Ahcyl2 (adenosylhomocysteinase-like 2) - Rat Genome Database

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Gene: Ahcyl2 (adenosylhomocysteinase-like 2) Rattus norvegicus
Analyze
Symbol: Ahcyl2
Name: adenosylhomocysteinase-like 2
RGD ID: 1564895
Description: Predicted to be involved in S-adenosylmethionine cycle. Predicted to be located in neuron projection. Predicted to be active in cytosol. Orthologous to human AHCYL2 (adenosylhomocysteinase like 2); PARTICIPATES IN cysteine and methionine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenosylhomocysteinase 3; LOC312192; putative adenosylhomocysteinase 3; RGD1564895; S-adenosylhomocysteine hydrolase-like 2; similar to RIKEN cDNA 4631427C17
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,348,747 - 59,498,503 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl459,348,217 - 59,498,502 (+)EnsemblGRCr8
mRatBN7.2458,381,290 - 58,531,061 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,381,218 - 58,531,060 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,360,156 - 63,508,894 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,276,324 - 59,425,048 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,678,200 - 57,826,928 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,050,241 - 57,199,870 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,050,214 - 57,199,900 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,817,402 - 56,967,031 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,654,054 - 56,801,641 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera453,483,136 - 53,632,390 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dizocilpine maleate  (EXP)
doxorubicin  (ISO)
gentamycin  (EXP)
GW 4064  (ISO)
isoflurane  (ISO)
ivermectin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (EXP)
ozone  (ISO)
paracetamol  (EXP)
permethrin  (EXP)
pirinixic acid  (ISO)
propiconazole  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA,IEA,ISO)
neuron projection  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:19220705  


Genomics

Comparative Map Data
Ahcyl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8459,348,747 - 59,498,503 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl459,348,217 - 59,498,502 (+)EnsemblGRCr8
mRatBN7.2458,381,290 - 58,531,061 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,381,218 - 58,531,060 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx463,360,156 - 63,508,894 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,276,324 - 59,425,048 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0457,678,200 - 57,826,928 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,050,241 - 57,199,870 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,050,214 - 57,199,900 (+)Ensemblrn6Rnor6.0
Rnor_5.0456,817,402 - 56,967,031 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4456,654,054 - 56,801,641 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera453,483,136 - 53,632,390 (+)NCBICelera
Cytogenetic Map4q22NCBI
AHCYL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,225,030 - 129,430,211 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7129,225,021 - 129,430,211 (+)Ensemblhg38GRCh38
GRCh377128,864,871 - 129,070,052 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,652,100 - 128,857,288 (+)NCBIBuild 36Build 36hg18NCBI36
Celera7123,661,585 - 123,866,795 (+)NCBICelera
Cytogenetic Map7q32.1NCBI
HuRef7123,225,638 - 123,431,372 (+)NCBIHuRef
CHM1_17128,798,444 - 129,003,618 (+)NCBICHM1_1
T2T-CHM13v2.07130,537,959 - 130,743,182 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27128,248,814 - 128,454,023 (+)NCBI
Ahcyl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39629,768,378 - 29,912,309 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl629,768,010 - 29,912,309 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38629,768,379 - 29,912,310 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl629,768,011 - 29,912,310 (+)Ensemblmm10GRCm38
MGSCv37629,718,443 - 29,862,310 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36629,718,543 - 29,862,319 (+)NCBIMGSCv36mm8
Celera629,779,462 - 29,923,287 (+)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.36NCBI
Ahcyl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547910,008,891 - 10,214,868 (+)Ensembl
ChiLan1.0NW_00495547910,008,814 - 10,211,370 (+)NCBIChiLan1.0ChiLan1.0
AHCYL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26166,035,491 - 166,243,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1718,045,740 - 18,253,401 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07121,180,259 - 121,387,972 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17133,845,851 - 133,909,907 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7133,704,551 - 133,909,907 (+)EnsemblpanPan2panpan1.1
AHCYL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,347,173 - 7,509,113 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,350,102 - 7,509,157 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha147,035,306 - 7,196,500 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0147,113,464 - 7,274,725 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl147,111,486 - 7,275,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,318,654 - 7,480,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0147,060,736 - 7,221,924 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0147,205,378 - 7,366,837 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ahcyl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511825,564,830 - 25,752,001 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365795,700,668 - 5,758,131 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365795,697,427 - 5,884,587 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AHCYL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1819,260,228 - 19,441,883 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11819,260,226 - 19,441,839 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,331,006 - 20,511,345 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AHCYL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12197,823,901 - 98,033,724 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2197,971,154 - 98,033,738 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660425,370,523 - 5,578,808 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ahcyl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247836,792,215 - 7,003,698 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247836,792,366 - 7,003,642 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Ahcyl2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16109,647,784 - 109,793,704 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ahcyl2
751 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:635
Count of miRNA genes:265
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000025165
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat

Markers in Region
D4Got35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,489,833 - 58,490,031 (+)MAPPERmRatBN7.2
Rnor_6.0457,158,648 - 57,158,845NCBIRnor6.0
Rnor_5.0456,925,809 - 56,926,006UniSTSRnor5.0
RGSC_v3.4456,762,563 - 56,762,761RGDRGSC3.4
RGSC_v3.4456,762,564 - 56,762,761UniSTSRGSC3.4
Celera453,591,161 - 53,591,358UniSTS
RGSC_v3.1457,038,694 - 57,038,891RGD
RH 3.4 Map4334.4UniSTS
RH 3.4 Map4334.4RGD
RH 2.0 Map4409.8RGD
Cytogenetic Map4q22UniSTS
D4Got39  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,432,133 - 58,432,232 (+)MAPPERmRatBN7.2
Rnor_6.0457,101,077 - 57,101,175NCBIRnor6.0
Rnor_5.0456,868,238 - 56,868,336UniSTSRnor5.0
RGSC_v3.4456,704,868 - 56,704,967RGDRGSC3.4
RGSC_v3.4456,704,869 - 56,704,967UniSTSRGSC3.4
Celera453,533,780 - 53,533,878UniSTS
RGSC_v3.1456,980,168 - 56,980,266RGD
RH 3.4 Map4305.0RGD
RH 3.4 Map4305.0UniSTS
RH 2.0 Map4430.9RGD
Cytogenetic Map4q22UniSTS
D4Wox37  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,395,151 - 58,395,257 (+)MAPPERmRatBN7.2
Rnor_6.0457,064,098 - 57,064,203NCBIRnor6.0
Rnor_5.0456,831,259 - 56,831,364UniSTSRnor5.0
RGSC_v3.4456,667,890 - 56,667,995UniSTSRGSC3.4
Celera453,496,801 - 53,496,906UniSTS
Cytogenetic Map4q22UniSTS
D7S2964  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,527,868 - 58,527,962 (+)MAPPERmRatBN7.2
Rnor_6.01939,462,574 - 39,462,641NCBIRnor6.0
Rnor_6.0457,196,684 - 57,196,777NCBIRnor6.0
Rnor_5.01950,326,444 - 50,326,511UniSTSRnor5.0
Rnor_5.0456,963,845 - 56,963,938UniSTSRnor5.0
RGSC_v3.4456,800,403 - 56,800,496UniSTSRGSC3.4
Celera453,629,198 - 53,629,291UniSTS
Cytogenetic Map4q22UniSTS
AU049056  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,465,634 - 58,465,781 (+)MAPPERmRatBN7.2
Rnor_6.0457,134,452 - 57,134,598NCBIRnor6.0
Rnor_5.0456,901,613 - 56,901,759UniSTSRnor5.0
RGSC_v3.4456,738,368 - 56,738,514UniSTSRGSC3.4
Celera453,567,004 - 53,567,150UniSTS
Cytogenetic Map4q22UniSTS
IB809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,530,654 - 58,530,836 (+)MAPPERmRatBN7.2
Rnor_6.0457,199,464 - 57,199,645NCBIRnor6.0
Rnor_5.0456,966,625 - 56,966,806UniSTSRnor5.0
RGSC_v3.4456,803,189 - 56,803,370UniSTSRGSC3.4
Celera453,631,984 - 53,632,165UniSTS
Cytogenetic Map4q22UniSTS
RH142399  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2458,530,601 - 58,530,751 (+)MAPPERmRatBN7.2
Rnor_6.0457,199,411 - 57,199,560NCBIRnor6.0
Rnor_5.0456,966,572 - 56,966,721UniSTSRnor5.0
RGSC_v3.4456,803,136 - 56,803,285UniSTSRGSC3.4
Celera453,631,931 - 53,632,080UniSTS
RH 3.4 Map4305.3UniSTS
Cytogenetic Map4q22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
23 13 80 217 91 90 59 145 59 6 474 268 22 195 116 122 31 34 34

Sequence


Ensembl Acc Id: ENSRNOT00000025165   ⟹   ENSRNOP00000025165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,348,699 - 59,498,502 (+)Ensembl
mRatBN7.2 Ensembl458,381,218 - 58,531,060 (+)Ensembl
Rnor_6.0 Ensembl457,050,214 - 57,199,900 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100143   ⟹   ENSRNOP00000091272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,348,458 - 59,498,502 (+)Ensembl
mRatBN7.2 Ensembl458,470,975 - 58,531,060 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102598   ⟹   ENSRNOP00000078402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,454,306 - 59,494,458 (+)Ensembl
mRatBN7.2 Ensembl458,486,863 - 58,527,016 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109374   ⟹   ENSRNOP00000087181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,444,156 - 59,498,502 (+)Ensembl
mRatBN7.2 Ensembl458,476,657 - 58,531,060 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000133936   ⟹   ENSRNOP00000108445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,438,526 - 59,497,492 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000138735   ⟹   ENSRNOP00000107350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,348,217 - 59,497,492 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000158595   ⟹   ENSRNOP00000103278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl459,348,699 - 59,496,351 (+)Ensembl
RefSeq Acc Id: NM_001173510   ⟹   NP_001166981
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,348,747 - 59,498,503 (+)NCBI
mRatBN7.2458,381,290 - 58,531,061 (+)NCBI
Rnor_6.0457,050,241 - 57,199,870 (+)NCBI
Rnor_5.0456,817,402 - 56,967,031 (+)NCBI
Celera453,483,136 - 53,632,390 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236194   ⟹   XP_006236256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,439,776 - 59,498,503 (+)NCBI
mRatBN7.2458,476,336 - 58,531,061 (+)NCBI
Rnor_6.0457,145,056 - 57,199,870 (+)NCBI
Rnor_5.0456,817,402 - 56,967,031 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762771   ⟹   XP_008760993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,382,710 - 59,498,503 (+)NCBI
mRatBN7.2458,470,791 - 58,531,061 (+)NCBI
Rnor_6.0457,139,367 - 57,199,870 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063285980   ⟹   XP_063142050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,433,651 - 59,498,503 (+)NCBI
RefSeq Acc Id: XM_063285981   ⟹   XP_063142051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8459,382,837 - 59,498,503 (+)NCBI
RefSeq Acc Id: NP_001166981   ⟸   NM_001173510
- UniProtKB: D3ZWL6 (UniProtKB/TrEMBL),   A6IEE7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236256   ⟸   XM_006236194
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A7Z2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760993   ⟸   XM_008762771
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ABA9 (UniProtKB/TrEMBL),   A0A8I6A7Z2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025165   ⟸   ENSRNOT00000025165
Ensembl Acc Id: ENSRNOP00000078402   ⟸   ENSRNOT00000102598
Ensembl Acc Id: ENSRNOP00000087181   ⟸   ENSRNOT00000109374
Ensembl Acc Id: ENSRNOP00000091272   ⟸   ENSRNOT00000100143
RefSeq Acc Id: XP_063142051   ⟸   XM_063285981
- Peptide Label: isoform X3
- UniProtKB: A0A8I5ZKU2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142050   ⟸   XM_063285980
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A7Z2 (UniProtKB/TrEMBL),   A0A8I6ABA9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000107350   ⟸   ENSRNOT00000138735
Ensembl Acc Id: ENSRNOP00000103278   ⟸   ENSRNOT00000158595
Ensembl Acc Id: ENSRNOP00000108445   ⟸   ENSRNOT00000133936
Protein Domains
S-adenosyl-L-homocysteine hydrolase NAD binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWL6-F1-model_v2 AlphaFold D3ZWL6 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692930
Promoter ID:EPDNEW_R3455
Type:initiation region
Name:Ahcyl2_1
Description:adenosylhomocysteinase-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0457,050,228 - 57,050,288EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1564895 AgrOrtholog
BioCyc Gene G2FUF-45379 BioCyc
BioCyc Pathway METHIONINE-DEG1-PWY [L-methionine degradation I (to L-homocysteine)] BioCyc
  PWY-5041 [S-adenosyl-L-methionine salvage II] BioCyc
BioCyc Pathway Image METHIONINE-DEG1-PWY BioCyc
  PWY-5041 BioCyc
Ensembl Genes ENSRNOG00000039300 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025165.9 UniProtKB/TrEMBL
  ENSRNOT00000100143 ENTREZGENE
  ENSRNOT00000100143.2 UniProtKB/TrEMBL
  ENSRNOT00000102598 ENTREZGENE
  ENSRNOT00000102598.2 UniProtKB/TrEMBL
  ENSRNOT00000109374 ENTREZGENE
  ENSRNOT00000109374.2 UniProtKB/TrEMBL
  ENSRNOT00000133936 ENTREZGENE
  ENSRNOT00000133936.1 UniProtKB/TrEMBL
  ENSRNOT00000138735.1 UniProtKB/TrEMBL
  ENSRNOT00000158595.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1480 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Adenosylhomocyst_ase-like_sf UniProtKB/TrEMBL
  Ado_hCys_hydrolase_NAD-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  S-Ado-L-homoCys_hydrolase UniProtKB/TrEMBL
  S-Ado-L-homoCys_hydrolase_CS UniProtKB/TrEMBL
KEGG Report rno:312192 UniProtKB/TrEMBL
NCBI Gene 312192 ENTREZGENE
PANTHER Ad_hcy_hydrolase UniProtKB/TrEMBL
  ADENOSYLHOMOCYSTEINASE 3 UniProtKB/TrEMBL
Pfam AdoHcyase UniProtKB/TrEMBL
  AdoHcyase_NAD UniProtKB/TrEMBL
PhenoGen Ahcyl2 PhenoGen
PIRSF Ad_hcy_hydrolase UniProtKB/TrEMBL
PROSITE ADOHCYASE_1 UniProtKB/TrEMBL
  ADOHCYASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039300 RatGTEx
SMART AdoHcyase UniProtKB/TrEMBL
  AdoHcyase_NAD UniProtKB/TrEMBL
Superfamily-SCOP Formate/glycerate dehydrogenase catalytic domain-like UniProtKB/TrEMBL
  SSF51735 UniProtKB/TrEMBL
UniProt A0A8I5ZKU2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7Z2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABA9 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LG11_RAT UniProtKB/TrEMBL
  A0ABK0LNC2_RAT UniProtKB/TrEMBL
  A0ABK0M0X5_RAT UniProtKB/TrEMBL
  A6IEE7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWL6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-09-17 Ahcyl2  adenosylhomocysteinase-like 2  Ahcyl2  S-adenosylhomocysteine hydrolase-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Ahcyl2  S-adenosylhomocysteine hydrolase-like 2  RGD1564895_predicted  similar to RIKEN cDNA 4631427C17 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1564895_predicted  similar to RIKEN cDNA 4631427C17 (predicted)  LOC312192  similar to RIKEN cDNA 4631427C17  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC312192  similar to RIKEN cDNA 4631427C17      Symbol and Name status set to provisional 70820 PROVISIONAL