|
.001 |
.0 |
.936 |
1.0 |
1.0 |
1.0 |
.968 |
.765 |
1.0 |
.997 |
.005 |
.062 |
.017 |
.015 |
.008 |
.017 |
.018 |
.016 |
.01 |
.008 |
.005 |
.002 |
.02 |
.003 |
.013 |
.005 |
.01 |
.007 |
.002 |
.015 |
.373 |
.009 |
.004 |
.003 |
.098 |
.014 |
.002 |
.0 |
.15 |
.0 |
.0 |
.001 |
.001 |
.03 |
.045 |
.0 |
.316 |
.02 |
.001 |
.006 |
.0 |
.878 |
.884 |
1.0 |
.0 |
.0 |
.001 |
.0 |
.003 |
.001 |
.078 |
.664 |
.941 |
.015 |
.001 |
.001 |
.001 |
.024 |
.03 |
.011 |
.004 |
.003 |
.003 |
.003 |
.0 |
.002 |
.056 |
.118 |
.009 |
.001 |
.004 |
.013 |
.07 |
.019 |
.005 |
.007 |
.004 |
.165 |
.085 |
.004 |
.229 |
.005 |
.002 |
.001 |
.007 |
.0 |
.001 |
.0 |
.001 |
.011 |
.001 |
.023 |
.044 |
.006 |
.0 |
.001 |
.0 |
.025 |
.001 |
.005 |
.011 |
.002 |
.05 |
.482 |
.001 |
.0 |
.0 |
.003 |
.27 |
.001 |
.001 |
.001 |
.961 |
.905 |
.006 |
.003 |
.001 |
.164 |
.001 |
.018 |
.2 |
.0 |
.034 |
.155 |
.004 |
.025 |
.008 |
-- |
-- |
-- |
.034 |
.0 |
.023 |
.031 |
.001 |
.008 |
.09 |
.003 |
.04 |
.002 |
.0 |
.005 |
.015 |
.007 |
.003 |
.08 |
.004 |
.011 |
.01 |
.001 |
.002 |
.0 |
.158 |
.001 |
.002 |
.004 |
.005 |
.001 |
.0 |
.0 |
.0 |
.051 |
.01 |
.062 |
.004 |
.0 |
.149 |
.076 |
.145 |
.0 |
.0 |
.009 |
.124 |
.004 |
.0 |
.001 |
.001 |
.0 |
.036 |
.013 |
.003 |
.0 |
.009 |
.001 |
.001 |
.551 |
.819 |
.007 |
.038 |
.006 |
.002 |
.001 |
.0 |
.942 |
1.0 |
.0 |
.244 |
.001 |
-- |
-- |
.001 |
.001 |
.964 |
.506 |
.007 |
.006 |
.005 |
.001 |
.0 |
.0 |
.008 |
1.0 |
.975 |
.824 |
.922 |
.0 |
.001 |
.001 |
.005 |
.0 |
.069 |
.003 |
.046 |
.0 |
.008 |
.002 |
.001 |
.01 |
.008 |
.003 |
.013 |
.003 |
.019 |
.003 |
.003 |
.002 |
.0 |
.003 |
.066 |
.948 |
.987 |
.968 |
.978 |
.159 |
.001 |
.0 |
.001 |
.0 |
.217 |
.001 |
.001 |
.084 |
.001 |
.0 |
.002 |
.01 |
.006 |
.015 |
.01 |
.734 |
.002 |
.0 |
.055 |
.001 |
.006 |
.198 |
.206 |
.018 |
.03 |
.264 |
.228 |
.192 |
.211 |
.018 |
.019 |
.03 |
-- |
-- |
.014 |
.099 |
.085 |
.18 |
.139 |
.001 |
.022 |
.098 |
1.0 |
.998 |
.256 |
.014 |
.009 |
.085 |
.078 |
.029 |
.001 |
.0 |
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
Scn9a
|
|
C |
T |
A |
A |
A |
G |
A |
A |
C |
G |
G |
A |
A |
C |
G |
T |
C |
C |
C |
C |
T |
T |
A |
T |
T |
C |
C |
T |
G |
A |
T |
A |
A |
T |
G |
G |
C |
A |
T |
A |
T |
A |
T |
T |
C |
G |
A |
G |
C |
G |
T |
G |
G |
C |
G |
G |
C |
G |
A |
G |
A |
T |
4 |
T |
T |
A |
A |
T |
G |
G |
T |
T |
A |
A |
T |
C |
T |
T |
T |
A |
T |
T |
G |
C |
C |
T |
C |
T |
T |
T |
T |
C |
T |
T |
A |
C |
T |
C |
G |
T |
G |
G |
T |
A |
G |
G |
T |
C |
G |
A |
A |
T |
A |
A |
G |
G |
A |
A |
T |
C |
C |
C |
A |
A |
A |
T |
C |
A |
C |
C |
G |
T |
A |
T |
A |
A |
G |
G |
T |
C |
T |
C |
C |
G |
T |
G |
A |
G |
A |
A |
A |
G |
T |
T |
A |
A |
C |
C |
C |
C |
C |
G |
A |
A |
T |
G |
G |
T |
T |
A |
T |
A |
C |
G |
C |
A |
T |
A |
A |
A |
T |
T |
A |
T |
T |
T |
A |
A |
T |
G |
T |
C |
C |
A |
A |
G |
G |
G |
T |
T |
C |
2 |
T |
A |
T |
G |
T |
A |
G |
A |
C |
2 |
T |
A |
T |
G |
C |
A |
C |
C |
T |
C |
C |
C |
A |
A |
A |
T |
A |
G |
A |
T |
A |
C |
G |
T |
A |
8 |
3 |
4 |
5 |
C |
T |
T |
T |
T |
C |
2 |
G |
T |
4 |
T |
T |
G |
C |
A |
C |
G |
2 |
G |
A |
T |
C |
T |
A |
16 |
22 |
G |
A |
C |
C |
T |
T |
C |
A |
C |
C |
G |
C |
A |
G |
C |
T |
T |
T |
G |
C |
T |
A |
A |
T |
10 |
2 |
C |
2 |
T |
8 |
5 |
T |
C |
C |
G |
A |
A |
A |
T |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
A
|
G
|
A/G
|
G
|
G
|
A
|
G
|
G
|
G
|
G/A
|
T
|
T
|
G
|
C/T
|
T
|
T/2
|
C/T
|
C/T
|
C/T
|
T
|
T/C
|
T/C
|
C
|
C
|
C
|
T
|
T
|
C
|
A
|
A/T
|
2
|
G
|
G
|
2
|
9
|
C
|
A
|
G
|
C
|
2
|
C
|
2
|
C
|
G
|
T
|
T
|
T
|
A
|
A
|
A
|
C
|
5
|
G/A
|
T
|
C
|
A
|
T
|
-
|
-
|
A
|
T
|
-
|
-
|
C
|
G
|
3/4
|
-
|
C
|
A
|
A
|
C
|
C
|
G
|
25
|
C
|
G
|
A
|
C
|
G
|
G
|
C
|
G
|
A
|
G
|
T
|
G
|
T
|
A
|
2
|
C
|
G
|
T
|
C
|
C
|
G
|
G
|
G
|
T
|
A
|
C
|
A
|
A
|
A
|
G
|
C
|
T
|
C
|
T
|
A
|
-
|
C
|
A
|
3
|
G
|
T
|
A
|
G
|
-
|
C
|
A
|
T
|
T
|
G
|
-
|
T
|
C
|
T
|
-
|
T
|
2
|
A
|
G
|
C
|
C
|
G
|
G
|
A
|
C
|
G
|
A
|
A
|
CT/3
|
CT/3
|
A
|
C
|
A
|
G
|
C
|
2
|
G
|
G
|
?
|
A
|
5
|
G
|
C
|
T
|
T
|
A
|
A
|
A
|
A
|
-
|
G
|
A
|
A
|
C
|
C
|
G
|
3
|
3
|
T
|
-
|
T
|
T
|
G
|
C
|
G
|
C
|
5
|
C
|
A
|
G
|
C
|
C
|
C
|
G
|
C
|
C
|
T
|
T/A
|
C/T
|
C/T
|
T
|
G
|
A
|
T
|
A
|
C
|
A
|
T
|
-
|
C
|
G
|
G
|
T
|
C
|
G
|
T
|
G
|
C/G
|
2/-
|
C
|
T
|
C
|
A
|
G
|
C
|
T
|
A
|
C
|
G
|
C/G
|
C/T
|
G
|
G
|
C
|
C
|
T
|
T
|
C
|
C
|
2
|
-
|
A
|
C
|
C
|
-
|
3/-
|
4/-
|
5/-
|
T
|
T/C
|
T/C
|
T/C
|
T/C
|
C/T
|
2/-
|
A
|
C
|
-
|
T/-
|
C
|
A
|
T
|
G
|
T
|
A
|
-
|
2
|
2
|
A
|
T
|
C
|
2
|
16/-
|
-
|
A
|
G
|
T
|
2
|
C
|
G
|
T
|
T
|
C/T
|
T
|
A
|
T
|
5
|
G/C
|
5
|
T/5
|
2
|
15
|
G/-
|
T
|
C
|
G
|
C
|
3
|
10/-
|
2/-
|
C/G
|
2/-
|
A
|
8/-
|
5/-
|
C
|
T
|
T
|
C
|
G
|
G
|
T
|
-
|
|