|
.017 |
.28 |
.001 |
-- |
.007 |
.007 |
-- |
.001 |
.0 |
.0 |
.474 |
.008 |
.002 |
.004 |
.005 |
.036 |
.047 |
.001 |
.001 |
.0 |
.0 |
.002 |
.025 |
.038 |
.0 |
.011 |
.0 |
.0 |
.0 |
-- |
-- |
.001 |
.001 |
.024 |
.022 |
-- |
.0 |
.632 |
.0 |
.0 |
-- |
.046 |
.003 |
.0 |
.033 |
.004 |
.0 |
.0 |
.0 |
.005 |
.004 |
-- |
-- |
.0 |
.001 |
.001 |
-- |
.003 |
.0 |
-- |
.001 |
.003 |
.001 |
.001 |
.0 |
.002 |
.011 |
.001 |
.0 |
.0 |
.199 |
.0 |
.31 |
.0 |
.003 |
.001 |
.066 |
.001 |
.0 |
.001 |
.008 |
.012 |
.028 |
.034 |
.033 |
.005 |
.0 |
.001 |
.001 |
.021 |
.001 |
.199 |
.0 |
.001 |
.0 |
-- |
-- |
-- |
-- |
-- |
.0 |
.005 |
.006 |
.021 |
.008 |
.002 |
.014 |
.002 |
.111 |
.002 |
.025 |
.002 |
.1 |
.02 |
.013 |
.006 |
.0 |
.002 |
.028 |
.013 |
.002 |
.0 |
.0 |
.001 |
.001 |
.001 |
.001 |
.007 |
.005 |
.0 |
.011 |
.0 |
.112 |
.001 |
-- |
.0 |
.008 |
.002 |
.001 |
.0 |
.017 |
.001 |
.002 |
.004 |
.004 |
.003 |
.102 |
.098 |
.027 |
.023 |
.008 |
.038 |
.0 |
.001 |
.0 |
.0 |
.0 |
.001 |
.0 |
.0 |
.0 |
.464 |
.001 |
.0 |
.0 |
.001 |
.0 |
.001 |
.0 |
.003 |
.989 |
.001 |
.005 |
.0 |
.0 |
.0 |
.009 |
.012 |
.001 |
.007 |
.048 |
.955 |
.0 |
.017 |
.015 |
.004 |
.006 |
.001 |
.001 |
.013 |
.019 |
.004 |
.001 |
.022 |
.041 |
.004 |
.002 |
.0 |
-- |
-- |
-- |
-- |
.125 |
.0 |
.0 |
.003 |
.001 |
.0 |
.0 |
.0 |
.0 |
.001 |
.0 |
.0 |
.0 |
.001 |
.003 |
.001 |
.0 |
.005 |
.0 |
.0 |
.0 |
.0 |
.002 |
.005 |
.066 |
.006 |
.001 |
.001 |
.047 |
.001 |
.011 |
.0 |
.001 |
.127 |
.07 |
.0 |
.0 |
.008 |
-- |
.109 |
.001 |
.056 |
.002 |
.002 |
.004 |
.0 |
.0 |
.005 |
.007 |
.007 |
.0 |
.005 |
.004 |
.0 |
.028 |
.018 |
.001 |
.001 |
.002 |
.008 |
.018 |
.027 |
.79 |
.027 |
.03 |
.012 |
.008 |
.0 |
.0 |
.013 |
.053 |
.205 |
.259 |
.001 |
.001 |
.059 |
.001 |
.002 |
.008 |
.002 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.002 |
.0 |
.0 |
.0 |
.0 |
.001 |
.001 |
.0 |
.0 |
.0 |
.0 |
.005 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.0 |
.002 |
.119 |
.096 |
.996 |
1.0 |
1.0 |
.343 |
.0 |
.0 |
.225 |
.037 |
.002 |
.001 |
.001 |
.0 |
.011 |
.028 |
.095 |
.09 |
.095 |
.038 |
.023 |
.007 |
.001 |
.001 |
.005 |
.001 |
.009 |
.015 |
.0 |
.0 |
.984 |
.05 |
.0 |
.003 |
.0 |
.001 |
.001 |
.0 |
1.0 |
.001 |
.001 |
.001 |
.006 |
.001 |
1.0 |
.0 |
.056 |
.056 |
.732 |
.045 |
.006 |
.006 |
.01 |
1.0 |
.0 |
.004 |
.001 |
.001 |
.002 |
.003 |
.122 |
.378 |
.115 |
.132 |
-- |
.001 |
.0 |
.0 |
.005 |
-- |
-- |
.0 |
.002 |
.002 |
.0 |
.191 |
.002 |
.005 |
.01 |
.0 |
.004 |
.002 |
.001 |
.006 |
.008 |
.0 |
.033 |
.035 |
-- |
-- |
-- |
-- |
.003 |
.0 |
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
Lrrk2
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
Hmgb1-ps3
|
Hmgb1-ps3
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
T |
A |
C |
T |
C |
T |
C |
C |
C |
G |
T |
C |
C |
A |
G |
T |
A |
C |
C |
A |
T |
C |
A |
T |
T |
C |
T |
G |
G |
G |
A |
C |
C |
A |
T |
C |
A |
G |
A |
T |
A |
A |
G |
A |
G |
C |
G |
C |
G |
C |
C |
T |
C |
C |
A |
T |
T |
A |
G |
A |
C |
C |
G |
A |
T |
G |
T |
G |
G |
T |
T |
A |
T |
G |
T |
C |
A |
T |
T |
A |
C |
C |
T |
G |
T |
G |
T |
G |
G |
T |
A |
A |
A |
A |
T |
T |
G |
C |
T |
T |
T |
C |
T |
C |
T |
T |
T |
C |
T |
T |
A |
C |
T |
T |
C |
T |
T |
T |
A |
G |
G |
G |
C |
T |
C |
G |
T |
A |
T |
T |
A |
G |
G |
C |
T |
C |
T |
C |
T |
C |
T |
C |
T |
T |
A |
T |
G |
C |
G |
G |
T |
T |
C |
T |
G |
T |
A |
A |
T |
C |
T |
A |
A |
T |
C |
A |
T |
A |
G |
A |
C |
A |
T |
T |
G |
T |
G |
G |
T |
A |
C |
G |
G |
T |
T |
T |
C |
A |
G |
T |
T |
C |
C |
A |
G |
C |
C |
T |
C |
C |
C |
T |
A |
C |
A |
T |
G |
C |
C |
G |
G |
C |
T |
A |
A |
C |
C |
A |
T |
A |
C |
C |
T |
T |
G |
T |
T |
A |
C |
A |
G |
C |
T |
C |
G |
A |
T |
T |
C |
C |
G |
G |
A |
T |
G |
T |
T |
C |
C |
T |
A |
G |
A |
A |
T |
C |
T |
C |
G |
G |
A |
T |
A |
A |
C |
T |
T |
T |
G |
G |
T |
G |
C |
T |
T |
C |
T |
G |
G |
C |
A |
T |
T |
T |
C |
T |
T |
G |
A |
C |
C |
C |
C |
G |
G |
C |
A |
C |
T |
C |
T |
A |
C |
T |
T |
C |
T |
C |
T |
C |
C |
C |
A |
T |
T |
C |
T |
C |
G |
A |
A |
G |
A |
A |
G |
G |
T |
A |
A |
C |
C |
T |
A |
T |
T |
C |
T |
C |
T |
G |
A |
C |
C |
T |
T |
T |
C |
A |
G |
T |
T |
C |
G |
A |
G |
A |
G |
G |
A |
T |
C |
G |
A |
C |
G |
T |
C |
T |
T |
G |
T |
C |
T |
A |
C |
C |
T |
C |
C |
A |
T |
G |
C |
G |
C |
A |
G |
A |
C |
T |
G |
T |
A |
T |
C |
C |
A |
T |
T |
A |
G |
A |
A |
C |
G |
C |
T |
C |
C |
C |
A |
T |
C |
G |
G |
T |
C |
T |
T |
C |
A |
G |
T |
A |
C |
G |
C |
C |
T |
A |
A |
T |
G |
T |
G |
C |
T |
T |
T |
T |
G |
C |
A |
C |
T |
T |
C |
T |
G |
T |
T |
A |
T |
C |
T |
C |
G |
G |
A |
G |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
T
|
A
|
G
|
C/T
|
G
|
A
|
C
|
A
|
G
|
T
|
C
|
C
|
T
|
T
|
G
|
A
|
C
|
G
|
T
|
T
|
G
|
A
|
T
|
G
|
G
|
C
|
T
|
C
|
A
|
T
|
A
|
C
|
A
|
T
|
C
|
G
|
T
|
G
|
A
|
G
|
C
|
G
|
T
|
A
|
G
|
A
|
T
|
C
|
T
|
A
|
T
|
T
|
C
|
T
|
T
|
G
|
C
|
T/A
|
G
|
A
|
G
|
T
|
T
|
T
|
C
|
C
|
T
|
C
|
T
|
A
|
C
|
C
|
T
|
G
|
A
|
C
|
T
|
G
|
C
|
C
|
G
|
G
|
T
|
C
|
A
|
T/C
|
C
|
C
|
A
|
C
|
A
|
C
|
C
|
C
|
G
|
C
|
C
|
A
|
T
|
G
|
G
|
C
|
T
|
C
|
A
|
C
|
C
|
C
|
T
|
G
|
C
|
C
|
G
|
C
|
C
|
A
|
C
|
C
|
C
|
T
|
C
|
T
|
A
|
A
|
C
|
T
|
C
|
C
|
C
|
C
|
A
|
G
|
A
|
A
|
T
|
C
|
T
|
C
|
A
|
C
|
T
|
C
|
T
|
C
|
C
|
G
|
C
|
A
|
T
|
A
|
T
|
C
|
A
|
T
|
C
|
A
|
C
|
G
|
G
|
G
|
T
|
C
|
G
|
G
|
C
|
A
|
G
|
C
|
G
|
A
|
G
|
T
|
C
|
C
|
A
|
A
|
G
|
A
|
A
|
G
|
G
|
T
|
A
|
A
|
C
|
C
|
C
|
T
|
G
|
A
|
C
|
C
|
G
|
T
|
G
|
A
|
T
|
T
|
T/C
|
T
|
C/T
|
C/T
|
C
|
G
|
T
|
G
|
C
|
A
|
T
|
T
|
C
|
A
|
A
|
C
|
G
|
G
|
T
|
T
|
T
|
C
|
G
|
G
|
G
|
C
|
C
|
T
|
C
|
C
|
G
|
T
|
G
|
A
|
T
|
C
|
T
|
T
|
T
|
G
|
C
|
T
|
G
|
A
|
T
|
G
|
C
|
T
|
G
|
C
|
T
|
A
|
C
|
C
|
A
|
G
|
G
|
A
|
C/T
|
C
|
A
|
A
|
C
|
G
|
C
|
T
|
G
|
T
|
C
|
C
|
A
|
A
|
C
|
C
|
A
|
T
|
A
|
A
|
T
|
C
|
C
|
A
|
A
|
T
|
G
|
C
|
C
|
T
|
C
|
C
|
T
|
G
|
T
|
T
|
T
|
T
|
A
|
A
|
T
|
T
|
T
|
A
|
T
|
C
|
G
|
T
|
C
|
G
|
T
|
A
|
A
|
A
|
A
|
G
|
G
|
G
|
C
|
A
|
T
|
C
|
A
|
T
|
G
|
C
|
A
|
G
|
G
|
A
|
A
|
C
|
T
|
T
|
T
|
T
|
C
|
G
|
C
|
C
|
G
|
G
|
T
|
C
|
A
|
G
|
T
|
A
|
C
|
A
|
C
|
T
|
G
|
A
|
C
|
C
|
T
|
T
|
G
|
A
|
G
|
A
|
A
|
G
|
G
|
G
|
C
|
C
|
T
|
A
|
C
|
T
|
C
|
C
|
A
|
C
|
T
|
C
|
G
|
A
|
G
|
C
|
T
|
T
|
G
|
C
|
A
|
T
|
A
|
T
|
C
|
A
|
G
|
T
|
C
|
A
|
C
|
G
|
C
|
T
|
T
|
G
|
C
|
C
|
C
|
A
|
C
|
C
|
G
|
A
|
T
|
C
|
T
|
T
|
T
|
T
|
C
|
A
|
G/C
|
G/C
|
C
|
T
|
C
|
G
|
T
|
G
|
A
|
C
|
G
|
T
|
A
|
T
|
T
|
C
|
G
|
G
|
C
|
A
|
C
|
A
|
T
|
T/A
|
T/C
|
C
|
C
|
A
|
T
|
G
|
T
|
C
|
C
|
T
|
C
|
A
|
C
|
C
|
G
|
C
|
T
|
C
|
T
|
C
|
C
|
G
|
A
|
A/T
|
|