|
.0 |
.0 |
.0 |
.003 |
.126 |
.254 |
.026 |
.001 |
.316 |
.024 |
.171 |
.331 |
.161 |
.014 |
.012 |
.003 |
.051 |
.005 |
.148 |
.243 |
.44 |
.005 |
.145 |
.002 |
.001 |
.001 |
.0 |
.063 |
.083 |
.083 |
.114 |
.043 |
.0 |
.0 |
.303 |
.001 |
.031 |
.002 |
.0 |
.004 |
.003 |
.003 |
.041 |
.034 |
.0 |
.001 |
.01 |
.004 |
.0 |
.001 |
.111 |
.0 |
.0 |
.0 |
.01 |
.01 |
-- |
-- |
-- |
.001 |
.002 |
.0 |
.0 |
.275 |
.007 |
.003 |
.047 |
.033 |
.099 |
-- |
-- |
-- |
.677 |
.018 |
.16 |
.993 |
.988 |
.992 |
.007 |
.017 |
.003 |
.001 |
.02 |
.003 |
.0 |
.006 |
.009 |
.02 |
.003 |
.003 |
.01 |
-- |
-- |
-- |
-- |
.1 |
.002 |
.019 |
-- |
.159 |
.014 |
.006 |
.986 |
.003 |
.002 |
.003 |
.005 |
.277 |
.003 |
.001 |
.0 |
.004 |
.001 |
.011 |
.117 |
.218 |
.435 |
.014 |
.026 |
.025 |
.021 |
.016 |
.017 |
.075 |
.024 |
.046 |
.637 |
.03 |
.118 |
.025 |
.063 |
.486 |
.01 |
.016 |
.125 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.004 |
.001 |
.002 |
.368 |
.046 |
.005 |
.002 |
.013 |
.011 |
.207 |
.029 |
.022 |
.042 |
.032 |
.055 |
.002 |
.027 |
.001 |
.003 |
.154 |
.003 |
.0 |
.0 |
.01 |
.0 |
.001 |
.0 |
.004 |
.005 |
.001 |
.0 |
.001 |
.001 |
.001 |
.045 |
.018 |
.195 |
.241 |
.0 |
.002 |
.0 |
.0 |
.003 |
.113 |
.004 |
-- |
.003 |
.0 |
.004 |
.001 |
.003 |
.037 |
.002 |
.007 |
.0 |
.006 |
.0 |
.001 |
.174 |
.018 |
.017 |
.001 |
.001 |
.02 |
.022 |
.062 |
.016 |
.001 |
.016 |
.041 |
.041 |
.037 |
.044 |
.0 |
.013 |
.001 |
.023 |
.972 |
.989 |
.002 |
.003 |
.023 |
.0 |
.059 |
.02 |
.078 |
.123 |
.104 |
.1 |
.532 |
.057 |
.001 |
.013 |
-- |
-- |
-- |
.218 |
.315 |
.003 |
.213 |
.434 |
.004 |
.01 |
.015 |
.895 |
.99 |
.109 |
.02 |
-- |
-- |
-- |
.023 |
.015 |
.152 |
.059 |
.083 |
.097 |
.234 |
.031 |
.116 |
.0 |
.006 |
.002 |
.004 |
.001 |
.002 |
.034 |
.025 |
.006 |
.0 |
.012 |
.882 |
.049 |
.107 |
.341 |
.002 |
.0 |
.001 |
.01 |
.001 |
.001 |
.001 |
.0 |
.001 |
.007 |
.008 |
.004 |
.037 |
.279 |
.001 |
.001 |
.108 |
.021 |
.012 |
.054 |
.08 |
.347 |
.122 |
.42 |
.085 |
.168 |
.176 |
.004 |
.001 |
.002 |
.002 |
.047 |
.042 |
.001 |
.27 |
.419 |
.006 |
.0 |
.018 |
.067 |
.067 |
.023 |
.009 |
.002 |
.093 |
.001 |
.003 |
.217 |
.005 |
.0 |
.003 |
.0 |
.002 |
.008 |
.002 |
.003 |
.004 |
.002 |
.023 |
.001 |
.001 |
.001 |
.002 |
.005 |
.004 |
.018 |
.0 |
.916 |
.996 |
.462 |
.024 |
.148 |
.01 |
.002 |
.006 |
.002 |
.001 |
.002 |
.001 |
.047 |
.109 |
.011 |
.002 |
.065 |
.006 |
.034 |
.015 |
.331 |
.318 |
.04 |
.022 |
.023 |
.055 |
.008 |
.017 |
.002 |
.002 |
.001 |
.0 |
.0 |
.001 |
.006 |
.004 |
.003 |
.001 |
.023 |
.019 |
.02 |
.016 |
.001 |
.001 |
.001 |
.001 |
.092 |
.046 |
.004 |
.005 |
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
Pik3c3
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
A |
A |
A |
T |
C |
G |
G |
A |
C |
C |
C |
A |
T |
T |
T |
A |
G |
C |
G |
C |
4 |
T |
T |
A |
C |
C |
A |
G |
A |
G |
G |
G |
T |
G |
T |
G |
C |
G |
G |
T |
A |
5 |
G |
T |
A |
T |
T |
C |
4 |
A |
A |
5 |
C |
T |
C |
G |
T |
T |
T |
C |
G |
C |
T |
A |
G |
G |
T |
G |
G |
T |
A |
C |
T |
T |
C |
G |
A |
A |
G |
T |
G |
T |
A |
C |
T |
T |
T |
C |
A |
A |
C |
A |
G |
A |
G |
A |
G |
A |
C |
G |
C |
G |
C |
A |
T |
G |
G |
T |
C |
T |
A |
T |
T |
A |
T |
C |
A |
6 |
10 |
G |
G |
G |
A |
T |
G |
C |
A |
A |
C |
A |
A |
T |
A |
T |
T |
C |
A |
C |
T |
G |
A |
3 |
T |
C |
A |
G |
C |
G |
G |
C |
A |
G |
T |
4 |
A |
C |
T |
T |
A |
G |
C |
G |
C |
C |
T |
G |
C |
C |
G |
G |
T |
C |
G |
G |
T |
A |
C |
A |
A |
T |
A |
T |
A |
T |
C |
C |
C |
G |
C |
A |
G |
T |
T |
G |
G |
T |
C |
G |
G |
C |
C |
G |
G |
A |
A |
A |
T |
A |
A |
C |
A |
A |
A |
T |
G |
A |
T |
G |
A |
G |
A |
T |
T |
C |
A |
G |
G |
T |
T |
C |
G |
G |
T |
C |
T |
A |
A |
T |
G |
C |
T |
T |
G |
A |
C |
G |
C |
G |
A |
A |
A |
A |
A |
5 |
A |
G |
G |
2 |
G |
G |
C |
A |
T |
C |
A |
C |
C |
G |
T |
G |
G |
G |
A |
A |
T |
T |
G |
T |
A |
C |
T |
T |
C |
C |
T |
G |
C |
A |
G |
C |
C |
C |
T |
G |
C |
T |
A |
A |
T |
T |
C |
G |
A |
T |
T |
A |
G |
T |
A |
G |
T |
4 |
A |
A |
T |
C |
A |
T |
A |
T |
A |
T |
A |
G |
G |
A |
G |
T |
G |
C |
G |
G |
C |
A |
A |
A |
C |
T |
A |
G |
T |
G |
A |
C |
T |
A |
C |
T |
C |
A |
A |
A |
G |
A |
C |
G |
A |
C |
T |
G |
C |
A |
A |
T |
A |
G |
C |
C |
T |
A |
C |
2 |
A |
A |
A |
A |
C |
C |
T |
C |
T |
G |
T |
A |
A |
G |
C |
G |
T |
T |
A |
A |
G |
A |
A |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
G
|
G
|
C
|
G
|
4
|
4
|
T
|
C
|
A
|
G
|
C/T
|
G
|
C
|
C
|
C
|
C
|
A
|
2
|
5
|
T
|
-
|
C
|
5
|
G
|
T
|
A
|
G
|
A
|
A/G
|
A
|
A
|
A
|
A
|
C
|
C
|
A
|
G
|
A
|
T
|
C
|
G
|
-
|
A
|
C
|
C
|
C
|
-
|
T
|
-
|
3
|
A/G
|
-
|
T
|
2
|
T
|
A
|
C
|
G
|
C
|
T
|
A
|
T
|
G
|
C
|
A
|
A
|
C
|
A
|
A
|
C
|
G
|
C/3
|
A
|
C
|
T
|
A
|
G
|
G
|
A
|
3
|
A
|
C
|
G
|
T
|
G
|
C
|
C
|
A
|
C
|
G
|
T
|
A/-
|
G/A
|
A/G
|
G/A
|
9
|
A
|
T
|
3
|
T
|
G
|
2
|
T
|
G
|
C
|
A
|
C
|
C
|
T
|
C
|
C
|
G
|
3
|
3
|
C
|
G
|
T
|
-
|
-
|
G/C
|
G/A
|
G/A
|
G
|
-
|
-
|
4
|
G
|
G
|
C/2
|
C
|
T
|
C
|
G
|
C
|
C
|
G
|
T
|
G
|
C
|
2
|
G
|
-
|
C
|
T
|
G
|
C
|
T
|
A
|
A
|
G
|
G
|
A
|
A
|
-
|
G
|
T
|
G
|
C
|
C
|
A
|
A
|
A
|
G
|
T
|
C
|
A
|
T
|
T
|
4
|
A
|
G
|
A
|
-
|
T
|
C
|
T
|
T
|
G
|
T
|
C
|
4
|
C
|
G
|
C
|
T
|
G
|
G
|
A
|
G
|
3
|
C
|
C
|
G
|
A
|
A
|
C
|
T
|
A
|
3
|
A
|
T
|
A
|
A
|
C
|
G
|
G
|
G
|
G
|
G
|
T
|
G
|
G
|
2
|
C
|
A
|
-
|
C
|
A
|
3
|
A
|
G
|
C
|
C
|
2
|
G
|
C
|
A
|
C
|
C
|
A
|
A
|
A
|
C
|
4
|
A
|
G
|
G
|
A
|
A
|
T
|
A
|
2
|
A
|
C
|
T
|
A
|
T
|
A
|
5
|
C
|
C
|
G
|
T
|
-
|
C
|
C
|
A
|
-
|
A
|
2
|
T
|
2
|
C
|
3
|
G
|
T
|
T
|
A
|
C
|
C
|
A
|
A
|
G
|
G
|
C
|
C
|
A
|
C
|
G
|
T
|
C
|
C
|
T
|
T
|
G
|
A
|
A
|
T
|
T
|
T
|
T
|
T
|
C
|
T
|
T
|
A
|
G
|
G
|
C
|
C
|
T
|
T
|
7
|
T/5
|
C
|
A/T
|
A
|
C
|
G
|
A
|
G
|
-
|
G
|
C
|
C
|
T
|
G
|
C
|
G
|
C
|
G
|
C
|
G
|
A
|
A
|
G
|
A
|
C
|
6
|
G
|
C
|
5
|
T
|
G
|
T
|
G
|
A
|
C
|
G
|
C
|
A
|
A
|
G
|
G
|
A
|
G
|
T
|
C
|
T
|
G
|
G
|
G
|
A
|
G
|
T
|
A
|
G
|
T
|
C
|
A
|
T
|
G
|
2
|
G
|
G
|
A
|
G
|
T
|
A
|
G
|
G
|
-
|
G
|
G
|
C
|
G
|
T
|
T
|
C
|
T
|
2
|
A
|
C
|
G
|
C
|
T
|
T
|
A
|
2
|
G
|
T
|
C
|
C
|
G
|
C
|
C
|
|