|
.054 |
.009 |
.001 |
.001 |
.001 |
.078 |
.176 |
-- |
.0 |
.0 |
.004 |
.0 |
.005 |
.007 |
.021 |
.003 |
.001 |
.001 |
.001 |
.061 |
.001 |
.002 |
.005 |
.001 |
.483 |
.091 |
.299 |
.049 |
.017 |
.035 |
.101 |
.062 |
.108 |
.126 |
.153 |
.132 |
.126 |
.021 |
.032 |
.226 |
.036 |
.072 |
.454 |
.066 |
.004 |
.002 |
.093 |
.019 |
.046 |
.036 |
.08 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
.007 |
.033 |
.308 |
.066 |
.009 |
.062 |
.001 |
.015 |
.227 |
.003 |
.03 |
-- |
-- |
.056 |
.005 |
.006 |
.027 |
.043 |
.042 |
.001 |
.088 |
.234 |
.001 |
.442 |
.193 |
.009 |
.068 |
.24 |
.008 |
.001 |
.003 |
.003 |
.01 |
.832 |
.856 |
.999 |
1.0 |
-- |
.001 |
.065 |
.321 |
.088 |
-- |
.034 |
.855 |
.948 |
.154 |
.006 |
.051 |
.024 |
-- |
.165 |
.174 |
.007 |
.134 |
.041 |
.006 |
.0 |
.117 |
.176 |
.02 |
.07 |
.015 |
.423 |
.385 |
.001 |
.003 |
.037 |
.178 |
.035 |
.004 |
.004 |
.002 |
.001 |
-- |
-- |
.073 |
.039 |
.033 |
.206 |
.002 |
.074 |
-- |
-- |
-- |
-- |
-- |
-- |
.749 |
.44 |
.14 |
.253 |
.581 |
.052 |
.055 |
.028 |
.128 |
.057 |
.144 |
.115 |
.079 |
.096 |
.097 |
.101 |
.16 |
.001 |
.048 |
.003 |
.036 |
.007 |
.062 |
.14 |
.381 |
.094 |
.004 |
.004 |
.001 |
.002 |
.001 |
.024 |
.117 |
.122 |
.004 |
.002 |
.036 |
.035 |
.42 |
.365 |
.211 |
-- |
-- |
.008 |
.0 |
.011 |
-- |
.022 |
.0 |
.0 |
.323 |
.01 |
.034 |
.006 |
.087 |
.2 |
.045 |
.067 |
.066 |
.017 |
.021 |
.001 |
.024 |
.008 |
.051 |
.034 |
.115 |
.002 |
.008 |
.078 |
.247 |
.095 |
.102 |
.006 |
.039 |
.021 |
.001 |
.005 |
.005 |
.166 |
.005 |
.005 |
.047 |
-- |
.009 |
.0 |
.001 |
.002 |
.0 |
.075 |
.07 |
.002 |
.003 |
.01 |
.132 |
.013 |
.009 |
.01 |
.06 |
.046 |
.276 |
.04 |
.002 |
.087 |
.008 |
.0 |
.0 |
.019 |
.001 |
.012 |
.004 |
.023 |
.014 |
.001 |
.005 |
.0 |
.0 |
.984 |
.884 |
.029 |
.001 |
.004 |
.004 |
.001 |
.0 |
.003 |
.503 |
.0 |
.007 |
.002 |
.001 |
.111 |
.003 |
-- |
-- |
-- |
.133 |
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
Col18a1
|
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
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--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
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--
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--
|
--
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--
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--
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--
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--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
--
|
|
C |
C |
A |
A |
A |
T |
G |
A |
A |
A |
T |
C |
C |
A |
C |
A |
C |
G |
G |
A |
A |
C |
C |
A |
C |
T |
G |
C |
A |
A |
C |
G |
A |
C |
C |
T |
C |
5 |
G |
A |
T |
C |
81 |
T |
A |
T |
C |
G |
C |
A |
T |
A |
G |
3 |
C |
T |
G |
A |
C |
C |
G |
C |
T |
A |
G |
A |
T |
G |
G |
T |
T |
T |
G |
C |
20 |
T |
3 |
G |
C |
T |
A |
G |
C |
T |
C |
C |
C |
C |
C |
T |
C |
A |
G |
A |
T |
G |
A |
G |
G |
C |
C |
C |
A |
T |
C |
A |
T |
G |
G |
2 |
T |
2 |
A |
3 |
T |
C |
T |
A |
A |
C |
G |
C |
C |
G |
A |
C |
T |
G |
C |
2 |
C |
C |
C |
2 |
14 |
G |
T |
G |
G |
G |
A |
G |
2 |
C |
G |
C |
C |
A |
C |
G |
T |
3 |
C |
3 |
G |
G |
A |
T |
T |
T |
A |
T |
A |
T |
T |
T |
T |
A |
A |
6 |
A |
A |
T |
A |
T |
T |
G |
A |
A |
G |
T |
C |
C |
G |
G |
3 |
A |
A |
G |
T |
C |
T |
3 |
T |
A |
A |
12 |
G |
G |
T |
T |
C |
T |
G |
A |
A |
G |
2 |
T |
A |
A |
C |
A |
C |
T |
G |
A |
G |
3 |
G |
T |
T |
T |
G |
C |
A |
C |
C |
T |
T |
2 |
C |
T |
C |
T |
T |
A |
T |
A |
G |
T |
G |
A |
G |
G |
A |
T |
A |
G |
G |
G |
C |
G |
T |
A |
A |
C |
G |
T |
A |
A |
C |
C |
C |
A |
C |
C |
A |
G |
C |
T |
T |
C |
C |
A |
G |
T |
C |
A |
G |
T |
C |
A |
A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6
|
T
|
G
|
C
|
C
|
2
|
C
|
A/5
|
G
|
C
|
A
|
G
|
G
|
C
|
T
|
G
|
T
|
A
|
A
|
G
|
G
|
A
|
G
|
T
|
T
|
C
|
A
|
T
|
G
|
-
|
A
|
A
|
G
|
C/T
|
T
|
A
|
T
|
-
|
A
|
G
|
C
|
C/2
|
81/-
|
G
|
C
|
C
|
T
|
A
|
T
|
C
|
C
|
G
|
2
|
-
|
T
|
C
|
A
|
C
|
T
|
A
|
A
|
C/T
|
C
|
G
|
A
|
G
|
C
|
-
|
A
|
C
|
G
|
C
|
A
|
T
|
-
|
C
|
-
|
A
|
G
|
C
|
G
|
A
|
T
|
T/C
|
T
|
-
|
C/4
|
T
|
A
|
C
|
T
|
2
|
2
|
T
|
T/C
|
G/2
|
G
|
T
|
T
|
T
|
T
|
T
|
G
|
C
|
A
|
G
|
C
|
A
|
A
|
-
|
T/3
|
2/-
|
G
|
-
|
10
|
C/T
|
G
|
G
|
G
|
G
|
C
|
A
|
T
|
T
|
G
|
T
|
C
|
G/A
|
-
|
-
|
C/5
|
C/5
|
5
|
2/-
|
14/-
|
A
|
C
|
A
|
A
|
35
|
G
|
A
|
2/-
|
T
|
A
|
T
|
A
|
G
|
2
|
A
|
G
|
3/-
|
T
|
-
|
C
|
2
|
A/2
|
C
|
C
|
C
|
G
|
G
|
3
|
10
|
A
|
C
|
C
|
G
|
G
|
6/-
|
G
|
G
|
C
|
G
|
C
|
C
|
A
|
G
|
G
|
T
|
3
|
T
|
A
|
G/A
|
G/A
|
3/-
|
A/5
|
G
|
G/A
|
C
|
A
|
G
|
-
|
C
|
G
|
G
|
12/-
|
A
|
A
|
C
|
2
|
-
|
-
|
C
|
A/G
|
G
|
G/2
|
2/-
|
C
|
G
|
T
|
T
|
A/G
|
A
|
C
|
A
|
G
|
A
|
-
|
2
|
C
|
C
|
G
|
A
|
-
|
G
|
T
|
T
|
3
|
A
|
-
|
T
|
C
|
T
|
C
|
T/C
|
A/G
|
C
|
G
|
C
|
G
|
-
|
G
|
A
|
G/A
|
G
|
C
|
3
|
A
|
A
|
A
|
T
|
A
|
C
|
A/G
|
2
|
T
|
G/C
|
C
|
G
|
C
|
T
|
G
|
T
|
G
|
C/T
|
T
|
T
|
A
|
T
|
T/G
|
C
|
-
|
T
|
G
|
A
|
C
|
T
|
2
|
G/A
|
C
|
T
|
G
|
A/-
|
|