|
.008 |
.01 |
.004 |
.004 |
.001 |
.001 |
.004 |
.402 |
.01 |
.0 |
.007 |
.0 |
.158 |
.026 |
.001 |
.0 |
.007 |
.001 |
.046 |
.034 |
.197 |
.001 |
.003 |
.273 |
.089 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.094 |
.011 |
.521 |
-- |
-- |
.581 |
.008 |
.001 |
.0 |
.005 |
.009 |
.001 |
.015 |
.031 |
.041 |
.003 |
.001 |
.004 |
.171 |
.001 |
.0 |
.057 |
.008 |
.065 |
.009 |
.011 |
.004 |
.002 |
.0 |
.174 |
.067 |
-- |
-- |
-- |
-- |
.009 |
.013 |
.092 |
1.0 |
1.0 |
.031 |
.001 |
.131 |
.019 |
.001 |
.001 |
.002 |
.014 |
.001 |
.0 |
.0 |
.001 |
.007 |
.002 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.0 |
.001 |
.086 |
.008 |
.0 |
.121 |
.04 |
.02 |
.049 |
.003 |
.3 |
.16 |
.059 |
.001 |
.0 |
.0 |
.0 |
.261 |
.006 |
.001 |
.001 |
.074 |
.429 |
.022 |
.001 |
.0 |
.032 |
.001 |
.0 |
.003 |
.005 |
.002 |
.036 |
.024 |
.0 |
.947 |
.067 |
.039 |
.0 |
.013 |
.848 |
.741 |
.009 |
.065 |
.203 |
.429 |
-- |
.0 |
.079 |
.01 |
.023 |
.022 |
.001 |
.001 |
.029 |
.959 |
.004 |
.077 |
.004 |
.115 |
.702 |
.128 |
-- |
-- |
-- |
-- |
-- |
.416 |
.367 |
.007 |
.048 |
.075 |
.004 |
.0 |
.001 |
.0 |
.002 |
.0 |
.001 |
.0 |
.0 |
.001 |
.011 |
.001 |
.006 |
.0 |
.989 |
.855 |
.903 |
.997 |
.001 |
.0 |
.057 |
.039 |
.005 |
.002 |
.028 |
.193 |
.176 |
.002 |
.008 |
.311 |
.031 |
.001 |
.001 |
.014 |
.006 |
.004 |
.096 |
.04 |
.012 |
.074 |
.003 |
.003 |
.001 |
.002 |
.003 |
.003 |
.0 |
.013 |
.007 |
.0 |
.005 |
.008 |
.001 |
.011 |
.014 |
.133 |
.079 |
.03 |
.027 |
.002 |
.049 |
.001 |
.052 |
.0 |
.014 |
.946 |
.296 |
.025 |
-- |
.001 |
.0 |
.0 |
.001 |
.086 |
.001 |
.0 |
.707 |
.001 |
.007 |
.052 |
.001 |
.001 |
.025 |
.012 |
.003 |
.88 |
.016 |
.461 |
-- |
-- |
-- |
-- |
.01 |
.012 |
.016 |
.079 |
.09 |
.023 |
.001 |
.032 |
.478 |
.054 |
.12 |
.0 |
.043 |
.003 |
.004 |
.038 |
.0 |
.002 |
.0 |
.001 |
.003 |
.015 |
.0 |
.036 |
.0 |
.003 |
.539 |
.132 |
.0 |
.002 |
.003 |
.007 |
.06 |
.0 |
.002 |
.001 |
.133 |
.0 |
.023 |
.0 |
.013 |
.026 |
.001 |
.001 |
.005 |
.01 |
.0 |
.0 |
.011 |
.013 |
.052 |
.033 |
.001 |
.0 |
.046 |
.011 |
.0 |
.0 |
.0 |
.001 |
.0 |
.001 |
.0 |
.0 |
.001 |
.515 |
.0 |
.0 |
.0 |
.003 |
.046 |
.087 |
.456 |
.407 |
.098 |
.0 |
.827 |
.01 |
.002 |
.002 |
.008 |
.007 |
.003 |
.17 |
.285 |
.618 |
.046 |
.018 |
.115 |
.092 |
.171 |
.01 |
.001 |
.005 |
.133 |
.103 |
.001 |
.006 |
.0 |
.0 |
.028 |
.001 |
.001 |
.006 |
.034 |
.005 |
.001 |
.001 |
.295 |
.087 |
.002 |
.194 |
.183 |
.067 |
.332 |
.008 |
.038 |
.331 |
.938 |
.295 |
.991 |
.018 |
.415 |
.014 |
.002 |
.007 |
.046 |
.011 |
.007 |
-- |
-- |
.022 |
.001 |
.026 |
.004 |
.0 |
.029 |
.265 |
.007 |
.12 |
.072 |
.001 |
.016 |
.001 |
.0 |
.094 |
.102 |
.361 |
.328 |
-- |
-- |
.005 |
.31 |
.412 |
.001 |
.036 |
.0 |
.0 |
.0 |
.009 |
.0 |
.034 |
.001 |
.004 |
.0 |
.0 |
.004 |
.218 |
.313 |
.169 |
.057 |
.007 |
.057 |
-- |
.019 |
.021 |
.158 |
.07 |
.022 |
.097 |
.075 |
.009 |
.015 |
.016 |
.0 |
.009 |
.001 |
.022 |
.001 |
.066 |
.692 |
.041 |
.004 |
.075 |
.026 |
.01 |
.058 |
.023 |
.187 |
.317 |
.003 |
.272 |
.263 |
.046 |
-- |
-- |
.12 |
.597 |
.231 |
.006 |
.005 |
.015 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.592 |
.075 |
.12 |
.005 |
.391 |
.0 |
.004 |
.0 |
.112 |
.0 |
.118 |
.198 |
.297 |
.33 |
.185 |
.133 |
.038 |
-- |
-- |
.081 |
.144 |
.019 |
.003 |
.003 |
.034 |
.842 |
.002 |
.021 |
.001 |
.129 |
.134 |
.254 |
.578 |
.001 |
.005 |
.029 |
.014 |
.004 |
.0 |
.005 |
.244 |
.001 |
.002 |
.0 |
.238 |
.253 |
.003 |
.005 |
.006 |
.004 |
.048 |
.001 |
.035 |
.008 |
.043 |
.011 |
.012 |
.006 |
.022 |
.001 |
.008 |
.004 |
.004 |
.0 |
.079 |
.002 |
.0 |
.002 |
.998 |
.043 |
.01 |
.028 |
.0 |
.395 |
.002 |
.111 |
.206 |
.252 |
.007 |
.266 |
.008 |
.004 |
.001 |
.027 |
.0 |
.0 |
.002 |
.007 |
.005 |
.008 |
-- |
-- |
.017 |
.006 |
.0 |
.033 |
.003 |
.0 |
.004 |
.034 |
.443 |
.525 |
.036 |
.001 |
.009 |
.025 |
.007 |
.004 |
.002 |
.105 |
.118 |
1.0 |
|
Pcsk2
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Pcsk2
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--
|
|
C |
T |
C |
G |
C |
C |
G |
A |
T |
A |
2 |
G |
G |
G |
T |
G |
C |
C |
A |
A |
G |
3 |
G |
G |
G |
A |
A |
T |
A |
G |
2 |
T |
G |
G |
C |
T |
T |
T |
G |
C |
G |
C |
G |
C |
G |
T |
T |
G |
G |
A |
A |
A |
G |
G |
T |
7 |
A |
C |
G |
G |
A |
8 |
C |
T |
C |
G |
G |
A |
G |
C |
G |
A |
A |
A |
G |
G |
C |
T |
A |
C |
G |
A |
A |
C |
G |
G |
A |
A |
C |
C |
A |
A |
G |
A |
C |
T |
A |
G |
115 |
G |
A |
T |
T |
T |
C |
C |
T |
G |
G |
C |
A |
C |
G |
G |
G |
T |
C |
G |
T |
T |
G |
T |
G |
A |
C |
C |
A |
A |
G |
C |
C |
C |
C |
G |
T |
A |
G |
C |
T |
A |
C |
A |
A |
A |
A |
T |
T |
A |
G |
A |
G |
A |
T |
T |
G |
T |
T |
C |
T |
T |
G |
G |
G |
C |
2 |
A |
G |
T |
C |
A |
G |
G |
T |
A |
T |
A |
A |
G |
A |
T |
A |
G |
G |
G |
A |
G |
T |
A |
T |
A |
G |
C |
T |
G |
5 |
A |
A |
G |
T |
A |
A |
A |
C |
G |
A |
T |
T |
C |
G |
T |
G |
T |
G |
C |
A |
A |
G |
G |
C |
C |
A |
A |
T |
C |
T |
C |
C |
A |
T |
C |
G |
T |
T |
C |
A |
A |
G |
A |
T |
C |
G |
A |
G |
A |
T |
A |
G |
G |
C |
T |
C |
T |
C |
C |
A |
T |
A |
C |
G |
T |
T |
A |
2 |
T |
C |
A |
A |
A |
T |
C |
T |
A |
A |
A |
G |
A |
T |
G |
A |
G |
A |
A |
C |
C |
T |
G |
T |
C |
C |
C |
C |
A |
T |
G |
T |
T |
C |
C |
A |
C |
G |
G |
T |
11 |
T |
C |
A |
G |
A |
T |
G |
G |
G |
T |
G |
A |
G |
G |
G |
A |
C |
G |
C |
A |
G |
G |
A |
A |
C |
5 |
A |
A |
C |
G |
T |
T |
A |
C |
G |
G |
A |
G |
A |
C |
2 |
C |
A |
A |
A |
T |
G |
G |
G |
6 |
4 |
A |
T |
G |
G |
G |
C |
C |
G |
A |
T |
T |
C |
14 |
G |
A |
G |
14 |
A |
A |
A |
G |
T |
G |
G |
A |
C |
T |
A |
T |
A |
G |
C |
G |
C |
G |
T |
G |
G |
T |
C |
A |
A |
G |
A |
T |
G |
T |
T |
C |
A |
T |
G |
G |
4 |
T |
T |
T |
T |
G |
A |
G |
C |
A |
A |
C |
A |
T |
T |
G |
G |
G |
T |
C |
A |
T |
C |
G |
A |
C |
T |
C |
A |
G |
T |
T |
T |
C |
C |
T |
G |
G |
A |
T |
T |
T |
T |
C |
T |
T |
A |
T |
A |
A |
T |
C |
A |
G |
T |
C |
C |
4 |
A |
T |
G |
G |
T |
G |
C |
A |
C |
T |
C |
4 |
A |
C |
G |
T |
C |
A |
A |
A |
C |
G |
A |
T |
A |
A |
C |
C |
G |
T |
T |
A |
T |
T |
G |
C |
G |
G |
10 |
6 |
G |
G |
T |
A |
C |
A |
A |
A |
A |
G |
G |
7 |
T |
G |
G |
T |
T |
C |
G |
G |
A |
A |
G |
T |
G |
A |
A |
T |
C |
T |
C |
5 |
T |
C |
C |
C |
G |
T |
T |
A |
A |
A |
A |
C |
G |
G |
T |
T |
T |
C |
T |
A |
T |
G |
A |
T |
A |
G |
T |
2 |
T |
A |
C |
G |
G |
G |
T |
A |
T |
G |
A |
T |
C |
T |
A |
G |
T |
T |
A |
C |
T |
G |
A |
A |
G |
G |
T |
A |
C |
A |
G |
|
|
|
|
|
|
|
|
|
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
T
|
C
|
G
|
T
|
G
|
T
|
A
|
C
|
C
|
2
|
-
|
A
|
C
|
A
|
2
|
C
|
C/2
|
T
|
G
|
-
|
A
|
-
|
T
|
A
|
A
|
G
|
2
|
2
|
T
|
-
|
-
|
T/C
|
A
|
A
|
C/T
|
C
|
G
|
C
|
-
|
C/A
|
G/A
|
G
|
A
|
T
|
T
|
C
|
C
|
A
|
A
|
A/G
|
C
|
G
|
A
|
A
|
C
|
-
|
G
|
C/2
|
2
|
8
|
T
|
8/-
|
-
|
C
|
G
|
A
|
A
|
C
|
-
|
T
|
-
|
2
|
G
|
G
|
2
|
T
|
C/T
|
C
|
C
|
G
|
G/A
|
G
|
G
|
T
|
A
|
A
|
G
|
G
|
A
|
G
|
C
|
C
|
C
|
-
|
T
|
A
|
C
|
G/A
|
-
|
A
|
A/-
|
C
|
C
|
C
|
T
|
T
|
C
|
A
|
A
|
A
|
G
|
T
|
A
|
A
|
2
|
C
|
T
|
A
|
-
|
C
|
T
|
C
|
A
|
A/T
|
T
|
G
|
G
|
G
|
A
|
C/2
|
G
|
A
|
T
|
G/T
|
T/C
|
G
|
A
|
T
|
A
|
C
|
T
|
G
|
T
|
G
|
-
|
A
|
-
|
G
|
T
|
G
|
A
|
G
|
C
|
C
|
A
|
-
|
-
|
C/3
|
C
|
C
|
A
|
A
|
A
|
C/G
|
-
|
T
|
T
|
C
|
C/G
|
G
|
A
|
A
|
C
|
T
|
G
|
C
|
G
|
G/A
|
G
|
A
|
G
|
A
|
T
|
T
|
G
|
A
|
C
|
G
|
C
|
G
|
A
|
T
|
C
|
3
|
-
|
6
|
9
|
C
|
C
|
T
|
G
|
T
|
T
|
A
|
G
|
16
|
C
|
C/T
|
A
|
-
|
G/2
|
G
|
A
|
C/T
|
G
|
G
|
A
|
A
|
T
|
T
|
C
|
G
|
C
|
A
|
4
|
G
|
T
|
G
|
T/3
|
T
|
A
|
A
|
G
|
A
|
-
|
G
|
A
|
T
|
C
|
T
|
A
|
G
|
A
|
G
|
C
|
T
|
A
|
A
|
G
|
C
|
A
|
T/3
|
T
|
T
|
-
|
T/C
|
C
|
G
|
G/A
|
G
|
T/C
|
G
|
-
|
C
|
T
|
C
|
G
|
T
|
A
|
T
|
C
|
G
|
G
|
G
|
G/A
|
A/G
|
C
|
A
|
G
|
A
|
2
|
A/4
|
A
|
T
|
C
|
-
|
T/C
|
C/T
|
2
|
T
|
13
|
A/G
|
A
|
A
|
C
|
T/2
|
T
|
T
|
G
|
T
|
A
|
A
|
C
|
-
|
C
|
T
|
G
|
A
|
A/T
|
T/-
|
T
|
G/C
|
G/C
|
A
|
C
|
C
|
A
|
C
|
C
|
C
|
C/A
|
C
|
T
|
T
|
A
|
-
|
C
|
G
|
A
|
-
|
G
|
A/G
|
T
|
A
|
A
|
A
|
A/G
|
A
|
A
|
C
|
G
|
C
|
A/T
|
T
|
-
|
A
|
C
|
A/C
|
A/C
|
T/2
|
G/C
|
A
|
A
|
6/-
|
4/-
|
G
|
A
|
A
|
A
|
A
|
T
|
T
|
G/T
|
G
|
G
|
2
|
C/T
|
-
|
A
|
G
|
G/4
|
-
|
G
|
A/G
|
G
|
A
|
C
|
A
|
T
|
G
|
G
|
G
|
G
|
C
|
G
|
A
|
A
|
A
|
-
|
T
|
C
|
A
|
A
|
C
|
6
|
T
|
A/2
|
A
|
G
|
-
|
A
|
C
|
C
|
T
|
G
|
T/C
|
A
|
G/-
|
-
|
C
|
C
|
T/-
|
A
|
A
|
G
|
A
|
T
|
G
|
C
|
T
|
G
|
C
|
C
|
A
|
C
|
C
|
C
|
T
|
C
|
C
|
T
|
A
|
C
|
G
|
C
|
T
|
G
|
A
|
G
|
C
|
G
|
T
|
A
|
C
|
A
|
G/A
|
G
|
C
|
-
|
C
|
C
|
T
|
-
|
C
|
G
|
A
|
G
|
G
|
C
|
A
|
G
|
A
|
T/G
|
A
|
2
|
-
|
G
|
A
|
A
|
3
|
G
|
A
|
T
|
G
|
T
|
2
|
C/T
|
-
|
T
|
T
|
A
|
A
|
G
|
T
|
A/G
|
G
|
T
|
26
|
2
|
2
|
A/G
|
G
|
C/T
|
T
|
G/T
|
A
|
G
|
G
|
2
|
G
|
G/A
|
A
|
A
|
A
|
10/-
|
6/-
|
A
|
A
|
G
|
G
|
C/G
|
C
|
A/T
|
G
|
G
|
A
|
A
|
7/-
|
C
|
A
|
A
|
C
|
A
|
T
|
A
|
A
|
C
|
G
|
A
|
T/C
|
G/A
|
G
|
G
|
C
|
T
|
A
|
T
|
5/-
|
C
|
A
|
T
|
T
|
T
|
C
|
A
|
G
|
T
|
G
|
C
|
T
|
A
|
G/A
|
C
|
C
|
G
|
A
|
C
|
G
|
C
|
T
|
G
|
C
|
G
|
G/T
|
T/C
|
-
|
C
|
A/2
|
C/19
|
G/T
|
G/A
|
A
|
2
|
A/G
|
G
|
A
|
2
|
C
|
T
|
C
|
G
|
G/A
|
C
|
G
|
G
|
T
|
T/-
|
A
|
G
|
G
|
G/A
|
A
|
C
|
C
|
2
|
-
|
A
|
|