 |
.161 |
.007 |
.001 |
.007 |
-- |
-- |
.225 |
.367 |
.003 |
.001 |
.0 |
.462 |
.009 |
.836 |
-- |
.006 |
-- |
.021 |
.006 |
.0 |
.268 |
.001 |
.002 |
.304 |
-- |
-- |
-- |
-- |
-- |
.004 |
-- |
.0 |
.004 |
.012 |
.039 |
.221 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.281 |
.004 |
.0 |
.001 |
.001 |
.027 |
.003 |
.005 |
.002 |
.005 |
.94 |
.001 |
.005 |
.004 |
.007 |
.506 |
.507 |
.662 |
.001 |
.002 |
.001 |
.011 |
.0 |
.001 |
.011 |
-- |
-- |
.014 |
.001 |
.0 |
.0 |
.397 |
.012 |
.018 |
.001 |
.0 |
.223 |
.086 |
.086 |
.0 |
.0 |
.0 |
.023 |
.004 |
.993 |
.999 |
.352 |
.0 |
-- |
.022 |
.011 |
.028 |
.873 |
.01 |
.0 |
.0 |
.001 |
.0 |
.001 |
.015 |
.017 |
.0 |
.0 |
.005 |
.007 |
.028 |
.007 |
.085 |
.0 |
.995 |
.326 |
.002 |
.0 |
.125 |
.023 |
.004 |
.001 |
.005 |
.066 |
.998 |
-- |
.963 |
-- |
-- |
.005 |
.0 |
.073 |
.111 |
.096 |
.001 |
.001 |
.002 |
.001 |
.007 |
.001 |
.014 |
.007 |
.001 |
.049 |
.02 |
.157 |
-- |
.005 |
.005 |
.002 |
.005 |
.001 |
.001 |
.0 |
.016 |
.998 |
.69 |
.991 |
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
Smad3
|
|
A |
A |
A |
G |
C |
G |
T |
T |
C |
A |
A |
G |
T |
6 |
T |
A |
10 |
T |
G |
C |
C |
C |
G |
T |
T |
C |
2 |
A |
G |
A |
G |
A |
A |
18 |
G |
T |
A |
T |
A |
T |
A |
C |
2 |
C |
8 |
2 |
T |
T |
A |
C |
C |
2 |
G |
T |
20 |
G |
G |
G |
10 |
T |
G |
C |
G |
6 |
G |
C |
G |
G |
2 |
G |
G |
30 |
A |
C |
A |
C |
C |
C |
2 |
G |
G |
C |
C |
T |
T |
G |
T |
A |
G |
C |
G |
T |
A |
T |
A |
C |
T |
T |
C |
G |
C |
C |
24 |
C |
A |
A |
T |
G |
A |
G |
G |
A |
A |
T |
A |
T |
A |
A |
G |
C |
C |
A |
A |
A |
A |
T |
C |
C |
G |
G |
C |
G |
T |
C |
A |
T |
A |
G |
C |
G |
T |
G |
A |
A |
G |
C |
C |
A |
G |
T |
C |
A |
C |
G |
C |
C |
6 |
A |
T |
A |
A |
T |
G |
C |
C |
G |
C |
T |
5 |
C |
C |
G |
G |
2 |
A |
5 |
G |
A |
6 |
G |
A |
A |
T |
T |
2 |
16 |
A |
T |
11 |
C |
A |
A |
T |
T |
T |
T |
C |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
G
|
2
|
A
|
T
|
A
|
C
|
C
|
T
|
G
|
G
|
A
|
A
|
-
|
C
|
G
|
-
|
A
|
A
|
A
|
T
|
T
|
6
|
C
|
C
|
T
|
-
|
G
|
C
|
G
|
A
|
G
|
G
|
18/-
|
T
|
C
|
T
|
8
|
C
|
G
|
-
|
C/3
|
2/-
|
T
|
8/-
|
-
|
A
|
-
|
T
|
2
|
A
|
-
|
T
|
C
|
20/-
|
5
|
A
|
2
|
-
|
2
|
A
|
T
|
C
|
-
|
T
|
7
|
3
|
-
|
-
|
25/5
|
C
|
-
|
C
|
-
|
-
|
A
|
T
|
T
|
-
|
A
|
T
|
G
|
T
|
106
|
C
|
A
|
-
|
G
|
A
|
T
|
A
|
C
|
G
|
C
|
G
|
T
|
G
|
C
|
T
|
A
|
2
|
A
|
-
|
T
|
G
|
3
|
C
|
A
|
C
|
A
|
T
|
G
|
G
|
G
|
G
|
C
|
3
|
G
|
5
|
T
|
T
|
A/7
|
T
|
T
|
G
|
C
|
T
|
A
|
A
|
A
|
T
|
A
|
G
|
T
|
G
|
2
|
C
|
A
|
4
|
3
|
A
|
T
|
G
|
G
|
A
|
A
|
T
|
C
|
T
|
C
|
T
|
AG/3
|
T
|
A
|
T
|
A
|
-
|
G
|
A
|
G
|
T
|
C
|
11
|
-
|
3
|
11
|
3
|
3
|
-
|
C/4
|
T
|
A
|
A
|
-
|
A/-
|
5/-
|
A
|
C
|
-
|
A
|
3
|
T
|
C
|
C
|
-
|
16/-
|
G
|
C
|
11/-
|
T
|
G
|
9
|
A
|
C
|
C
|
C
|
T
|
T
|
|