| The following 193 regions match your request. |
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Matches on Chr1
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| RGD620112 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| RGD620112 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| RGD620112 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| Cited2 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| Cited2.t01 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| Cited2 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| Cited2.t01 | transcription factor coactivator; may be involved in angiogenesis | Chr1:12.72..12.72 Mbp (2.444 kbp) | score=10.48 |
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| Vegfb.t01 | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| RGD619799 | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| Vegfb.t01 | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| Vegfb | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| RGD619799 | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| Vegfb | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| RGD619799 | mouse homolog is a growth factor; involved in the promotion of angiogenesis | Chr1:209.7..209.7 Mbp (3.64 kbp) | score=10.25 |
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| RGD1322186 | The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration. [provided by RefSeq] | Chr1:53.59..53.63 Mbp (38.26 kbp) | score=7.33 |
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| RGD10241 | This gene encodes a member of the carcinoembryonic antigen (CEA) gene family‚ which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family‚ the CEA cell adhesion molecules and the pregnancy-specific glycoproteins‚ are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently‚ it was found to be a cell-cell adhesion molecule detected on leukocytes‚ epithelia‚ and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein‚ including roles in the differentiation and arrangement of tissue three-dimensional structure‚ angiogenesis‚ apoptosis‚ tumor suppression‚ metastasis‚ and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported‚ but the full-length nature of only two has been determined. [provided by RefSeq] | Chr1:79.64..79.66 Mbp (21.18 kbp) | score=5.25 |
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Matches on Chr10
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| Tnfsf12.t01 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| RGD1359620 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| Tnfsf12.t01 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| Tnfsf12 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| RGD1359620 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| RGD1359620 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| Tnfsf12 | may activate NF-kappaB and induce angiogenesis and apoptosis | Chr10:56.5..56.51 Mbp (9.298 kbp) | score=10.48 |
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| Baiap2 | brain-specific angiogenesis inhibitor 1-associated protein 2 | Chr10:109.4..109.4 Mbp (62.5 kbp) | score=10.48 |
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| Baiap2.t01 | brain-specific angiogenesis inhibitor 1-associated protein 2 | Chr10:109.4..109.4 Mbp (62.5 kbp) | score=10.48 |
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| RGD619814 | brain-specific angiogenesis inhibitor 1-associated protein 2 | Chr10:109.4..109.4 Mbp (62.5 kbp) | score=10.48 |
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| RGD631369 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| Serpinf1 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| Serpinf1.t01 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| Serpinf1 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| RGD631369 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| Serpinf1.t01 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| RGD631369 | serine protease inhibitor‚ inhibits angiogenesis‚ may be involved in the pathogenesis of diabetic nephropathy | Chr10:62.71..62.74 Mbp (26 kbp) | score=10.04 |
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| Tnfrsf12a | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| RGD631329 | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| RGD631329 | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| Tnfrsf12a.t01 | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| Tnfrsf12a.t01 | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| Tnfrsf12a | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| RGD631329 | human homolog is a receptor that binds TWEAK‚ a member of the TNF family‚ and is involved in cell proliferation‚ adhesion and angiogenesis | Chr10:12.94..12.94 Mbp (2.014 kbp) | score=9.73 |
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| RGD2050 | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| Adora2b | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| Adora2b.t01 | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| Adora2b | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| Adora2b.t01 | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| RGD2050 | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| RGD2050 | regulates renal medulla blood flow and sodium excretion; involved in angiogenesis and blood vessel remodeling after injury | Chr10:48.42..48.44 Mbp (16.38 kbp) | score=9.20 |
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| RGD732926 | The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein‚ which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene‚ which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins‚ which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function. [provided by RefSeq] | Chr10:109.3..109.4 Mbp (82.27 kbp) | score=6.24 |
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| RGD1350160 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF‚ but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells‚ and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977‚ TNFSF12-TNFSF13. [provided by RefSeq] | Chr10:53.98..53.99 Mbp (8.833 kbp) | score=6.15 |
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| RGD1606584 | Chemokines are a group of small (approximately 8 to 14 kD)‚ mostly basic‚ structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane‚ G protein-coupled receptors. Chemokines also play fundamental roles in the development‚ homeostasis‚ and function of the immune system‚ and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies‚ CXC and CC‚ based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al.‚ 2002 [PubMed 11821900]).[supplied by OMIM] | Chr10:90.23..90.23 Mbp (2.426 kbp) | score=5.83 |
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Matches on Chr14
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| RGD620714 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| Fgfr3.t01 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| RGD620714 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| Fgfr3.t01 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| Fgfr3 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| RGD620714 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| Fgfr3 | may play a role in regulation and differentiation of various cell types‚ in the processes of regeneration‚ angiogenesis‚ and chemotaxis | Chr14:82.68..82.7 Mbp (14.04 kbp) | score=9.93 |
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| RGD1343759 | Chemokines are a group of small (approximately 8 to 14 kD)‚ mostly basic‚ structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane‚ G protein-coupled receptors. Chemokines also play fundamental roles in the development‚ homeostasis‚ and function of the immune system‚ and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies‚ CXC and CC‚ based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CXC chemokines are further subdivided into ELR and non-ELR types based on the presence or absence of a glu-leu-arg sequence adjacent and N terminal to the CXC motif. ELR types are chemotactic for neutrophils‚ while non-ELR types are chemotactic for lymphocytes.[supplied by OMIM] | Chr14:23.8..23.8 Mbp (1.845 kbp) | score=5.90 |
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| RGD1316122 | Chemokines are a group of small (approximately 8 to 14 kD)‚ mostly basic‚ structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane‚ G protein-coupled receptors. Chemokines also play fundamental roles in the development‚ homeostasis‚ and function of the immune system‚ and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies‚ CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq] | Chr14:11.76..11.77 Mbp (2.399 kbp) | score=5.85 |
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Matches on Chr15
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| RGD1347278 | This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature‚ secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] | Chr15:60.99..61.03 Mbp (36.55 kbp) | score=5.62 |
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Matches on Chr16
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| RGD621861 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| Angpt2.t01 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| RGD621861 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| Angpt2 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| Angpt2 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| RGD621861 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| Angpt2.t01 | endothelial cell tyrosine kinase receptor ligand; involved in the modulation of angiogenesis‚ vascular regression and endothelial cell survival | Chr16:75.89..75.94 Mbp (50.7 kbp) | score=8.73 |
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| RGD619800 | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| Vegfc.t01 | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| Vegfc.t01 | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| Vegfc | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| RGD619800 | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| Vegfc | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| RGD619800 | platelet-derived growth factor/vascular derived growth factor (PDGF/VEGF); active in angiogenesis and endothelial cell growth | Chr16:40.62..40.74 Mbp (115.3 kbp) | score=8.02 |
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| RGD1317652 | This gene encodes one of the six subunits of type IV collagen‚ the major structural component of basement membranes. The C-terminal portion of the protein‚ known as canstatin‚ is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family‚ this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq] | Chr16:87.27..87.47 Mbp (205.7 kbp) | score=7.19 |
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| RGD732214 | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family‚ is active in angiogenesis and endothelial cell growth‚ and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation‚ generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D. [provided by RefSeq] | Chr16:40.65..40.76 Mbp (109.2 kbp) | score=6.21 |
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Matches on Chr17
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| RGD1352881 | This gene encodes a member of the EDG family of receptors‚ which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq] | Chr17:18.23..18.25 Mbp (13.56 kbp) | score=8.37 |
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Matches on Chr19
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| RGD621316 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| Mmp2.t01 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| Mmp2.t01 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| RGD621316 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| RGD621316 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| Mmp2 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| Mmp2 | plays important roles in wound healing‚ angiogenesis‚ platelet aggregation‚ and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli | Chr19:15.25..15.27 Mbp (28.71 kbp) | score=9.18 |
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| RGD733081 | NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis‚ axon guidance‚ cell survival‚ migration‚ and invasion.[supplied by OMIM] | Chr19:56.95..57.11 Mbp (157.4 kbp) | score=8.05 |
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Matches on Chr2
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| RGD1310888 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| Aggf1.t01 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| Aggf1.t01 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| Aggf1 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| Aggf1 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| RGD1310888 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| RGD1310888 | human homolog plays a role in angiogenesis | Chr2:25.72..25.76 Mbp (35.83 kbp) | score=10.48 |
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| RGD2606 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.87..50.94 Mbp (73.52 kbp) | score=9.73 |
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| Fgf10 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.87..50.94 Mbp (73.52 kbp) | score=9.73 |
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| RGD2606 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.87..50.94 Mbp (73.52 kbp) | score=9.73 |
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| Fgf10 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.87..50.94 Mbp (73.52 kbp) | score=9.73 |
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| RGD2606 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.87..50.94 Mbp (73.52 kbp) | score=9.73 |
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| Fgf10.t01 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.93..50.94 Mbp (7.375 kbp) | score=9.73 |
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| Fgf10.t01 | binds the KGFR receptor‚ a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis | Chr2:50.93..50.94 Mbp (7.375 kbp) | score=9.73 |
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| RGD735257 | FGF2 (MIM 134920) is a highly conserved‚ multifunctional heparin-binding growth factor involved in neuroectoderm development‚ angiogenesis‚ and wound healing. Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene‚ NUDT6‚ may regulate FGF2 expression.[supplied by OMIM] | Chr2:123.4..123.5 Mbp (30.32 kbp) | score=7.75 |
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| RGD1344147 | The protein encoded by this gene is a cytokine that is specifically induced by apoptosis‚ and it is involved in the control of angiogenesis‚ inflammation‚ and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit‚ which is associated with the multi-tRNA synthetase complex‚ and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq] | Chr2:229..229 Mbp (31.9 kbp) | score=6.30 |
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Matches on Chr20
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| Col18a1.t01 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
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| RGD70936 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
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| Col18a1 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
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| RGD70936 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
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| Col18a1 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
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| RGD70936 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
|---|
| Col18a1.t01 | intermediate filament protein; a precursor of the angiogenesis inhibitor endostatin | Chr20:11.87..11.98 Mbp (110.9 kbp) | score=10.25 |
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Matches on Chr3
|
|---|
| RGD1316792 | Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq] | Chr3:142.2..142.3 Mbp (43.66 kbp) | score=12.30 |
|---|
| RGD1353227 | Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. The protein encoded by this gene is an integral membrane protein and G protein-coupled receptor for prokineticins. The encoded protein is similar in sequence to GPR73‚ another G protein-coupled receptor for prokineticins. [provided by RefSeq] | Chr3:120.8..120.8 Mbp (12.33 kbp) | score=7.25 |
|---|
| RGD736739 | Prostaglandin-endoperoxide synthase (PTGS)‚ also known as cyclooxygenase‚ is the key enzyme in prostaglandin biosynthesis‚ and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2‚ which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1‚ which regulates angiogenesis in endothelial cells‚ and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq] | Chr3:16.5..16.52 Mbp (24.75 kbp) | score=6.30 |
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Matches on Chr4
|
|---|
| Lep.t01 | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| RGD3000 | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| Lep | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| Lep.t01 | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| RGD3000 | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| Lep | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| RGD3000 | involved in regulation of body weight; may have a role in angiogenesis | Chr4:55.93..55.95 Mbp (11.54 kbp) | score=10.36 |
|---|
| RGD69123 | This gene encodes a protein that is secreted by white adipocytes‚ and which plays a major role in the regulation of body weight. This protein‚ which acts through the leptin receptor‚ functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions‚ and is involved in the regulation of immune and inflammatory responses‚ hematopoiesis‚ angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity‚ and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq] | Chr4:55.08..55.1 Mbp (16.35 kbp) | score=6.41 |
|---|
| RGD70837 | Hepatocyte growth factor regulates cell growth‚ cell motility‚ and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis‚ cell motility‚ and matrix invasion gives it a central role in angiogenesis‚ tumorogenesis‚ and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active‚ heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq] | Chr4:15.06..15.13 Mbp (68.01 kbp) | score=5.48 |
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Matches on Chr5
|
|---|
| RGD1319770 | BAI1‚ a p53-target gene‚ encodes brain-specific angiogenesis inhibitor‚ a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure‚ have similar tissue specificities and may also play a role in angiogenesis. [provided by RefSeq] | Chr5:149.3..149.3 Mbp (36.93 kbp) | score=15.51 |
|---|
| RGD1309431 | brain-specific angiogenesis inhibitor 2 (predicted) | Chr5:149..149 Mbp (38.92 kbp) | score=10.48 |
|---|
| Bai2 | brain-specific angiogenesis inhibitor 2 (predicted) | Chr5:149..149 Mbp (38.92 kbp) | score=10.48 |
|---|
| Bai2.t01 | similar to brain-specific angiogenesis inhibitor 2 | Chr5:149..149 Mbp (31.89 kbp) | score=10.48 |
|---|
| Wasf2.t01 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| Wasf2.t01 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| RGD1307299 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| Wasf2 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| RGD1307299 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| Wasf2 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| RGD1307299 | exhibits actin binding; invovled in actin cytoskelton organization and biogenesis‚ G-protein signaling‚ Rac protein signal transduction‚ ameboidal cell migration‚ endocytosis‚ lamellipodium biogeneisis‚ angiogenesis (homolog) | Chr5:151.9..151.9 Mbp (18.07 kbp) | score=8.47 |
|---|
| RGD1346260 | The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver‚ and has the characteristic structure of angiopoietins‚ consisting of a signal peptide‚ N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins‚ and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. [provided by RefSeq] | Chr5:119.5..119.5 Mbp (7.994 kbp) | score=7.00 |
|---|
| RGD737096 | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells‚ but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases‚ and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation‚ and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq] | Chr5:81.17..81.19 Mbp (16.81 kbp) | score=6.11 |
|---|
Matches on Chr7
|
|---|
| RGD1313737 | Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth‚ tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron‚ and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes‚ designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures‚ however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family‚ an inhibitor of angiogenesis and a growth suppressor of glioblastomas | Chr7:113.1..113.1 Mbp (80.99 kbp) | score=14.01 |
|---|
| RGD1305608 | brain-specific angiogenesis inhibitor 1 (predicted) | Chr7:112.6..112.7 Mbp (61.15 kbp) | score=10.48 |
|---|
| Bai1 | brain-specific angiogenesis inhibitor 1 (predicted) | Chr7:112.6..112.7 Mbp (61.15 kbp) | score=10.48 |
|---|
| Bai1.t01 | similar to brain-specific angiogenesis inhibitor 1 | Chr7:112.6..112.7 Mbp (61.15 kbp) | score=10.48 |
|---|
| RGD1605693 | This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1)‚ a key regulator of the hypoxic response and angiogenesis‚ and promotes the degradation of one of its subunits. Alternate transcriptional splice variants‚ encoding different isoforms‚ have been characterized. [provided by RefSeq] | Chr7:67.87..67.9 Mbp (27.45 kbp) | score=8.31 |
|---|
| RGD1313979 | This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced variants‚ encoding the same protein‚ have been identified. [provided by RefSeq] | Chr7:128.3..128.3 Mbp (4.275 kbp) | score=7.60 |
|---|
| RGD733136 | Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability‚ and may be involved in early development of the heart. [provided by RefSeq] | Chr7:78.82..79.07 Mbp (248.5 kbp) | score=6.76 |
|---|
Matches on Chr8
|
|---|
| Ubp1.t01 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (51.57 kbp) | score=9.73 |
|---|
| Ubp1.t01 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (51.57 kbp) | score=9.73 |
|---|
| RGD1564700 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (52.1 kbp) | score=9.73 |
|---|
| RGD1564700 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (52.1 kbp) | score=9.73 |
|---|
| Ubp1 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (52.1 kbp) | score=9.73 |
|---|
| Ubp1 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (52.1 kbp) | score=9.73 |
|---|
| RGD1564700 | mouse homolog is a member of the grainyhead transcription factor family; appears to have a function in regulation of extraembryonic angiogenesis | Chr8:118.6..118.6 Mbp (52.1 kbp) | score=9.73 |
|---|
| Cspg4.t01 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| RGD619942 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| Cspg4.t01 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| RGD619942 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| Cspg4 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| Cspg4 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| RGD619942 | extracellular matrix protein secreted by many cell types; member of the large chondroitin sulfate proteoglycan (CSPG) family; may be involved with angiogenesis -dependent processes such as wound healing or tumor growth | Chr8:60.61..60.65 Mbp (35.04 kbp) | score=8.92 |
|---|
| Plcd1.t01 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
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| RGD3346 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
|---|
| RGD3346 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
|---|
| Plcd1 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
|---|
| RGD3346 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
|---|
| Plcd1 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
|---|
| Plcd1.t01 | exhibits calcium binding‚ hydrolase activity‚ phosphoinositide phospholipase C activity‚ signal transducer activity; involved in angiogenesis‚ intracellular signaling cascade‚ lipid catabolism and metabolism and placenta development (homolog) | Chr8:124..124.1 Mbp (29.1 kbp) | score=8.54 |
|---|
| RGD737053 | Angiomotin is a protein that binds angiostatin‚ a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family. [provided by RefSeq] | Chr8:107.4..107.4 Mbp (19.22 kbp) | score=7.53 |
|---|
| RGD1347259 | The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1‚ RANTES‚ TARC and MCP-1. Chemokines are a group of small polypeptide‚ structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development‚ homeostasis‚ and function of the immune system‚ and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq] | Chr8:116.6..116.6 Mbp (3.338 kbp) | score=6.98 |
|---|
| RGD1318322 | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules‚ including a propeptide region‚ a metalloproteinase domain‚ a disintegrin-like domain‚ and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs‚ and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs‚ and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene‚ most notably lung neoplasms. [provided by RefSeq] | Chr8:29.69..29.71 Mbp (23.72 kbp) | score=6.18 |
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Matches on Chr9
|
|---|
| RGD1320187 | This p53-target gene encodes a brain-specific angiogenesis inhibitor‚ a seven-span transmembrane protein‚ and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure‚ have similar tissue specificities‚ and may also play a role in angiogenesis. [provided by RefSeq] | Chr9:30.86..31.61 Mbp (753.8 kbp) | score=15.87 |
|---|
| RGD1309703 | brain-specific angiogenesis inhibitor 3 (predicted) | Chr9:23.76..24.5 Mbp (736.5 kbp) | score=10.48 |
|---|
| Bai3 | brain-specific angiogenesis inhibitor 3 (predicted) | Chr9:23.76..24.5 Mbp (736.5 kbp) | score=10.48 |
|---|
| Bai3.t01 | similar to Brain-specific angiogenesis inhibitor 3 precursor | Chr9:23.76..24.49 Mbp (733.2 kbp) | score=10.36 |
|---|
| RGD620776 | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| Ptprm.t01 | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| Ptprm.t01 | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| Ptprm | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| RGD620776 | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| Ptprm | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| RGD620776 | expressed in blood capillaries in the developing nervous system; may play a role in angiogenesis | Chr9:105.8..106.5 Mbp (718.2 kbp) | score=10.04 |
|---|
| RGD619991 | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| Vegfa.t01 | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| Vegfa.t01 | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| RGD619991 | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| Vegfa | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| RGD619991 | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| Vegfa | mediates broad spectrum of biological processes‚ including stimulating cell proliferation‚ inducing cell migration‚ promoting cell survival‚ and regulating physiological and pathological angiogenesis | Chr9:10.52..10.53 Mbp (12.44 kbp) | score=8.70 |
|---|
| RGD1322840 | The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells‚ and has been shown to stimulate the production of several other cytokines‚ including IL6‚ IL8‚ and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2‚ TGFB1/TGFB‚ and monocyte chemoattractant protein-1. [provided by RefSeq] | Chr9:19.35..19.36 Mbp (7.815 kbp) | score=7.36 |
|---|
| RGD731073 | This gene product is a member of the PDGF/VEGF growth factor family. It is a mitogen that specifically acts on endothelial cells and has various effects‚ including mediating increased vascular permeability‚ inducing angiogenesis‚ vasculogenesis‚ endothelial cell growth‚ promoting cell migration‚ and inhibiting apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Also‚ alternative translation initiation from non-AUG (CUG) and AUG start sites in some transcript variants‚ give rise to additional isoforms. [provided by RefSeq] | Chr9:15.61..15.63 Mbp (14.76 kbp) | score=6.62 |
|---|
| RGD731072 | This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects‚ including mediating increased vascular permeability‚ inducing angiogenesis‚ vasculogenesis and endothelial cell growth‚ promoting cell migration‚ and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome‚ also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants‚ encoding either freely secreted or cell-associated isoforms‚ have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of‚ and in-frame with the first AUG‚ leading to additional isoforms. [provided by RefSeq] | Chr9:10.44..10.46 Mbp (16.27 kbp) | score=5.83 |
|---|
Matches on ChrX
|
|---|
| RGD620938 | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| RGD620938 | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| Tnmd.t01 | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| Tnmd | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| Tnmd | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| Tnmd.t01 | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| RGD620938 | transmembrane protein; may be an angiogenesis inhibitor; may play a regulatory role in eye and skeletal muscle development | ChrX:121.4..121.4 Mbp (15.46 kbp) | score=9.93 |
|---|
| RGD731830 | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis‚ lymphangiogenesis‚ and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation‚ generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. [provided by RefSeq] | ChrX:52.1..52.14 Mbp (38.86 kbp) | score=6.73 |
|---|
