|
.001 |
.111 |
.996 |
.0 |
.003 |
.328 |
.0 |
.005 |
.0 |
.004 |
.941 |
.973 |
.34 |
.019 |
.007 |
.0 |
.001 |
.001 |
.0 |
.002 |
.001 |
.001 |
.0 |
.575 |
.491 |
.0 |
.002 |
.025 |
-- |
.256 |
.633 |
.0 |
.0 |
.0 |
.356 |
.0 |
.0 |
.001 |
.002 |
.004 |
.013 |
.007 |
.012 |
.002 |
.0 |
.007 |
.017 |
.001 |
.0 |
.001 |
.001 |
.0 |
.675 |
.0 |
.008 |
.0 |
.0 |
.002 |
.002 |
.047 |
.039 |
.001 |
.001 |
.002 |
.003 |
.119 |
.004 |
.001 |
.888 |
.001 |
.002 |
.002 |
.121 |
.001 |
.001 |
.0 |
.071 |
.004 |
.007 |
.14 |
.042 |
.002 |
.148 |
.037 |
.006 |
.045 |
.002 |
.017 |
.008 |
.073 |
.181 |
.003 |
.323 |
.0 |
.0 |
.0 |
.007 |
.918 |
-- |
.052 |
.005 |
.002 |
.024 |
.002 |
.007 |
.005 |
.013 |
.008 |
.97 |
.04 |
.193 |
.073 |
.197 |
.096 |
.098 |
-- |
.03 |
.004 |
.0 |
.005 |
.092 |
.019 |
.0 |
.098 |
.12 |
.257 |
.005 |
.002 |
.006 |
.063 |
.13 |
.0 |
.007 |
.001 |
.001 |
.001 |
.02 |
.001 |
.007 |
.0 |
.001 |
.027 |
.676 |
.123 |
.017 |
.009 |
.143 |
.009 |
.014 |
.007 |
.018 |
.031 |
.225 |
-- |
.307 |
.053 |
.002 |
.073 |
.003 |
.0 |
.998 |
.978 |
.977 |
.001 |
.005 |
.03 |
.0 |
.016 |
.018 |
.069 |
.046 |
.021 |
.012 |
.001 |
.01 |
.808 |
.002 |
.002 |
.018 |
.0 |
.0 |
.002 |
.0 |
.022 |
.004 |
.0 |
.018 |
.0 |
.024 |
.003 |
.046 |
.002 |
.006 |
.006 |
.965 |
.003 |
.059 |
.001 |
.158 |
.003 |
.003 |
.004 |
.006 |
.015 |
.013 |
.014 |
.037 |
.069 |
.03 |
.144 |
.064 |
.0 |
.0 |
.011 |
.002 |
.003 |
.035 |
.025 |
.003 |
.0 |
.056 |
.057 |
.013 |
.055 |
.0 |
.192 |
.019 |
.0 |
.001 |
.003 |
.001 |
.0 |
.003 |
.005 |
.0 |
.002 |
.008 |
.008 |
.005 |
.008 |
.008 |
.008 |
.424 |
.65 |
.723 |
.0 |
.021 |
.106 |
.003 |
.018 |
.004 |
.994 |
.521 |
.0 |
.002 |
.008 |
.996 |
.002 |
.011 |
.015 |
.308 |
-- |
.079 |
.057 |
.012 |
.463 |
.454 |
.036 |
.032 |
.017 |
.009 |
.123 |
.153 |
.002 |
.001 |
.005 |
.004 |
.003 |
.005 |
.349 |
.472 |
.031 |
.004 |
.001 |
.017 |
.001 |
.244 |
-- |
-- |
.003 |
.036 |
.008 |
.005 |
.003 |
.002 |
.001 |
.0 |
.001 |
.076 |
.014 |
.0 |
.014 |
.0 |
.024 |
.002 |
.026 |
.002 |
.003 |
.015 |
.001 |
.009 |
.003 |
.022 |
-- |
-- |
-- |
.008 |
.162 |
.0 |
.0 |
.96 |
.0 |
.008 |
.0 |
.0 |
.001 |
.026 |
.271 |
.007 |
.007 |
.001 |
.007 |
.216 |
.222 |
.018 |
.019 |
.002 |
.008 |
.001 |
.0 |
.0 |
.004 |
.004 |
.006 |
.003 |
.93 |
.132 |
.094 |
.0 |
.003 |
.0 |
.001 |
.077 |
.053 |
.005 |
.017 |
.0 |
.005 |
.001 |
.013 |
.021 |
.019 |
.001 |
.0 |
.0 |
.001 |
.044 |
.019 |
.088 |
.036 |
.001 |
.0 |
.0 |
.031 |
.0 |
.017 |
.001 |
.006 |
.847 |
.844 |
.863 |
.004 |
.001 |
.006 |
.015 |
.185 |
.027 |
.029 |
.007 |
.001 |
.051 |
.0 |
.911 |
.002 |
.004 |
.022 |
.0 |
.0 |
.369 |
.12 |
.0 |
.058 |
.111 |
.129 |
.001 |
.206 |
.025 |
.029 |
.033 |
.003 |
.0 |
.0 |
.004 |
.0 |
.001 |
.001 |
.002 |
.012 |
.01 |
.004 |
.0 |
.002 |
.001 |
.069 |
.003 |
.004 |
.001 |
.012 |
.052 |
.0 |
.017 |
.001 |
.0 |
.0 |
.0 |
.071 |
.0 |
.033 |
.001 |
.002 |
.0 |
.0 |
.0 |
.002 |
.0 |
.0 |
.008 |
.003 |
.001 |
.002 |
.001 |
.173 |
.271 |
.044 |
.001 |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.832 |
.961 |
.032 |
.017 |
.005 |
.007 |
.001 |
.0 |
.007 |
.418 |
.0 |
.008 |
.001 |
.0 |
.033 |
.051 |
.126 |
.01 |
.087 |
.001 |
.041 |
.012 |
.035 |
.379 |
.002 |
.001 |
.001 |
.0 |
.023 |
.017 |
.016 |
.003 |
.0 |
.006 |
.001 |
.016 |
.095 |
.063 |
-- |
.004 |
.001 |
.043 |
.995 |
.993 |
.0 |
.0 |
.01 |
.001 |
.0 |
.004 |
.059 |
.012 |
.091 |
.098 |
.0 |
.0 |
.0 |
.936 |
.0 |
-- |
-- |
-- |
.014 |
.007 |
.004 |
.997 |
.0 |
.001 |
.005 |
.0 |
.0 |
.001 |
.002 |
.007 |
.744 |
.004 |
.003 |
.007 |
.02 |
.001 |
.257 |
.76 |
.895 |
.904 |
-- |
.009 |
.016 |
.005 |
.002 |
.006 |
.0 |
.002 |
.119 |
.199 |
.001 |
.005 |
.0 |
.024 |
.002 |
.001 |
.011 |
.0 |
.0 |
.008 |
.006 |
.001 |
.003 |
.0 |
.11 |
.118 |
.038 |
.037 |
.043 |
-- |
-- |
-- |
.012 |
.001 |
.0 |
.289 |
.004 |
.743 |
.056 |
.011 |
.001 |
.33 |
.001 |
-- |
-- |
.027 |
.0 |
.753 |
.008 |
.036 |
.001 |
.198 |
-- |
-- |
.001 |
.324 |
.998 |
.001 |
.024 |
.0 |
.001 |
.001 |
-- |
.011 |
.009 |
.015 |
.454 |
.001 |
.129 |
.001 |
.006 |
.002 |
.003 |
.003 |
.002 |
.08 |
.055 |
.002 |
.441 |
.18 |
.001 |
.0 |
.091 |
.015 |
.999 |
.002 |
.0 |
.017 |
.087 |
.019 |
.132 |
.002 |
.005 |
.004 |
.005 |
.008 |
.053 |
.003 |
.086 |
1.0 |
.0 |
.012 |
.071 |
.002 |
.01 |
.001 |
.001 |
.002 |
.0 |
.004 |
.002 |
-- |
.081 |
.03 |
.012 |
.023 |
.007 |
.0 |
.132 |
.061 |
.068 |
.992 |
.994 |
.0 |
.001 |
.01 |
.001 |
.0 |
.0 |
.0 |
.001 |
.0 |
.015 |
.003 |
.003 |
.001 |
.001 |
.0 |
.0 |
.004 |
.002 |
.02 |
.034 |
.0 |
.012 |
.001 |
.243 |
.04 |
.0 |
.0 |
.003 |
.0 |
.001 |
.229 |
.324 |
.002 |
.0 |
.002 |
.034 |
.0 |
.015 |
.153 |
.0 |
.004 |
.001 |
.0 |
.0 |
.004 |
.001 |
-- |
.155 |
.315 |
.0 |
.001 |
.0 |
.001 |
.0 |
.001 |
.063 |
.0 |
.002 |
.003 |
.266 |
.001 |
.088 |
.0 |
.0 |
.001 |
.001 |
.041 |
.003 |
.0 |
.0 |
.044 |
.047 |
.701 |
.002 |
.665 |
.646 |
.131 |
.003 |
.001 |
.0 |
.024 |
.016 |
.006 |
.006 |
.018 |
.0 |
.015 |
.072 |
.103 |
.0 |
.001 |
.002 |
.063 |
.092 |
.002 |
.07 |
.224 |
.069 |
.207 |
.0 |
.043 |
.002 |
-- |
.021 |
.001 |
.031 |
.0 |
.002 |
.19 |
.204 |
.942 |
.08 |
.0 |
.0 |
.0 |
.031 |
.0 |
.007 |
.008 |
.004 |
.0 |
.009 |
.003 |
.003 |
.007 |
.931 |
.0 |
.002 |
.002 |
.005 |
.022 |
.0 |
.09 |
.0 |
1.0 |
.938 |
.002 |
.013 |
.001 |
.0 |
.418 |
.007 |
.0 |
.013 |
.026 |
.005 |
.993 |
.689 |
.0 |
1.0 |
.154 |
.725 |
1.0 |
.001 |
.72 |
1.0 |
.952 |
.96 |
.519 |
.222 |
.679 |
.001 |
.998 |
|
Igf1r
|
Igf1r
|
Igf1r
|
Igf1r
|
Igf1r
|
Igf1r
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Igf1r
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Igf1r
|
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--
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2 |
T |
T |
3 |
2 |
A |
T |
A |
A |
T |
G |
A |
G |
5 |
A |
C |
C |
C |
A |
A |
C |
C |
G |
T |
A |
G |
C |
C |
G |
G |
C |
C |
2 |
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C |
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C |
A |
C |
A |
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C |
T |
T |
C |
C |
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G |
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4 |
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3 |
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8 |
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8 |
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14 |
C |
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18 |
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7 |
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9 |
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6 |
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5 |
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14 |
2 |
2 |
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C |
A |
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C |
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G |
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A |
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2 |
2 |
C |
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A |
8 |
4 |
A |
C |
A |
T |
G |
G |
C |
2 |
T |
T |
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C |
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C |
A |
G |
A |
C |
T |
C |
13 |
G |
T |
G |
A |
A |
C |
T |
C |
G |
C |
T |
C |
T |
A |
T |
T |
T |
C |
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C |
T |
G |
C |
C |
T |
T |
A |
G |
A |
C |
C |
T |
C |
A |
G |
A |
G |
A |
C |
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17 |
A |
G |
T |
A |
T |
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8 |
A |
G |
T |
T |
T |
G |
G |
2 |
G |
G |
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C |
C |
G |
C |
T |
G |
T |
C |
4 |
C |
G |
C |
T |
A |
T |
A |
G |
C |
C |
42 |
A |
A |
T |
C |
7 |
C |
A |
C |
A |
A |
2 |
14 |
T |
A |
T |
T |
G |
C |
T |
3 |
C |
T |
C |
T |
G |
G |
A |
T |
A |
A |
A |
T |
T |
4 |
G |
3 |
C |
A |
2 |
C |
T |
T |
A |
T |
A |
T |
C |
G |
G |
C |
A |
C |
C |
G |
G |
A |
5 |
A |
T |
A |
2 |
2 |
C |
14 |
A |
C |
C |
C |
T |
C |
A |
4 |
2 |
6 |
2 |
T |
T |
G |
G |
G |
22 |
A |
G |
3 |
G |
T |
T |
G |
C |
C |
A |
T |
G |
A |
C |
C |
G |
G |
A |
T |
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G |
T |
A |
T |
C |
C |
A |
A |
T |
4 |
A |
G |
T |
A |
G |
A |
4 |
2 |
8 |
T |
24 |
T |
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C |
2 |
C |
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T |
A |
T |
T |
G |
4 |
A |
A |
A |
T |
T |
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G |
6 |
14 |
3 |
A |
A |
G |
C |
C |
C |
A |
C |
C |
C |
C |
G |
T |
30 |
T |
A |
C |
T |
G |
A |
A |
A |
A |
G |
T |
G |
A |
A |
G |
G |
C |
A |
A |
T |
C |
G |
G |
G |
A |
C |
C |
C |
G |
C |
G |
G |
A |
T |
T |
T |
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2 |
A |
A |
G |
G |
C |
A |
T |
T |
T |
C |
T |
A |
2 |
G |
95 |
G |
C |
T |
G |
T |
C |
G |
C |
G |
T |
T |
G |
C |
G |
T |
C |
C |
A |
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A |
A |
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A |
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A |
A |
A |
2 |
A |
C |
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C |
C |
C |
C |
A |
A |
2 |
T |
2 |
A |
A |
G |
T |
C |
A |
A |
G |
G |
C |
C |
T |
T |
16 |
T |
15 |
G |
T |
4 |
3 |
T |
G |
A |
T |
A |
A |
A |
C |
G |
G |
A |
A |
A |
24 |
22 |
T |
T |
G |
G |
T |
A |
A |
24 |
G |
C |
G |
C |
T |
T |
T |
A |
T |
A |
4 |
A |
T |
A |
A |
G |
T |
2 |
A |
4 |
C |
G |
T |
2 |
T |
G |
T |
A |
G |
A |
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|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
-
|
4
|
C
|
-
|
-
|
T
|
C
|
G
|
G
|
A
|
A
|
C
|
A
|
-
|
5
|
35
|
T
|
A
|
G
|
G
|
C/3
|
C/T
|
A
|
C
|
G
|
A
|
13
|
5
|
A
|
A
|
T
|
C/6
|
2/-
|
-
|
T
|
2
|
A
|
T
|
G
|
T
|
T
|
C
|
A
|
T
|
C
|
C
|
A
|
T
|
C
|
G
|
T
|
C
|
2
|
T
|
T
|
C
|
C
|
G
|
C
|
2
|
A
|
C
|
G
|
C
|
4
|
G
|
A
|
A
|
G
|
C
|
G
|
G
|
2
|
G
|
A
|
G
|
-
|
G
|
T
|
G
|
6
|
G
|
G
|
A
|
2
|
C
|
2
|
A
|
C
|
G
|
G
|
A
|
A
|
C
|
A
|
T
|
2
|
G
|
C
|
C
|
-
|
G
|
A
|
A
|
T/3
|
3
|
C
|
C
|
?
|
C
|
C
|
T
|
-
|
T
|
T
|
-
|
2
|
T
|
A
|
A
|
G
|
A
|
C
|
T
|
T
|
C
|
G
|
T
|
T
|
-
|
T
|
T
|
12
|
C
|
C
|
G
|
-
|
G
|
A/2
|
A
|
T
|
T
|
T
|
T
|
-
|
4
|
T
|
A
|
T
|
9
|
A
|
C
|
20
|
C/2
|
G
|
A
|
2
|
T
|
T
|
G
|
T
|
2/-
|
-
|
C
|
T
|
A
|
A
|
-
|
C
|
G
|
3
|
3
|
T
|
G
|
G
|
-
|
C
|
-
|
T
|
G
|
G
|
G
|
-
|
T
|
A
|
A
|
C
|
G
|
-
|
-
|
T
|
G
|
C
|
T
|
-
|
2
|
G
|
-
|
G
|
G
|
G
|
G
|
A
|
T
|
C
|
T
|
G
|
G
|
A
|
-
|
T
|
G
|
A
|
C
|
T
|
-
|
T
|
C
|
A
|
G
|
C
|
2
|
C
|
2
|
T
|
-
|
2
|
T
|
T
|
T
|
A
|
-
|
G
|
T
|
A
|
A
|
C
|
A
|
G
|
C
|
-
|
G
|
11
|
19
|
39
|
A
|
G
|
T
|
C
|
2
|
G
|
T
|
A
|
-
|
2
|
G
|
2
|
-
|
4
|
2
|
T
|
2
|
G
|
C
|
C
|
-
|
C
|
T
|
C
|
11
|
C
|
17
|
-
|
T
|
C
|
T
|
9/7
|
C
|
G
|
CT/3
|
G
|
G
|
C
|
2
|
-
|
T
|
A
|
T
|
9/-
|
2
|
-
|
A
|
G
|
A
|
A
|
G
|
G
|
A
|
T
|
G
|
A
|
A
|
35
|
T
|
G
|
2
|
T
|
31
|
15
|
G
|
8
|
C
|
C
|
-
|
A
|
C
|
T
|
A
|
G
|
A
|
A
|
C
|
G
|
C
|
T
|
T
|
G/2
|
T
|
T
|
C
|
2
|
G
|
G
|
A
|
6/-
|
-
|
2
|
A/-
|
C
|
C
|
T
|
T
|
C
|
-
|
-
|
G
|
C
|
2
|
A
|
C
|
-
|
T
|
G
|
C
|
5
|
G
|
2
|
-
|
T
|
-
|
-
|
-
|
G
|
T
|
T
|
G
|
2
|
T
|
T
|
C
|
G
|
T
|
T
|
19
|
C
|
G
|
6
|
4
|
A
|
G
|
A
|
4
|
12
|
2
|
T
|
G
|
9
|
A
|
G
|
T
|
G
|
5
|
A
|
-
|
-
|
G
|
2
|
G
|
-
|
-
|
G
|
T
|
-
|
-
|
G/18
|
A
|
C/2
|
-
|
T/-
|
G
|
A
|
T
|
C
|
G
|
G
|
A
|
G
|
T
|
-
|
2
|
-
|
A
|
C
|
C
|
T
|
T
|
T
|
C
|
T
|
A
|
T
|
C
|
T
|
C
|
G
|
A
|
C
|
C
|
T
|
C
|
T
|
C
|
C
|
4
|
T
|
G
|
C
|
T
|
A
|
G
|
T
|
T
|
6
|
-
|
G
|
C
|
G
|
2
|
C
|
T
|
T
|
-
|
C
|
T
|
C
|
G
|
5
|
T
|
C
|
C
|
-
|
G
|
A
|
-
|
C
|
C
|
A
|
8
|
-
|
A
|
A
|
C
|
A
|
G
|
T
|
T
|
C
|
T
|
G
|
C
|
C
|
G
|
-
|
A
|
C
|
T
|
C
|
G
|
C
|
G
|
A
|
T
|
T
|
-
|
T
|
G
|
A
|
T
|
-
|
T
|
C
|
A
|
-
|
13
|
-
|
-
|
C
|
G
|
-
|
T/117
|
T
|
5
|
-
|
-
|
G
|
2
|
2
|
A
|
2
|
2
|
G
|
C
|
T
|
G
|
G
|
C
|
C
|
-
|
A
|
-
|
T
|
T
|
-
|
T
|
C
|
2
|
-
|
C
|
3
|
G
|
T
|
A
|
A
|
A
|
G
|
2
|
C/3
|
3
|
A
|
G
|
-
|
12
|
C
|
C
|
-
|
-
|
T
|
-
|
G
|
T
|
A
|
A
|
C
|
T
|
G
|
4/-
|
-
|
-
|
-
|
C
|
C
|
A
|
2
|
C
|
-
|
G
|
A
|
-
|
A
|
44
|
2
|
10
|
G
|
G
|
G
|
-
|
C
|
G
|
3
|
2
|
32
|
A
|
G
|
C
|
C
|
A
|
C
|
10
|
123
|
C/3
|
T
|
G
|
-
|
C
|
4/-
|
G
|
T
|
G
|
-
|
A
|
2
|
-
|
2/-
|
-
|
3
|
-
|
19
|
3
|
T
|
-
|
T
|
A
|
C
|
G
|
C
|
23
|
3
|
-
|
G
|
C
|
G
|
-
|
5
|
T
|
A
|
-
|
-
|
-
|
A/-
|
G
|
A
|
T
|
T
|
A
|
G
|
2
|
T
|
15
|
T
|
A
|
C
|
-
|
5
|
G
|
T
|
C
|
A
|
G
|
G
|
G
|
17
|
A
|
C
|
A
|
T
|
G
|
A
|
A
|
T
|
T
|
C
|
G
|
T
|
A
|
C
|
A
|
G
|
G
|
3
|
T
|
C
|
T
|
A
|
A
|
G
|
C
|
T/-
|
C
|
-
|
-
|
3
|
7
|
A
|
T
|
T
|
G
|
2
|
G
|
C
|
T
|
-
|
5
|
-
|
A
|
-
|
3
|
G
|
21
|
A
|
G
|
T
|
A
|
T
|
A
|
C
|
C
|
4
|
T
|
6/7
|
C
|
T
|
G
|
G
|
A
|
G
|
14
|
C
|
A
|
G
|
C
|
G
|
C
|
G
|
-
|
7
|
2
|
-
|
-
|
T
|
G/13
|
C/7
|
C/G
|
-
|
G
|
G
|
3
|
-
|
3
|
-
|
G
|
G
|
2
|
A
|
G
|
-
|
G
|
A
|
A
|
T
|
T
|
C
|
G
|
16/-
|
A
|
-
|
A
|
9
|
4/-
|
3/-
|
C
|
A
|
G
|
C
|
G
|
G
|
2
|
4
|
9
|
8
|
G
|
G
|
G
|
24/-
|
22/-
|
C
|
C
|
T
|
A
|
C
|
G
|
G
|
-
|
A
|
T
|
A
|
T
|
G
|
C
|
2
|
G
|
-
|
G
|
-
|
T
|
C
|
G
|
2
|
2
|
-
|
-
|
3
|
-
|
T
|
6
|
C
|
-
|
T/-
|
-
|
C
|
2
|
T
|
-
|
|